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| 1 | Is diabetes a causal agent for colorectal cancer? Pathophysiological and molecular mechanisms显示文摘The possible relationship between diabetes mellitus (DM) and colorectal cancer (CRC), concerning pathophysiological and molecular mechanisms is highlighted in this review. The most recent and complete articles and developments in this particular field were thoroughly reviewed. Common risk factors, such as obesity, sedentary lifestyle, and Western diet between DM and CRC, led to the theory that DM might be a causal agent for CRC development. Various studies have connected type 2 DM and CRC, either proximal or distal, in both sexes. Additionally, chronic insulin treatment has been linked with increased colorectal tumor risk among type 2 diabetic patients. Interestingly, elevated hemoglobin A1c has been proven to be an independent predictor of aggressive clinical behavior in CRC patients. These mechanisms include the insulin-like growth factor-hyperinsulinemia theory and the participation of oncogenic intracellular signaling pathways. Furthermore, it has been proposed that Cox-2 inhibitors might have a role in decreasing the incidence of CRC. Finally, the use of statins to reduce the risk for colon cancer in patients with diabetes has remained controversial. Diabetic patients over 50 should receive counseling regarding their elevated risk for CRC, and screening colonoscopy should be recommended before initiating insulin therapy. However, there are no current guidelines, and this strategy is not yet applicable to some countries, as the corresponding risk would not allow screening colonoscopy to be adopted. There is strong evidence to indicate that DM is a causal agent for CRC development. This conclusion provides new impetus for re-evaluating CRC screening worldwide. | Olga Giouleme Michael D Diamantidis Marios G Katsaros | 2011 | World Journal of Gastroenterology2011，17，4： | 15 |
| 2 | Preassembly and ligand-induced restructuring of the chains of the IFN-γ receptor complex: the roles of Jak kinases, Statl and the receptor chains显示文摘 | Christopher D Krause Natasha Lavnikova Junxia Xie Erwen Mei Olga V Mirochnitchenko Yiwei Jia Robin M Hochstrasser Sidney Pestka | 2006 | Cell Research2006，16，1： | 7 |
| 3 | Effects of glutamine supplementation on gut barrier,glutathione content and acute phase response in malnourished rats during inflammatory shock显示文摘AIM: To evaluate the effect of glutamine on intestinal mucosa integrity,glutathione stores and acute phase response in protein-depleted rats during an inflammatory shock. METHODS: Plasma acute phase proteins (APP),jejunal APP mRNA levels,liver and jejunal glutathione concentrations were measured before and one,three and seven days after turpentine injection in 4 groups of control,protein-restricted,protein-restricted rats supplemented with glutamine or protein powder. Bacterial translocation in mesenteric lymph nodes and intestinal morphology were also assessed. RESULTS: Protein deprivation and turpentine injection significantly reduced jejunal villus height,and crypt depths. Mucosal glutathione concentration significantly decreased in protein-restricted rats. Before turpentine oil,glutamine supplementation restored villus heights and glutathione concentration (3.24 ± 1.05 vs 1.72 ± 0.46 μmol/g tissue,P < 0.05) in the jejunum,whereas in the liver glutathione remained low. Glutamine markedly increased jejunal α1-acid glycoprotein mRNA level after turpentine oil but did not affect its plasma concentration. Bacterial translocation in protein-restricted rats was not prevented by glutamine or protein powder supplementation. CONCLUSION: Glutamine restored gut glutathione stores and villus heights in malnourished rats but had no preventive effect on bacterial translocation in our model. | Liliana Belmonte Mose Co■ffier Florence Le Pessot Olga Miralles-Barrachina Martine Hiron Antony Leplingard Jean-Franois Lemeland Bernadette Hecketsweiler Maryvonne Daveau Philippe Ducrotté Pierre Déchelotte | 2007 | World Journal of Gastroenterology2007，13，20： | 6 |
| 4 | GP73, a resident Golgi glycoprotein, is a novel serum marker for hepatocellular carcinoma显示文摘 | Jorge A. Marrero Patrick R. Romano Olga Nikolaeva Laura Steel Anand Mehta Claus J. Fimmel Mary Ann Comunale Anthony D’Amelio Anna S. Lok Timothy M. Block | 2005 | Journal of Hepatology2005，，6： | 5 |
| 5 | The presence of ANP in rat peritoneal mast cells显示文摘Atrial natriuretic peptide (ANP) is an important component of the natriuretic peptide system. A great role in many regulatory systems is played by mast cells. Meanwhile involvement of these cells in ANP activity is poorly studied. In this work, we have shown the presence of ANP in rat peritoneal mast cells. Pure fraction of mast cells was obtained by separation of rat peritoneal cells on a Percoll density gradient. By Western blotting, two ANP-immunoreactive proteins of molecular masses of 2.5 kDa and 16.9 kDa were detected in lysates from these mast cells. Electron microscope immunogold labeling has revealed the presence of ANP-immunoreactive material in storage, secreting and released granules of mast cells. Our findings indicate the rat peritoneal mast cells to contain both ANP prohormone and ANP. These both peptides are located in mast cell secretory granules and released by mechanism of degranulation. It is discussed that many mast cell functions might be due to production of natriuretic peptides by these cells. | Marina G MARTYNOVA Olga A BYSTROVA Olga M MOISEEVA Anton L EVDONIN Kirill A KONDRATOV Natalja D MEDVEDEVA | 2005 | Cell Research2005，15，10： | 3 |
| 6 | Panax ginseng natural populations: their past, current state and perspectives显示文摘瞄准:人参属人参,遗传和它 Primorye (俄国) 的自然人口的个体发生的结构的交配系统被调查。方法:基因差异用紧密相联的酶和荧光灯地基于的自动化放大碎片长度多型性(AFLP ) 和简单顺序被估计重复(SSR ) 标记。结果:在种类水平的全部的基因差异与紧密相联的酶是低的试金(0.023 ) ,和有 AFLP (0.255 ) 和 SSR (0.259 ) 的高度方法。它根据紧密相联的酶(>99%) 在人口以内被观察, AFLP (>85%) ,和 SSR (>73%) 试金。基因可变性分发的索引指出开拓殖民地在早 Holocene 在温暖的时期期间从南部的避难处由人参的 Sikhote-Alin 种。到异花受粉和自花传粉的人参植物的能力被显示出,人参属人参是容许的单性生殖的植物的假设被证实。人参的繁殖系统拥有授精进程的高粘性和稳定性帮助种类处于压力条件幸存。外部或内部的因素引起的骚乱能由于人参小卵或单性生殖的胚胎开发的形态基因的潜力被减少。因为一些生活阶段是不在的或很少发生,人参人口的生活阶段结构的分析证明所有他们不是完整成分的。结论:在所有 3 张人口,处女和年轻生产个人是占优势的。人口学习了的这个工具是可行的,自然人参人口的再介绍还是可能的。 | Yuri N ZHURAVLEV Olga G KOREN Galina D REUNOVA Tamara I MUZAROK Tatiyana Yu GORPENCHENKO Irina L KATS Yuliya A KHROLENKO | 2008 | Acta Pharmacologica Sinica2008，29，9： | 3 |
| 7 | Trabecular Bone Score: A Noninvasive Analytical Method Based Upon the DXA Image显示文摘 | Barbara C Silva William D Leslie Heinrich Resch Olivier Lamy Olga Lesnyak Neil Binkley Eugene V McCloskey John A Kanis John P Bilezikian | 2014 | J Bone Miner Res2014，，3： | 2 |
| 8 | Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db / db Mice显示文摘 | Hong Chen Olga Charlat Louis A Tartaglia Elizabeth A Woolf Xun Weng Stephen J Ellis Nathan D Lakey Janice Culpepper Karen J More Roger E Breitbart Geoffrey M Duyk Robert I Tepper Jay P Morgenstern | 1996 | Cell1996，，3： | 2 |
| 9 | Impact of ovine whey protein concentrates and clarification by products on the yield and quality of whey cheese显示文摘 | CARLOS D P OLGA D ANGEL C | 2007 | Food Technology Biotechnology2007，4，2： | 1 |
| 10 | Anodic stripping voltammetry of arsenic using gold nanoparticle - modified electrodes 显示文摘 | Xuan D Olga N Michael E H | 2004 | Anal Chem2004，76，： | 1 |
| 11 | Pipe inspection using a laser-based trans- ducer and automated analysis techniques显示文摘 | OLGA D | 2003 | IEEE2003，8，3： | 1 |
| 12 | Sol-gel based fabrication and characterization of new bioactive glass-ceramic composites for dental applications显示文摘 | Xanthippi Chatzistavrou Olga Tsigkou Harsh D Amin Konstantinos M Paraskevopoulos Vehid Salih Aldo R Boccaccini | | 0，，： | 1 |
| 13 | Regeneration of hepatocyte ‘buds’ in cirrhosis from intrabiliary stem cells显示文摘 | Olga Falkowski Hee Jung An I.Andreea Ianus Luis Chiriboga Herman Yee A.Brian West Neil D Theise | 2003 | Journal of Hepatology2003，，3： | 1 |
| 14 | Flavonoids can replace α -tocopherol as an antioxidant显示文摘 | Fr é d é rique A A Schouten Olga | 2000 | FEBS Letters2000，473，2： | 1 |
| 15 | GP73, a resident Golgi glycoprotein, is a novel serum marker for hepatocellular carcinoma显示文摘 | Jorge A. Marrero Patrick R. Romano Olga Nikolaeva Laura Steel Anand Mehta Claus J. Fimmel Mary Ann Comunale Anthony D’Amelio Anna S. Lok Timothy M. Block | 2005 | Journal of Hepatology2005，，6： | 1 |
| 16 | Benzene and toluene gas-phase photocatalytic degradation over H 2 O and HCL pretreated TiO 2 : by-products and mechanisms显示文摘 | Olga d'Hennezel Pierre Pichat David F Ollis | 1998 | Journal of Photochemistry & Photobiology A: Chemistry1998，，3： | 1 |
| 17 | STM study of the geometric and electronic structure of ZnO (0001)-Zn, (000 i )-O, (10 i 0), and (11 0) surfaces显示文摘 | OLGA D LYNN A B ULRIKE D | 2002 | Surface Science2002，519，3： | 1 |
| 18 | Reactivity of Benzoyl Peroxide/ Amine System as an Initiator for Free Radical Polymerization of Dental and Orthopaedic Dimethacrylate Monomers : Effect of the A- mine and Monomer Chemical Structure 显示文摘 | Irini D S Dimitris S A Olga K | 2006 | Macromoleeules2006，39，： | 1 |
| 19 | Integration of the FISH pachytene and genetic maps of Medicago truncatula显示文摘 | Gustavo G Rene A G Kim Dong-Jin Cook D | 2001 | The Plant Journal2001，27，1： | 1 |
| 20 | Caspases and programmed cell death in the hypersensitive response of plants to pathogens显示文摘 | OLGA D P ERIC L | 1998 | Current Biology1998，8，： | 1 |
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