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| 1 | siRNA, miRNA and HIV: promises and challenges显示文摘Small interfering RNA (siRNA) and microRNA (miRNA) are small RNAs of 18-25 nucleotides (nt) in length that play important roles in regulating gene expression. They are incorporated into an RNA-induced silencing complex (RISC) and serve as guides for silencing their corresponding target mRNAs based on complementary base-pairing. The promise of gene silencing has led many researchers to consider siRNA as an anti-viral tool. However, in long-term settings, many viruses appear to escape from this therapeutical strategy. An example of this may be seen in the case of human immunodeficiency virus type-1 (HIV-1) which is able to evade RNA silencing by either mutating the siRNA- targeted sequence or by encoding for a partial suppressor of RNAi (RNA interference). On the other hand, because miRNA targeting does not require absolute complementarity of base-pairing, mutational escape by viruses from miRNA- specified silencing may be more difficult to achieve. In this review, we discuss stratagems used by various viruses to avoid the cells’ antiviral si/mi-RNA defenses and notions of how viruses might control and regulate host cell genes by encoding viral miRNAs (vmiRNAs). | Man Lung YEUNG Yamina BENNASSER Shu Yun LE Kuan Teh JEANG | 2005 | Cell Research2005，15，11： | 7 |
| 2 | Origin of Field-Dependent Optical Transmission of Magnetic Fluid Films显示文摘 | Chiu Y P Jeang B Y | 2001 | Applied Physics Letters2001，79，： | 1 |
| 3 | miRNAs in the biology of cancers and viral infections显示文摘 | Yeung M L Bennasser Y Jeang K T | 2007 | Curr Med Chem2007，14，： | 1 |
| 4 | Simultaneous process mean and process toleranee determination with adjustment and compensation for precision manufacturing显示文摘 | Jeang A Chen T Li H C | 2007 | International Journal of Advanced Manufacturing Technology2007，，33： | 1 |
| 5 | Multifaceted activities of the HIV 1 transactivator of transcription, Tat 显示文摘 | Jeang KT Xiao H Rich EA | | JB iol Chem0，，： | 1 |
| 6 | Purification and characterization of a raw-starch digesting amylase from a Soilhacterium cytophaga sp显示文摘 | Jeang CL Lee YH Chang LW | | 0，，： | 1 |
| 7 | Combined parameter and tolerance design for quality via computer experiment:a design for thermo-electric micro-actuator显示文摘 | Jeang A | 2008 | IEEE Transactions on Electronics Packging Manufacturing2008，131，3： | 1 |
| 8 | HIV-1 TAR RNA subverts RNA interference in transfected cells through sequestration of TAR RNA-binding protein,TRBP显示文摘 | Bennasser Y Yeung M L Jeang K T | 2006 | J Biol Chem2006，281，27： | 1 |
| 9 | Role of RNA helicases in HIV-1replication 显示文摘 | Jeang KT Yedavalli V | 2006 | Nucleic Acids Res2006，34，15： | 1 |
| 10 | Biochemical and functional interactions between HIV-1 Tat protein and TAR RNA 显示文摘 | Rana T M Jeang K T | 1999 | Arch Biochem Biophys1999，365，2： | 1 |
| 11 | Robust tolerance design by computer experiment显示文摘 | LEU E | 1999 | INT J PROD RES1999，37，9： | 1 |
| 12 | Human T cell leukemia virus type 1 oneoprotein Tax targets the human mitotic checkpoint protein MADI 显示文摘 | Jin DY Spencer F Jeang KT | 1998 | Cell1998，93，1： | 1 |
| 13 | Isolation of full-length cDNA and chromosomal localiztion of human NF-κB modulator NEMO to Xq28显示文摘 | Jin DY Jeang KT | 1999 | J Biomed Sci1999，6，2： | 1 |
| 14 | Robust tolerance design by response surface methodology显示文摘 | | 1999 | Advanced Manufacturing Technology1999，，15： | 1 |
| 15 | Multifaceted activities of the HIV-1 Transactivator of Transcription, Tat 显示文摘 | Jeang K T Xiao H Rich E A | 1999 | J Biol Chem1999，274，28： | 1 |
| 16 | Economic and quality scheduling for effective utilization of operating rooms显示文摘 | Jeang A Chiang A J | 2012 | Journal of Medi- cal Systems2012，36，3： | 1 |
| 17 | Rearrangement of Mirror Elements显示文摘 | Wang H Y Chang S H Jeang Y L | 2006 | Analog Integrnled Circuits and Signal Processing2006，49，： | 1 |
| 18 | Multifaceted activities of the H Ⅳ-1 transactivator of transcription,Tat 显示文摘 | JEANG KT XIAO H RICH EA | 1999 | J Biol Chem1999，274，28： | 1 |
| 19 | Combined parameter and tolerance design optimization with quality and cost 显示文摘 | Jeang A | 2001 | Int J Prod Res2001，39，5： | 1 |
| 20 | Optimizing process parameters of hot-bar soldering process through quality function deployment and Taguchi method显示文摘 | JEANG A G CHUNG C P CHEN C W | 2009 | Journal of Materials Processing Technology2009，209，6： | 1 |
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