3篇
您的检索式：作者名="Zaiming Tang"
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| 1 | Psychosocial impact of mothers with perinatal loss and its contributing factors:an insight显示文摘Objective:To evaluate the psychosocial impact among mothers with perinatal loss and its contributing factors.Methods:A cross sectional study was conducted in University Kebangsaan Malaysia Medical Centre (UKMMC) from April 2008 to May 2009 using Edinburgh Postnatal Depression Scale (EPDS) and self administered questionnaire.Results:Sixty-two respondents were included and most of them were working mothers (77.4%).The mean age of the respondents was (31.0±5.6) years and a majority of the subjects aged between 20-34 years (77.4%).According to the EPDS score,53.2% of the respondents had a psychosocial impact with a total score of >9,out of 30.There was a significant relationship between psychosocial impact after perinatal loss and support from friends (P=0.019).However,there were no significant differences between psychosocial impact and history of previous perinatal loss,ethnicity,occupation,educational level,age or total income.Conclusion:Mothers with perinatal loss should be screened for psychosocial impact and offered support when needed.Family and friends should continue to provide emotional support.People who have experienced similar problem before will be able to provide better support than those who have not. | Rosnah SUTAN Rosnah Mohamad AMIN Khatija Banu ARIFFIN Tang Zoun TENG Mohd Faiz KAMAL Rusli Zaim RUSLI | 2010 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2010，11，3： | 2 |
| 2 | Nanopolyphenol rejuvenates microglial surveillance of multiple misfolded proteins through metabolic reprogramming显示文摘Microglial surveillance plays an essential role in clearing misfolded proteins such as amyloid-beta,tau,andα-synuclein aggregates in neurodegenerative diseases.However,due to the complex structure and ambiguous pathogenic species of the misfolded proteins,a universal approach to remove the misfolded proteins remains unavailable.Here,we found that a polyphenol,α-mangostin,reprogrammed metabolism in the disease-associated microglia through shifting glycolysis to oxidative phosphorylation,which holistically rejuvenated microglial surveillance capacity to enhance microglial phagocytosis and autophagy-mediated degradation of multiple misfolded proteins.Nanoformulation ofα-mangostin efficiently deliveredα-mangostin to microglia,relieved the reactive status and rejuvenated the misfolded-proteins clearance capacity of microglia,which thus impressively relieved the neuropathological changes in both Alzheimer’s disease and Parkinson’s disease model mice.These findings provide direct evidences for the concept of rejuvenating microglial surveillance of multiple misfolded proteins through metabolic reprogramming,and demonstrate nanoformulatedα-mangostin as a potential and universal therapy against neurodegenerative diseases. | Dayuan Wang Xiao Gu Xinyi Ma Jun Chen Qizhi Zhang Zhihua Yu Juan Li Meng Hu Xiaofang Tan Yuyun Tang Jianrong Xu Minjun Xu Qingxiang Song Huahua Song Gan Jiang Zaiming Tang Xiaoling Gao Hongzhuan Chen | 2023 | Acta Pharmaceutica Sinica B2023，13，2： | 1 |
| 3 | Neddylation inhibitor MLN4924 suppresses cilia formation by modulating AKT1显示文摘The primary cilium is a microtubule-based sensory organelle.The molecular mechanism that regulates ciliary dynamics remains elusive.Here,we report an unexpected finding that MLN4924,a small molecule inhibitor of NEDD8-activating enzyme(NAE),blocks primary ciliary formation by inhibiting synthesis/assembly and promoting disassembly.This is mainly mediated by MLN4924-induced phosphorylation of AKT1 at Ser473 under serum-starved,ciliary-promoting conditions.Indeed,pharmaceutical inhibition(by MK2206)or genetic depletion(via siRNA)of AKT1 rescues MLN4924 effect,indicating its causai role.Interestingly,pAKT 1-Ser473 activity regulates both ciliary synthesis/assembly and disassembly in a MLN4924 dependent manner,whereas pAKT-Thr308 determines the ciliary length in MLN4924-independent but VHL-dependent manner.Finally,MLN4924 inhibits mouse hair regrowth,a process requires ciliogenesis?Collectively,our study dem on strates an unexpected role of a neddylation inhibitor in regulation of ciliogenesis via AKT1,and pro?vides a proof-of-concept for potential utility of MLN4924 in the treatment of human diseases associated with abnormal ciliogenesis. | Hongmei Mao Zaiming Tang Hua Li Bo Sun Mingjia Tan Shaohua Fan Yuan Zhu Yi Sun | 2019 | Protein & Cell2019，10，10： | 1 |
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