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| 1 | 超声微泡作为基因或药物载体的研究进展显示文摘随着新型超声微泡造影剂的研究和应用,超声微泡不仅能增强超声造影,而且也能作为运送基因或药物的载体。在超声作用下,含基因或药物的微泡能穿透血管内皮,释放基因或药物,达到靶向治疗目的。本文综述了超声微泡的生物学效应、制备和应用等方面的研究进展。 | 沈圆圆 高钟镐 Natalya Rapoport | 2009 | 药学学报2009，44，9： | 12 |
| 2 | Association of Streptococcus bovis presence in colonic content with advanced colonic lesion显示文摘AIM:To prospectively examine the association between presence of Streptococcus bovis(S.bovis)in colonic suction fluid and the endoscopic findings on colonoscopy.METHODS:From May 2012 to March 2013,203 consecutivepatients who underwent colonoscopy for any reason were enrolled in the study.Exclusion criteria included:antibiotic use in the previous month,age younger than18 years,and inadequate preparation for colonoscopy.The colonoscopy was performed for the total length of the colon or to the occluding tumor.The endoscopic findings were registered.Samples were obtained proximal to the colonoscopic part of the suction tube from each patient and sent to the clinical microbiology laboratory for isolation and identification of S.bovis.Samples were incubated in enrichment media with addition of antibiotic disks for inhibition of growth of Gram-negative rods.The samples were seeded on differential growth media;suspected positive colonies were isolated and identified with Gram staining,catalase,and pyrrolidonyl arylamidase tests,and further identified using a VITEK2 system.Statistical analyses were performed using the Student’s t andχ2 tests.RESULTS:Of the 203 patients recruited,49(24%)patients were found to be S.bovis carriers;of them,the endoscopic findings included:17(34.7%)cases with malignant tumors,11(22.4%)with large polyps,5(10.2%)with medium-sized polyps,6(12.2%)with small polyps,4(8.1%)with colitis,and 6(12.2%)normal colonoscopies.Of 154 patients found negative for S.bovis,the endoscopic findings included:none with malignant tumors,9(5.8%)cases with large polyps,11(7.1%)with medium-sized polyps,26(16.9%)with small polyps,7(4.5%)with colitis,and101(65.6%)normal colonoscopies.S.bovis(Grampositive coccus)is considered part of the normal intestinal flora.There is an association between S.bovis bacteremia and colonic neoplasia.It is not well understood whether the bacterium has a pathogenetic role in the development of neoplasia or constitutes an epiphenomenon of colorectal neoplasms.There was a clear relationship between positivity for S.bovis in colonic suction fluid and findings of malignant tumors and large polyps in the colon.CONCLUSION:There is an association between S.bovis bacteremia and malignant colonic lesions;this should prompt for development of a reliable screening method for advanced colonic lesions. | Maya Paritsky Nina Pastukh Diana Brodsky Natalya Isakovich Avi Peretz | 2015 | World Journal of Gastroenterology2015，21，18： | 9 |
| 3 | 男性不育的手术技术显示文摘男性不育的评估和手术治疗领域经过数次演变和扩展后,目前已经有了更精确的诊断和适应个人的治疗方法,死亡率逐渐降低,成功率逐渐提高.男性不育手术目前被分为四个主要的大类:1)诊断手术;2)改善精子生成的手术;3)提高精子运输的手术;4)提取精子用于IVF—ICSI的手术.尽管现在的男性不育治疗效果比以前有了显著的提高,但还是有些达不到妊娠的要求,这可能是由一些我们还不知道的因素造成的。医生在治疗不育时应提倡“夫妻双方共同治疗”的准则,要求在实施具体的治疗方案之前,夫妻双方都进行彻底的评估,并进行广泛讨论决定方案。 | Natalya A Lopushnyan Thomas J Walsh | 2012 | Asian Journal of Andrology2012，14，1： | 7 |
| 4 | Choice of conodont Idiognathodus simulator (sensu stricto) as the event marker for the base of the global Gzhelian Stage (Upper Pennsylvanian Series, Carboniferous System)显示文摘 | Philip H. Heckel Aleksandr S. Alekseev James E. Barrick Darwin R. Boardman Natalya V. Goreva Tatiana N. Isakova Tamara I. Nemyrovska Katsumi Ueno Elisa Villa David M. Work | 2008 | Episodes2008，31，3： | 5 |
| 5 | Contribution of pancreatic enzyme replacement therapy to survival and quality of life in patients with pancreatic exocrine insufficiency显示文摘The objective of this study was to analyze the current evidence for the use of pancreatic enzyme replacement therapy (PERT) in affecting survival and quality of life in patients with pancreatic exocrine insufficiency (PEI). Systematic searches of the literature were performed using the PubMed database. Articles were selected for inclusion if they reported findings from trials assessing the effects of PERT on quality of life, survival, malabsorption, growth parameters (such as height, body weight and body mass index), or gastrointestinal symptoms (such as abdominal pain, stool consistency and flatulence). PERT improved PEI-related malabsorption and weight maintenance in patients with cystic fibrosis, chronic pancreatitis, pancreatic cancer, and post-surgical states. In patients with chronic pancreatitis, PERT improved PEI-related symptoms and quality of life measures. Several small retrospective studies have also suggested that PERT may have a positive impact on survival, but long-term studies assessing this effect were not identified. PERT is effective for treating malnutrition and supporting weight maintenance, and it is associated with improved quality of life and possibly with enhanced survival in patients with PEI. However, there is evidence that not all patients with PEI receive adequate PERT. Future work should aim to assess the long-term effects of PERT on the survival of patients with PEI. | Peter Layer Nataliya Kashirskaya Natalya Gubergrits | 2019 | World Journal of Gastroenterology2019，25，20： | 4 |
| 6 | 俄罗斯的土地政策和农业土地市场显示文摘从1917年10月到1990年10月,俄罗斯在70多年的时间里不存在私有产权。土地国有化始于1917年布尔什维克革命,经过1929~1930年强制集体化后,到1930年末,98%的农业用地由为数不多的集体农场和国家农场(共约3万个)控制。然而,尽管集体化和国有化非常普遍和深入,私营(或者更合适的说法是“个体的”)农业仍在数百万小规模(不超过0.5公顷)的以生活为目的的家庭土地上存留了下来。 | Zvi Lerman Natalya Shagaida 张迪 | 2007 | 国土资源情报2007，，3： | 4 |
| 7 | Incorporating shape constraints in generalized additive modelling of the height-diameter relationship for Norway spruce显示文摘Background:Measurements of tree heights and diameters are essential in forest assessment and modelling.Tree heights are used for estimating timber volume,site index and other important variables related to forest growth and yield,succession and carbon budget models.However,the diameter at breast height(dbh) can be more accurately obtained and at lower cost,than total tree height.Hence,generalized height-diameter(h-d) models that predict tree height from dbh,age and other covariates are needed.For a more flexible but biologically plausible estimation of covariate effects we use shape constrained generalized additive models as an extension of existing h-d model approaches.We use causal site parameters such as index of aridity to enhance the generality and causality of the models and to enable predictions under projected changeable climatic conditions.Methods:We develop unconstrained generalized additive models(GAM) and shape constrained generalized additive models(SCAM) for investigating the possible effects of tree-specific parameters such as tree age,relative diameter at breast height,and site-specific parameters such as index of aridity and sum of daily mean temperature during vegetation period,on the h-d relationship of forests in Lower Saxony,Germany.Results:Some of the derived effects,e.g.effects of age,index of aridity and sum of daily mean temperature have significantly non-linear pattern.The need for using SCAM results from the fact that some of the model effects show partially implausible patterns especially at the boundaries of data ranges.The derived model predicts monotonically increasing levels of tree height with increasing age and temperature sum and decreasing aridity and social rank of a tree within a stand.The definition of constraints leads only to marginal or minor decline in the model statistics like AlC.An observed structured spatial trend in tree height is modelled via 2-dimensional surface fitting.Conclusions:We demonstrate that the SCAM approach allows optimal regression modelling flexibility similar to the standard GAM but with the additional possibility of defining specific constraints for the model effects.The longitudinal character of the model allows for tree height imputation for the current status of forests but also for future tree height prediction. | Natalya Pya Matthias Schmidt | 2016 | Forest Ecosystems2016，3，2： | 3 |
| 8 | Predictors and consequences of pneumonia in critically ill patients with stroke显示文摘 | Anupama Upadya Natalya Thorevska Kanaga N Sena Constantine Manthous Yaw Amoateng-Adjepong | 2004 | Journal of Critical Care2004，，1： | 3 |
| 9 | The Corporate Governance Role of the Media: Evidence from Russia显示文摘 | ALEXANDER DYCK NATALYA VOLCHKOVA LUIGI ZINGALES | 2008 | The Journal of Finance2008，，3： | 3 |
| 10 | 早期形态发生:一种解决贻贝科(软体动物门:双壳纲)分类、系统发育和进化问题的方法(英文)显示文摘作者对贻贝科贝类的幼虫和幼贝期发育阶段形态结构的出现和变化顺序进行了研究,其约60个不同分类单元的个体发生可归纳为4种形态发生类型或模式。主要对3个形态发生区域的阶段形态结构的起源、发育变化和同源性做了研究。其一,即中央区域,开始形成于前双壳Ⅰ期(PD-Ⅰ),在某个分类单元它可以在前双壳Ⅱ期(PD-Ⅱ)和幼贝期(N)形成,而在其它分类单元则在前双壳Ⅱ期、幼贝期和双壳期(D)形成;第二区域,即背部后区,在幼贝期出现;第三区域,即背部前区,出现于双壳期。双壳期背部后区在某个分类单元起源于幼贝期的形态构造,在其它分类单元则可能起源于双壳期的形态构造。与在贻贝分类学上应用的成体特征相比,早期发育阶段中央和背部后区的形态结构显示出很明显的发育顺序或特征变化规律。根据以前人们熟知而尚未应用到分类和系统发育研究中的早期发育阶段形态特征,作者重新修订了Soot-Ryen的现生贻贝科种上阶元分类系统,重新提出了科内系统发育关系。修订的分类系统表明,Scarlato and Starobogatov(1984)提出的贻贝科各亚科由偏顶蛤亚科开始,沿4条系统发育路线演化发展,对应其早期发育阶段的4类形态发生类型或模式。 | George A. EVSEEV Olga Ya. SEMENIKHINA Natalya K. KOLOTUKHINA | 2005 | 动物学报2005，51，6： | 2 |
| 11 | Influence of friction on buckling of a drill string in the circular channel of a bore hole显示文摘Enhancement of technology and techniques for drilling deep directed oil and gas bore hole is one of the most important problems of the current petroleum industry.Not infrequently, the drilling of these bore holes is attended by occurrence of extraordinary situations associated with technical accidents. Among these is the Eulerian loss of stability of a drill string in the channel of a curvilinear bore hole. Methods of computer simulation should play a dominant role in prediction of these states. In this paper, a new statement of the problem of critical buckling of the drill strings in 3D curvilinear bore holes is proposed. It is based on combined use of the theory of curvilinear elastic rods, Eulerian theory of stability, theory of channel surfaces, and methods of classical mechanics of systems with nonlinear constraints. It is noted that the stated problem is singularly perturbed and its solutions have the shapes of localized harmonic wavelets. The calculation results showed that the friction effects lead to essential redistribution of internal axial forces, as well as changing the eigenmode shapes and sites of their localization. These features make the buckling phenomena less predictable and raise the role of computer simulation of these effects. | Valery Gulyayev Natalya Shlyun | 2016 | Petroleum Science2016，13，4： | 2 |
| 12 | Synergistic effect of chitin nanofibers and polyacrylamide on electrochemical performance of their ternary composite with polypyrrole显示文摘Development of simple methods for preparation of polymeric electrode materials with nanofibrous network structure is a perspective way toward cheap supercapacitors with high specific capacitance and energy density. In this work one-pot synthesis of electroactive ternary composite based on polypyrrole, polyacrylamide and chitin nanofibers with beneficial morphology was elaborated. Ternary system demonstrates better electrochemical performance in comparison with both polypyrrole–polyacrylamide and polypyrrole–chitin binary composites. Possible mechanism of synergistic effect of simultaneous influence of polyacrylamide and chitin nanofibers on the formation of composite's structure is discussed.The highest attained specific capacitance of electroactive polypyrrole in ternary composite reached 249 F/g at 0.5 A/g and 150 F/g at 32 A/g. Symmetrical supercapacitor was assembled using the elaborated electrode material. High specific capacitance 89 F/g and good cycling stability with capacitance retention of 90% after 3000 cycles at 2 A/g were measured. | Michael A.Smirnov Maria P.Sokolova Natalya V.Bobrova Alexander M.Toikka Pierfrancesco Morganti Erkki Lahderanta | 2018 | Journal of Energy Chemistry2018，27，3： | 2 |
| 13 | Analysis of Sonic Well Logs Applied to Erosion Estimates in the Bighorn Basin,Wyoming显示文摘 | Natalya A K | 1996 | AAPG Bull1996，80，5： | 1 |
| 14 | Dynamical Shannon Entropy and Information Tsallis Entropy in Complex Systems显示文摘 | Renat M Y Natalya A E Faii M G | 2004 | Physica A:Statistical Mechanics and its Applications2004，341，： | 1 |
| 15 | Differences in the elicitation of soluble and ionic bound enzymes in tomato leaves using chitin derivatives显示文摘 | Noah B S Natalya K Riki P | 2002 | Israel J Plant Sci2002，50，4： | 1 |
| 16 | Effect of heavy metals and PAHs on soil assessed via dehydrogenase assay 显示文摘 | Natalya I Jorgen S Valter P | 2003 | Environment Interna- tional2003，28，8： | 1 |
| 17 | Molecular genetics of heat tolerance and heat shock proteins in cereals显示文摘 | Elena M Natalya K Carla P | 2002 | Plant Molec- ular Biology2002，48，： | 1 |
| 18 | Phase‐shift, stimuli‐responsive perfluorocarbon nanodroplets for drug delivery to cancer显示文摘 | Natalya Rapoport | 2012 | WIREs Nanomed Nanobiotechnol2012，，： | 1 |
| 19 | Phage Mu-driven two-plasmid system for integration of recombinant DNA in the Methylophilus methylotrophus genome显示文摘 | Elena G. Abalakina Irina L. Tokmakova Natalya V. Gorshkova Evgueni R. Gak Valerii Z. Akhverdyan Sergey V. Mashko Yurgis A. V. Yomantas | 2008 | Applied Microbiology and Biotechnology2008，，1： | 1 |
| 20 | Erlotinib and sorafenib in an orthotopic rat model of hepatocellular carcinoma显示文摘 | Wolfgang Sieghart Matthias Pinter Bernhard Dauser Natalya Rohr-Udilova Anne-Christine Piguet Gerald Prager Hubert Hayden Hans-Peter Dienes Jean-Francois Dufour Markus Peck-Radosavljevic | 2012 | Journal of Hepatology2012，，3： | 1 |
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