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| 1 | Prevalence of clonorchiasis in patients with gastrointestinal disease: A Korean nationwide multicenter survey显示文摘AIM: To investigate prevalence of Clonorchis sinensis in patients with gastrointestinal symptoms, and the relation of the infection to hepatobiliary diseases in 26 hospitals in Korea.METHODS: Consecutive patients who had been admitted to the Division of Gastroenterology with gastrointestinal symptoms were enrolled from March to April 2005. Of those who had been diagnosed with clonorchiasis, epidemiology and correlation between infection and hepatobiliary diseases were surveyed by questionnaire.RESULTS: Of 3080 patients with gastrointestinal diseases, 396 (12.9%) had clonorchiasis and 1140 patients (37.2%) had a history of eating raw freshwater fish. Of those with a history of raw freshwater fish ingestion, 238 (20.9%) patients had clonorchiasis. Cholangiocarcinoma was more prevalent in C. sinensis-infected patients than non-infected patients [34/396 (8.6%) vs 145/2684 (5.4%), P = 0.015]. Cholangiocarcinoma and clonorchiasis showed statistically significant positive cross-relation (P = 0.008). Choledocholithiasis, cholecystolithiasis, cholangitis, hepatocellular carcinoma, and biliary pancreatitis did not correlate with clonorchiasis.CONCLUSION: Infection rate of clonorchiasis was still high in patients with gastrointestinal diseases in Korea, and has not decreased very much during the last two decades. Cholangiocarcinoma was related to clonorchiasis, which suggested an etiological role for the parasite. | Ho Gak Kim Jimin Han Myung-Hwan Kim Kyu Hyun Cho Im Hee Shin Gwang Ha Kim Jae Seon Kim Jin Bong Kim Tae Nyeun Kim Tae Hyeon Kim Tae Hyo Kim Jae Woo Kim Ji Kon Ryu Young-Soo Moon Jong Ho Moon Sung Jae Park Chan Guk Park Sung-Jo Bang Chang Heon Yang Kyo-Sang Yoo Byung Moo Yoo Kyu Taek Lee Dong Ki Lee Byung Seok Lee Sang Soo Lee Seung Ok Lee Woo Jin Lee Chang Min Cho Young-Eun Joo Gab Jin Cheon Young Woo Choi Jae Bok Chung Yong Bum Yoon | 2009 | World Journal of Gastroenterology2009，15，1： | 15 |
| 2 | Balloon dilation itself may not be a major determinant of post-endoscopic retrograde cholangiopancreatography pancreatitis显示文摘Endoscopic retrograde cholangiopancreatography(ERCP)is the essential first modality for common bile duct(CBD)stone therapy.The conventional endoscopic treatment for CBD stones is stone removal after endoscopic sphincterotomy(EST).Stone removal after papillary stretching using balloon dilation instead of the conventional method has been widely adopted.There are many reports regarding endoscopic papillary balloon dilation(EPBD)utilizing a small balloon(<10 mm)instead of EST for the removal of small CBD stones.In contrast,two cases of mortality due to postERCP pancreatitis(PEP)were reported after an EPBD clinical trial in the Western world,and the psychological barrier caused by these incidences hinders the use of this technique in Western countries.Endoscopic papillar large balloon dilation(EPLBD),which is used to treat large CBD stones,was not widely adopted when firstintroduced due to concerns about perforation and severe pancreatitis from the use of a large balloon(12-20mm).However,as experience with this procedure accumulates,the occurrence of PEP with EPLBD is confirmed to be much lower than with EPBD.This report reviews whether EPBD and EPLBD,two procedures that use balloon dilation but differ in terms of indications and concept,contribute to the occurrence of PEP. | Sung Ill Jang Gak Won Yun Dong Ki Lee | 2014 | World Journal of Gastroenterology2014，20，45： | 6 |
| 3 | Multicenter phase Ⅱ trial of modified FOLFIRINOX in gemcitabine-refractory pancreatic cancer显示文摘AIM To evaluate the efficacy and safety of modified FOLFIRINOX as a second-line treatment for gemcitabine(GEM)-refractory unresectable pancreatic cancer(PC).METHODS This study was a prospective, multicenter, one-arm, open-label, phase Ⅱ trial. Patients with unresectable PC, who showed disease progression during GEMbased chemotherapy were enrolled. All patients were administered FOLFIRINOX with reduced irinotecan and oxaliplatin(RIO; irinotecan 120 mg/m^2 and oxaliplatin 60 mg/m^2), which was set according to the phase Ⅰ study of FOLFIRINOX. The objective response rate(ORR), disease control rate(DCR), progressionfree survival(PFS), overall survival(OS), adverse events were evaluated. Additionally, changes in quality of life(QoL) were assessed using a questionnaire on QoL.RESULTS Between August 2015 and May 2016, a total of 48 patients were enrolled. The median follow-up time was 259 d with a median of 8.5 cycles. The ORR and DCR were 18.8% and 62.5%, respectively, including one patient who showed complete remission. The median PFS was 5.8 mo [95% confidence interval(CI): 3.7-7.9] and median OS was 9.0 mo(95%CI: 6.4-11.6). Neutropenia(64.6%) was the most common grade 3-4 adverse event, followed by febrile neutropenia(16.7%). Although 14.6% of patients experienced grade 3 fatigue, most non-hematologic AEs were under grade 2. In the QoL analysis, the global health status score before treatment was not different from the score at the last visit after treatment(45.43 ± 22.88 vs 48.66 ± 24.14, P = 0.548).CONCLUSION FOLFIRINOX with RIO showed acceptable toxicity and promising efficacy for GEM-refractory unresectable PC. However, this treatment requires careful observation of treatment-related hematologic toxicities. | Moon Jae Chung Huapyong Kang Ho Gak Kim Jong Jin Hyun Jun Kyu Lee Kwang Hyuck Lee Myung Hwan Noh Dae Hwan Kang Sang Hyub Lee Seungmin Bang 无 | 2018 | World Journal of Gastrointestinal Oncology2018，10，12： | 3 |
| 4 | Efficacy of a Metallic Stent Covered with a Paclitaxel-Incorporated Membrane Versus a Covered Metal Stent for Malignant Biliary Obstruction: A Prospective Comparative Study显示文摘 | Sung Ill Jang Jie-Hyun Kim Jung Whan You Kwangwon Rhee Se Joon Lee Ho Gak Kim Jimin Han Im Hee Shin Sang-Heum Park Dong Ki Lee | 2013 | Digestive Diseases and Sciences2013，，3： | 2 |
| 5 | Factors Predictive of Adverse Events Following Endoscopic Papillary Large Balloon Dilation: Results from a Multicenter Series显示文摘 | Soo Jung Park Jin Hong Kim Jae Chul Hwang Ho Gak Kim Don Haeng Lee Seok Jeong Sang-Woo Cha Young Deok Cho Hong Ja Kim Jong Hyeok Kim Jong Ho Moon Sang-Heum Park Takao Itoi Hiroyuki Isayama Hirofumi Kogure Se Joon Lee Kyo Tae Jung Hye Sun Lee Todd H. Baron | 2013 | Digestive Diseases and Sciences2013，，4： | 2 |
| 6 | Prenatal diagnosis of nail - pa- tella syndrome显示文摘 | McIntosh I Clough MV Gak E | 1999 | Prenat Diagn1999，19，3： | 1 |
| 7 | Phage Mu-driven two-plasmid system for integration of recombinant DNA in the Methylophilus methylotrophus genome显示文摘 | Elena G. Abalakina Irina L. Tokmakova Natalya V. Gorshkova Evgueni R. Gak Valerii Z. Akhverdyan Sergey V. Mashko Yurgis A. V. Yomantas | 2008 | Applied Microbiology and Biotechnology2008，，1： | 1 |
| 8 | A comparative analysis of productivity growth and productivity dispersion:Microeconomic evidence based on listed firms from Japan,Korea,and China显示文摘 | Ito Keiko Moosup Jung Young Gak Kim Tangjun Yuan | | 0，，01： | 1 |
| 9 | Steal from skeletonized internal thoracic artery graft during hemodialysis after coronary artery bypass graftin显示文摘 | Kinoshita T Asai T l sh i gak i T | 2010 | Heart Surg Forum2010，13，： | 1 |
| 10 | CAG repeat polymorphism within the KCNN3 gene is a significant contributor to susceptibility to anorexia nervosa:a case-control study of female patients and several ethnic groups in the Israeli Jewish population显示文摘 | Koronyo-Hamaoui M Gak E Stein D Frisch A Danziger Y Leor S | 2004 | Am J Med Genet B Neuropsychiatr Genet2004，131，1： | 1 |
| 11 | Incidence, Risk Factors and Clinical Course of Pancreatic Fluid Collections in Acute Pancreatitis显示文摘 | Mei Lan Cui Kook Hyun Kim Ho Gak Kim Jimin Han Hyunsoo Kim Kwang Bum Cho Min Kyu Jung Chang Min Cho Tae Nyeun Kim | 2014 | Digestive Diseases and Sciences2014，，5： | 1 |
| 12 | Effects of Self Stretching on Pain and Musculoskeletal Symptom of Bus Drivers显示文摘 | Lee JH Gak HB | 2014 | J Phys Ther Sci2014，26，12： | 1 |
| 13 | Relationship between activation of the sympathetic nervous system and renal blood flow auto regulation in cirrhosis 显示文摘 | Stadlbauer V Wright GAK Banaji M | 2008 | Gastroenterology2008，134，1： | 1 |
| 14 | Effects of closed kinetic chain ex- ercises on proprioception and functional scores of the knee af- ter anterior cruciate ligament reconstruction 显示文摘 | Cho SH Bae CH Gak HB | 2013 | J Phys Ther Sci2013，25，10： | 1 |
| 15 | Effects of closed kinetic chain exercises on proprioception and functional scores of the knee after anterior cruciate ligament reconstruction 显示文摘 | Cho SHI Bae CH Gak HB | 2013 | J Phys Ther Sci2013，25，10： | 1 |
| 16 | CT-guided transthoracic fineneedle aspiration of pulmonary lesions: accuracy and complicationsin 134 cases显示文摘 | Usku I B T Tu rker H Gak^e M | 2009 | Tuberk Toraks2009，57，2： | 1 |
| 17 | Increaseof platinum group element concentrations in soils and airborne dust inan urban area in Germany显示文摘 | WICHMANN H ANQUANDAH GAK SCHMIDT C | 2007 | Science of the Total Environment2007，388，： | 1 |
| 18 | Laboratory and theoretical models of plane periodic flows显示文摘 | Bondarenko N F Gak M Z Dolzhanskiy F V | 1979 | Izvestiya Atmospheric and Oceanic Physics1979，15，10： | 1 |
| 19 | Increased neutrophil toll-like-receptor 2,4 and 9 expression in alcoholic hepatitis is a result of its activation rather than its cause显示文摘 | Stadlbauer V Mookerjee RP Wright GAK | 2008 | J Hepatology2008，48，2： | 1 |
| 20 | The use of bibliometric indicators to help peer-review assessment 显示文摘 | Haeffner- Cavaillon N GraiUot- Gak C | 2009 | Archivum Immu- nologiae Et Therapiae Experimentalis2009，，57： | 1 |
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