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| 1 | Survival of geriatric patients after percutaneous endoscopic gastrostomy in Japan显示文摘AIM: To examine the long term survival of geriatric patients treated with percutaneous endoscopic gastrostomy (PEG) in Japan. METHODS: We retrospectively included 46 Japanese community and tertiary hospitals to investigate 931 consecutive geriatric patients (≥ 65 years old) with swallowing difficulty and newly performed PEG between Jan 1st 2005 and Dec 31st 2008. We set death as an outcome and explored the associations among patient’s characteristics at PEG using log-rank tests and Cox proportional hazard models. RESULTS: Nine hundred and thirty one patients were followed up for a median of 468 d. A total of 502 deaths were observed (mortality 53%). However, 99%, 95%, 88%, 75% and 66% of 931 patients survived more than 7, 30, 60 d, a half year and one year, respectively. In addition, 50% and 25% of the patients survived 753 and 1647 d, respectively. Eight deaths were considered as PEG-related, and were associated with lower serum albumin levels (P = 0.002). On the other hand, among 28 surviving patients (6.5%), PEG was removed. In a multivariate hazard model, older age [hazard ratio (HR), 1.02; 95% confidence interval (CI), 1.00-1.03; P = 0.009], higher C-reactive protein (HR, 1.04; 95% CI: 1.01-1.07; P = 0.005), and higher blood urea nitrogen (HR, 1.01; 95% CI: 1.00-1.02; P = 0.003) were significant poor prognostic factors, whereas higher albumin (HR, 0.67; 95% CI: 0.52-0.85; P = 0.001), female gender (HR, 0.60; 95% CI: 0.48-0.75; P < 0.001) and no previous history of ischemic heart disease (HR, 0.69; 95% CI: 0.54-0.88, P = 0.003) were markedly better prognostic factors. CONCLUSION: These results suggest that more than half of geriatric patients with PEG may survive longer than 2 years. The analysis elucidated prognostic factors. | Yutaka Suzuki Seryna Tamez Akihiko Murakami Akihiko Taira Akihiro Mizuhara Akira Horiuchi Chie Mihara Eiji Ako Hirohito Muramatsu Hitoshi Okano Hitoshi Suenaga Kazuaki Jomoto Junya Kobayashi Katsunari Takifuji Kazuhiro Akiyama Koh Tahara Koji Onishi Makoto Shimazaki Masami Matsumoto Masashi Ijima Masato Murakami Masato Nakahori Michiaki Kudo Michio Maruyama Mikako Takahashi Naohiro Washizawa Shigeru Onozawa Satoshi Goshi Satoyoshi Yamashita Shigeki Ono Shin Imazato Shinji Nishiwaki Shuichirou Kitahara Takao Endo Takao Iiri Takeshi Nagahama Takuto Hikichi Tatsuya Mikami Tetsuo Yamamoto Tetsushi Ogawa Tomoko Ogawa Tomoyuki Ohta Toshifumi Matsumoto Toshiroh Kura Tsutomu Kikuchi Tsuyoshi Iwase Tsuyotoshi Tsuji Yukio Nishiguchi Mitsuyoshi Urashima | 2010 | World Journal of Gastroenterology2010，16，40： | 4 |
| 2 | Adenomyoepithelioma of the breast with malignant transformation and repeated local recurrence:A case report显示文摘BACKGROUND Adenomyoepithelioma(AME)of the breast is a rare type of benign breast tumor.Many AMEs show benign behavior,but reports of the malignant type are rare.We present the case of a patient with AME with repeated local recurrences and further malignant transformation.CASE SUMMARY A 53-year-old woman visited our hospital with a 16-mm palpable mass in the right breast.A core needle biopsy was performed.The pathological diagnosis was AME.Lumpectomy with a safety margin was performed without axillary lymph node dissection(ALND).Two years later,local recurrence developed,and the patient again underwent lumpectomy with a safety margin.The pathology showed malignant AME,and the margin was negative.Eight months later,local recurrence developed again in the same location,and a total mastectomy was performed without ALND.The pathological diagnosis was malignant AME.The patient was disease-free for three years posttreatment.CONCLUSION The treatment of AME requires caution,as it may exhibit repeated recurrences after local excision as well as malignant transformation. | Goshi Oda Tsuyoshi Nakagawa Mio Mori Tomoyuki Fujioka Iichiro Onishi | 2021 | World Journal of Clinical Cases2021，9，29： | 2 |
| 3 | In vivo transfer of hepatocyte growth factor gene accelerates proliferation of hepatic oval cells in a 2-acetylaminofluorene/partial hepatectomy model in rats显示文摘 | Goshi Shiota Takahiro Kunisada Kenji Oyama Akihide Udagawa Takahiro Nomi Kiwamu Tanaka Atsushi Tsutsumi Masato Isono Takafumi Nakamura Hirofumi Hamada Takashi Sakatani Stewart Sell Kenzo Sato Hisao Ito Hironaka Kawasaki | 2000 | FEBS Letters2000，，： | 1 |
| 4 | Protective action of hepatocyte growth factor for acute liver injury caused by D-galactosamine in transgenic mice显示文摘 | JUN-ICHI OKANO GOSHI SHIOTA HIRONAKA KAWASAKI | 1997 | Hepatology1997，26，5： | 1 |
| 5 | Enhancement of spine fusion using combined gene therapy and tissue engineering BMP-7-expressing bone marrow cells and allograft bone显示文摘 | Hidaka C Goshi K Rawlins B | 2003 | Spine2003，28，18： | 1 |
| 6 | Expressionof hepatocyte growth factor (HGF) and HGF receptor (C-met) proteins in liver diseases:an immunohistochemical study显示文摘 | Okano Jun-Ichi Shiota Goshi Kawasaki Hironaka | 1999 | Liver1999，19，2： | 1 |
| 7 | Basic fibroblast growth factor treatment for various types of recalcitrant skin ulcers: reports of nine cases显示文摘 | O'Goshi K Tagami H | 2007 | J Dermatolog Treat2007，18，6： | 1 |
| 8 | CD4 and CD8 homologues in Japanese flounder, Paralichthys olivaceus: Dif- ferences in the expressions and localizations of CD-1, CD4-2, CDSα and CDSβ 显示文摘 | Goshi Kato Kana Goto Ikuyo Akune | 2013 | Deve Compar Immunol2013，39，3： | 1 |
| 9 | An algorithm for power line detection and warning based on a millimeter-wave radar video显示文摘 | MA Qi-rong GOSHI D S SHIH Y C | 2011 | IEEE Trans on Image Processing2011，20，12： | 1 |
| 10 | Safety of sodium fluorescein for in vivo study of skin显示文摘 | O' goshi K Setup J | 2006 | Skin Res Technol2006，12，3： | 1 |
| 11 | W-Band BPSK and QPSK Transceivers With Costas-Loop Carrier Recovery in 65-nm CMOS Technology 显示文摘 | Goshi D S Liu Y Mai K | 2011 | IEEE Journal of Solid- State Circuits2011，46，12： | 1 |
| 12 | Circulating p53 Antibody in Patients with Colorectal Cancer显示文摘 | Goshi Shiota Masato Ishida Naoya Noguchi Kenji Oyama Yuji Takano Michiko Okubo Shunsuke Katayama Yasushi Tomie Kenichi Harada Kotaro Hori Kumiyo Ashida Yosuke Kishimoto Akihide Hosoda Takeaki Suou Takamasa Kanbe Kiwamu Tanaka Kimiyasu Nosaka Osamu Tanida | 2000 | Digestive Diseases and Sciences2000，，1： | 1 |
| 13 | Antibiotic conjugated fluorescent car- bon dots as a theranostic agent for controlled drug release, bioimaging, and enhanced antimicrobial activity 显示文摘 | Thakur M Pandey S Mewada A Patil V Khade M Goshi E Sharon M | 2014 | Jour- nal of Drug Delivery2014，2014，28： | 1 |
| 14 | Reduction of hepatocarcinogenesis by ursodeoxycholic acid in rats显示文摘 | Kenji Oyama Goshi Shiota Hisao lto | 2002 | Carcinogenesis2002，23，： | 1 |
| 15 | Clinical usefulness of telomerase activity and telomere length in the preoperative diagnosis of gastric and colorectal cancer显示文摘 | Shunsuke Katayama Goshi Shiota Mitsuo Oshimura Hironaka Kawasaki | 1999 | Journal of Cancer Research and Clinical Oncology1999，，7： | 1 |
| 16 | Emergenee of elarlthromyclin resistant to Helieobaeter Pytori (CRHP)with a high Prevalence in children compared with their parents显示文摘 | Taneike I Goshi S Tamura Y | 2002 | Helicobaeter2002，7，： | 1 |
| 17 | Enhancement of spine fusion using combined gene therapy and tissue engineering BMP-7 expressing bone marrow cells and allograft bone显示文摘 | Hidaka C Goshi K Rawlins B | 2003 | Spine2003，28，18： | 1 |
| 18 | Digital stereoscopic video system with embedded high resolution images显示文摘 | Goshi K Matsunaga K | 2001 | Virtual Reality2001，42，5： | 1 |
| 19 | Safety of sodium fluorescein for in vivo study of skin 显示文摘 | O'goshi K Serup J | 2006 | Skin Res Techno12006，12，3： | 1 |
| 20 | Three-dimen-sional analyses of individual corneocytes with atomic force microscope: morphological changes related to age,location and to the pathologic skin conditions显示文摘 | Kashibuchi N Hirai Y O'Goshi K | 2002 | Skin Research and Technology2002，8，4： | 1 |
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