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| 1 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 2 | Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013显示文摘 | Marie Ng Tom Fleming Margaret Robinson Blake Thomson Nicholas Graetz Christopher Margono Erin C Mullany Stan Biryukov Cristiana Abbafati Semaw Ferede Abera Jerry P Abraham Niveen M E Abu-Rmeileh Tom Achoki Fadia S AlBuhairan Zewdie A Alemu Rafael Alfonso | 2014 | The Lancet2014，，： | 7 |
| 3 | Irritable bowel syndrome显示文摘 | Alexander C Ford Nicholas J Talley | 2012 | BMJ (sep )2012，，041： | 4 |
| 4 | Barrett’s metaplasia glands are clonal, contain multiple stem cells and share a common squamous progenitor显示文摘 | Anna M Nicholson Trevor A Graham Ashley Simpson Adam Humphries Nicola Burch Manuel Rodriguez-Justo Marco Novelli Rebecca Harrison Nicholas A Wright Stuart A C McDonald Janusz A Jankowski | 2012 | Gut2012，，10： | 3 |
| 5 | Apoptosis of osteocytes in glucocorticoid-induced osteonecrosis of the hip显示文摘 | WEINSTEIN R S NICHOLAS R W MANOLAGAS S C | 2000 | J Clin Endocrinol Metab2000，85，8： | 1 |
| 6 | Helicobacer pylori initiate or perpetuate immune thrombocytopenic purpura? 显示文摘 | Marc M Nichola C Christelle J | 2004 | Blood2004，103，3： | 1 |
| 7 | Ediacaran-Cambrian Sirab Formation of the A1 Huqf region, Sultanate of Oman 显示文摘 | Nicholas C J Gold S E P | 2012 | Geo Arabia Journal of the Middle East Petroleum Geosciences2012，17，1： | 1 |
| 8 | Structural and mechanistic investigation of a phosphatemodified HZSM-5 catalyst for methanol conversion显示文摘 | Abubakar S M Marcus D M Lee J C Ehresmann J O Chen C Y Kletnieks P W Guenther D R Hayman M J Pavlova M Nicholas J B Haw J F | | 0，，10： | 1 |
| 9 | Quality of life and depression following childbirth : impact of social support 显示文摘 | Webster J Nicholas C Velacott C | 2011 | Midwifery2011，27，5： | 1 |
| 10 | The influence of highcarbohydrate meals with different glycaemic indices on substrate utilisation during subsequent exercise显示文摘 | Wu CL Nicholas C Williams C | 2003 | Br J Nutr2003，90，6： | 1 |
| 11 | Field and laboratory studies of Desmodora cazca Gerlach,1956 (Desmodoridae:Nematoda) from mangrove mud-flats显示文摘 | Nicholas W L Stewart A C Marples T G | 1988 | Nematologica1988，34，3： | 1 |
| 12 | Tourism dynamics: Cyprus' hotel value chain and profitability显示文摘 | Nicholas C G | 2003 | System Dynamics Review2003，19，3： | 1 |
| 13 | Cholinergie neu- ronal and axonal abnormalities are present early in aging and in Alzheime' s disease 显示文摘 | Geula C Nagykery N Nicholas A | 2008 | J Neuropathol Exp Neu- rol2008，67，2： | 1 |
| 14 | An observational study comparing quality of care in walk-in centres with general practice and NHS Direct using standardized patients显示文摘 | Grant C Nicholas R Moore L | 2002 | BMJ2002，324，7353： | 1 |
| 15 | Increased number of coagulation products in relationship to red blood cell products transfused improves mortality in trauma patients显示文摘 | Shaz BH Dente C J Nicholas J | 2010 | Transfusion2010，50，2： | 1 |
| 16 | Prediction and evaluation of sintering aids for cerium gadolinium oxide显示文摘 | Nicholas J D de Jonghe L C | | 0，，： | 1 |
| 17 | Plant antitumor agents(29): Synthesis and biological activity of ring D and ring E modified analogues of camptothecin显示文摘 | Nicholas A W Wani M C Manikumar G | 1990 | J Med Chem1990，33，3： | 1 |
| 18 | Remote instrument diagnosis on the internet显示文摘 | Nicholas H M C Bernard B C David M H | 1998 | IEEE Intelligent System & Their Application1998，13，3： | 1 |
| 19 | Corporate financing and in-vestment decisions when firms have information that investors do not have显示文摘 | Myers Stewart C Nicholas S Majluf | 1984 | Journal of Financial Economics1984，，： | 1 |
| 20 | African Americans,hypertension and the renin angiotensin system显示文摘African Americans have exceptionally high rates of hypertension and hypertension related complications. It is commonly reported that the blood pressure lowering efficacy of renin angiotensin system(RAS) inhibitors is attenuated in African Americans due to a greater likelihood of having a low renin profile. Therefore these agents are often not recommended as initial therapy in African Americans with hypertension. However, the high prevalence of comorbid conditions, such as diabetes, cardiovascular and chronic kidney disease makes treatment with RAS inhibitors more compelling. Despite lower circulating renin levels and a less significant fall in blood pressure in response to RAS inhibitors in African Americans, numerous clinical trials support the efficacy of RAS inhibitors to improve clinical outcomes in this population, especially in those with hypertension and risk factors for cardiovascular and related diseases. Here, we discuss the rationale of RAS blockade as part of a comprehensive approach to attenuate the high rates of premature morbidity and mortality associated with hypertension among African Americans. | Sandra F Williams Susanne B Nicholas Nosratola D Vaziri Keith C Norris | 2014 | World Journal of Cardiology2014，6，9： | 1 |
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