|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Schistosoma japonicum infection induces macrophage polarization显示文摘The role of macrophages(Mφ)as the first line of host defense is well accepted.These cells play a central role in orchestrating crucial functions during schistosomal infection.Thus,understanding the functional diversity of these cells in the process of infection as well as the mechanisms underlying these events is crucial for developing disease control strategies.In this study,we adopted a Mφpolarization recognition system.Ml macrophage was characterized by expressing CD16/32,IL-12 and iNOS.M2 macrophage was characterized by expressing CD206,IL-10 and arg-1.In vivo(mouse peritoneal macrophages of different infection stages were obtained)and in vitro(different 5.japonicum antigens were used to stimulate RAW264.7)were characterized by using the above mentioned system.NCA and ACA stimulated RAW264.7 express significantly higher levels of IL-12 while significantly higher levels of IL-10 were detected after soluble egg antigen(SEA)stimulation.The results showed that dramatic changes of antigen in the microenvironment before and after egg production led to macrophage polarization.Furthermore,through TLR blocking experiments,the TLR4 signaling pathway was found to play a role in the process of macrophage polarization toward Ml.Our data suggest that macrophage polarization during S.japonicum infection had significant effects on host immune responses to S.japonicum. | Jingwei Xu Hao Zhang Lin Chen Donghui Zhang Minjun Ji Haiwei Wu Guanling Wu | 2014 | The Journal of Biomedical Research2014，28，4： | 20 |
| 2 | Antimicrobial susceptibility of Gram-negative bacteria causing intra-abdominal infections in China: SMART China 2011显示文摘 | Zhang Hui Yang Qiwen Xiao Meng Chen Minjun Robert E. Badal Xu Yingchun | 2014 | Chinese Medical Journal2014，，13： | 10 |
| 3 | Particulate matter(PM(2.5)) exposure season-dependently induces neuronal apoptosis and synaptic injuries显示文摘Epidemiological studies have shown that particulate matter 2.5(PM_(2.5)) not only increases the incidence of cardiopulmonary illnesses but also relates to the development of neurodegenerative diseases. Considering that PM_(2.5)is highly heterogeneous with regional disparity and seasonal variation, we investigated whether PM_(2.5)exposure induced neuronal apoptosis and synaptic injuries in a season-dependent manner. The results indicated that PM_(2.5)altered the expression of apoptosis-related proteins(mainly bax and bcl-2), activated caspase-3 and caused neuronal apoptosis. Additionally, PM_(2.5)decreased the levels of synaptic structural protein postsynaptic density(PSD-95) and synaptic functional protein N-methyl-D-aspartate(NMDA) receptor subunit(NR2B) expression. These effects occurred in a season-dependent manner, and PM_(2.5)collected from the winter showed the strongest changes. Furthermore, the effect was coupled with the inhibition of phosphorylated extracellular signal-regulated kinase 1/2(p-ERK1/2) and phosphorylated c AMP-response element binding protein(p-CREB). Based on the findings, we analyzed the correlations between the chemical composition of PM_(2.5)samples and the biological effects, and confirmed that winter PM_(2.5)played a major role in causing neuronal apoptosis and synaptic injuries among different season samples. | Minjun Chen Ben Li Nan Sang | 2017 | Journal of Environmental Sciences2017，29，4： | 10 |
| 4 | Flexible Wing Kinematics of a Free-Flying Beetle (Rhinoceros Beetle Trypoxylus Dichotomus)显示文摘 | Tien Van Truong Tuyen Quang Le Doyoung Byun Hoon Choel Park Minjun Kim | 2012 | Journal of Bionic Engineering2012，9，2： | 8 |
| 5 | Xeno-repopulation of Fah^(-/-)Nod/Scid mice livers by human hepatocytes显示文摘Functional human hepatocytes xenografted into the liver of mice can be used as a model system to study pharmacokinetics,infection of hepatitis viruses,and the efficacy of hepatitis vaccines.Significant levels of liver xeno-repopulation have been reported in Fah-/-Rag2-/-Il2rg-/-mice.However,the high mortality and low breeding rate of this model may hinder its application.A new model,termed Fah-/-Nod/Scid mice,which combines the advantages of liver repopulation in Fah-/-mice with the ease of xenotransplantation in Nod/Scid mice was obtained by gradual cross-breeding.Fah-/-Nod/Scid mice were easily maintained in breeding colonies and in adult animal care facilities.FK506 treatment combined with gradual withdrawal of NTBC before cell transplantation ensured that Fah-/-Nod/Scid mice were susceptible to liver xeno-repopulation by human hepatocytes;the proportion of engrafted human hepatocytes reached 33.6%.The function of the expanded human hepatocytes within the chimeric liver was confirmed by weight curve analysis,the expression of characteristic proteins,and the biochemical analysis of liver function.These results show that Fah-/-Nod/Scid mice are an ideal humanized liver mouse model with many useful applications. | SU BaoLiang LIU ChangCheng XIANG Dao ZHANG HaiBin YUAN SiMing WANG MinJun CHEN Fei ZHU HaiYing HE ZhiYing WANG Xin HU YiPing | 2011 | Science China(Life Sciences)2011，54，3： | 5 |
| 6 | Bioinformatic analysis of expressed sequence tags from sporophyte of Porphyra yezoensis (Bagiaceae, Rhodophyta)显示文摘719 个表示顺序标签(EST ) 的一个总数非聚类进 329 - 冗余的 EST 组从红 alage 的 sporophte cDNA 图书馆被获得, Porphyra yezoensis。基因本体论(去) 分析在描绘 60 最严格的 annotatd 被采用从象与在房间工作的酶和蛋白质有关的 COXI, Sod_Fe_C, GST_N, SHMT,和 RNase_PH 那样的 329 个 EST 组和一些领域的唯一的基因被 HMMPFAM 搜索识别了。作为它的叶状的配偶体,有 storong 偏爱的用法上的类似的鳕鱼在 P 被发现。yezoensis 细丝状的孢子体,不管在给定的氨基酸发现的一些差别。329 唯一的基因的平均 GC 内容是 53.0 % 。相反,鳕鱼在上的第三核苷酸比的展出一个更高的 GC 内容(72 %) 第一(58 %) 并且第二(42 %) 核苷酸。现在的学习的类似搜索显示出对 Porphyra EST 数据库的 60.2 % 的 noves EST 比率,建议向阐明的进一步的调查 Porphyrafunctional 的特征染色体。 | XU Minjun MAO Yunxiang ZHANG Xuecheng ZHOU Xiaojun SUI Zhenghong ZHOU Hailin LI Jinhong | 2006 | Progress in Natural Science:Materials International2006，16，1： | 4 |
| 7 | Impacts of Carbon Tax Policy on CO_2 Mitigation and Economic Growth in China显示文摘在这份报纸,我们由使用可计算出来的一般平衡( CGE ) model.The 结果显示出的动态 energy-environment-economy 在中国检验在 CO2 缓解效果和经济生长上的碳税政策的影响那 30,60 ,并且 90 RMB 将每碳税率的吨 CO2 导致 CO2 的减小在 4.52,8.59 ,和 12.26 的排出物,以及在在 2020 的在 0.11,0.25 ,和 0.39 的 GDP 的衰落,分别地如果碳税收入由 government.Moreover 是镇定的。 | Shenglii Zhou Minjun Shi Na Li Yongna Yuan | 2011 | Advances in Climate Change Research2011，2，3： | 3 |
| 8 | A specific aggregation-induced emission-conjugated polymer enables visual monitoring of osteogenic differentiation显示文摘Osteogenic differentiation is the basis of bone growth and repair related to many diseases,in which evaluating the degree and ability of osteogenic transformation is quite important and highly desirable.However,fixing or stopping the growth of cells is required for conventional methods to monitor osteogenic differentiation,which cannot realize the full investigation of the dynamic process.Herein,a new anion conjugated polymer featuring aggregation-induced emission(AIE)characteristics is developed with excellent solubility for in-situ monitoring the process of osteogenic differentiation.This novel polymer can bind with osteogenic differentiated cells,and the intracellular fluorescence increases gradually with the enhancement of osteogenic differentiation.Moreover,it possesses good biosafety with negligible effect on cell activity and osteogenic differentiation,which cannot be realized by the typical method of Alizarin Red S staining.Further study shows that the polymer crosses the cell membrane through endocytosis and enriches in lysosomes,whereas no obvious fluorescence is detected with other cells,including non-differentiated osteoblast cells,under the same conditions,demonstrating the high selectivity.This is the first fluorescent probe with excellent specificity to realize real-time observation of the process of osteogenic differentiation.Therefore,PTB-EDTA shows great promise in the study of osteogenic differentiation and related applications. | Zhenyu Zheng Taotao Zhou Rong Hu Minjun Huang Xiang Ao Jun Chu Tao Jiang Anjun Qin Zhongmin Zhang | 2020 | Bioactive Materials2020，5，4： | 3 |
| 9 | Non-destructive Measurement of Magnetic Properties of Claw Pole显示文摘The magnetic properties of the claw pole have a direct effect on the output power of a generator Many methods can be used to measure these magnetic properties,each with its own advantages,but an important shortcoming is that all are destructive.In this study,a new non-destructive method to measure the magnetic properties of claw pole was proposed and a corresponding testing set-up was designed.A finite-element model was constructed to simulate the measurement process.Results proved that the measured magnetization-like curves had good agreement with the trend of the input magnetic curves and the effect of the positioning error in the measuring process could be neglected.To further validate the new method,seven types of claw poles of different materials subjected to different heat-treatment processes were forged and tested by both the new method and the conventional ring-sample method.Compared with the latter,the new method showed better consistency,relatively higher accuracy,and much stronger stability of measurement results;however,its sensitivity needs to be improved.The effects of material compositions and heat-treatment parameters on the magnetic properties of the claw pole were briefly analyzed. | Chengliang Hu Xuejiao Bai Minjun Tang Xiaofeng Tang Zhen Zhao | 2019 | Chinese Journal of Mechanical Engineering2019，32，5： | 2 |
| 10 | IFN-inducible p47 GTPases display differential responses to Schistosoma japonicum acute infection显示文摘Interferon gamma induced GTPase(IGTP)(also named lrgm3)and interferon gamma inducible protein 47(IRG-47)(also named lIrgd)are interferon(IFN)-inducible p47 GTPases that have been shown to regulate host resistance to intracellular pathogens.Little knowledge has been known about the role of p47 GTPases in host responses against extracellular pathogens.To investigate possible roles of IGTP and IRG-47 in the course of Schistosoma japonicum infection,IGTP and IRG-47 knockout and wild-type(WT)mice were challenged with cercariae of S.japonicum,and host responses were analyzed.At the acute stage of S.japonicum infection,mice that lacked IGTP displayed similar parasite burden and pathological damage to WT mice.Importantly,S.japonicum-infected lRG-47-deficient mice,in contrast to IGTP-deficient mice and WT mice,showed significantly reduced worms and lower egg-burden,but intense granulomatous reaction evoked by schistosome eggs in peripheral parts of liver lobes.In addition,upregulation of inflammation-related gene expression was observed in the spleen of IRG-47-deficient mice using oligonucleotide microarrays,in which multiple pathways of cytokine-cytokine receptor interaction,T-cell receptor signaling,complement,coagulation cascades and cell adhesion molecules were highlighted.Taken together,these data suggest that IGTP and IRG-47 might have distinct features that were differentially required for resistance to S.japonicum. | Xuesong Chen Xiaotang Du Meijuan Zhang Donghui Zhang Minjun Ji Guanling Wu | 2010 | Cellular & Molecular Immunology2010，7，1： | 2 |
| 11 | Roadway layout for recycling residual coal pillar in room-and-pillar mining of thick coal seam显示文摘In the context of a room-and-pillar mining gob in Shanxi province in China,this paper numerically investigates the stress distribution and deformation rules of roadway surrounding rocks at various locations of residual coal pillars in room-and-pillar mining gobs using software FLAC3 D.It is found that the concentrated stress beneath coal pillars distributes in a shape of ellipse.A reasonable roadway layout is then proposed.In this design,it is indicated that roadways should be designed to avoid the supporting zones of pillars with increasing compression and take into account the roof falling and crushing in the upper gob.According to the surrounding rock deformation characteristics and mining roadway locations as well as the supporting principles of timely support,rock reinforcing,piecewise management and suiting local conditions,a new asymmetric shield supporting plan is proposed.The field surveying results show that this supporting plan can effectively control the roadway rock deformation,thus guarantee the safe and smooth construction of roadways. | Jin Gan Wang Lianguo Zhang Jihua Hu Minjun Duan Ning | 2015 | International Journal of Mining Science and Technology2015，25，5： | 2 |
| 12 | The Scorpion Venom Peptide Smp76 Inhibits Viral Infection by Regulating Type-Ⅰ Interferon Response显示文摘Dengue virus(DENV) and Zika virus(ZIKV) have spread throughout many countries in the developing world and infect millions of people every year, causing severe harm to human health and the economy. Unfortunately, there are few effective vaccines and therapies available against these viruses. Therefore, the discovery of new antiviral agents is critical.Herein, a scorpion venom peptide(Smp76) characterized from Scorpio maurus palmatus was successfully expressed and purified in Escherichia coli BL21(DE3). The recombinant Smp76(rSmp76) was found to effectively inhibit DENV and ZIKV infections in a dose-dependent manner in both cultured cell lines and primary mouse macrophages. Interestingly,rSmp76 did not inactivate the viral particles directly but suppressed the established viral infection, similar to the effect of interferon(IFN)-b. Mechanistically, rSmp76 was revealed to upregulate the expression of IFN-b by activating interferon regulatory transcription factor 3(IRF3) phosphorylation, enhancing the type-Ⅰ IFN response and inhibiting viral infection.This mechanism is significantly different from traditional virucidal antimicrobial peptides(AMPs). Overall, the scorpion venom peptide Smp76 is a potential new antiviral agent with a unique mechanism involving type-Ⅰ IFN responses,demonstrating that natural AMPs can enhance immunity by functioning as immunomodulators. | Zhenglin Ji Fangfang Li Zhiqiang Xia Xingchen Guo Minjun Gao Fang Sun Yuting Cheng Yingliang Wu Wenxin Li Syed Abid Ali Zhijian Cao | 2018 | Virologica Sinica2018，33，6： | 2 |
| 13 | Filling polygonal holes using C1 cubic triangular spline patches显示文摘 | Charles K Chui Lai Minjun | 2002 | Computer Aided Geometric Design2002，，17： | 1 |
| 14 | Mid-trimester fetal blood derived adherent cells share characteristics similar to mesenchymal stem cells but fullterm umbilical cord blood does not显示文摘 | Lu Minjun Xiao Zhifeng Shen L | 2003 | British Hematology2003，124，5： | 1 |
| 15 | Can China realize mitigation target toward 2020? 显示文摘 | Shi Minjun Na Li Zbou Shenglv | 2010 | Journal of resources and ecology2010，1，2： | 1 |
| 16 | Drug-induced liver injury: Interactions between drug properties and host factors显示文摘 | Minjun Chen Ayako Suzuki Jürgen Borlak Raúl J. Andrade M Isabel Lucena | 2015 | Journal of Hepatology2015，，2： | 1 |
| 17 | An IOanalysis of the trend in virtual water trade and the impacton water resources and uses in China 显示文摘 | ZHANG Zhuoying SHI Minjun YANG Hong | 2011 | EconomicSystems Research2011，23，4： | 1 |
| 18 | Nanopolyphenol rejuvenates microglial surveillance of multiple misfolded proteins through metabolic reprogramming显示文摘Microglial surveillance plays an essential role in clearing misfolded proteins such as amyloid-beta,tau,andα-synuclein aggregates in neurodegenerative diseases.However,due to the complex structure and ambiguous pathogenic species of the misfolded proteins,a universal approach to remove the misfolded proteins remains unavailable.Here,we found that a polyphenol,α-mangostin,reprogrammed metabolism in the disease-associated microglia through shifting glycolysis to oxidative phosphorylation,which holistically rejuvenated microglial surveillance capacity to enhance microglial phagocytosis and autophagy-mediated degradation of multiple misfolded proteins.Nanoformulation ofα-mangostin efficiently deliveredα-mangostin to microglia,relieved the reactive status and rejuvenated the misfolded-proteins clearance capacity of microglia,which thus impressively relieved the neuropathological changes in both Alzheimer’s disease and Parkinson’s disease model mice.These findings provide direct evidences for the concept of rejuvenating microglial surveillance of multiple misfolded proteins through metabolic reprogramming,and demonstrate nanoformulatedα-mangostin as a potential and universal therapy against neurodegenerative diseases. | Dayuan Wang Xiao Gu Xinyi Ma Jun Chen Qizhi Zhang Zhihua Yu Juan Li Meng Hu Xiaofang Tan Yuyun Tang Jianrong Xu Minjun Xu Qingxiang Song Huahua Song Gan Jiang Zaiming Tang Xiaoling Gao Hongzhuan Chen | 2023 | Acta Pharmaceutica Sinica B2023，13，2： | 1 |
| 19 | Silymarin Inhibits In Vitro T-Cell Proliferation and Cytokine Production in Hepatitis C Virus Infection显示文摘 | Chihiro Morishima Margaret C. Shuhart Chia C. Wang Denise M. Paschal Minjun C. Apodaca Yanze Liu Derek D. Sloan Tyler N. Graf Nicholas H. Oberlies David Y.–W. Lee Keith R. Jerome Stephen J. Polyak | 2010 | Gastroenterology2010，，2： | 1 |
| 20 | Toward predictive models for drug induced liver injury in humans: are we there yet? 显示文摘 | Minjun Chen Halil Bisgin Lillian Tong | 2014 | Biomarkers Med2014，8，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员