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| 1 | Diagnostic endoscopic ultrasonography:Assessment of safety and prevention of complications显示文摘Endoscopic ultrasonography (EUS) has gained wide acceptance as an important, minimally invasive diagnostic tool in gastroenterology, pulmonology, visceral surgery and oncology. This review focuses on data regarding risks and complications of non-interventional diagnostic EUS and EUS-guided fine-needle biopsy (EUS-FNB). Measures to improve the safety of EUS und EUS-FNB will be discussed. Due to the specific mechanical properties of echoendoscopes in EUS, there is a low but noteworthy risk of perforation. To minimize this risk, endoscopists should be familiar with the specific features of their equipment and their patients' specific anatomical situations (e.g., tumor stenosis, diverticula). Most diagnostic EUS complications occur during EUS-FNB. Pain, acute pancreatitis, infection and bleeding are the primary adverse effects, occurring in 1% to 2% ofpatients. Only a few cases of needle tract seeding and peritoneal dissemination have been reported. The mortality associated with EUS and EUS-FNB is 0.02%. The risks associated with EUS-FNB are affected by endoscopist experience and target lesion. EUS-FNB of cystic lesions is associated with an increased risk of infection and hemorrhage. Peri-interventional antibiotics are recommended to prevent cyst infection. Adequate education and training, as well consideration of contraindications, are essential to minimize the risks of EUS and EUS-FNB. Restricting EUS-FNB only to patients in whom the cytopathological results may be expected to change the course of management is the best way of reducing the number of complications. | Christian Jenssen Maria Victoria Alvarez-Sánchez Bertrand Napoléon Siegbert Faiss | 2012 | World Journal of Gastroenterology2012，18，34： | 33 |
| 2 | Review of endoscopic radiofrequency in biliopancreatic tumours with emphasis on clinical benefits, controversies and safety显示文摘Most pancreatic cancers and extrahepatic cholangiocarcinomas are unresectable at the time of diagnosis, and even in case of a resectable cancer, for elderly or patients with coexistent comorbidities, surgery is not an option. Current treatment alternatives in these scenarios are very limited. Biliary stenting with selfexpanding metal stents(SEMS) is the mainstay palliative treatment of biliary obstruction due to unresectable pancreatic cancer or cholangiocarcinoma. Nevertheless, more than 50% of SEMS become occluded after 6 mo due to tumour over- and ingrowth, leading to hospital readmissions and reinterventions that significantly impair quality of life. Regimes of chemotherapy or chemoradiotherapy also provide minimal survival benefits. Therefore, novel therapies are eagerly awaited. Radiofrequency(RF) energy causes coagulative necrosis leading to local destruction of the accessed malignant tissue and has an established role in the treatment of malignancies in several solid organs, especially liver cancers. However, pancreatic and extrahepatic biliary cancers are not easily accessed by a percutaneous route, making the procedure dangerous. Over the past five years, the development of dedicated devices compatible with endoscopic instruments has offered a minimally invasive option for RF energy delivery in biliopancreatic cancers. Emerging experience with endoscopic RF ablation(RFA) in this setting has been reported in the literature, but little is known about its feasibility, efficacy and safety. A literature review makes it clear that RFA in biliopancreatic tumours is feasible with high rates of technical success and acceptable safety profile. Although available data suggest a benefit of survival with RFA, there is not enough evidence to draw a firm conclusion about its efficacy. For this reason, prospective randomized trials comparing RFA with standard palliative treatments with quality-of-life and survival endpoints are required. Anecdotal reportshave also highlighted a potential curative role of RFA in small pancreatic tumours and benign conditions, such as ductal extension of ampullomas, intrahepatic adenomas or non-tumoural biliary strictures. These newest indications also deserve further examination in larger series of studies. | María-Victoria Alvarez-Sánchez Bertrand Napoléon | 2016 | World Journal of Gastroenterology2016，22，37： | 16 |
| 3 | Contrast-enhanced harmonic endoscopic ultrasound imaging: Basic principles, present situation and future perspectives显示文摘Over the last decade, the development of stabilised microbubble contrast agents and improvements in available ultrasonic equipment, such as harmonic imaging, have enabled us to display microbubble enhancements on a greyscale with optimal contrast and spatial resolution. Recent technological advances made contrast harmonic technology available for endoscopic ultrasound(EUS) for the first time in 2008. Thus, the evaluation of microcirculation is now feasible with EUS, prompting the evolution of contrast-enhanced EUS from vascular imaging to images of the perfused tissue. Although the relevant experience is still preliminary, several reports have highlighted contrast-enhanced harmonic EUS(CHEUS) as a promising noninvasive method to visualise and characterise lesions and to differentiate benign from malignant focal lesions. Even if histology remains the gold standard, the combination of CH-EUS and EUS fine needle aspiration(EUS-FNA) can not only render EUS more accurate but may also assist physicians inmaking decisions when EUS-FNA is inconclusive,increasing the yield of EUS-FNA by guiding the puncture with simultaneous imaging of the vascularity.The development of CH-EUS has also opened up exciting possibilities in other research areas,including monitoring responses to anticancer chemotherapy or to ethanolinduced pancreatic tissue ablation,anticancer therapies based on ultrasound-triggered drug and gene delivery,and therapeutic adjuvants by contrast ultrasound-induced apoptosis.Contrast harmonic imaging is gaining popularity because of its efficacy,simplicity and noninvasive nature,and many expectations are currently resting on this technique.If its potential is confirmed in the near future,contrast harmonic imaging will become a standard practice in EUS. | María-Victoria Alvarez-Sánchez Bertrand Napoléon | 2014 | World Journal of Gastroenterology2014，20，42： | 7 |
| 4 | New horizons in the endoscopic ultrasonography-based diagnosis of pancreatic cystic lesions显示文摘Pancreatic cystic lesions(PCLs) are increasingly being identified because of the widespread use of highresolution abdominal imaging. These cysts encompass a spectrum from malignant disease to benign lesions, and therefore, accurate diagnosis is crucial to determine the best management strategy, either surgical resection or surveillance. However, the current standard of diagnosis is not accurate enough due to limitations of imaging and tissue sampling techniques, which entail the risk of unnecessary burdensome surgery for benign lesions or missed opportunities of prophylactic surgery for potentially malignant PCLs. In the last decade, endoscopic innovations based on endoscopic ultrasonography(EUS) imaging have emerged, aiming to overcome the present limitations. These new EUS-based technologies are contrast harmonic EUS, needle-based confocal endomicroscopy, through-the-needle cystoscopy and through-the needle intracystic biopsy. Here, we present a comprehensive and critical review of these emerging endoscopic tools for the diagnosis of PCLs, with a special emphasis on feasibility, safety and diagnostic performance. | María-Victoria Alvarez-Sánchez Bertrand Napoléon | 2018 | World Journal of Gastroenterology2018，24，26： | 3 |
| 5 | Interventional endoscopic ultrasonography: an overview of safety and complications显示文摘 | María Victoria Alvarez-Sánchez Christian Jenssen Siegbert Faiss Bertrand Napoléon | 2014 | Surgical Endoscopy2014，，3： | 2 |
| 6 | Statin effects beyond lipid lowering are they clinically relevant显示文摘 | Bonetti PO Leman LO Napolic C | 2003 | Eur Heart J2003，24，3： | 1 |
| 7 | Variations in inflammatory markers in acute myocardial infarction:a longitudinal study显示文摘 | Napole(a)o P Santos MC Selas M | 2007 | Rev Port Cardiol2007，26，12： | 1 |
| 8 | Urine metabolic signa- ture of pancreatic ductal adenocarcinoma by (1) h nuclear magnetic resonance: identification, evolution 显示文摘 | Napoll C Sperandio N Lawlor R T | 2012 | Jmapping and Proteome Res2012，11，2： | 1 |
| 9 | A flexible selective harmonic mitigation technique to meet grid codes in three-level PWM converters 显示文摘 | Franquelo L G Napoles J Guisado R C P | 2007 | IEEE Transactions on Industrial Electronics2007，54，6： | 1 |
| 10 | Polycomb group proteins Ring1A/B Link ubiquitylation of histone H2A to heritable gene silencing and X inactivation显示文摘 | Napoles M Jacqueline EM Wakao R | 2004 | Developmental Cell2004，7，： | 1 |
| 11 | Groundwater quality monitoring显示文摘 | Belgiorno V Napol R M A | 2000 | Water Sei Teehnol2000，42，12： | 1 |
| 12 | Selective harmonic mitigation technique for high-power converters显示文摘 | Napoles J Leon J I Portillo R | 2010 | IEEE Transactions on Industrial Electronics2010，57，7： | 1 |
| 13 | Transforming growth factor-beta 1 and insulin-like growth factor-1 expression in ovarian endometriotic cysts:a preliminary study显示文摘 | Loverro G Maiorano E Napol I A | 2001 | Int J mole med2001，7，4： | 1 |
| 14 | Effect of Moringa oleifera lectins on survival and enzyme activities of Aedes aegypti larvae susceptible and resistant to organophosphate显示文摘 | Afonso Cordeiro Agra-Neto Thiago Henrique Napole?o Emmanuel Viana Pontual Nataly Diniz Lima Santos Luciana Andrade Luz Cláudia Maria Fontes Oliveira Maria Alice Varjal Melo-Santos Luana Cassandra Breitenbach Barroso Coelho Daniela Maria Amaral Ferraz Nava | 2014 | Parasitology Research2014，，1： | 1 |
| 15 | Chronic treatment with rosuvastatin modulates nitric oxide synthase expression and reduces ischemia-reperfusion injury in rat hearts显示文摘 | Di Napoll P Taceardi AA Grilli A | 2005 | Cardiovasc Res2005，66，3： | 1 |
| 16 | The Brazilian version of Shoulder Pain and Disability Index: translation, cultural adaptation and reliability显示文摘 | Martins J Napoles BV Hoffman CB | 2010 | Rev Bras Fisioter2010，14，6： | 1 |
| 17 | Synthesis of filamentary iron nanoparticles in a mesoporous silica matrix显示文摘 | Napol'skii K S Kolesnik I V Eliseev A A | 2002 | Doklady Chemistry2002，386，13： | 1 |
| 18 | The efficacy and safety of duodenal stenting: a prospective multicenter study显示文摘 | I. Graber R. Dumas B. Filoche J. Boyer D. Coumaros H. Lamouliatte J. Legoux B. Napoléon T. Ponchon | 2007 | Endoscopy2007，，09： | 1 |
| 19 | Groundwater quality monitoring显示文摘 | BELGIORNO V NAPOLL R M | 2000 | Water Science Technology2000，42，12： | 1 |
| 20 | Introduction of a chalacome synthase gene into Petunia results in reversible co-suppression of homologous genes in trans显示文摘 | Napolic C Lemirux C Jorgensen R | 1990 | Plant Cell1990，2，： | 1 |
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