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| 1 | Microfluidic actuators based on temperature-responsive hydrogels显示文摘The concept of using stimuli-responsive hydrogels to actuate fluids in microfluidic devices is particularly attractive,but limitations,in terms of spatial resolution,speed,reliability and integration,have hindered its development during the past two decades.By patterning and grafting poly(N-isopropylacrylamide)PNIPAM hydrogel films on plane substrates with a 2μm horizontal resolution and closing the system afterward,we have succeeded in unblocking bottlenecks that thermo-sensitive hydrogel technology has been challenged with until now.In this paper,we demonstrate,for the first time with this technology,devices with up to 7800 actuated micro-cages that sequester and release solutes,along with valves actuated individually with closing and opening switching times of 0.6±0.1 and 0.25±0.15 s,respectively.Two applications of this technology are illustrated in the domain of single cell handling and the nuclear acid amplification test(NAAT)for the Human Synaptojanin 1 gene,which is suspected to be involved in several neurodegenerative diseases such as Parkinson’s disease.The performance of the temperature-responsive hydrogels we demonstrate here suggests that in association with their moderate costs,hydrogels may represent an alternative to the actuation or handling techniques currently used in microfluidics,that are,pressure actuated polydimethylsiloxane(PDMS)valves and droplets. | Loïc D'Eramo Benjamin Chollet Marie Leman Ekkachai Martwong Mengxing Li Hubert Geisler Jules Dupire Margaux Kerdraon Clémence Vergne Fabrice Monti Yvette Tran Patrick Tabeling | 2018 | Microsystems & Nanoengineering2018，4，1： | 3 |
| 2 | Statin effects beyond lipid lowering are they clinically relevant显示文摘 | Bonetti PO Leman LO Napolic C | 2003 | Eur Heart J2003，24，3： | 1 |
| 3 | Kidney in early atherosclerosis显示文摘 | Leman A Leman LO | 2005 | Hypertension2005，45，： | 1 |
| 4 | Endothelial dysfunction, a markerof abterosclerotie risk 显示文摘 | Boneti PO Leman LO leman A | 2003 | Arterioseler Thromb Vase Bio2003，23，： | 1 |
| 5 | Statin effects be- yond lipid lowering:are they clinically relevant 显示文摘 | Bonetti PO Leman LO Napoli C | 2003 | Eur Heart J2003，24，： | 1 |
| 6 | Endothelial dysfunction, a mark- er of atheroselerotie risk 显示文摘 | Bonetti PO Leman LO Lerman A | 2003 | Arterioseler Thromb Vase Biol2003，23，4： | 1 |
| 7 | Endothelial dysfunction: a marker of athemsclerotic risk 显示文摘 | Bonetti PO Lezrnan LO Leman A | 2003 | Arterioscler Thromb Vasc Biol2003，23，2： | 1 |
| 8 | Statin 6 effects beyondlowenig-are they clinically relevant显示文摘 | Bonetti po Leman Lo Napoli C Leman A | 2003 | Eur Heart J2003，24，： | 1 |
| 9 | Cardiac production of angiotensin Ⅱ and its pharmacologic inhibition:effects on the coronary circulation显示文摘 | Schmerand A Leman LO Rmitman E L | 1999 | Mayo Chin Proc1999，74，： | 1 |
| 10 | Endothelial dysfunction,a marker of ahterosclerotic risk显示文摘 | Boneti PO Leman LO Leman A | 2003 | Arterioscler Thromb Vase Bio2003，23，： | 1 |
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