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| 1 | Structural insights into Cas13b-guided CRISPR RNA maturation and recognition显示文摘Dear Editor,CRISPR-Cas (clustered regularly interspaced short palindromic repeats and CRISPR-associated proteins)systems are RNA-guided adaptive immune systems in prokaryotes.^1,2 Class 2 CRISPR-Cas systems (including type Ⅱ,Ⅴ,and Ⅵ)involve large single effector proteins in complex with crRNA for interference. | Bo Zhang Weiwei Ye Yangmiao Ye Huan Zhou Abdullah F.U.H.Saeed Jing Chen Jinying Lin Vanja Perculija Qi Chen Chun-Jung Chen Ming-Xian Chang Muhammad lqbal Choudhary Songying Ouyang | 2018 | Cell Research2018，28，12： | 5 |
| 2 | Differential hepatoprotective mechanisms of rutin and quercetin in CCl_(4)-intoxicated BALB/cN mice显示文摘 | Rbert DOMITROVIC Hrvoje JAKOVAC Vanja VASILJEV MARCHESI Sanda VLADIMIR-KNEZEVIC Olga CVIJANOVIC Zarko TADIC Zeljko ROMIC Dario RAHELIC | 2012 | Acta Pharmacologica Sinica2012，33，10： | 4 |
| 3 | Metastatic pancreatic cancer: Is there a light at the end of the tunnel?显示文摘Due to extremely poor prognosis,pancreatic cancer(PDAC)represents the fourth leading cause of cancerrelated death in Western countries.For more than a decade,gemcitabine(Gem)has been the mainstay of first-line PDAC treatment.Many efforts aimed at improving single-agent Gem efficacy by either combining it with a second cytotoxic/molecularly targeted agent or pharmacokinetic modulation provided disappointing results.Recently,the field of systemic therapy of advanced PDAC is finally moving forward.Polychemotherapy has shown promise over single-agent Gem:regimens like PEFG-PEXG-PDXG and GTX provide significant potential advantages in terms of survival and/or disease control,although sometimes at the cost of poor tolerability.The PRODIGE 4/ACCORD 11 was the first phaseⅢtrial to provide unequivocal benefit using the polychemotherapy regimen FOLFIRINOX;however the less favorable safety profile and the characteristics of the enrolled population,restrict the use of FOLFIRINOX to young and fit PDAC patients.The nanoparticle albumin-bound paclitaxel(nab-Paclitaxel)formulation was developed to overcome resistance due to the desmoplastic stroma surrounding pancreatic cancer cells.Regardless of whether or not this is its main mechanisms of action,the combination of nabPaclitaxel plus Gem showed a statistically and clinically significant survival advantage over single agent Gem and significantly improved all the secondary endpoints.Furthermore,recent findings on maintenance therapy are opening up potential new avenues in the treatment of advanced PDAC,particularly in a new era in which highly effective first-line regimens allow patients to experience prolonged disease control.Here,we provide an overview of recent advances in the systemic treatment of advanced PDAC,mostly focusing on recent findings that have set new standards in metastatic disease.Potential avenues for further development in the metastatic setting and current efforts to integratenew effective chemotherapy regimens in earlier stages of disease(neoadjuvant,adjuvant,and multimodal approaches in both resectable and unresectable patients)are also briefly discussed. | Vanja Vaccaro Isabella Sperduti Sabrina Vari Emilio Bria Davide Melisi Carlo Garufi Carmen Nuzzo Aldo Scarpa Giampaolo Tortora Francesco Cognetti Michele Reni Michele Milella | 2015 | World Journal of Gastroenterology2015，21，16： | 2 |
| 4 | Querying XML streams显示文摘 | Vanja Marcus F Attila B | 2005 | The VLDB Journal2005，，14： | 1 |
| 5 | Modelling the abrasive flow machining process on advanced ceramic materi- als显示文摘 | Eckart Uhlmann Vanja Mihotovic Andre Coenen | 2009 | Journal of Materials Processing Technology2009，，209： | 1 |
| 6 | On the memory requirements of XPath evaluation over XML streams显示文摘 | Ziv B Y Marcus F Vanja J | 2007 | Journal of Computer and System Sciences2007，73，3： | 1 |
| 7 | KRAS and BRAF mutation status in circulating colorectal tumor cells and their correlation with primary and metastatic tumor tissue显示文摘 | Bianca Mostert Yuqiu Jiang Anieta M. Sieuwerts Haiying Wang Joan Bolt‐de Vries Katharina Biermann Jaco Kraan Zarina Lalmahomed Anne Galen Vanja Weerd Petra Spoel Raquel Ramírez‐Moreno Cornelis Verhoef Jan N.M. IJzermans Yixin Wang Jan‐Willem Gratama John | 2013 | Int. J. Cancer2013，，： | 1 |
| 8 | A method for dead reckoning parameter correction in pedestrian navigation system显示文摘 | ROMMANEE J PIOTR P VANJA G | 2003 | IEEE Transactions on Instrumentation and Measurement2003，52，1： | 1 |
| 9 | Effect of different ultrasound contrast materials and tem- peratures on patient comfort during intrauterine and tubal assessment for infertility 显示文摘 | Vanja Fenzl | 2012 | European Journal of Radiology2012，81，12： | 1 |
| 10 | O -GlcNAc-glycosylation of β-catenin regulates its nuclear localization and transcriptional activity显示文摘 | Ria Sayat Brian Leber Vanja Grubac Lesley Wiltshire Sujata Persad | 2008 | Experimental Cell Research2008，，15： | 1 |
| 11 | Adhesion development and morbidity after repeat cesarean delivery显示文摘 | Togas Tulandi Mohammed Agdi Afsoon Zarei Louise Miner Vanja Sikirica | 2009 | American Journal of Obstetrics and Gynecology2009，，1： | 1 |
| 12 | A crosstalk between intracellular CXCR7 and CXCR4 involved in rapid CX-CL12-triggered integrin activation but not in chemokine-triggered motility of human T lymphocytes and CD34+显示文摘 | Vanja Nicole Hartmann Valentin Grabovsky | 2008 | Cells2008，84，： | 1 |
| 13 | Crosslinking of an unsaturated polyester resin in the mould:Modelling and heat transfer studies显示文摘 | Vanja Kosar Zoran Gomzi | 2010 | Ap-plied Mathematical Modeling2010，34，6： | 1 |
| 14 | Direct current control-a new current regulation principle显示文摘 | Rastko Fis(^)er | 2003 | IEEE Trans onPE2003，18，1： | 1 |
| 15 | Prevalence and genotyping of the human papillomavirusin the cervical specimens among women of Southern Cro-atia (Dalmatia County) 显示文摘 | Vanja Kalitema Mariano Kalitema Lidija and so on | 2013 | Central European Journal ofPublic Health2013，21，1： | 1 |
| 16 | Direct Current Control A New Current Regulation Principle显示文摘 | Vanja Ambrozic Rastko Fiser David Nedeljkovic | 2003 | IEEE Transactions on Power Electronics JANUARY2003，18，1： | 1 |
| 17 | Structural basis of AimP signaling molecule recognition by AimR in Spbeta group of bacteriophages显示文摘Dear Editor,Quorum sensing(QS)is a widespread phenomenon in bacteria which enables them to participate in cell-to-cell communication by producing and responding to small signal molecules,thus synchronously altering their behavior depending on population density(Singh et al.,2000;Miller and Bassler,2001).Through QS,bacteria coordinate processes such as expression of virulenee factors(Slamti and Lereclus,2002),biofilm formation(Parashar et al.,2011),sporulation(Perego et al.,1996),conjugation(Kozlowicz et al.,2006),antibiotic synthesis(Miller and Bassler,2001;Whiteley et al.,2017)etc. | Xiangkai Zhen Huan Zhou Wei Ding Biao Zhou Xiaolong Xu Vanja Perculija Chun-Jung Chen Ming-Xian Chang Muhammad Iqbal Choudhary Songying Ouyang | 2019 | Protein & Cell2019，10，2： | 1 |
| 18 | Prognostic factors in gemcitabine–cisplatin polychemotherapy regimens in pancreatic cancer: XPD‐Lys751Gln polymorphism strikes back显示文摘 | Amir Avan Paola Pacetti Michele Reni Michele Milella Enrico Vasile Andrea Mambrini Vanja Vaccaro Sara Caponi Stefano Cereda Godefridus J. Peters Maurizio Cantore Elisa Giovannetti | 2013 | Int. J. Cancer2013，，4： | 1 |
| 19 | Genetic differentiation in functional traits among wild cherry (Prunus avium L.) half-sib lines显示文摘Understanding intra-specific variation in leaf functional traits is one of the key requirements for the evaluation of species adaptive capacity to ongoing climate change, as well as for designing long-term breeding and conservation strategies. Hence, data of 19 functional traits describing plant physiology, antioxidant properties, anatomy and morphology were determined on 1-year-old seedlings of wild cherry (Prunus avium L.) half-sib lines. The variability within and among half-sib lines, as well as the estimation of multi-trait association, were examined using analysis of variance (ANOVA) followed by Tukey's honestly significant difference test and multivariate analyses: principal component analysis (PCA), canonical discriminant analysis (CDA) and stepwise discriminant analysis (SDA). Pearson’s correlation coefficient was used to evaluate linear correlation between the study parameters. The results of the ANOVA showed the presence of statistically significant differences (P < 0.01) among half-sib lines for all study traits. The differences within half-sib lines, observed through the contribution of the examined sources of variation to the total variance (%), had higher impact on total variation in the majority of the examined traits. Pearson’s correlation analysis and PCA showed strong relationships between gas exchange in plants and leaf size and stomatal density, as well as between leaf biomass accumulation, intercellular CO_(2) concentration and parameters related to antioxidant capacity of plants. Likewise, the results of SDA indicate that transpiration and stomatal conductance contributed to the largest extent, to the discrimination of the wild cherry half-sib lines. In addition, PCA and CDA showed separation of the wild cherry half-sib lines along the first principal component and first canonical variable with regards to humidity of their original sites. Multiple adaptive differences between the wild cherry half-sib lines indicate high potential of the species to adapt rapidly to climate change. The existence of substantial genetic variability among the wild cherry half-sib lines highlights their potential as genetic resources for reforestation purposes and breeding programmes. | Srđan Stojnić Branislav Kovačević Marko Kebert Verica Vasić Vanja Vuksanović Branislav Trudić Saša Orlović | 2022 | Journal of Forestry Research2022，33，3： | 1 |
| 20 | Effects of soybean D-LeciVita product on serum lipids and {atty acid composition in type 2 diabetic patients with hyperlipidemia 显示文摘 | Danijela Ristic Medic Vanja Ristic Aleksandra Arsic | 2006 | Nutrition Metabolism Cardiovascular Diseases2006，16，6： | 1 |
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