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| 1 | Intragenic antagonistic roles of protein and circRNA in tumorigenesis显示文摘circRNAs arise from back splicing events during mRNA processing, and when deregulated can play an active role in cancer. Here we characterize a new circRNA (circPOK) encoded by the Zbtb7a gene (also kown as POKEMON, LRF) in the context of mesenchymal tumor progression. circPOK functions as a non-coding proto-oncogenic RNA independently and antithetically to its linear transcript counterpart, which acts as a tumor suppressor by encoding the Pokemon transcription factor. We find that circPOK regulates pro-proliferative and pro-angiogenic factors by co-activation of the ILF2/3 complex. Importantly, the expression of Pokemon protein and circRNA is aberrantly uncoupled in cancer through differential post-transcriptional regulation. Thus, we identify a novel type of genetic unit, the iRegulon, that yields biochemically distinct RNA products, circular and linear, with diverse and antithetical functions. Our findings further expand the cellular repertoire towards the control of normal biological outputs, while aberrant expression of such components may underlie disease pathogenesis including cancer. | Jlenia Guarnerio Yang Zhang Giulia Cheloni Riccardo Panella Jesse Mae Katon Mark Simpson Akinobu Matsumoto Antonella Papa Cristian Loretelli Andreas Petri Sakari Kauppinen Cassandra Garbutt Gunnlaugur Petur Nielsen Vikram Deshpande Mireia Castillo-Martin Carlos Cordon-Cardo Spentzos Dimitrios John G. Clohessy Mona Batish Pier Paolo Pandolfi | 2019 | Cell Research2019，29，8： | 15 |
| 2 | Unsedated peroral endoscopy with a video ultrathin endoscope: patient acceptance, tolerance, and diagnostic accuracy显示文摘 | Atif Zaman Ronald Hapke Geronimo Sahagun RonaldM Katon | 1998 | The American Journal of Gastroenterology1998，，8： | 2 |
| 3 | A randomized trial of peroral versus transnasal unsedated endoscopy using an ultrathin videoendoscope显示文摘 | Atif Zaman Martin Hahn Ronald Hapke Kandice Knigge M.Brian Fennerty Ronald M. Katon | 1999 | Gastrointestinal Endoscopy1999，，3： | 2 |
| 4 | Theassociation of comorbid depression with mortality in patients withtype 2 diabetes显示文摘 | Katon Wayne J Rutter Carolyn PHD Simon Greg MD | 2005 | Diabetes Care2005，28，11： | 1 |
| 5 | Effect of improving depression care on pain and functional outcomes among older adults with arthritis: a randomized controlled trial 显示文摘 | Lin EHB Katon W von Korff M | 2003 | JAMA2003，290，： | 1 |
| 6 | Dialogue on Diabetes and Depression: dealing with the double burden of co-morbidity显示文摘 | Holt RI Katon WJ | 2012 | J Affect Disord2012，142，： | 1 |
| 7 | Collaborative care management of late-life depression in the primary care setting:Arandomized controlled trial显示文摘 | Unutzer J Katon W Callahan CM | 2002 | Journal of the American Medical Association2002，288，22： | 1 |
| 8 | Urinary incontinence in US women:a population-based study显示文摘 | Melville JL Katon W Delaney K | 2005 | Arch Intern Med2005，165，5： | 1 |
| 9 | Racial and ethnic differences in microalbuminuria prevalence in a diabetes population:the pathways study显示文摘 | Young BA Katon WJ von Korff M | 2005 | J Am Soc Nephrol2005，16，1： | 1 |
| 10 | Improving Primary Care for Depression in Late Life: the Design of a Multicenter Randomized Trial显示文摘 | Unutzer J Katon W Williams JW | 2001 | Med-Care2001，39，8： | 1 |
| 11 | Mutation of ras oncongene in disoproanol nitrosamine induced rat thyroid carcinogenesis 显示文摘 | KobayBhi Y Kawaoi A Katon R | 2002 | Virchows Archly2002，441，3： | 1 |
| 12 | Molecular cloning and characterization of a novel DNA virus (TTV) associated with posttransfusion hepatitis of unknown etiology显示文摘 | Okamoto H Nishizawa T Katon | 1998 | Hepatol Ras1998，10，1： | 1 |
| 13 | Panic disorder and somatization显示文摘 | Katon W | 1984 | Am J Med1984，77，： | 1 |
| 14 | Depression and pain comor- bidity: a literature review 显示文摘 | Bair MJ Robinson RL Katon W | 2003 | Arch Intern Med2003，163，20： | 1 |
| 15 | Psychiatric illness and irritable bowel syndrome:A comparison with inflammatory bowel disease显示文摘 | Walker EA Roy-Byrne PP Katon WJ | 1990 | Am Psychiarty1990，147，12： | 1 |
| 16 | Psychiatric morbidity and functional impairments in survivors of bums,traumatic injuries,and ICU stays for other critical illnesses:a review of the literature显示文摘 | Davydow DS Katon WJ Zatzick DF | 2009 | Int Rev Psychiatry2009，21，6： | 1 |
| 17 | Epidemiology of depression in primary care显示文摘 | Katon W Schulberg H | 1992 | Gen Hosp Psychiatry1992，14，： | 1 |
| 18 | The associationof comorbid depression with mortality in patients with type 2 diabetes 显示文摘 | KATON WJ RUTYER C SIMON G | 2005 | Diabetes Care2005，28，11： | 1 |
| 19 | Predictors of outcome in a primary care depression trial显示文摘 | Walker E Katon W Russo J | 2000 | J Gen Intern Med2000，15，： | 1 |
| 20 | Depression and disability in seasonal and migrant Hispanic agricultural workers 显示文摘 | Mazzoni SE Boiko PE Katon WJ | 2007 | Gen Hosp Psychiatry2007，29，5： | 1 |
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