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| 1 | New insight in expression, transport, and secretion of brain-derived neurotrophic factor: Implications in brainrelated diseases显示文摘Brain-derived neurotrophic factor(BDNF) attracts increasing attention from both research and clinical fields because of its important functions in the central nervous system. An adequate amount of BDNF is critical to develop and maintain normal neuronal circuits in the brain. Given that loss of BDNF function has beenreported in the brains of patients with neurodegenerative or psychiatric diseases, understanding basic properties of BDNF and associated intracellular processes is imperative. In this review, we revisit the gene structure, transcription, translation, transport and secretion mechanisms of BDNF. We also introduce implications of BDNF in several brain-related diseases including Alzheimer's disease, Huntington's disease, depression and schizophrenia. | Naoki Adachi Tadahiro Numakawa Misty Richards Shingo Nakajima Hiroshi Kunugi | 2014 | World Journal of Biological Chemistry2014，5，4： | 30 |
| 2 | 建筑用甲硅烷基化的聚氨酯显示文摘 | Misty W Huang 刘鹏 | 2001 | 粘接2001，22，4： | 10 |
| 3 | Functional interactions between steroid hormones and neurotrophin BDNF显示文摘Brain-derived neurotrophic factor(BDNF),a critical neurotrophin,regulates many neuronal aspects including cell differentiation,cell survival,neurotransmission,and synaptic plasticity in the central nervous system(CNS) .Though BDNF has two types of receptors,high affinity tropomyosin-related kinase(Trk) B and low affinity p75 receptors,BDNF positively exerts its biological effects on neurons via activation of TrkB and of resultant intracellular signaling cascades including mitogenactivated protein kinase/extracellular signal-regulated protein kinase,phospholipase Cγ,and phosphoinositide 3-kinase pathways.Notably,it is possible that alteration in the expression and/or function of BDNF in the CNS is involved in the pathophysiology of various brain diseases such as stroke,Parkinson's disease,Alzheimer's disease,and mental disorders.On the other hand,glucocorticoids,stress-induced steroid hormones,also putatively contribute to the pathophysiology of depression.Interestingly,in addition to the reduction in BDNF levels due to increased glucocorticoid exposure,current reports demonstrate possible interactions between glucocorticoids and BDNF-mediated neuronal functions. Other steroid hormones,such as estrogen,are involved in not only sexual differentiation in the brain,but also numerous neuronal events including cell survival and synaptic plasticity.Furthermore,it is well known that estrogen plays a role in the pathophysiology of Parkinson's disease,Alzheimer's disease,and mental illness,while serving to regulate BDNF expression and/or function.Here,we present a broad overview of the current knowledge concerning the association between BDNF expression/function and steroid hormones(glucocorticoids and estrogen). | Tadahiro Numakawa Daisaku Yokomaku Misty Richards Hiroaki Hori Naoki Adachi Hiroshi Kunugi | 2010 | World Journal of Biological Chemistry2010，1，5： | 7 |
| 4 | 用于水性体系的稳定的粘合促进剂和交联剂显示文摘有机功能烷氧基硅烷作为粘合促进剂和交联剂 ,广泛用于胶粘剂、密封胶和涂料等领域。然而 ,传统硅烷在水性环境中的不稳定性限制了其在水性体系中的应用。本文叙述了专用于水性体系的硅烷新技术 ,以及新旧环氧硅烷在含有羧基和氨基基团的单组分水性胶粘剂、密封胶体系 ,如丙烯酸乳液、丁苯胶乳和聚氨酯分散体中的应用 ,并讨论了影响贮存稳定性、固化机理和性能表现的因素。 | Misty W.Huang Bruce A.Waldman | 2000 | 粘接2000，21，5： | 6 |
| 5 | Evidence for colorectal sarcomatoid carcinoma arising from tubulovillous adenoma显示文摘Sarcomatoid carcinomas of the colorectum are rare tu- mors that display both malignant epithelial and stromal components. Clinically, they are aggressive tumors with early metastasis. Due to their infrequent occurrence, the pathogenesis is poorly understood. We report a case of a 52-year-old woman who presented with a rectal mass and intermittent hematochezia. Superficial biopsies during colonoscopy revealed a tubulovillous adenoma with high-grade dysplasia. Endoscopic ultra- sonography confirmed an invasive nature of the mass, and deeper biopsies revealed the presence of neoplasm with mixed histological components. The surgically- excised specimen demonstrated the presence of poorly differentiated spindle cells underneath the tubulovillous adenoma and an intermediate stage of invasive adeno- carcinoma. Based on the histological appearance and immunohistochemical studies, a diagnosis of sarcoma- toid carcinoma was made. Only nine cases of sarcoma- toid carcinomas of the colorectum have been reported to date. As a result, the terminology and pathogenesis of sarcomatoid carcinoma remain speculative. To the best of our knowledge, this is the first report of co- existence of sarcomatoid carcinoma and invasive ad- enocarcinoma with tubulovillous adenoma; all stages represented within the same tumor. This observation supports the 'monoclonal theory' of pathogenesis with an adenoma-sarcoma progression with or without an intermediate stage of carcinoma. | Jeffrey K Lee Pradipta Ghosh Valerie McWhorter Misty Payne Ryan Olson Mary L Krinsky Sonia Ramamoorthy John M Carethers | 2008 | World Journal of Gastroenterology2008，14，27： | 2 |
| 6 | Advances in the development of new biomarkers for Alzheimer’s disease显示文摘Alzheimer’s disease(AD)is a complex,heterogeneous,progressive disease and is the most common type of neurodegenerative dementia.The prevalence of AD is expected to increase as the population ages,placing an additional burden on national healthcare systems.There is a large need for new diagnostic tests that can detect AD at an early stage with high specificity at relatively low cost.The development of modern analytical diagnostic tools has made it possible to determine several biomarkers of AD with high specificity,including pathogenic proteins,markers of synaptic dysfunction,and markers of inflammation in the blood.There is a considerable potential in using microRNA(miRNA)as markers of AD,and diagnostic studies based on miRNA panels suggest that AD could potentially be determined with high accuracy for individual patients.Studies of the retina with improved methods of visualization of the fundus are also showing promising results for the potential diagnosis of the disease.This review focuses on the recent developments of blood,plasma,and ocular biomarkers for the diagnosis of AD. | Timofey O.Klyucherev Pawel Olszewski Alena A.Shalimova Vladimir N.Chubarev Vadim V.Tarasov Misty M.Attwood Stina Syvänen Helgi B.Schiöth | 2022 | Translational Neurodegeneration2022，11，1： | 2 |
| 7 | Associations of the shared and unique aspects of positive and negative emotional factors with sleep quality 显示文摘 | Stewart JC Rand KL Hawkins Misty AW | 2011 | Personality and Individual Differences2011，50，5： | 1 |
| 8 | Teaching typically developing children to promote social play with their siblings with autism显示文摘 | Misty L. Oppenheim-Leaf Justin B. Leaf Claudia Dozier Jan B. Sheldon James A. Sherman | 2011 | Research in Autism Spectrum Disorders2011，，2： | 1 |
| 9 | Synthesis of surface initiated diblock copolymer brushes from flat silicon substrates utilizing the RAFY polymerization technique显示文摘 | Misty D Rowe-Konopacki Stephen G Boyes | 2007 | Macromolecules2007，，40： | 1 |
| 10 | Persons Living with HIVAIDS Contemplating a Return to Work: A Social Cognitive Career Theory and Constructivist Theory Perspective 显示文摘 | Misty Trujillo | 2010 | Journal of Rehabilitation2010，76，1： | 1 |
| 11 | Two Arabidopsis ADP-glucose pyrophosphorylase large subunits APL1 and APL2) are catalytic显示文摘 | TIZIANA V MISTY L K MA T R | | 0，，01： | 1 |
| 12 | Outcomes of covered versus bare-metal balloon-expandable stents for aortoiliac occlusive disease显示文摘 | Misty DH Ehrin A John L | 2014 | J Vasc Surg2014，60，： | 1 |
| 13 | Associations of the shared and unique aspects of positive and negative emotional factors with sleep quality 显示文摘 | Stewart J C Rand K L Hawkins Misty A W | 2011 | Personality and Individual Dif- fer-ences2011，50，5： | 1 |
| 14 | Small molecule inhibitors of a glycoside hydrolase attenuate inducible AmpC-mediated β-laetam resistance显示文摘 | Keith A S Misty B Brian L M | 2007 | J Biol Chem2007，282，21： | 1 |
| 15 | Selective extractions to assess the biogeochemically relevant fractionation of inorganic mercury in sediments and soils显示文摘 | Nicolas S Bloom Eve Preus Jodie Katon Misti Hiltner | 2002 | Analytica Chimica Acta2002，，2： | 1 |
| 16 | Kainate-induced calcium overload of cortical neurons in vitro : Dependence on expression of AMPAR GluA2-subunit and down-regulation by subnanomolar ouabain显示文摘 | Polina A. Abushik Dmitry A. Sibarov Misty J. Eaton Serguei N. Skatchkov Sergei M. Antonov | 2013 | Cell Calcium2013，，2： | 1 |
| 17 | Gaucher Disease:a model for mourned management of a genetic disease显示文摘 | Misty PK | 1999 | J Hepatology1999，30，： | 1 |
| 18 | A comparison of oral micronized estradiol with soy phytoestrogen effects on tail temperatures of ovariectomized rats显示文摘 | YUANLONG P MARY A MISTI B | 2001 | Menopause2001，8，3： | 1 |
| 19 | PUPPI: The Pressure Ulcer Prevention Protocol Interventions显示文摘 | Kimberly Catania Cheryl Huang Polly James Michelle Madison Molly Moran Misty Ohr | 2007 | AJN, American Journal of Nursing2007，，4： | 1 |
| 20 | Certification and clinical ladder as the impetus for professional development显示文摘 | Misty DW | 2010 | Crit Care Nurs Q2010，33，1： | 1 |
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