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| 1 | Generation of Pluripotent Stem Cells from Neonatal Mouse Testis显示文摘 | Mito Kanatsu-Shinohara Kimiko Inoue Jiyoung Lee Momoko Yoshimoto Narumi Ogonuki Hiromi Miki Shiro Baba Takeo Kato Yasuhiro Kazuki Shinya Toyokuni Megumi Toyoshima Ohtsura Niwa Mitsuo Oshimura Toshio Heike Tatsutoshi Nakahata Fumitoshi Ishino Atsuo Ogura T | 2004 | Cell2004，，7： | 2 |
| 2 | Mapping of metastasis suppressor genes for prostate cancer by microcell-mediated chromosome transfer显示文摘Aim: To identify the metastasis suppressor genes for prostate cancer. Methods: A copy of human chromosomes was introduced into the highly metastatic Dunning R-3327 rat prostate cancer cells by the use of microcell-mediated chromosome transfer. Relationships between the size of human chromosomes introduced into microcell hybrid clones and the number of lung metastases produced by the clones were analyzed to determine which part of human chromosomes contained the metastasis suppressor gene (s) for prostate cancer. To determine portions of human chromosomes introduced, G-banding chromosomal analysis, fluorescence in situ hybridization analysis, and polymerase chain reaction analysis were performed. Results: Each of microcell hybrid clones containing human chromosomes 7, 8, 10, 11, 12, or 17 showed decreased ability to metastasize to the lung without any loss of ttmaorigenicity. This demonstrates that these human chromosomes contain metastasis suppressor genes for prostate cancer. Spontaneous deletion of portions of human chromosomes was observed in the human chromosome 7, 10, 11, 12, and 17 studies. In the human chromosome 8 study, irradiated microcell-mediated chromosome transfer was performed to enrich chromosomal ann deletions of human chromosome 8. Molecular and cytogenetic analyses of microcell hybrid clones demonstrated that metastasis suppressor genes on human chromosomes were located on 7q21-22, 7q31.2-32, 8p21-12, 10q11-22, 11p13-11.2, 12p11-q13, 12q24-ter, and 17pter-q23. KAI1 and MKK4/SEKI were identified as metastasis suppressor genes from 11p11.2 and 17p12, respectively. Conclusion: This assay system is useful to identify metastasis suppressor gene (s) for prostate cancer. | Tomohiko ICHIKAWA Shigeru HOSOKI Hiroyoshi SUZUKI Koichiro AKAKURA Tatsuo IGARASHI Yuzo FURUYA Mitsuo OSHIMURA Carrie W.RINKER-SCHAEFFER Naoki NIHEI J.Carl BARRETT John T.ISAACS Haruo ITO | 2000 | Asian Journal of Andrology2000，2，3： | 2 |
| 3 | Stability of transferred human chromosome fragments in cultured cells and in mice显示文摘 | Tokuyuki Shinohara Kazuma Tomizuka Shoko Takehara Kaori Yamauchi Motonobu Katoh Atsuko Ohguma Isao Ishida Mitsuo Oshimura | 2000 | Chromosome Research2000，，8： | 1 |
| 4 | Human monochromosome hybrid cell panel characterized by FISH in the JCRB/HSRRB显示文摘 | Hideyuki Tanabe Yuzuki Nakagawa Daisuke Minegishi Katsuyuki Hashimoto Noriho Tanaka Mitsuo Oshimura Toshio Sofuni Hiroshi Mizusawa | 2000 | Chromosome Research2000，，4： | 1 |
| 5 | Clinical usefulness of telomerase activity and telomere length in the preoperative diagnosis of gastric and colorectal cancer显示文摘 | Shunsuke Katayama Goshi Shiota Mitsuo Oshimura Hironaka Kawasaki | 1999 | Journal of Cancer Research and Clinical Oncology1999，，7： | 1 |
| 6 | MAD1 (mitotic arrest deficiency 1) is a candidate for a tumor suppressor gene in human stomach显示文摘 | Mitsuhiko Osaki Toshiaki Inoue Shigeyuki Yamaguchi Aiko Inaba Naruo Tokuyasu Kuan-Teh Jeang Mitsuo Oshimura Hisao Ito | 2007 | Virchows Archiv2007，，4： | 1 |
| 7 | Generation of Pluripotent Stem Cells from Neonatal Mouse Testis显示文摘 | Mito Kanatsu-Shinohara Kimiko Inoue Jiyoung Lee Momoko Yoshimoto Narumi Ogonuki Hiromi Miki Shiro Baba Takeo Kato Yasuhiro Kazuki Shinya Toyokuni Megumi Toyoshima Ohtsura Niwa Mitsuo Oshimura Toshio Heike Tatsutoshi Nakahata Fumitoshi Ishino Atsuo Ogura T | 2004 | Cell2004，，7： | 1 |
| 8 | Clinical usefulness of telomerase activity and telomere length in the preoperative diagnosis of gastric and colorectal cancer显示文摘 | Shunsuke Katayama Goshi Shiota Mitsuo Oshimura Hironaka Kawasaki | 1999 | Journal of Cancer Research and Clinical Oncology1999，，7： | 1 |
| 9 | Telomerase activity significantly correlates with cell differentiation, proliferation and lymph node metastasis in colorectal carcinomas显示文摘 | Isao Okayasu Hiroyuki Mitomi Kazuya Yamashita Tetuo Mikami Mutsunori Fujiwara Motonobu Kato Mitsuo Oshimura | 1998 | Journal of Cancer Research and Clinical Oncology1998，，8： | 1 |
| 10 | Clinical usefulness of telomerase activity and telomere length in the preoperative diagnosis of gastric and colorectal cancer显示文摘 | Shunsuke Katayama Goshi Shiota Mitsuo Oshimura Hironaka Kawasaki | 1999 | Journal of Cancer Research and Clinical Oncology1999，，7： | 1 |
| 11 | Enhanced apoptosis during early neuronal differentiation in mouse ES cells with autosomal imbalance显示文摘尽管特别 chromosomal 症候群是 phenotypically 并且临床上不同的,有正染色体的不平衡的个人的多数例如 aneuploidy,表明智力迟钝。普通反常显型在症候群(DS ) 下面,最流行的正染色体的 aneuploidy,在大脑在数字和神经原的密度显示出减小。作为一个 DS 模型,我们最近从包含一个单个人的染色体的 ES 房间创造了妄想的老鼠 21。老鼠模仿了 DS 的典型 phenotypic 特征,并且 ES 房间在 vitro 在早 neuronal 区别期间显示出 apoptosis 的更高的发生。在这研究,我们由转移各种各样的人的染色体或另外的鼠标染色体在鼠标 ES 房间由 aneuploidy 检验了异常早神经的开发的正式就职。结果在在 vitro 在早 neuronal 区别期间检验的所有 autosome-aneuploid 克隆显示出 apoptosis 的提高的发生。进一步, cDNA microarray 分析揭示了下面调整的基因,八已知的基因与房间增长,神经突长出和区别有关是的普通的簇。重要地,由在正常老鼠 ES 房间击倒的 siRNA 这些基因指向在早 neuronal 区别期间导致了提高的 apoptosis。这些调查结果强烈建议那正染色体的不平衡为 apoptosis 通过普通分子的机制与一般 neuronal 损失被联系。 | Yoshiteru Kai Chi Chiu Wang Satoshi Kishigami Yasuhiro Kazuki Satoshi Abe Masato Takiguchi Yasuaki Shirayoshi Toshiaki Inoue Hisao Ito Teruhiko Wakayama Mitsuo Oshimura | 2009 | Cell Research2009，19，2： | 0 |
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