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| 1 | Metabolic aspects of adult patients with nonalcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease(NAFLD) is a major cause of chronic liver disease and it encompasses a spectrum from simple steatosis to steatohepatitis, fibrosis, or cirrhosis. The mechanisms involved in the occurrence of NAFLD and its progression are probably due to a metabolic profile expressed within the context of a genetic predisposition and is associated with a higher energy intake. The metabolic syndrome(MS) is a cluster of metabolic alterations associated with an increased risk for the development of cardiovascular diseases and diabetes. NAFLD patients have more than one feature of the MS, and now they are considered the hepatic components of the MS. Several scientific advances in understanding the association between NAFLD and MS have identified insulin resistance(IR) as the key aspect in the pathophysiology of both diseases. In the multi parallel hits theory of NAFLD pathogenesis, IR was described to be central in the predisposition of hepatocytes to be susceptible to other multiple pathogenetic factors. The recent knowledge gained from these advances can be applied clinically in the prevention and management of NAFLD and its associated metabolic changes. The present review analyses the current literature and highlights the new evidence on the metabolic aspects in the adult patients with NAFLD. | Ludovico Abenavoli Natasa Milic Laura Di Renzo Tomislav Preveden Milica Medi?-Stojanoska Antonino De Lorenzo | 2016 | World Journal of Gastroenterology2016，22，31： | 17 |
| 2 | Insulin resistance and liver steatosis in chronic hepatitis C infection genotype 3显示文摘Hepatitis C virus(HCV) infection is a common chronic liver disease worldwide.Non-alcoholic fatty liver disease and insulin resistance(IR) are the major determinants of fibrosis progression and response to antiviral therapy.The pathogenetic link between IR and chronic HCV infection is complex,and is associated with HCV genotype.Liver steatosis is the most common in the patients infected with genotype 3 virus,possibly due to direct effects of genotype 3 viral proteins.To the contrary,hepatic steatosis in the patients infected with other genotypes is thought to be mostly due to the changes in host metabolism,involving IR.In HCV genotype 3,liver steatosis correlates with viral load,reverts after reaching the sustained virologic response and reoccurs in the relapsers.A therapeutic strategy to improve IR and liver steatosis and subsequently the response to antiviral treatment in these patients is warranted. | Ludovico Abenavoli Mario Masarone Valentina Peta Natasa Milic Nazarii Kobyliak Samir Rouabhia Marcello Persico | 2014 | World Journal of Gastroenterology2014，20，41： | 7 |
| 3 | Alimentary regimen in non-alcoholic fatty liver disease:Mediterranean diet显示文摘Non-alcoholic fatty liver disease(NAFLD)is the most common liver disease worldwide.The mechanisms of the underlying disease development and progression are awaiting clarification.Insulin resistance and obesity-related inflammation status,among other possible genetic,dietary,and lifestyle factors,are thought to play the key role.There is no consensus concerning the pharmacological treatment.However,the dietary nutritional management to achieve weight loss is an essential component of any treatment strategy.On the basis of its components,the literature reports on the effectiveness of the Mediterranean diet in reducing cardiovascular risk and in preventing major chronic diseases,including obesity and diabetes.New evidence supports the idea that the Mediterranean diet,associated with physical activity and cognitive behaviour therapy,may have an important role in the prevention and the treatment of NAFLD. | Ludovico Abenavoli Natasa Milic Valentina Peta Francesco Alfieri Antonino De Lorenzo Stefano Bellentani | 2014 | World Journal of Gastroenterology2014，20，45： | 7 |
| 4 | Metabolic syndrome attenuates ulcerative colitis: Correlation with interleukin-10 and galectin-3 expression显示文摘BACKGROUND Ulcerative colitis(UC)is a chronic disease characterized by inflammation of intestinal epithelium,primarily of the colon.An increasing prevalence of metabolic syndrome(MetS)in patients with UC has been documented recently.Still,there is no evidence that MetS alters the course of the UC.AIM To test the influence of the MetS on the severity of UC and the local and systemic immune status.METHODS Eighty nine patients with de novo histologically confirmed UC were divided in two groups,according to ATP III criteria:Group without MetS(no MetS)and group with MetS.RESULTS Clinically and histologically milder disease with higher serum level of immunosuppressive cytokine interleukin-10(IL-10)and fecal content of Galectin-3(Gal-3)was observed in subjects with UC and MetS,compared to subjects suffering from UC only.This was accompanied with predomination of IL-10 over pro-inflammatory cytokines tumor necrosis factorα(TNF-α),interleukin-6(IL-6),and interleukin-17(IL-17)in the sera as well as Gal-3 over TNF-αand IL-17 in feces of UC patients with MetS.Further,the patients with both conditions(UC and MetS)had higher percentage of IL-10 producing and Gal-3 expressing innate and acquired immune cells in lamina propria.CONCLUSION Local dominance of Gal-3 and IL-10 over pro-inflammatory mediators in patients with MetS may present a mechanism for limiting the inflammatory process and subsequent tissue damage in UC. | Marina Jovanovic Bojana Simovic Markovic Nevena Gajovic Milena Jurisevic Aleksandar Djukic Ivan Jovanovic Nebojsa Arsenijevic Aleksandra Lukic Natasa Zdravkovic | 2019 | World Journal of Gastroenterology2019，25，43： | 5 |
| 5 | Presence and role of stem cells in ovarian cancer显示文摘Ovarian cancer is the deadliest gynecological malignancy.It is typically diagnosed at advanced stages of the disease,with metastatic sites disseminated widely within the abdominal cavity.Ovarian cancer treatment is challenging due to high disease recurrence and further complicated pursuant to acquired chemoresistance.Cancer stem cell(CSC)theory proposes that both tumor development and progression are driven by undifferentiated stem cells capable of self-renewal and tumor-initiation.The most recent evidence revealed that CSCs in terms of ovarian cancer are not only responsible for primary tumor growth,metastasis and relapse of disease,but also for the development of chemoresistance.As the elimination of this cell population is critical for increasing treatment success,a deeper understanding of ovarian CSCs pathobiology,including epithelial-mesenchymal transition,signaling pathways and tumor microenvironment,is needed.Finally,before introducing new therapeutic agents for ovarian cancer,targeting CSCs,accurate identification of different ovarian stem cell subpopulations,including the very small embryoniclike stem cells suggested as progenitors,is necessary.To these ends,reliable markers of ovarian CSCs should be identified.In this review,we present the current knowledge and a critical discussion concerning ovarian CSCs and their clinical role. | Natasa Kenda Suster Irma Virant-Klun | 2019 | World Journal of Stem Cells2019，11，7： | 4 |
| 6 | Adiponectin serum level in chronic hepatitis C infection and therapeutic profile显示文摘Hepatic steatosis is commonly seen in the patients with chronic hepatitis C virus(HCV) infection. HCV is closely associated with lipid metabolism,and viral steatosis is more common in genotype 3 infection owing to a direct cytopathic effect of HCV core protein. In non-genotype3 infection,hepatic steatosis is considered largely to be the result of the alterations in host metabolism; metabolic steatosis is primarily linked with HCV genotype 1. A d i p o s e t i s s u e s e c r e t e s d i f f e r e n t h o r m o n e s involved in glucose and lipid metabolisms. It has been demonstrated that adipocytokines are involved in the pathogenesis of non-alcoholic fatty liver disease,as the decreased plasma adiponectin levels,a soluble matrix protein expressed by adipoctyes and hepatocyte,are associated with liver steatosis. Various studies have shown that steatosis is strongly correlated negatively with adiponectin in the patients with HCV infection. The role of adiponectin in hepatitis C virus induced steatosis is still not completely understood,but the relationship between adiponectin low levels and liver steatosis is probably due to the ability of adiponectin to protect hepatocytes from triglyceride accumulation by increasing β-oxidation of free fatty acid and thus decreasing de novo free fatty acid production. | Valentina Peta Carlo Torti Natasa Milic Alfredo Foca Ludovico Abenavoli | 2015 | World Journal of Hepatology2015，7，1： | 4 |
| 7 | Galectin-3 possible involvement in antipsychotic-induced metabolic changes of schizophrenia:A minireview显示文摘Recently,specific immunometabolic profiles have been postulated in patients with schizophrenia,even before full-blown disease and independent of antipsychotic treatment.Proteomic profiling studies offer a promising potential for elucidating the cellular and molecular pathways that may be involved in the onset and progression of schizophrenia symptoms,and co-occurrent metabolic changes.In view of all this,we were intrigued to explore galectin-3(Gal-3)as a glycan,and in our previous study,we measured its elevated levels in remission of schizophrenia.The finding may be a consequence of antipsychotic treatment and may have an impact on the onset of inflammation,the development of obesity,and the presumed cognitive changes in schizophrenia.In the animal study,it was shown that downregulation of Gal-3 was beneficial in insulin regulation of obesity and cognitive preservation.Strategies involving plasma exchange are discussed in this review,particularly in the context of Gal-3 elimination. | Milica M Borovcanin Katarina Vesic Milena Jovanovic Natasa R Mijailovic | 2021 | World Journal of Diabetes2021，12，10： | 4 |
| 8 | Frequency-dependent random fatigue of panel-type structures made of ceramic matrix composites显示文摘The panel-type structures used in aerospace engineering can be subjected to severe highfrequency acoustic loadings in service. This paper evaluates the frequency-dependent random fatigue of panel-type structures made of ceramic matrix composites(CMCs) under acoustic loadings. Firstly, the high-frequency random responses from the broadband random excitation will result in more stress cycles in a deinite period of time. The probability density distributions of stress amplitudes will be different in different frequency bandwidths, though the peak stress estimations are identical. Secondly, the fatigue properties of CMCs can be highly frequency-dependent. The fatigue evaluation method for the random vibration case is adopted to evaluate the fatigue damage of a representative stiffened panel structure. The frequency effect through S-N curves on random fatigue damage is numerically veriied. Finally, a parameter is demonstrated to characterize the mean vibration frequency of a random process, and hence this parameter can further be considered as a reasonable loading frequency in the fatigue tests of CMCs to obtain more reliable S-N curves.Therefore, the inluence of vibration frequency can be incorporated in the random fatigue model from the two perspectives. | Yadong Zhou Xiaochen Hang Shaoqing Wu Qingguo Fei Natasa Trisovic | 2017 | Acta Mechanica Solida Sinica2017，30，2： | 2 |
| 9 | Analysis of the CAG repeat number in exon 1 of the androgen receptor gene in Slovene men with idiopathic azoospermia and oligoasthenoteratozoospermia显示文摘 | Borut Peterlin Branko Zorn Natasa Teran Tanja Kunej | 2007 | Asian Journal of Andrology2007，9，2： | 2 |
| 10 | The influence of single and combined IL28B polymorphisms on response to treatment of chronic hepatitis C显示文摘 | Ivana Lazarevic Jelena Djordjevic Maja Cupic Danijela Karalic Dragan Delic Neda Svirtlih Jasmina Simonovic Petar Svorcan Natasa Milic Tanja Jovanovic | 2013 | Journal of Clinical Virology2013，，： | 2 |
| 11 | Meta-analysis of stent thrombosis after drug-eluting stent implantation: 4-year follow-up显示文摘背景 Drug-eluting stents (DES ) 是在冠的动脉疾病的经皮的治疗使用的最普通的设备。最近,关于他们的安全侧面有一颗增加的担心,与赤裸的金属 stents (BMS ) 相比的特别地晚并且很迟了的 stent 血栓率。学习的目的是近来并且很晚比较报导发生在从有到四 years.Methods 的一个扩大后续时期的出版临床的研究的病人的 DES 和 BMS 的 stent 血栓搜索策略被开发识别在 BMS 和可得到的 DES 的晚或很迟了的血栓上报导的出版物通过 MEDLINE 和 Cochrane 图书馆数据库。二个独立评论家估价了合格研究并且提取了数据。机会比率(或) 为每结果被计算并且与 95% 信心间隔(CI ) 介绍了 .Results 十四使随机化控制试用,是使失明的至少单身者,被识别。近来在发生没有差别,在病人的很迟了的 stent 血栓与与 BMS 对待的病人相比与 DES 对待(迟了或 0.55, 95%Cl 0.23-1.31 和晚 / 很迟了的 OR=1.08, 95%CI 0.61-1.91 ).Conclusions 安全侧面 DES 以 stent 血栓类似于 BMS。我们没近来并且很晚发现增加的风险的证据为 DES 的血栓。 | Natasa M Milic Biljana J Parapid Miodrag C Ostojic Milan A Nedeljkovic Jelena M Marinkovic | 2010 | Chinese Medical Journal2010，，24： | 2 |
| 12 | 抗人组织蛋白酶B人-鼠嵌合抗体的表达及体外对癌细胞浸润的抑制效应显示文摘目的 制备抗人组织蛋白酶B人 鼠嵌合抗体。方法 从分泌抗人组织蛋白酶B单克隆抗体的杂交瘤细胞株提取总RNA ,通过RT PCR扩增单克隆抗体VH 和VL 的DNA片段 ,对其进行序列分析 ,证实具有小鼠可变区完整的结构 ,利用基因工程技术将它们分别和人Ig的Cγ1和Cκ恒定区基因连接组建人鼠嵌合轻链和重链Fab抗体 ,并克隆到pcDNA3真核细胞表达载体。将重组体转染到中国仓鼠卵巢细胞 (CHO) ,通过G4 18筛选、ELISA检测和Westernblot鉴定 ,分离纯化抗人组织蛋白酶B人 鼠嵌合抗体 ,用于体外抑制癌细胞浸润的试验。结果 得到分泌抗人组织蛋白酶B人 鼠嵌合抗体的中国仓鼠卵巢细胞克隆 (C6 2A2 ) ,分泌的抗人组织蛋白酶B人 鼠嵌合抗体在体外能抑制癌细胞浸润。结论 人 鼠嵌合抗体的成功表达 ,将有可能用于组织蛋白酶B过度表达的有关疾病的治疗。 | 樊晓晖 Kopitar-Jerala Natasa Premzl Ales Kos Janko | 2003 | 中华微生物学和免疫学杂志2003，23，11： | 2 |
| 13 | Selective dorsal rhizotomy in cerebral palsy spasticity-a newly established operative technique in Slovenia: A case report and review of literature显示文摘BACKGROUND Spasticity affects a large number of children,mainly in the setting of cerebral palsy,however,only a few paediatric neurosurgeons deal with this problem.This is mainly due to the fact that until 1979,when Fasano has published the first series of selective dorsal rhizotomy(SDR),neurosurgeons were able to provide such children only a modest help.The therapy of spasticity has made a great progress since then.Today,peroral drugs,intramuscular and intrathecal medicines are available,that may limit the effects of the disease.In addition,surgical treatment is gaining importance,appearing in the form of deep brain stimulation,peripheral nerve procedures and SDR.All these options offer the affected children good opportunities of improving the quality of life.CASE SUMMARY A 15-year old boy is presented that was surgically treated for spasticity as a result of cerebral palsy.Laminotomy at L1 level was performed and L1 to S1 nerve roots were isolated and divided in smaller fascicles.Then,the SDR was made.CONCLUSION We describe a patient report and surgical technique of SDR that was performed in Slovenia for the first time. | Tomaz Velnar Peter Spazzapan Zoran Rodi Natasa Kos Roman Bosnjak | 2019 | World Journal of Clinical Cases2019，7，10： | 2 |
| 14 | Neutrophil and monocyte CD64 indexes, lipopolysaccharide-binding protein, procalcitonin and C-reactive protein in sepsis of critically ill neonates and children显示文摘 | Mojca Groselj-Grenc Alojz Ihan Maja Pavcnik-Arnol Andreja Natasa Kopitar Tanja Gmeiner-Stopar Metka Derganc | 2009 | Intensive Care Medicine2009，，11： | 2 |
| 15 | Comparative application of four methods of groundwater vulnerability mapping in a Slovene Karst catchment显示文摘 | Natasa Ravbar Nico Goldscheider | 2009 | Hydrogeology Journal2009，17，： | 1 |
| 16 | Copper-catalyzed enantioselective conjugate addition of Grignard reagents to acyclic enones using monodentate phosphoramidite ligands显示文摘 | Beatriz Macia M Angeles Fernandez-Ibanez Natasa Mrsic | 2008 | Tetrahedron Letters2008，49，： | 1 |
| 17 | Linka- ges Between Manufacturing Strategy, Benchmarking, Perform- ance Measurement anti Business Process Reengineering 显示文摘 | Herzog Natasa Vujica Tonchia Stefano Polajnar Andrej | 2009 | Computers & Industrial Engineering2009，57，3： | 1 |
| 18 | Evaluation and management of hypo-osmolality in hospitalized patients显示文摘 | Natasa Janicic Joseph G. Verbalis | 2003 | Endocrinology and Metabolism Clinics of North America2003，，2： | 1 |
| 19 | What Determines Consumers’ Ratings of Service Providers? An Exploratory Study of Online Traveler Reviews显示文摘 | Pradeep Racherla DanielJ. Connolly Natasa Christodoulidou | 2013 | Journal of Hospitality Marketing & Management2013，，2： | 1 |
| 20 | Chronic peroxisome proliferator-activated receptor γ (PPARγ) activation of epi- didymally derived white adipocyte cultures reveals a popula- tion of thermogenically competent, UCPl-containing adipocytes molecularly distinct from classic brown adipocytes 显示文摘 | Natasa P Tomas BW Irina GS | 2010 | J Biol Chem2010，285，10： | 1 |
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