|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Schistosoma japonicum infection induces macrophage polarization显示文摘The role of macrophages(Mφ)as the first line of host defense is well accepted.These cells play a central role in orchestrating crucial functions during schistosomal infection.Thus,understanding the functional diversity of these cells in the process of infection as well as the mechanisms underlying these events is crucial for developing disease control strategies.In this study,we adopted a Mφpolarization recognition system.Ml macrophage was characterized by expressing CD16/32,IL-12 and iNOS.M2 macrophage was characterized by expressing CD206,IL-10 and arg-1.In vivo(mouse peritoneal macrophages of different infection stages were obtained)and in vitro(different 5.japonicum antigens were used to stimulate RAW264.7)were characterized by using the above mentioned system.NCA and ACA stimulated RAW264.7 express significantly higher levels of IL-12 while significantly higher levels of IL-10 were detected after soluble egg antigen(SEA)stimulation.The results showed that dramatic changes of antigen in the microenvironment before and after egg production led to macrophage polarization.Furthermore,through TLR blocking experiments,the TLR4 signaling pathway was found to play a role in the process of macrophage polarization toward Ml.Our data suggest that macrophage polarization during S.japonicum infection had significant effects on host immune responses to S.japonicum. | Jingwei Xu Hao Zhang Lin Chen Donghui Zhang Minjun Ji Haiwei Wu Guanling Wu | 2014 | The Journal of Biomedical Research2014，28，4： | 20 |
| 2 | Antimicrobial susceptibility of Gram-negative bacteria causing intra-abdominal infections in China: SMART China 2011显示文摘 | Zhang Hui Yang Qiwen Xiao Meng Chen Minjun Robert E. Badal Xu Yingchun | 2014 | Chinese Medical Journal2014，，13： | 10 |
| 3 | Xeno-repopulation of Fah^(-/-)Nod/Scid mice livers by human hepatocytes显示文摘Functional human hepatocytes xenografted into the liver of mice can be used as a model system to study pharmacokinetics,infection of hepatitis viruses,and the efficacy of hepatitis vaccines.Significant levels of liver xeno-repopulation have been reported in Fah-/-Rag2-/-Il2rg-/-mice.However,the high mortality and low breeding rate of this model may hinder its application.A new model,termed Fah-/-Nod/Scid mice,which combines the advantages of liver repopulation in Fah-/-mice with the ease of xenotransplantation in Nod/Scid mice was obtained by gradual cross-breeding.Fah-/-Nod/Scid mice were easily maintained in breeding colonies and in adult animal care facilities.FK506 treatment combined with gradual withdrawal of NTBC before cell transplantation ensured that Fah-/-Nod/Scid mice were susceptible to liver xeno-repopulation by human hepatocytes;the proportion of engrafted human hepatocytes reached 33.6%.The function of the expanded human hepatocytes within the chimeric liver was confirmed by weight curve analysis,the expression of characteristic proteins,and the biochemical analysis of liver function.These results show that Fah-/-Nod/Scid mice are an ideal humanized liver mouse model with many useful applications. | SU BaoLiang LIU ChangCheng XIANG Dao ZHANG HaiBin YUAN SiMing WANG MinJun CHEN Fei ZHU HaiYing HE ZhiYing WANG Xin HU YiPing | 2011 | Science China(Life Sciences)2011，54，3： | 5 |
| 4 | Bioinformatic analysis of expressed sequence tags from sporophyte of Porphyra yezoensis (Bagiaceae, Rhodophyta)显示文摘719 个表示顺序标签(EST ) 的一个总数非聚类进 329 - 冗余的 EST 组从红 alage 的 sporophte cDNA 图书馆被获得, Porphyra yezoensis。基因本体论(去) 分析在描绘 60 最严格的 annotatd 被采用从象与在房间工作的酶和蛋白质有关的 COXI, Sod_Fe_C, GST_N, SHMT,和 RNase_PH 那样的 329 个 EST 组和一些领域的唯一的基因被 HMMPFAM 搜索识别了。作为它的叶状的配偶体,有 storong 偏爱的用法上的类似的鳕鱼在 P 被发现。yezoensis 细丝状的孢子体,不管在给定的氨基酸发现的一些差别。329 唯一的基因的平均 GC 内容是 53.0 % 。相反,鳕鱼在上的第三核苷酸比的展出一个更高的 GC 内容(72 %) 第一(58 %) 并且第二(42 %) 核苷酸。现在的学习的类似搜索显示出对 Porphyra EST 数据库的 60.2 % 的 noves EST 比率,建议向阐明的进一步的调查 Porphyrafunctional 的特征染色体。 | XU Minjun MAO Yunxiang ZHANG Xuecheng ZHOU Xiaojun SUI Zhenghong ZHOU Hailin LI Jinhong | 2006 | Progress in Natural Science:Materials International2006，16，1： | 4 |
| 5 | A specific aggregation-induced emission-conjugated polymer enables visual monitoring of osteogenic differentiation显示文摘Osteogenic differentiation is the basis of bone growth and repair related to many diseases,in which evaluating the degree and ability of osteogenic transformation is quite important and highly desirable.However,fixing or stopping the growth of cells is required for conventional methods to monitor osteogenic differentiation,which cannot realize the full investigation of the dynamic process.Herein,a new anion conjugated polymer featuring aggregation-induced emission(AIE)characteristics is developed with excellent solubility for in-situ monitoring the process of osteogenic differentiation.This novel polymer can bind with osteogenic differentiated cells,and the intracellular fluorescence increases gradually with the enhancement of osteogenic differentiation.Moreover,it possesses good biosafety with negligible effect on cell activity and osteogenic differentiation,which cannot be realized by the typical method of Alizarin Red S staining.Further study shows that the polymer crosses the cell membrane through endocytosis and enriches in lysosomes,whereas no obvious fluorescence is detected with other cells,including non-differentiated osteoblast cells,under the same conditions,demonstrating the high selectivity.This is the first fluorescent probe with excellent specificity to realize real-time observation of the process of osteogenic differentiation.Therefore,PTB-EDTA shows great promise in the study of osteogenic differentiation and related applications. | Zhenyu Zheng Taotao Zhou Rong Hu Minjun Huang Xiang Ao Jun Chu Tao Jiang Anjun Qin Zhongmin Zhang | 2020 | Bioactive Materials2020，5，4： | 3 |
| 6 | IFN-inducible p47 GTPases display differential responses to Schistosoma japonicum acute infection显示文摘Interferon gamma induced GTPase(IGTP)(also named lrgm3)and interferon gamma inducible protein 47(IRG-47)(also named lIrgd)are interferon(IFN)-inducible p47 GTPases that have been shown to regulate host resistance to intracellular pathogens.Little knowledge has been known about the role of p47 GTPases in host responses against extracellular pathogens.To investigate possible roles of IGTP and IRG-47 in the course of Schistosoma japonicum infection,IGTP and IRG-47 knockout and wild-type(WT)mice were challenged with cercariae of S.japonicum,and host responses were analyzed.At the acute stage of S.japonicum infection,mice that lacked IGTP displayed similar parasite burden and pathological damage to WT mice.Importantly,S.japonicum-infected lRG-47-deficient mice,in contrast to IGTP-deficient mice and WT mice,showed significantly reduced worms and lower egg-burden,but intense granulomatous reaction evoked by schistosome eggs in peripheral parts of liver lobes.In addition,upregulation of inflammation-related gene expression was observed in the spleen of IRG-47-deficient mice using oligonucleotide microarrays,in which multiple pathways of cytokine-cytokine receptor interaction,T-cell receptor signaling,complement,coagulation cascades and cell adhesion molecules were highlighted.Taken together,these data suggest that IGTP and IRG-47 might have distinct features that were differentially required for resistance to S.japonicum. | Xuesong Chen Xiaotang Du Meijuan Zhang Donghui Zhang Minjun Ji Guanling Wu | 2010 | Cellular & Molecular Immunology2010，7，1： | 2 |
| 7 | Roadway layout for recycling residual coal pillar in room-and-pillar mining of thick coal seam显示文摘In the context of a room-and-pillar mining gob in Shanxi province in China,this paper numerically investigates the stress distribution and deformation rules of roadway surrounding rocks at various locations of residual coal pillars in room-and-pillar mining gobs using software FLAC3 D.It is found that the concentrated stress beneath coal pillars distributes in a shape of ellipse.A reasonable roadway layout is then proposed.In this design,it is indicated that roadways should be designed to avoid the supporting zones of pillars with increasing compression and take into account the roof falling and crushing in the upper gob.According to the surrounding rock deformation characteristics and mining roadway locations as well as the supporting principles of timely support,rock reinforcing,piecewise management and suiting local conditions,a new asymmetric shield supporting plan is proposed.The field surveying results show that this supporting plan can effectively control the roadway rock deformation,thus guarantee the safe and smooth construction of roadways. | Jin Gan Wang Lianguo Zhang Jihua Hu Minjun Duan Ning | 2015 | International Journal of Mining Science and Technology2015，25，5： | 2 |
| 8 | An IOanalysis of the trend in virtual water trade and the impacton water resources and uses in China 显示文摘 | ZHANG Zhuoying SHI Minjun YANG Hong | 2011 | EconomicSystems Research2011，23，4： | 1 |
| 9 | Nanopolyphenol rejuvenates microglial surveillance of multiple misfolded proteins through metabolic reprogramming显示文摘Microglial surveillance plays an essential role in clearing misfolded proteins such as amyloid-beta,tau,andα-synuclein aggregates in neurodegenerative diseases.However,due to the complex structure and ambiguous pathogenic species of the misfolded proteins,a universal approach to remove the misfolded proteins remains unavailable.Here,we found that a polyphenol,α-mangostin,reprogrammed metabolism in the disease-associated microglia through shifting glycolysis to oxidative phosphorylation,which holistically rejuvenated microglial surveillance capacity to enhance microglial phagocytosis and autophagy-mediated degradation of multiple misfolded proteins.Nanoformulation ofα-mangostin efficiently deliveredα-mangostin to microglia,relieved the reactive status and rejuvenated the misfolded-proteins clearance capacity of microglia,which thus impressively relieved the neuropathological changes in both Alzheimer’s disease and Parkinson’s disease model mice.These findings provide direct evidences for the concept of rejuvenating microglial surveillance of multiple misfolded proteins through metabolic reprogramming,and demonstrate nanoformulatedα-mangostin as a potential and universal therapy against neurodegenerative diseases. | Dayuan Wang Xiao Gu Xinyi Ma Jun Chen Qizhi Zhang Zhihua Yu Juan Li Meng Hu Xiaofang Tan Yuyun Tang Jianrong Xu Minjun Xu Qingxiang Song Huahua Song Gan Jiang Zaiming Tang Xiaoling Gao Hongzhuan Chen | 2023 | Acta Pharmaceutica Sinica B2023，13，2： | 1 |
| 10 | A Frame Breaking Based Hybrid Algorithm for UHF RFIDAnti-Collision显示文摘Multi-tag collision imposes a vital detrimental effect on reading performanceof an RFID system. In order to ameliorate such collision problem and to improve thereading performance, this paper proposes an efficient tag identification algorithm termedas the Enhanced Adaptive Tree Slotted Aloha (EATSA). The key novelty of EATSA is toidentify the tags using grouping strategy. Specifically, the whole tag set is divided intogroups by a frame of size F. In cases multiple tags fall into a group, the tags of the groupare recognized by the improved binary splitting (IBS) method whereas the rest tags arewaiting in the pipeline. In addition, an early observation mechanism is introduced toupdate the frame size to an optimum value fitting the number of tags. Theoretical analysisand simulation results show that the system throughput of our proposed algorithm canreach as much as 0.46, outperforming the prior Aloha-based protocols. | Xinyan Wang Minjun Zhang Zengwang Lu | 2019 | Computers, Materials & Continua2019，，6： | 1 |
| 11 | Understanding Beijing's water challenge: a decomposition analysis of changes in Beijing's water footprint between 1997 and 2007 显示文摘 | Zhang Zhuoying Shi Minjun Yang Hong | 2012 | Environmental Science & Technology2012，46，12： | 1 |
| 12 | Analyses of water footprint of Beijing in an interregional input–output framework显示文摘 | Zhuoying Zhang Hong Yang Minjun Shi | 2011 | Ecological Economics2011，，12： | 1 |
| 13 | Modulating autophagic flux via ROS-responsive targeted micelles to restore neuronal proteostasis in Alzheimer’s disease显示文摘Compromised autophagy and defective lysosomal clearance significantly contribute to impaired neuronal proteostasis,which represents a hallmark of Alzheimer’s disease(AD)and other age-related neurodegenerative disorders.Growing evidence has implicated that modulating autophagic flux,instead of inducing autophagosome formation alone,would be more reliable to rescue neuronal proteostasis.Concurrently,selectively enhancing drug concentrations in the leision areas,instead of the whole brain,will maximize therapeutic efficacy while reduing non-selective autophagy induction.Herein,we design a ROS-responsive targeted micelle system(TT-NM/Rapa)to enhance the delivery efficiency of rapamycin to neurons in AD lesions guided by the fusion peptide TPL,and facilitate its intracellular release via ROS-mediated disassembly of micelles,thereby maximizing autophagic flux modulating efficacy of rapamycin in neurons.Consequently,it promotes the efficient clearance of intracellular neurotoxic proteins,β-amyloid and hyperphosphorylated tau proteins,and ameliorates memory defects and neuronal damage in 3×Tg-AD transgenic mice.Our studies demonstrate a promising strategy to restore autophagic flux and improve neuronal proteostasis by rationally-engineered nano-systems for delaying the progression of AD. | Shuting Xu Peng Yang Kang Qian Yixian Li Qian Guo Pengzhen Wang Ran Meng Jing Wu Jinxu Cao Yunlong Cheng Minjun Xu Qizhi Zhang | 2022 | Bioactive Materials2022，7，5： | 1 |
| 14 | Analyses of water footprint of Beijing in an interregional input–output framework显示文摘 | Zhuoying Zhang Hong Yang Minjun Shi | 2011 | Ecological Economics2011，，12： | 1 |
| 15 | Successful outcome of massive carbon dioxide embolism during laparoscopic hepatectomy显示文摘Carbon dioxide embolism is a rare but severe complication of laparoscopic hepatectomy.We reported a case of massive carbon dioxide embolism that developed into a rare paradoxical gas embolism during laparoscopic hepatectomy and resulted in reduced muscular power of the left upper extremity,severe pleural effusion and hypoalbuminemia after surgery.Fortunately,the patient fully recovered with positive prevention and postoperative treatment.This case report highlights that the surgeon and anaesthesiologist must be aware of the risks and the importance for prompt treatment when massive carbon dioxide embolism occurs. | Jun Zhang Jie Zhao Yue Fei Tieshuai Liu Minjun Liu | 2020 | Laparoscopic, Endoscopic and Robotic Surgery2020，3，2： | 1 |
| 16 | Understanding Beijing's water challenge: a decompositionanalysis of changes in Beijing's water footprint between1997 and 2007 显示文摘 | ZHANG Zhuoying SHI Minjun YANG Hong | 2012 | Environmental Science &Technology2012，46，12： | 1 |
| 17 | Covalent flavoproteins:types,occurrence,biogenesis and catalytic mechanisms显示文摘Flavoproteins are proteins that contain a nucleic acid derivative of riboflavin:flavin adenine dinucleotide(FAD)or flavin mononucleotide(FMN).Flavoproteins are involved in a wide array of biological processes,such as photosynthesis,DNA repair and natural product biosynthesis.It should be noted that 5%-10%of flavoproteins have a covalently linked flavin prosthetic group.Such covalent linkages benefit the holoenzyme in several ways including improving the stability and catalytic potency.During the past decade,significant progress has been made in covalent flavoproteins,especially with respect to enzyme-dependent biogenesis and discovery of novel linkage types.The present review gives a condensed overview of investigations published from March 2009 to December 2021,with emphasis on the discovery,biogenesis and their catalytic role in natural product biosynthesis. | WANG Minjun ZHANG Wenyuan WANG Nan | 2022 | Chinese Journal of Natural Medicines2022，20，10： | 0 |
| 18 | Insights on evolution of virulence and resistance from the whole-genome analysis of a predominant methicillin-resistant Staphylococcus aureus clone sequence type 239 in China显示文摘Earlier, we reported that ST239 was the15-year predominant methicillin-resistant Staphylococcus aureus(MRSA) clone in China. In this study, MRSA strain CN79 belonging to ST239 and isolated from blood was used to determine the whole genome sequence. Comparative genomics analysis was done between MRSA CN79and 25 sequenced S. aureus in the NCBI GenBank database. A total of 2,734 protein-encoding genes were identified in the MRSA CN79 genome, which carries 11antibiotic resistance genes and 65 virulence genes. Two prophages phiCN79A and phiNM3-like were found on the MRSA CN79 genome. MRSA CN79 carries 30 specific genes that are absent from the 25 sequenced S. aureus genomes. Most of them were prophage-related genes.Several antibiotic resistance genes, such as b-lactamase and ABC-type multidrug transport system gene, were located on the genomic island mSab. The antibiotic resistance genes, such as tet(M), ermA1, and blaZ, were also located on different transposons. The virulence genes sea,map, hlb, and sak are located on phiNM3-like prophage and the exotoxin genes are carried on the genomic island mSaa. These results suggest that ST239 MRSA strains are widespread owing to horizontal acquisition of the mobile genetic elements harbored antibiotic resistance genes and virulence genes in response to environmental selective pressures, such as antibiotics and the human immune system during evolution. | Hongbin Chen Xi Yang Qi Wang Chunjiang Zhao Henan Li Wenqiang He Xiaojuan Wang Feifei Zhang Zhanwei Wang Minjun Chen Baoli Zhu Hui Wang | 2014 | Chinese Science Bulletin2014，59，11： | 0 |
| 19 | Ultraviolet-attenuated cercariae ofSchistosoma japonicum fail to effectively induce a Th1 response in spite of up-regulating expression of cytotoxicity-related genes in C57BL/6 mice显示文摘Objective:To better understand the reason that Schistosoma japonicum(S.japonicum)ultraviolet(UV)-radiated cercariae could not induce high level of protection in C57BL/6 mice.Methods:Microarray technology was performed to investigate the gene transcription profile in skin draining lymph nodes(sdLNs)at 1 w after exposure to attenuated cercariae(AC)or normal cercariae(NC)of S.japonicum in C57BL/6 mice.The expressions of some representative genes were further confirmed by real-time PCR.Subsequently,the expressions of Th1/Th2 cytokine genes,cytotoxicity-related genes,as well as co-stimulator genes in spleens from AC-vaccinated and NC- infected mice were analyzed by real-time PCR at w 3 and 6 post-exposure.Results:The gene expressions of Th1 cytokines,including interferon-γ(IFN-γ),interleukin(IL)-12 and tumor necrosis factor-α(TNF-α)in the sdLNs were significantly lower in AC-vaccinated mice than in NC-infected mice.Furthermore,the gene expressions of Th1-and Th2-cytokines,including IFN-γ,IL-12,TNF-α,IL-4 and IL-10,in the spleens from AC-vaccinated mice showed little changes at w 3 and 6 post-vaccination.In addition,cytotoxicity-related molecules including granzyme A,granzyme B,granzyme K,perforin 1 and Fas L were up-regulated from the early stage of vaccination,and peaked at the 3rd w after vaccination with UV-AC.Conclusion:UV-AC of S.japonicum could not effectively induce a Th1 response in C57BL/6 mice,which may be an explanation for the low protection against parasite challenge,and the role played by up-regulated expression of cytotoxicity-related genes in mice needs to be further investigated. | Meijuan Zhang Fang Tian Yanan Gao Minjun Ji Guanling Wu | 2010 | The Journal of Biomedical Research2010，24，4： | 0 |
| 20 | Wearable and stretchable conductive polymer composites for strain sensors:How to design a superior one?显示文摘Wearable and stretchable strain sensors have potential values in the fields of human motion and health monitoring,flexible electronics,and soft robotic skin.The wearable and stretchable strain sensors can be directly attached to human skin,providing visualized detection for human motions and personal healthcare.Conductive polymer composites(CPC)composed of conductive fillers and flexible polymers have the advantages of high stretchability,good flexibility,superior durability,which can be used to prepare flexible strain sensors with large working strain and outstanding sensitivity.This review has put forward a comprehensive summary on the fabrication methods,advanced mechanisms and strain sensing abilities of CPC strain sensors reported in recent years,especially the sensors with superior performance.Finally,the structural design,bionic function,integration technology and further application of CPC strain sensors are prospected. | Liwei Lin Sumin Park Yuri Kim Minjun Bae Jeongyeon Lee Wang Zhang Jiefeng Gao Sun Ha Paek Yuanzhe Piao | 2023 | Nano Materials Science2023，5，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员