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| 1 | Nat Med:靶向两分子或有助于彻底治愈白血病显示文摘科学家在癌细胞内发现两个信号蛋白能够让癌细胞抵抗化疗。研究表明阻断这两种蛋白能够增强化疗对人类白血病小鼠模型的治疗效果。相关研究结果发表在国际学术期刊NatureMedicine上。研究人员发现在治疗中阻断c-Fos和Dusp1这两个蛋白能够治愈一些受激酶驱动且抵抗治疗的白血病和实体瘤。 | Meenu Kesarwani, Zachary Kincaid, Ahmed Gomaa, Erika Huber, Sara Rohrabaugh, Zain Siddiqui, Muhammad F Bouso, Kakajan Komurov, James C Mulloy, Jose A Cancelas, H Leighton Grimes Mohammad Azam Tahir Latif Ming Xu H Leighton Grimes Mohammad Azam | 2017 | 现代生物医学进展2017，17，17： | 4 |
| 2 | Application of the Dermatology Life Quality Index in Clinical Trials of Biologics for Psoriasis显示文摘The significance of patient-reported outcomes(PROs) is increasingly being acknowledged and quality of life(QOL) has become an integral element of the assessment of overall burden of disease.Psoriasis has been known for its major impact on patients' QOL and various generic,dermatology-specific and psoriasis-specific self- administered psychometric instruments have been used over the years to assess the QOL of psoriasis patients.However,the Dermatology Life Quality Index(DLQI) is the most widely used QOL measure among these measures in psoriasis-related clinical trials. A number of topical and systemic treatments have been used in the management of psoriasis and lately biologics have emerged as a new and promising treatment modality for difficuIt-to-treat psoriasis.The evidence on the efficacy of these agents has been growing dramatically with QOL being used as one of the primary outcome measures in many clinical trials.The aim of this paper is to give an overview of the use of the DLQI as an outcome measure for assessing the QOL impact of biologies on psoriasis patients.Furthermore,the efficacy of five commonly used biologics has been compared in terms of their ability to improve the QOL assessed by the DLQI.This review has revealed that there is a variation in the efficacy of various biologies in terms of QOL improvement with the mean reduction in the DLQI scores being highest for ustekinumab 90 mg(mean DLQI score reduction=9.5),followed by infliximab(8.5),etanercept 50 mg,twice a week(7.7),adalimumab(6.3),and alefacept(4.0). | Mohammad Khu rshid Azam Basra Sadath Hussain | 2012 | Chinese Journal of Integrative Medicine2012，18，3： | 4 |
| 3 | Differential reactivity of mouse monoclonal anti-HBs antibodies with recombinant mutant HBs antigens显示文摘AIM: To investigate the reactivity of a panel of 8 mouse anti-hepatitis B surface antigen (HBsAg) monoclonal antibodies (mAbs) using a collection of 9 recombinant HBsAg mutants with a variety of amino acid substitutions mostly located within the “a” region.METHODS: The entire HBs genes previously cloned into a mammalian expression vector were transiently transfected into COS7 cells. Two standard unmutated sequences of the ayw and adw subtypes served as controls. Secreted mutant proteins were collected and measured by three commercial diagnostic immunoassays to assess transfection efficiency. Reactivity of anti-HBs mAbs with mutated HBsAgs was determined by sandwich enzyme-linked immunosorbent assay (ELISA).RESULTS: Reactivity of anti-HBs mAbs with mutated HBsAgs revealed different patterns. While three mutants reacted strongly with all mAbs, two mutants reacted weakly with only two mAbs and the remaining proteins displayed variable degrees of reactivity towards different mAbs. Accordingly, four groups of mAbs with different but overlapping reactivity patterns could be envisaged. One group consisting of two mAbs (37C5-S7 and 35C6-S11) was found to recognize stable linear epitopes conserved in all mutants. Mutations outside the “a” determinant at positions 120 (P→S), 123(T→N) and 161(M→T) were found to affect reactivity of these mAbs.CONCLUSION: Our findings could have important implications for biophysical studies, vaccination strategies and immunotherapy of hepatitis B virus (HBV) mutants. | Azam Roohi Yaghoub Yazdani Jalal Khoshnoodi Seyed Mohammad Jazayeri William F Carman Mahmood Chamankhah Manley Rashedan Fazel Shokri | 2006 | World Journal of Gastroenterology2006，12，33： | 4 |
| 4 | Effects of the nitrification inhibitor nitrapyrin and tillage practices on yield-scaled nitrous oxide emission from a maize field in Iran显示文摘Nitrification inhibitors can effectively decrease nitrification rates and nitrous oxide(N_(2)O)emission while increasing crop yield under certain conditions.However,there is no information available on the effects of nitrification inhibitors and tillage practices on N_(2)O emissions from maize cropping in Iran.To study how tillage practices and nitrapyrin(a nitrification inhibitor)affect N_(2)O emission,a split factorial experiment using a completely randomized block design with three replications was carried out in Northeast Iran,which has a cold semiarid climate.Two main plots were created with conventional tillage and minimum tillage levels,and two nitrogen(N)fertilizer(urea)management systems(with and without nitrapyrin application)were created as subplots.Tillage level did not have any significant effect on soil ammonium(NH_(4)^(+))and nitrate(NO_(3)^(-))concentrations,cumulative amount and yield-scaled N_(2)O emission,and aboveground biomass of maize,whereas nitrapyrin application showed significant effect.Nitrapyrin application significantly reduced the cumulative amount of N_(2)O emission by 41%and 32%in conventional tillage and minimum tillage practices,respectively.A reduction in soil NO_(3)^(-)concentration by nitrapyrin was also observed.The average yield-scaled N_(2)O emission was 13.6 g N_(2)O-N kg^(-1)N uptake in both tillage systems without nitrapyrin application and was significantly reduced to 7.9 and 8.2 g N_(2)O-N kg^(-1)N uptake upon the application of nitrapyrin in minimum tillage and conventional tillage practices,respectively.Additionally,nitrapyrin application increased maize biomass yield by 4%and 13%in the minimum tillage and conventional tillage systems,respectively.Our results indicate that nitrapyrin has a potential role in reducing N_(2)O emission from agricultural systems where urea fertilizers are broadcasted,which is common in Iran due to the practice of traditional farming. | Azam BORZOUEI Ulo MANDER Alar TEEMUSK Alberto SANZ-COBENA Mohammad ZAMAN Dong-Gill KIM Christoph MÜLLER Ali Askary KELESTANIE Parvaneh SAYYAD AMIN Ebrahim MOGHISEH Khadim DAWAR Ana Gabriela PÉREZ-CASTILLO | 2021 | Pedosphere2021，31，2： | 4 |
| 5 | Effects of the nitrification inhibitor nitrapyrin and the plant growth regulator gibberellic acid on yield-scale nitrous oxide emission in maize fields under hot climatic conditions显示文摘Nitrification inhibitors are widely used in agriculture to mitigate nitrous oxide(N_(2)O)emission and increase crop yield.However,no concrete information on their mitigation of N_(2)O emission is available under soil and environmental conditions as in Pakistan.A field experiment was established using a silt clay loam soil from Peshawar,Pakistan,to study the effect of urea applied in combination with a nitrification inhibitor,nitrapyrin(2-chloro-6-tri-chloromethyl pyridine),and/or a plant growth regulator,gibberellic acid(GA_3),on N_(2)O emission and the nitrogen(N)uptake efficiency of maize.The experimental design was a randomized complete block with five treatments in four replicates:control with no N(CK),urea(200 kg N ha^(-1))alone,urea in combination with nitrapyrin(700 g ha^(-1)),urea in combination with GA_3(60 g ha^(-1)),and urea in combination with nitrapyrin and GA_3.The N_(2)O emission,yield,N response efficiency,and total N uptake were measured during the experimental period.The treatment with urea and nitrapyrin reduced total N_(2)O emission by 39%–43%and decreased yield-scaled N_(2)O emission by 47%–52%,relative to the treatment with urea alone.The maize plant biomass,grain yield,and total N uptake increased significantly by 23%,17%,and 15%,respectively,in the treatment with urea and nitrapyrin,relative to the treatment with urea alone,which was possibly due to N saving,lower N loss,and increased N uptake in the form of ammonium;they were further enhanced in the treatment with urea,nitrapyrin,and GA_3 by 27%,36%,and 25%,respectively,probably because of the stimulating effect of GA_3 on plant growth and development and the reduction in biotic and abiotic stresses.These results suggest that applying urea in combination with nitrapyrin and GA_3 has the potential to mitigate N_(2)O emission,improve N response efficiency,and increase maize yield. | Khadim DAWAR Kamil SARDAR Mohammad ZAMAN Christoph MÜLLER Alberto SANZ-COBENA Aamir KHAN Azam BORZOUEI Ana Gabriela PÉREZ-CASTILLO | 2021 | Pedosphere2021，31，2： | 2 |
| 6 | Petrogenesis of Volcanic Rocks in the Khabr-Marvast Tectonized Ophiolite:Evidence for Subduction Processes in the South-Western Margin of Central Iranian Microcontinent显示文摘迟了的白垩纪 Khabr Marvast tectonized ophiolite 位于 Nain Baft ophiolite 带的中间的部分,在中央伊朗的微大陆的西南的边。尽管在学习区域的所有暴烈的岩石显示subduction相关的 magmatism (例如高 LILE (大离子亲石元素元素)/ HFSE (高领域 strenght 元素)在 Nb 和 Ta 的比率和否定异例),地质并且 geochemical 数据清楚地在 tectonized 协会区分暴烈的岩石的二个不同的组:(1 ) 组 1 由 hyaloclastic 角砾岩,玄武岩的枕头熔岩,和安山岩表流动组成。这些岩石代表 Nain Baft 海洋的外壳;并且(2 ) 组 2 是从 ophiolite 套房的最高的节的碱的熔岩。这些熔岩显示出 shoshonite 亲密关系,但是不支持 ophiolite 的倾向。 | Azam SOLTANMOHAMMADI Mohammad RAHGOSHAY Morteza KHALATBARI-JAFARI | 2009 | Acta Geologica Sinica(English Edition)2009，83，5： | 2 |
| 7 | Mechanisms of autoinhibition and STI-571/Imatinib resistance revealed by mutagenesis of Bcr-Abl显示文摘 | Mohammad Azam Robert R Latek Q Daley | 2003 | Article Cell2003，112，： | 1 |
| 8 | Theoretic al and experimental results of high-birefringent fiber loop mirror with an outp ut port probe显示文摘 | Ricardo Manuel Silva Azam Layeghi Mohammad Ism ai l Zibaii | 2012 | Journal of Lightwave Technology2012，30，8： | 1 |
| 9 | Alignment of the hindfoot following total knee arthroplasty: A systematic review显示文摘BACKGROUND There appears to be a close relationship between deformities at the knee joint and at the hindfoot in patients with knee osteoarthritis(OA).Despite this intrinsic link,there is a dearth of studies investigating alterations in hindfoot alignment following total knee arthroplasty(TKA)in patients with knee OA.AIM To evaluate changes in alignment of the hindfoot following TKA,foot and ankle clinical outcomes in terms of subjective clinical scoring tools following surgical intervention,and to analyse the level of evidence(LOE)and quality of evidence(QOE)of the included studies.METHODS MEDLINE,EMBASE and Cochrane Library databases were systematically reviewed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.Studies reporting changes in the postoperative alignment of the hindfoot following TKA were included.The level and QOE were recorded and assessed.RESULTS Eleven studies with a total of 1142 patients(1358 knees)met the inclusion/exclusion criteria.Six studies were of LOE II and 5 studies were of LOE III.Patients with preoperative varus knee deformity and valgus hindfoot deformity demonstrated improvement in hindfoot alignment post TKA.Patients with preoperative varus knee deformity and varus hindfoot deformity demonstrated no improvement in hindfoot alignment following TKA.Twelve different radiographic parameters were used to measure the alignment of the hindfoot across the included studies,with the tibio-calcaneal angle most frequently utilised(27.3%).CONCLUSION This systematic review demonstrated that the hindfoot may display compensatory changes in alignment following TKA in patients with knee OA.However,the marked heterogeneity between the included studies and poor QOE limits any meaningful cross sectional comparisons between studies.Further,well designed studies are necessary to determine the changes and outcomes of hindfoot alignment following TKA. | James J Butler Nathaniel P Mercer Eoghan T Hurley Mohammad T Azam John G Kennedy | 2021 | World Journal of Orthopedics2021，12，10： | 1 |
| 10 | Ethanol production from cotton - based waste textiles显示文摘 | AZAM J MOHAMMAD J T | 2009 | Bioresource Technology2009，100，： | 1 |
| 11 | Ionic liquid triethylamine-bonded sulfonic acid {[Et 3 N–SO 3 H]Cl} as a novel, highly efficient and homogeneous catalyst for the synthesis of β-acetamido ketones, 1,8-dioxo-octahydroxanthenes and 14-aryl-14 H -dibenzo[ a,j ]xanthenes显示文摘 | Abdolkarim Zare Ahmad Reza Moosavi-Zare Maria Merajoddin Mohammad Ali Zolfigol Tahereh Hekmat-Zadeh Alireza Hasaninejad Ardeshir Khazaei Mohammad Mokhlesi Vahid Khakyzadeh Fatemeh Derakhshan-Panah Mohammad Hassan Beyzavi Esmael Rostami Azam Arghoon Razieh | 2011 | Journal of Molecular Liquids2011，，： | 1 |
| 12 | Electrical energy determination for an azo dye decolorization and mineralization by UV/H2O2 advanced oxidation process 显示文摘 | Azam Aleboyeh Mohammad E Olya Hamid Aleboyeh | 2008 | Chemical Engineering Journal2008，137，3： | 1 |
| 13 | Novel Pd( III)-salen complexes showing high in vitro anti- proliferative effects against human hepatoma cancer by modula- ting specific regulatory genes 显示文摘 | MOHAMMAD AZAM ZAHID HUSSAIN ISMAIL WARAD | 2012 | Dalton Trans2012，41，10： | 1 |
| 14 | Constrained sliding mode control of nonlinear fractional order input affine systems显示文摘Asymptotic stability of nonlinear fractional order affine systems with bounded inputs is dealt.The main contribution is to design a new bounded fractional order chattering free sliding mode controller in which the system states converge to the sliding surface at a determined finite time.To eliminate the chattering in the sliding mode and make the input controller bounded,hyperbolic tangent is used for designing the proposed fractional order sliding surface.Finally,the stability of the closed loop system using this bounded sliding mode controller is guaranteed by Lyapunov theory.A comparison with the integer order case is then presented and fractional order nonlinear polynomial systems are also studied as the special case.Finally,simulation results are provided to show the effectiveness of the designed controller. | TAHMINEH Vedadi Moghaddam SEYYED KAMALEDDIN Yadavar Nikravesh MOHAMMAD Azam Khosravi | 2019 | Journal of Systems Engineering and Electronics2019，30，5： | 1 |
| 15 | Nitrification inhibitor nitrapyrin does not affect yield-scaled nitrous oxide emissions in a tropical grassland显示文摘Urea is the most common nitrogen(N)fertilizer used in the tropics but it has the risk of high gaseous nitrogen(N)losses.Use of nitrification inhibitor has been suggested as a potential mitigation measure for gaseous N losses in N fertilizer-applied fields.In a field trial on a tropical Andosol pastureland in Costa Rica,gaseous emissions of ammonia(NH_(3))and nitrous oxide(N_(2)O)and grass yield were quantified from plots treated with urea(U;41.7 kg N ha^(-1)application^(-1))and urea plus the nitrification inhibitor nitrapyrin(U+NI;41.7 kg N ha^(-1)application^(-1)and 350 g of nitrapyrin for each 100 kg of N applied)and control plots(without U and NI)over a six-month period(rainy season).Volatilization of NH_(3)(August to November)in U(7.4%±1.3%of N applied)and U+NI(8.1%±0.9%of N applied)were not significantly different(P>0.05).Emissions of N_(2)O in U and U+NI from June to November were significantly different(P<0.05)only in October,when N_(2)O emission in U+NI was higher than that in U.Yield and crude protein production of grass were significantly higher(P<0.05)in U and U+NI than in the control plots,but they were not significantly different between U and U+NI.There was no significant difference in yield-scaled N_(2)O emission between U(0.31±0.10 g N kg^(-1)dry matter)and U+NI(0.47±0.10 g N kg^(-1)dry matter).The results suggest that nitrapyrin is not a viable mitigation option for gaseous N losses under typical N fertilizer application practices of pasturelands at the study site. | Ana Gabriela PÉREZ-CASTILLO Cristina CHINCHILLA-SOTO Jorge Alberto ELIZONDO-SALAZAR Ronny BARBOZA Dong-Gill KIM Christoph MÜLLER Alberto SANZ-COBENA Azam BORZOUEI Khadim DAWAR Mohammad ZAMAN | 2021 | Pedosphere2021，31，2： | 1 |
| 16 | Novel Pd (Ⅱ) complexes of 1-N-substituted 3-phenyl-2-pyrazoline derivatives and evaluation of antiamoebic activity 显示文摘 | Kakul Husain Mohammad Abid Amir Azam | 2008 | European Journal of Medicinal Chemistry2008，43，： | 1 |
| 17 | Nitrapyrin effectiveness in reducing nitrous oxide emissions decreases at low doses of urea in an Andosol显示文摘In the tropics,frequent nitrogen(N)fertilization of grazing areas can potentially increase nitrous oxide(N_(2)O)emissions.The application of nitrification inhibitors has been reported as an effective management practice for potentially reducing N loss from the soil-plant system and improving N use efficiency(NUE).The aim of this study was to determine the effect of the co-application of nitrapyrin(a nitrification inhibitor,NI)and urea in a tropical Andosol on the behavior of N and the emissions of N_(2)O from autotrophic and heterotrophic nitrification.A greenhouse experiment was performed using a soil(pH 5.9,organic matter content 78 g kg^(-1),and N 5.6 g kg^(-1))sown with Cynodon nlemfuensis at 60%water-filled pore space to quantify total N_(2)O emissions,N_(2)O derived from fertilizer,soil ammonium(NH_(4)^(+))and nitrate(NO_(3)^(-)),and NUE.The study included treatments that received deionized water only(control,NI).No significant differences were observed in soil NH_(4)^(+)content between the UR and UR+NI treatments,probably because of soil mineralization and NO_(3)^(-)produced by heterotrophic nitrification,which is not effectively inhibited by nitrapyrin.After 56 d,N_(2)O emissions in UR(0.51±0.12 mg N_(2)O-N concluded that the soil organic N mineralization and heterotrophic nitrification are the main processes of NH_(4)^(+)and NO_(3)^(-)production.Additionally,it was found that N_(2)O emissions were partially a consequence of the direct oxidation of the soil's organic N via heterotrophic nitrification coupled to denitrification.Finally,the results suggest that nitrapyrin would likely exert significant mitigation on N_(2)O emissions only if a substantial N surplus exists in soils with high organic matter content. | Mayela MONGE-MUÑOZ Segundo URQUIAGA Christoph MÜLLER Juan Carlos CAMBRONEROHEINRICHS Mohammad ZAMAN Cristina CHINCHILLA-SOTO Azam BORZOUEI Khadim DAWAR Carlos E.RODRÍGUEZ-RODRÍGUEZ Ana Gabriela PÉREZ-CASTILLO | 2021 | Pedosphere2021，31，2： | 1 |
| 18 | Oxalate decarboxylase from Collybia velutipes显示文摘 | MOHAMMAD Azam | 2000 | J Biol Chem2000，275，10： | 1 |
| 19 | Poly(4-vinylpyridine):As a green,efficient and commercial available basic catalyst for the synthesis of chromene derivatives显示文摘Poly(4-vinylpyridine) is reported as a green,commercial available and efficient basic recyclable catalyst for the synthesis of chromene derivatives.This catalyst can be easily recovered by simple filtration and recycled up to 5 consecutive runs without any loss of its efficiency. | Jalal Albadi Azam Mansournezhad Mohammad Darvishi-Paduk | 2013 | Chinese Chemical Letters2013，24，3： | 1 |
| 20 | Decreased expression of toll like receptor signaling molecules in chronic HBV infected patients显示文摘 | Mohammad Momeni Nahid Zainodini Reza Bidaki Gholamhossein Hassanshahi Hamid Daneshvar Mehdi Khaleghinia Maryam Ebrahim Masoud Karimi-Googheri Azam Askari Mohammad Kazemi Arababadi Derek Kennedy | 2014 | Human Immunology2014，，1： | 1 |
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