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| 1 | Diffusion-weighted magnetic resonance imaging to predict response of hepatocellular carcinoma to chemoembolization显示文摘AIM: To investigate whether intra-procedural diffusion- weighted magnetic resonance imaging can predict response of hepatocellular carcinoma (HCC) during trans- catheter arterial chemoembolization (TACE). METHODS: Sixteen patients (15 male), aged 59 ±11 years (range: 42-81 years) underwent a total of 21 separate treatments for unresectable HCC in a hybrid magnetic resonance/interventional radiology suite. Ana- tomical imaging and diffusion-weighted imaging (b = 0, 500 s/mm2) were performed on a 1.5-T unit. Tumor enhancement and apparent diffusion coefficient (ADC, mm2/s) values were assessed immediately before and at 1 and 3 mo after TACE. We calculated the percent change (PC) in ADC values at all time points. We compared follow-up ADC values to baseline values using a paired t test (α = 0.05). RESULTS: The intra-procedural sensitivity, specificity, and positive and negative predictive values (%) for detecting a complete or partial 1-mo tumor response using ADC PC thresholds of ±5%, ±10%, and ±15% were 77, 67, 91, and 40; 54, 67, 88, and 25; and 46, 100, 100, and 30, respectively. There was no clear predictive value for the 3-mo follow-up. Compared to baseline, the immediate post-procedure and 1-mo mean ADC values both increased; the latter obtaining statistical significance (1.48 ± 0.29 mm2/s vs 1.65 ± 0.35 × 10-3 mm2/s, P < 0.014). CONCLUSION: Intra-procedural ADC changes of > 15% predicted 1-mo anatomical HCC response with the greatest accuracy, and can provide valuable feedback at the time of TACE. | Johnathan C Chung Neel K Naik Robert J Lewandowski Mary F Mulcahy Laura M Kulik Kent T Sato Robert K Ryu Riad Salem Andrew C Larson Reed A Omary | 2010 | World Journal of Gastroenterology2010，16，25： | 13 |
| 2 | Augmented reality assisted surgery: a urologic training tool显示文摘扩充现实广泛地在航空学被使用并且是在外科以内的一个发展中的概念。在这个预研项目,我们在古格尔·格拉斯 ® 上为使用开发了一个应用程序训练在怎么放可膨胀的阴茎修复术的泌尿学居民的光装头的显示。我们使用扩充的短语现实帮助了外科在外科的设置描述扩充现实的这个新奇应用程序。应用程序表明可膨胀的阴茎修复术放置的外科的过程的步。它也包含允许的软件用一个照相机的点从光装头的显示喂使教师能在阴茎修复术的放置期间与居民一起交往的兴趣的察觉。自愿参加学习的泌尿学受训练者和教师被给时间经历技术在起作用或 perioperative 背景并且要求完成反馈调查。从用 10 点规模的 30 个全部的参加者,教育实用性被评估 8.6,航行的容易被评估 7.6,到使用的可能性的被评估 7.4,并且在操作空间的分心被评估 4.9。当在受训练者和教师之间成层时,受训练者发现技术更教育有用,并且少些分散。总的来说, 81% 参加者在他们的住处程序想要这种技术,并且 93% 以后在操作房间里看见这种技术。这种技术的进一步的开发在完整的版本前被保证,并且进一步的研究是必要的更好描绘扩充现实的有效性在泌尿科的外科的训练的帮助外科。 | Ryan M Dickey Neel Srikishen Larry I Lipshultz Philippe E Spiess Rafael E Carrion Tariq S Hakky | 2016 | Asian Journal of Andrology2016，18，5： | 6 |
| 3 | Outcomes of submucosal(T1b) esophageal adenocarcinomas removed by endoscopic mucosal resection显示文摘AIM To investigate the outcomes and recurrences of p T1 b esophageal adenocarcinoma(EAC) following endoscopic mucosal resection(EMR) and associated treatments.METHODS Patients undergoing EMR with pathologically confirmed T1 b EAC at two academic referral centers were retrospectively identified.Patients were divided into 4 groups based on treatment following EMR:Endoscopic therapy alone(group A),endoscopic therapy with either chemotherapy,radiation or both(group B),surgicalresection(group C) or no further treatment/lost to follow-up(<12 mo)(group D).Pathology specimens were reviewed by a central pathologist.Follow-up data was obtained from the academic centers,primary care physicians and/or referring physicians.Univariate analysis was performed to identify factors predicting recurrence of EAC.RESULTS Fifty-three patients with T1 b EAC underwent EMR,of which 32(60%) had adequate follow-up ≥ 12 mo(median 34 mo,range 12-103).There were 16 patients in group A,9 in group B,7 in group C and 21 in group D.Median follow-up in groups A to C was 34 mo(range 12-103).Recurrent EAC developed overall in 9 patients(28%) including 6(38%) in group A(median:21 mo,range:6-73),1(11%) in group B(median:30 mo,range:30-30) and 2(29%) in group C(median 21 mo,range:7-35.Six of 9 recurrences were local;of the 6 recurrences,5 were treated with endoscopy alone.No predictors of recurrence of EAC were identified.CONCLUSION Endoscopic therapy of T1 b EAC may be a reasonable strategy for a subset of patients including those either refusing or medically unfit for esophagectomy. | Darren D Ballard Neel Choksi Jingmei Lin Eun-Young Choi B Joseph Elmunzer Henry Appelman Douglas K Rex Hala Fatima William Kessler John M DeWitt | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，20： | 2 |
| 4 | IL 28 B genotype is not useful for predicting treatment outcome in A sian chronic hepatitis B patients treated with pegylated interferon‐α显示文摘 | Jacinta A Holmes Tin Nguyen Dilip Ratnam Neel M Heerasing Jane V Tehan Sara Bonanzinga Anouk Dev Sally Bell Stephen Pianko Robert Chen Kumar Visvanathan Rachel Hammond David Iser Ferry Rusli William Sievert Paul V Desmond D Scott Bowden Alexander J Thomps | 2013 | J Gastroenterol Hepatol2013，，5： | 2 |
| 5 | The role of Shp2 ( PTPN11 ) in cancer显示文摘 | M Golam Mohi Benjamin G Neel | 2007 | Current Opinion in Genetics & Development2007，，1： | 1 |
| 6 | High prevalence of methicillin resistant Staphylococcus aureusin pigs显示文摘 | De Neeling A J Van den Broek M J M Spalburg E C | 2007 | Vet Microbiol2007，122，： | 1 |
| 7 | Electro-optical missile plume deteetion显示文摘 | Neele F P Sehleijpen H M A | 2003 | SPIE2003，5075，： | 1 |
| 8 | Does Mandatory Adop- tion of IFRS Improve Accounting Quality? Preliminary Evidence 显示文摘 | Ahmed A S Neel M Wang D | 2013 | Contemporary Accounting Research2013，30，04： | 1 |
| 9 | Macrophage polarization: the epigcnetic point of view显示文摘 | Van den Bossche J Neele A E Hoeksema M A | 2014 | Curt' Opin Lipidol2014，25，5： | 1 |
| 10 | Chloroplast DNA diversity in populations of wild and cultivated barley显示文摘 | Neele D B Saghai M A Allard R W | 1988 | Genetics1988，120，： | 1 |
| 11 | Protein-tyrosine phosphatae 1B is required for HER2/Neu-induced breast cancer 显示文摘 | Bentires-Alj M Neel BG | 2007 | Cancer Res2007，67，6： | 1 |
| 12 | Benefits of the paraspinal muscle - sparing approach versus the conventional midline approach for poste- rior nonfusion stabilization:comparative analysis of clinical and func- tional outcomes显示文摘 | Neel A Eli M B Robert S B | 2007 | SAS Journal2007，1，： | 1 |
| 13 | Autoamplification of tumor necrosis factor-alpha- a potential mechanism for the maintenance of elevated tumor necrosis factor- alpha in male but not female obese mice 显示文摘 | Neels JG Pandey M Hotamisligil GS | 2006 | Am J Pathol2006，168，： | 1 |
| 14 | Behavior of class- level landscape metrics across gradients of class aggregation andarea显示文摘 | NEEL M C MCGARIGAL K CUSHMAN S A | 2004 | Landscape Ecology2004，19，： | 1 |
| 15 | L&p&roscopic Common BHe Duct Expior&tion显示文摘 | Neel&mek&m T K B&l&ch&ndr&n P | 2010 | World2010，5，2： | 1 |
| 16 | Fractional diffusion and reflective boundary condition显示文摘 | KREPYSHEVA N PIETRO L D NEEL M C | 2006 | Physica A2006，368，： | 1 |
| 17 | Protein - tyrosine phosphatase 1B is required for HER2/Neu - induced breast cancer 显示文摘 | Bentires - Ali M Neel BG | 2007 | Cancer Res2007，67，6： | 1 |
| 18 | Parsimony in landscape metrics : Strength, universality, and consistency显示文摘 | Cushman S A McGarigal K Neel M C | 2008 | Ecological Indicators2008，8，5： | 1 |
| 19 | Patterns of allozyme diversity in the threatened plant Erigeron pariskii (Asteraeeae) 显示文摘 | Neel M C Ellstrand N C | 2001 | American Journal of Botany2001，88，5： | 1 |
| 20 | High prevalence of methicillin-resistant Staphylococcus aureus in pigs 显示文摘 | DE NEELING A J VAN DEN BROEK M J M SPALBURG E C | 2007 | Vet Microbiol2007，122，34： | 1 |
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