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| 1 | 评估大气细颗粒物暴露引起的全球疾病负担的一个综合风险函数显示文摘[背景]评估由于环境空气中细颗粒物(PM2.5)长期暴露引起的疾病负担,需要了解相对风险度(RR)函数的图形和幅度。然而,在世界上很多观察到高PM2.5环境浓度的地方,都缺乏足够的直接证据确定死亡RR函数的图形。[目的]建立可用于全球PM2.5暴露范围内成人死因的RR函数:缺血性心脏病(IHD)、脑血管疾病(脑卒中)、慢性阻塞性肺病(COPD)和肺癌(LC)。建立急性下呼吸道感染(ALRI)发病的RR函数,用于估算〈5岁的儿童中死亡率和健康生活损失年数。[方法]通过整合现有的来自于环境空气污染(AAP)、二手烟草烟雾、家用固体烹饪用燃料和主动吸烟(AS)等研究的RR信息,拟合综合暴露-反应(IER)模型。采用颗粒物质的吸入剂量,通过转化AS暴露来估计全年PM2.5的暴露当量。在估算全球环境PM2.5浓度的基础上,得出各国的人群归因分数(PAFs)。[结果]与以往负担评估中使用的其他7种模型相比,IER模型是一种优越的RR预测方法。在不同国家中,归因于AAP暴露的PAF百分数各不相同,分别为:IHD,2~41;脑卒中,1~43;COPD,〈1~21;LC,〈1~25;ALRI,〈1~38。[结论]我们建立了一种以细颗粒物为基础的RR模型,它通过整合来自不同类型的燃烧所产生颗粒物排放的RR信息,涵盖全球范围的暴露。当获得新的RR信息时,可以对这个模型进行更新。 | Richard T.Burnett C.Arden Pope III Majid Ezzati Casey Olives Stephen S.Lim Sumi Mehta Hwashin H.Shin Gitanjali Singh Bryan Hubbell Michael Brauer H.Ross Anderson Kirk R.Smith John R.Balmes Nigel G.Bruce Haidong Kan Francine Laden Annette Prüss-Ustün Michelle C.Turner Susan M.Gapstur W.Ryan Diver Aaron Cohen 何蓉 张伊人 金泰廙 | 2014 | 环境与职业医学2014，31，11： | 80 |
| 2 | Competition between human cells by entosis显示文摘人的癌由被知道为营养素和生长因素间接地竞争的肿瘤房间的复杂混合物组成。肿瘤房间是否能也直接竞争,例如由对手的消除,不被知道。这里,我们证明人的房间能直接由称为 entosis 的吞没的机制竞争。由 entosis,当时,房间被吞没,或吃活,并且随后经历房间死亡。我们发现吞没的身份(“ winner”) 并且吞没(“ loser”) 房间被 RhoA 和肌动球朊控制的机械 deformability 支配,有高 deformability 的肿瘤房间在此优先地吞没并且 outcompete 有在异构的人口的低 deformability 的附近的房间。我们进一步发现那激活的 Kras 并且 Rac 发信号由 downregulating 给予获胜者地位到房间可收缩的肌浆球蛋白,允许最后经历房间死亡的附近的房间的成为主观。最后,我们计算 cell-in-cell 形成的精力风景,表明那一机械在获胜者和输家房间之间微分被要求让 entosis 继续。这些数据在发生在人的肿瘤的哺乳动物的房间定义竞争的机制。 | Qiang Sun Tianzhi Luo Yixin Ren Oliver Florey Senji Shirasawa Takehiko Sasazuki Douglas N Robinson Michael Overholtzer | 2014 | Cell Research2014，24，11： | 8 |
| 3 | Long-Term Follow-Up of Biopsy-Proven Viral Myocarditis显示文摘 | Stefan Grün Julia Schumm Simon Greulich Anja Wagner Steffen Schneider Oliver Bruder Eva-Maria Kispert Stephan Hill Peter Ong Karin Klingel Reinhardt Kandolf Udo Sechtem Heiko Mahrholdt | 2012 | Journal of the American College of Cardiology2012，，18： | 2 |
| 4 | Harnessing the power of immersive virtual reality-visualization and analysis of 3D earth science data sets显示文摘The availability and quantity of remotely sensed and terrestrial geospatial data sets are on the rise.Historically,these data sets have been analyzed and quarried on 2D desktop computers;however,immersive technologies and specifically immersive virtual reality(iVR)allow for the integration,visualization,analysis,and exploration of these 3D geospatial data sets.iVR can deliver remote and large-scale geospatial data sets to the laboratory,providing embodied experiences of field sites across the earth and beyond.We describe a workflow for the ingestion of geospatial data sets and the development of an iVR workbench,and present the application of these for an experience of Iceland’s Thrihnukar volcano where we:(1)combined satellite imagery with terrain elevation data to create a basic reconstruction of the physical site;(2)used terrestrial LiDAR data to provide a geo-referenced point cloud model of the magmatic-volcanic system,as well as the LiDAR intensity values for the identification of rock types;and(3)used Structure-from-Motion(SfM)to construct a photorealistic point cloud of the inside volcano.The workbench provides tools for the direct manipulation of the georeferenced data sets,including scaling,rotation,and translation,and a suite of geometric measurement tools,including length,area,and volume.Future developments will be inspired by an ongoing user study that formally evaluates the workbench’s mature components in the context of fieldwork and analyses activities. | Jiayan Zhao Jan Oliver Wallgrün Peter C.LaFemina Jim Normandeau Alexander Klippel | 2019 | Geo-Spatial Information Science2019，22，4： | 2 |
| 5 | Where are we now?Re-visiting the Digital Earth through human-centered virtual and augmented reality geovisualization environments显示文摘The original Digital Earth concept,formulated by Al Gore(1998),is essentially a virtual reality system.In this(imagined)system,users are able to freely explore all possible recorded knowledge or information about the Earth though an interactive interface.While we imagine such an interface primarily as visual for now,it can be expected that in the future other senses will be engaged,allowing for even more realistic virtual experiences.Even though‘realism’in the experience is desirable(i.e.,it feels real),immersive experiences provided by visualization environments can go beyond reality,as they can be enhanced with queryable information.Of course one can also create fictitious experiences and simulations in such environments;including information about possible pasts(e.g.,ancient Rome)and futures(e.g.,a planned neighborhood);or spaces that we cannot(easily)directly experience(e.g.,the Moon,Mars,other far-away spaces,under the oceans,core of the earth,etc.). | Arzu Çöltekin Danielle Oprean Jan Oliver Wallgrün Alexander Klippel | 2019 | International Journal of Digital Earth2019，12，2： | 2 |
| 6 | CMR Imaging Predicts Death and Other Adverse Events in Suspected Cardiac Sarcoidosis显示文摘 | Simon Greulich Claudia Christina Deluigi Steffen Gloekler Andreas Wahl Christine Zürn Ulrich Kramer Detlev Nothnagel Helmut Bültel Julia Schumm Stefan Grün Peter Ong Anja Wagner Steffen Schneider Kai Nassenstein Meinrad Gawaz Udo Sechtem Oliver Bruder Hei | 2013 | JACC: Cardiovascular Imaging2013，，： | 2 |
| 7 | The relative effects of deformation and thermal advection on fluid pathways in basin-related mineralization显示文摘 | Mclellan J G Oliver N H S Hobbs B E | 2006 | Journal of Geochemical Exploration2006，89，： | 1 |
| 8 | Compliance and results of treatment for amblyopia in children more than 8 years old显示文摘 | Oliver M Neumann R Chaimoviteh Y Gotesman N Shimshoni M | 1986 | Am J Ophthalmol1986，15，： | 1 |
| 9 | On the Measurement of Stress-strain Curves by Spherical Indentation显示文摘 | E G Herbert G M Pharr W C Oliver B N Lucas J L Hay | 2001 | Thin Solid Films2001，，： | 1 |
| 10 | A Bayesian computer vision system for modeling human interactions显示文摘 | Oliver N M Rosario B Pentland A P | 2000 | IEEE Trans PAMI2000，22，8： | 1 |
| 11 | Deciphering the biology of My cobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole S T Brosch R Parkhill J Gamier T Churcher C Harris D Gordon S V Eiglmeier K Gas S Barry C E Tekaia F Badcock K Basham D Brown D Chillingworth T Cormor R Davies R Devlin K FeltweU T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Kroghs A McLean J Moule S Murphy L Oliver K Osborne J Quail M A Rafandream M A Rogers J Rutter S Seeger K Skelton J Squaraes R Squares S Sulston J E Taylo K Whitehead S Barrell B G | 1998 | Nature1998，393，： | 1 |
| 12 | Indentation power-law creepof high-purity indium 显示文摘 | LUCAS B N OLIVER W C | 1999 | Metallurgical and MaterialsTransactions A1999，30，3： | 1 |
| 13 | Effect of feed deprivation and lairage time on carcass and meat quality traits on pigs under minimal stressful conditions显示文摘 | Panella-Riera N Gispert M Gil M Soler J Tibau J Oliver M A Velarde A Fàbrega E | | 0，，01： | 1 |
| 14 | OMEGA EP high-energy petawatt laser: progress and prospects显示文摘 | D N Maywar J H Kelly L J Waxer S F B Morse I A Begishev J Bromage C Dorrer J L Edwards L Folnsbee M J Guardalben S D Jacobs R Jungquist T J Kessler R W Kidder B E Kruschwitz S J Loucks J R Marciante R L McCrory D D Meyerhofer A V Okishev J B Oliver G Pien | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 15 | An antidia2betic thiazolidinedione is a high affinity ligand for peroxisome proliferator activated receptor gamma 显示文摘 | Lehmann J N Moore L B Smith Oliver T A | 1995 | J Biol Chem1995，270，12： | 1 |
| 16 | Prevention of atrial fibrillation with 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors显示文摘 | Oliver A Hans-Ruprecht N Michael B | 2008 | Circulation2008，118，： | 1 |
| 17 | Determina-tion of carbonyl content in oxidatively modified pro-teins显示文摘 | Levine R L Garland D Oliver C N | 1990 | Methods in Enzymology1990，，： | 1 |
| 18 | Long-term follow-up of occlusion therapy in amblyopia 显示文摘 | Shimshoni M Oliver M Gottesman N Levartovsky S | 2001 | Ophthalmology2001，108，9： | 1 |
| 19 | Effect of temperature on alkane extraction from faeces and herbage显示文摘 | Osoro K | 1999 | J Agri Sci Cambridge1999，132，： | 1 |
| 20 | LAFTER:a real-time face and lips tracker with facial expression recognition显示文摘 | PENTLAND A ERARD F B | 2000 | Pattern Recognition2000，33，： | 1 |
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