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| 1 | PTEN inhibition and axon regeneration and neural repair显示文摘The intrinsic growth ability of all the neurons declines during development although some may grow better than others. Numerous intracellular signaling proteins and transcription factors have been shown to regulate the intrinsic growth capacity in mature neurons. Among them, PI3 kinase/Akt pathway is important for controlling axon elongation. As a negative regulator of this pathway, the tumor suppressor phosphatase and tensin homolog(PTEN) appears critical to control the regenerative ability of young and adult neurons. This review will focus on recent research progress in axon regeneration and neural repair by PTEN inhibition and therapeutic potential of blocking this phosphatase for neurological disorders. Inhibition of PTEN by deletion in conditional knockout mice, knockdown by short-hairpin RNA, or blockade by pharmacological approaches, including administration of selective PTEN antagonist peptides, stimulates various degrees of axon regrowth in juvenile or adult rodents with central nervous system injuries. Importantly, post-injury PTEN suppression could enhance axonal growth and functional recovery in adult central nervous system after injury. | Yosuke Ohtake Umar Hayat Shuxin Li | 2015 | Neural Regeneration Research2015，10，9： | 14 |
| 2 | Edge detection based multi-material interface extraction on industrial CT volumes显示文摘X-ray CT scanning is recently becoming a popular technology for industrial applications as well as medical ones. Since the geometrical accuracy is often important for industrial applications, more precise methods for processing CT volumes are required. This paper proposes a method for extracting the multimaterial interfaces on CT volumes obtained by industrial CT scanners. Instead of extracting isosurfaces we detect edge-points, at which the norm of the volume gradient takes a local maximum in the gradient direction, and then interpolate the points as the material interfaces represented by the zero-level of compounded implicit functions. In order to achieve a robust material-identification, multilabel graph-cut is utilized in our method. Using edge-points, we can reduce the inaccuracy caused by CT scanning artifacts. | OHTAKE Yutaka SUZUKI Hiromasa | 2013 | Science China(Information Sciences)2013，56，9： | 5 |
| 3 | Protective effects of oral glutathione on fasting-induced intestinal atrophy through oxidative stress显示文摘AIM To determine whether oral glutathione(GSH)administration can alleviate the effects of fasting-induced intestinal atrophy in the small intestinal mucosa. METHODS Rats were divided into eight groups.One group was fed ad libitum,another was fed ad libitum and received oral GSH,and six groups were administrated saline(SA)or GSH orally during fasting.Mucosal height,apoptosis,and cell proliferation in the jejunum were histologically evaluated.i NOS protein expression(by immunohistochemistry),nitrite levels(by high performance liquid chromatography,as a measure of NO production),8-hydroxydeoxyguanosine formation(by ELISA,indicating ROS levels),glutathione/oxidized glutathione(GSH/GSSG)ratio(by enzymatic colorimetric detection),andγ-glutamyl transpeptidase(Ggt1)mR NA levels in the jejunum(by semi-quantitative RT-PCR)were also estimated. RESULTS O r a l G S H a d m i n i s t r a t i o n w a s d e m o n s t r a t e d t o drastically reduce fasting-induced intestinal atrophy in the jejunum.In particular,jejunal mucosal height was enhanced in GSH-treated animals compared to SA-treated animals[527.2±6.9 for 50 mg/kg GSH,567.6±5.4 for 500 mg/kg GSH vs 483.1±4.9(μm),P<0.01at 72 h].This effect was consistent with decreasing changes in GSH-treated animals compared to SA-treated animals for iN OS protein staining[0.337±0.016for 50 mg/kg GSH,0.317±0.017 for 500 mg/kg GSH vs 0.430±0.023(area of staining part/area of tissue),P<0.01 at 72 h]and NO[2.99±0.29 for 50 mg/kg GSH,2.88±0.19 for 500 mg/kg GSH vs 5.34±0.35(nmol/g tissue),P<0.01 at 72 h]and ROS[3.92±0.46for 50 mg/kg GSH,4.58±0.29 for 500 mg/kg GSH vs6.42±0.52(8-OHdG pg/μg DNA),P<0.01,P<0.05at 72 h,respectively]levels as apoptosis mediators in the jejunum.Furthermore,oral GSH administration attenuated cell proliferation decreases in the fasting jejunum[182.5±1.9 for 500 mg/kg GSH vs 155.8±3.4(5-Brd U positive cells/10 crypts),P<0.01 at 72h].Notably,both GSH concentration and Ggt1 m RNA expression in the jejunum were also attenuated in rats following oral administration of GSH during fasting as compared with fasting alone[0.45±0.12 vs 0.97±0.06(nmol/mg tissue),P<0.01;1.01±0.11 vs 2.79±0.39(Ggt1 m RNA/Gapdh m RNA),P<0.01 for 500 mg/kg GSH at 48 h,respectively]. CONCLUSION Oral GSH administration during fasting enhances jejunal regenerative potential to minimize intestinal mucosal atrophy by diminishing fasting-mediated ROS generation and enterocyte apoptosis and enhancing cell proliferation. | Hiroyuki Uchida Yukari Nakajima Kazuo Ohtake Junta Ito Masahiko Morita Ayako Kamimura Jun Kobayashi | 2017 | World Journal of Gastroenterology2017，23，36： | 5 |
| 4 | Iron overload and cofactors with special reference to alcohol,hepatitis C virus infection and steatosis/insulin resistance显示文摘有几个余因子,影响身体铁新陈代谢并且加速铁超载。酒精和肝的病毒的感染是为在铁超载澄清余因子的角色的最典型的例子。处于这些条件,铁在房间和通过 Fenton 反应生产的反应的氧种类(ROS ) 有的 hepatocytes 和 Kupffer 被扔便于 transferrin 固定的铁的细胞的举起的关键角色。而且, hepcidin,主要在肝生产的抗菌剂肽为肠的铁吸收和网状内皮组织的铁版本也负责。在有血浆铜蓝蛋白缺乏的病人,在肝和 neurodegeneration 的贫血症和第二等的铁超载被报导。而且,正在积累没有酒精和肥胖的脂肪酸累积自己修改铁超载状态的证据。无效红血球生成也是一个重要因素加速铁超载,它与象地中海贫血和 myelodysplastic 症候群那样的疾病被联系。当这个条件坚持时,饮食的铁吸收由于骨髓红血球生成的增长被增加,织物铁超载愿望此后发生。在迟发性皮肤卟啉症,铁是在肝积累的在第二。 | Yutaka Kohgo Katsuya Ikuta Takaaki Ohtake Yoshihiro Torimoto Junji Kato | 2007 | World Journal of Gastroenterology2007，13，35： | 4 |
| 5 | Ultraviolet short pulses from an all-solid-state Ce : LiCAF master-oscillator-power-amplifier system 显示文摘 | Sarukura N Liu Z Ohtake H | 1997 | Opt Lett1997，22，13： | 2 |
| 6 | Reactive astrocyte scar and axon regeneration:suppressor or facilitator?显示文摘Several major factors are known to contribute to CNS axon regenerative failure after injury,including reduced intrinsic growth capacity of developed neurons and extrinsic factors mediating axon outgrowth.For the latter,a non-permissive environment around the lesion and the lack of sufficient neurotrophic support within the adult CNS play important roles(Sil- | Yosuke Ohtake George M.Smith Shuxin Li | 2016 | Neural Regeneration Research2016，11，7： | 2 |
| 7 | Structure determination of metabolites isolated from urine and bile after administration of AY4166, a novel D-phenylalanine-derivative hypoglycemic agent 显示文摘 | Takesada H Matsuda K Ohtake R | 1996 | Bioorg Med Chem1996，4，10： | 2 |
| 8 | Allocation of photosymthetic products in soybean during the early stages of nodule formation 显示文摘 | Ito S Ohtake N Sueyoshi K | 2006 | Soil Science Plant Nutrition2006，52，： | 1 |
| 9 | Novel dithiocarbamate carbapenems with anti-MRSA activity 显示文摘 | Ohtake N Imamura H Kiyonaga H | 1997 | Bioorg Med (?hbm Lett1997，7，13： | 1 |
| 10 | Laparoscopic diagnosis and clinical course of chronic schistosomiasis japonica显示文摘 | Hayashi S Ohtake H Koike M | 2000 | Acta Trop2000，77，1： | 1 |
| 11 | Up-regulation of ADRP in fatty liver in human and liver steatosis in mice fed with high fat diet显示文摘 | Wataru Motomura Mitsutaka Inoue Takaaki Ohtake Nubuhiko Takahashi Miho Nagamine Satoshi Tanno Yutaka Kohgo Toshikatsu Okumura | 2005 | Biochemical and Biophysical Research Communications2005，，4： | 1 |
| 12 | Preserved ability to recognize keywords related to remote events in the absence of retrieval of relevant knowledge: A case of postencephalitic amnesia显示文摘 | Takashi Tsukiura Hiroya Ohtake Toshikatsu Fujii Rina Miura Tatsuji Ogawa Atsushi Yamadori | 2003 | Brain and Cognition2003，，1： | 1 |
| 13 | The clinical characteristics of CD7+ CD56+ acute myeloid leukemias other than M0显示文摘 | Suzuki R Ohtake S Takeuchi J | | 0，，02： | 1 |
| 14 | Blood purification for prevention and treatment of multiple organ failure显示文摘 | Sugai T Ohtake Y | 1996 | World J Surg1996，20，： | 1 |
| 15 | A novel in vitro experimental model for ovarian endometriosis: the three-dimensional culture of human ovarian surface epithelial cells in collagen gels显示文摘 | Hideyuki Ohtake Hidetaka Katabuchi Kohei Matsuura | 1999 | Fertility and sterility1999，7，1： | 1 |
| 16 | Response of nerve fibers in the poriodontium during experimental tooth movement显示文摘 | Ohtake M | 1982 | Nippon Kyosei Shika Gakkai Zasshi1982，41，1： | 1 |
| 17 | Mesh optimization for polygonizedisosurfaces显示文摘 | Ohtake Y Belyaev A G | 2001 | Computer Graphics Forum2001，20，3： | 1 |
| 18 | 显示文摘 | Ohtake K Maeno T Ueda H | 2003 | Pharm Res2003，20，2： | 1 |
| 19 | Diamond Film Preparation by Arc Discharge Plasma Jet Chemical Vapor Deposition in the Methane Atmosphere显示文摘 | Ohtake N Yoshikawa M | 1990 | Journal of Electrochemical Society1990，137，： | 1 |
| 20 | Improvements of hypertriglyce- ridemia and hyperlacticemia in Japanese children with glycogen storage disease type Ia by medium -chain triglyceride milk 显示文摘 | Nagasaka H Hirano K Ohtake A | 2007 | Eur J Pediatr2007，166，10： | 1 |
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