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| 1 | 幽门螺杆菌感染处理的新观念—Maastricht2-2000共识报告显示文摘 | Malfertheiner P Megraud F O’Morain C 刘文忠 梁晓 张丽 | 2002 | 中华消化杂志2002，22，12： | 36 |
| 2 | Antimicrobial susceptibility testing for Helicobacter pylori in times of increasing antibiotic resistance显示文摘The gram-negative bacterium Helicobacter pylori(H.pylori)causes chronic gastritis,gastric and duodenal ulcers,gastric cancer and mucosa-associated lymphoid tissue lymphoma.Treatment is recommended in all symptomatic patients.The current treatment options for H.pylori infection are outlined in this review in light of the recent challenges in eradication success,largely due to the rapid emergence of antibiotic resistant strains of H.pylori.Antibiotic resistance is a constantly evolving process and numerous studies have shown that the prevalence of H.pylori antibiotic resistance varies significantly from country to country,and even between regions within the same country.In addition,recent data has shown that previous antibiotic use is associated with harbouring antibiotic resistant H.pylori.Local surveillance of antibiotic resistance is warranted to guide clinicians in their choice of therapy.Antimicrobial resistance is assessed by H.pylori culture and antimicrobial susceptibility testing.Recently developed molecular tests offer an attractive alternative to culture and allow for the rapid molecular genetic identification of H.pylori and resistance-associated mutations directly from biopsy samples or bacterial culture material.Accumulating evidence indicates that surveillance of antimicrobial resistance by susceptibility testing is feasible and necessary to inform clinicians in their choice of therapy for management of H.pylori infection. | Sinéad M Smith Colm O’Morain Deirdre McNamara | 2014 | World Journal of Gastroenterology2014，20，29： | 40 |
| 3 | 幽门螺杆菌感染处理的当前观念——MaastrichtⅢ共识报告显示文摘名词缩写欧洲幽门螺杆菌研究小组:European Helicobacter Study Group,EHSG胃食管反流病:gastro-esophageal reflux disease。 | P Malfertheiner F Megraud C O'Morain F Bazzoli E El-Omar D Graham R Hunt T Rokkas N Vakil EJ Kuipers 朱琦 | 2007 | 胃肠病学2007，12，3： | 15 |
| 4 | Role of Helicobacter pylori in functional dyspepsia显示文摘消化不良的原因论在病人的多数是未知的。Helicobacter pylori (H pylori ) 是在病人的一个子集的原因。估计 H pylori 的存在的非侵略的测试在不到 50 与消化不良介绍给一个家庭专业人员岁的病人的管理被推荐。脲呼吸测试或凳子抗原测试是最可靠的非侵略的测试。H pylori 的根除将与开发消化性溃疡的消化不良把风险归结为病人,如果规定,复杂并发症评估的还原剂非类固醇反煽动性的药和以后的还原剂胃的癌症的风险。推荐治疗为非与 H pylori 感染联系的溃疡消化不良应该是有 PPI 和二抗菌素的一个 10-d 疗程。治疗功效四个星期应该在与脲呼吸测试或凳子抗原测试完成治疗以后被估计。 | Colm O'Morain | 2006 | World Journal of Gastroenterology2006，12，17： | 9 |
| 5 | Comparison of TRMM and Water District Rain Rates over New Mexico显示文摘这篇论文比较率从 Version5 ( V5 )和版本导出的每月、季节的雨 6 ( V6 ) TRMM 降水雷达( TPR , TSDIS 参考书 2A25 ), TRMM MicrowaveImager ( TMI , 2A12 ), TRMM 联合了仪器( TCI , 2B31 ),校准的红外雨估计的 TRMM ( 3B42 )和 TRMM 在新墨西哥( NM )上把计量器和卫星分析( 3B43 )算法与雨计量器分析由新墨西哥水区域( WD )提供了合并了。在为 1998-2002 的 NM 区域上的平均的雨率是 0.91 公里 d^( 为 WD 和 0.75, 1.38, 1.49, 1.27,和 1.07 公里 d^ 的 -1)( 为 V5 3B43,3B42, TMI, PR 和 TCA 的 -1) ;并且 0.74, 1.38, 0.87 和 0.97 公里 d^( 为 V6 3B43, TMI, TPR 和 TCA 的 -1) 分别地。有 WD 雨率和每日的 TRMM 使命索引( TPR andTMI )的 V5 3B43 的比较建议low V5 3B43 偏导湿月(早掉落的夏天)可能由于在在生产被使用的运作的计量器分析的一些雨事件的非包括 V5 3B43 。关联分析证明 WD 雨率在阶段变化,与在附近的 WD 之间的更高的关联。高时间的关联(> 0.8 ) 当卫星仪器算法(PR, TMI 和 TCI ) 在每月的规模在自己之中最好被相关时,在 WD 和联合算法(为 V5 和 V6 的 3B42, 3B43 和 TCA ) 之间存在。当没有重要差别在 WD 和另外的产品之间存在时, V5 3B42 和 TMI 与 WD 雨统计上不同的每月的时间序列表演的配对的 t 测试评价。在 theTRMM 卫星和 WD 计量器估计之间的协议是最好的春天和秋天和最糟冬季和夏天。在 V6 TMI 的减小(-7.4%) 和 TPR (-31%) 雨率(与 V5 相比) 在夏天期间在冬季和 TPR 导致在 WD 估计和 TMI 之间的更好的同意。 | Long S. CHIU Zhong LIU Jearanai VONGSAARD Stanley MORAIN Amy BUDGE Paul NEVILLE Chandra BALES | 2006 | Advances in Atmospheric Sciences2006，23，1： | 8 |
| 6 | Colorectal cancer screening显示文摘Colorectal cancer is a major public health burden worldwide. There is clear-cut evidence that screening will reduce colorectal cancer mortality and the only contentious issue is which screening tool to use. Mos evidence points towards screening with fecal occul blood testing. The immunochemical fecal occult blood tests have a higher sensitivity than the guaiac-based tests. In addition, their automation and haemoglobin quantification allows a threshold for colonoscopy to be selected that can be accommodated within individua health care systems. | Ramona M McLoughlin Colm A O'Morain | 2006 | World Journal of Gastroenterology2006，12，42： | 8 |
| 7 | Molecular detection of Helicobacter pylori antibiotic resistance in stool vs biopsy samples显示文摘AIM To compare(1) demographics in urea breath test(UBT) vs endoscopy patients; and(2) the molecular detection of antibiotic resistance in stool vs biopsy samples.METHODS Six hundred and sixteen adult patients undergoing endoscopy or a UBT were prospectively recruited to the study. The Geno Type Helico DR assay was used to detect Helicobacter pylori(H. pylori) and antibiotic resistance using biopsy and/or stool samples from CLOpositive endoscopy patients and stool samples from UBT-positive patients. RESULTS Infection rates were significantly higher in patients referred for a UBT than endoscopy(overall rates: 33% vs 19%; treatment-na?ve patients: 33% vs 14.7%, respectively). H. pylori-infected UBT patients were younger than H. pylori-infected endoscopy patients(41.4 vs 48.4 years, respectively, P < 0.005), with a higher percentage of H. pylori-infected males in the endoscopy-compared to the UBT-cohort(52.6% vs 33.3%, P = 0.03). The Geno Type Helico DR assay was more accurate at detecting H. pylori infection using biopsy samples than stool samples [98.2%(n = 54/55) vs 80.3%(n =53/66), P < 0.005]. Subset analysis using stool and biopsy samples from CLO-positive endoscopy patients revealed a higher detection rate ofresistance-associated mutations using stool samples compared to biopsies. The concordance rates between stool and biopsy samples for the detection of H. pylori DNA, clarithromycin and fluoroquinolone resistance were just 85%, 53% and 35%, respectively. CONCLUSION Differences between endoscopy and UBT patients provide a rationale for non-invasive detection of H. pylori antibiotic resistance. However, the Geno Type Helico DR assay is an unsuitable approach. | Denise E Brennan Joseph Omorogbe Mary Hussey Donal Tighe Grainne Holleran Colm O'Morain Sinéad M Smith Deirdre McNamara | 2016 | World Journal of Gastroenterology2016，22，41： | 6 |
| 8 | Helicobacter pylori resistance rates for levofloxacin, tetracycline and rifabutin among Irish isolates at a reference centre显示文摘 | A. O’Connor I. Taneike A. Nami N. Fitzgerald B. Ryan N. Breslin H. O’Connor D. McNamara P. Murphy C. O’Morain | 2013 | Irish Journal of Medical Science2013，，4： | 4 |
| 9 | Can bacterial virulence factors predict antibiotic resistant Helicobacter pylori infection?显示文摘AIM To evaluate the association between virulence factor status and antibiotic resistance in Helicobacter pylori(H. pylori)-infected patients in Ireland. METHODS DNA was extracted from antral and corpus biopsies obtained from 165 H. pylori-infected patients. Genotyping for clarithromycin and fluoroquinolone-mediating mutations was performed using the Genotype Helico DR assay. cag A and vac A genotypes were investigated using PCR. RESULTS Primary, secondary and overall resistance rates for clarithromycin were 50.5%(n = 53/105), 78.3%(n = 47/60) and 60.6%(n = 100/165), respectively. Primary, secondary and overall resistance rates for fluoroquinolones were 15.2%(n = 16/105) and 28.3%(n = 17/60) and 20%(n = 33/165), respectively. Resistance to both antibiotics was 12.4%(n = 13/105) in treatment-na?ve patients, 25%(n = 15/60) in those previously treated and 17%(n = 28/165) overall. A cag A-positive genotype was detected in 22.4%(n = 37/165) of patient samples. The dominant vac A genotype was S1/M2 at 44.8%(n = 74/165), followed by S2/M2 at 26.7%(n = 44/165), S1/M1 at 23.6%(n = 39/165) and S2/M1 at 4.8%(n = 8/165). Primary clarithromycin resistance was significantly lower in cag A-positive strains than in cag A-negative strains [32%(n = 8/25) vs 56.3%(n = 45/80); P = 0.03]. Similarly, in patients infected with more virulent H. pylori strains bearing the vac A s1 genotype, primary clarithromycin resistance was significantly lower than in those infected with less virulent strains bearing the vac A s2 genotype, [41%(n = 32/78) vs 77.8%(n = 21/27); P = 0.0001]. No statistically significant association was found between primary fluoroquinolone resistance and virulence factor status.CONCLUSION Genotypic H. pylori clarithromycin resistance is high and cag A-negative strains are dominant in our population. Less virulent(cag A-negative and vac A S2-containing) strains of H. pylori are associated with primary clarithromycin resistance. | Denise E Brennan Colin Dowd Colm O'Morain Deirdre McNamara Sinéad M Smith | 2018 | World Journal of Gastroenterology2018，24，9： | 4 |
| 10 | Nature meets nurture: molecular genetics of gastric cancer显示文摘 | Anya N. Milne F. Carneiro C. O’Morain G. J. A. Offerhaus | 2009 | Human Genetics2009，，5： | 4 |
| 11 | Vitamin D deficiency in Crohn’s disease: Prevalence, risk factors and supplement use in an outpatient setting显示文摘 | Treasa Nic Suibhne Gerry Cox Martin Healy Colm O’Morain Maria O’Sullivan | 2011 | Journal of Crohn’s and Colitis2011，，2： | 3 |
| 12 | The second European evidence-based Consensus on the diagnosis and management of Crohn’s disease: Current management显示文摘 | A. Dignass G. Van Assche J.O. Lindsay M. Lémann J. S?derholm J.F. Colombel S. Danese A. D’Hoore M. Gassull F. Gomollón D.W. Hommes P. Michetti C. O’Morain T. ?resland A. Windsor E.F. Stange S.P.L. Travis | 2010 | Journal of Crohn’s and Colitis2010，，1： | 2 |
| 13 | Validation of the Capsule Endoscopy Crohn’s Disease Activity Index (CECDAI or Niv score): a multicenter prospective study显示文摘 | Y. Niv S. Ilani Z. Levi M. Hershkowitz E. Niv Z. Fireman S. O’Donnel C. O’Morain R. Eliakim E. Scapa N. Kalantzis C. Kalantzis P. Apostolopoulos E. Gal | 2012 | Endoscopy2012，，01： | 2 |
| 14 | Oxidative stress in tumor microenvironment--Its role in angiogenesis显示文摘The tumor angiogenesis process is believed to be dependent on an 'angiogenic switch' formed by a cascade of biologic events as a consequence of the 'cross-talk' between tumor cells and several components of local microenvironment including endothelial cells, macrophages, mast cells and stromal components. Oxidative stress represents an important stimulus that widely contributes to this angiogenic switch, which is particularly relevant in lungs, where oxidative stress is originated from different sources including the incomplete reduction of oxygen during respiration, exposure to hypoxia/reoxygenation, stimulated resident or chemoattracted immune cells to lung tissues, as well as by a variety of chemicals compounds. In the present review we highlight the role of oxidative stress in tumor angiogenesis as a key signal linked to other relevant actors in this complex process. | Armando ROJAS Raul SILVA Hectcr FIGUEROA Miguel A MORAINES | 2008 | 中国肺癌杂志2008，11，3： | 2 |
| 15 | Treatment of H elicobacter pylori Infection 2013显示文摘 | Anthony O’Connor Javier Molina‐Infante Javier P. Gisbert Colm O’Morain | 2013 | Helicobacter2013，，： | 2 |
| 16 | Challenges to therapy in the future显示文摘 | O'morain C Montague S | 2000 | Helicobacter2000，5，1： | 1 |
| 17 | Current European Concepts in the management of Helicobacter pylori infection-the Maastricht Consensus Report显示文摘 | Malfertheiner P Megrand F O' Morain C | 1997 | Eur J Gastroenterol Hepatol1997，9，1： | 1 |
| 18 | Management of Helicobacter pylori infection--the Maastricht IV/ Florence Consensus Report显示文摘 | MALFERTHEINER P MEGRAUD F O'MORAIN C A | 2012 | Gut2012，61，5： | 1 |
| 19 | Current concepts in the management of Helicobacter pylori infection: the Maastricht IU Con- sensus Report 显示文摘 | Malfertheiner P Megraud F O'Morain C | 2007 | Gut2007，56，6： | 1 |
| 20 | Current concepts in the management of Helicobacter pylori infection--the Maastricht 2-2000 Consensus Reports显示文摘 | Megraud F O′Morain C | 2002 | Aliment Pharmacol Ther2002，16，2： | 1 |
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