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| 1 | Xeno-repopulation of Fah^(-/-)Nod/Scid mice livers by human hepatocytes显示文摘Functional human hepatocytes xenografted into the liver of mice can be used as a model system to study pharmacokinetics,infection of hepatitis viruses,and the efficacy of hepatitis vaccines.Significant levels of liver xeno-repopulation have been reported in Fah-/-Rag2-/-Il2rg-/-mice.However,the high mortality and low breeding rate of this model may hinder its application.A new model,termed Fah-/-Nod/Scid mice,which combines the advantages of liver repopulation in Fah-/-mice with the ease of xenotransplantation in Nod/Scid mice was obtained by gradual cross-breeding.Fah-/-Nod/Scid mice were easily maintained in breeding colonies and in adult animal care facilities.FK506 treatment combined with gradual withdrawal of NTBC before cell transplantation ensured that Fah-/-Nod/Scid mice were susceptible to liver xeno-repopulation by human hepatocytes;the proportion of engrafted human hepatocytes reached 33.6%.The function of the expanded human hepatocytes within the chimeric liver was confirmed by weight curve analysis,the expression of characteristic proteins,and the biochemical analysis of liver function.These results show that Fah-/-Nod/Scid mice are an ideal humanized liver mouse model with many useful applications. | SU BaoLiang LIU ChangCheng XIANG Dao ZHANG HaiBin YUAN SiMing WANG MinJun CHEN Fei ZHU HaiYing HE ZhiYing WANG Xin HU YiPing | 2011 | Science China(Life Sciences)2011，54，3： | 5 |
| 2 | Silymarin Inhibits In Vitro T-Cell Proliferation and Cytokine Production in Hepatitis C Virus Infection显示文摘 | Chihiro Morishima Margaret C. Shuhart Chia C. Wang Denise M. Paschal Minjun C. Apodaca Yanze Liu Derek D. Sloan Tyler N. Graf Nicholas H. Oberlies David Y.–W. Lee Keith R. Jerome Stephen J. Polyak | 2010 | Gastroenterology2010，，2： | 1 |
| 3 | Causative agent distribution and antibiotic therapy assessment among adult patients with community acquired pneumonia in Chinese urban population显示文摘 | Youning Liu Minjun Chen Tiemei Zhao | 2009 | BMC Infectious Diseases2009，9，： | 1 |
| 4 | Successful outcome of massive carbon dioxide embolism during laparoscopic hepatectomy显示文摘Carbon dioxide embolism is a rare but severe complication of laparoscopic hepatectomy.We reported a case of massive carbon dioxide embolism that developed into a rare paradoxical gas embolism during laparoscopic hepatectomy and resulted in reduced muscular power of the left upper extremity,severe pleural effusion and hypoalbuminemia after surgery.Fortunately,the patient fully recovered with positive prevention and postoperative treatment.This case report highlights that the surgeon and anaesthesiologist must be aware of the risks and the importance for prompt treatment when massive carbon dioxide embolism occurs. | Jun Zhang Jie Zhao Yue Fei Tieshuai Liu Minjun Liu | 2020 | Laparoscopic, Endoscopic and Robotic Surgery2020，3，2： | 1 |
| 5 | CHEMICAL VAPOUR GROWTH OF CARBON WHISKERS ON CARBON FIBERS显示文摘The secondary reinforcement,crbon whiskers,may grow on the surface of parent rein-forcement,carbon fibres,by chemical vapour growth from acetylene using Fe salt ascatalyzer.The optimal growing temperature is about 1000℃,and while the concentra-tion of catalytic solution is appropriate,the carbon whiskers may deposite uniformly andlink each other on the parent carbon fibre surface.If the temperature or concentration istoo high,the coarse clusters of carbon may deposite on the fibre surface.The mechanismof carbon whisker growth is believed that the carbon atoms in vapour phase dissolve inthe Fe salt drops over fibres,then the solid carbon grains precipitate on the fibre surface. | SUN Shoujin WEI Yongliang LIU Min LI Minjun Institute of Metal Research,Academia Sinica,Shenyang,China research associate,Institute of Metal Research,Academia Sinica,Shenyang 110015,China | 1993 | Acta Metallurgica Sinica(English Letters)1993，6，11： | 1 |
| 6 | Antimicrobial resistance among clinical isolates from the Chinese Meropenem Surveillance Study (CMSS), 2003–2008显示文摘 | Hui Wang Minjun Chen Yuxing Ni Yudong Liu Hongli Sun Yunsong Yu Xiujuan Yu Yaning Mei Min Liu Ziyong Sun Yunzhuo Chu Zhidong Hu Xinhong Huang | 2009 | International Journal of Antimicrobial Agents2009，，： | 1 |
| 7 | New power generation technology options under the greenhouse gases mitigation scenario in China显示文摘 | LIU Qiang SHI Minjun JIANG Kejun | 2009 | Energy Policy2009，37，6： | 1 |
| 8 | Observing single cells in whole organs with optical imaging显示文摘Cells are the basic unit of human organs that are not fully understood.The revolutionary advancements of optical imaging alowed us to observe single cells in whole organs,revealing the complicated composition of cells with spatial information.Therefore,in this review,we revisit the principles of optical contrast related to those biomolecules and the optical techniques that transform optical contrast into detectable optical signals.Then,we describe optical imaging to achieve threedimensional spatial discrimination for biological tisutes.Due to the milky appearance of tissues,the spatial information burred deep in the whole organ.Fortunately,strategies developed in the last decade could circumvent this issue and lead us into a new era of investigation of the cells with their original spatial information. | Xiaoquan Yang Tao Jiang Lirui Liu Xiaojun Zhao Ximiao Yu Minjun Yang Guangcai Liu Qingming Luo | 2023 | Journal of Innovative Optical Health Sciences2023，16，1： | 0 |
| 9 | The role of RhoA in the migration of endothelial cells stimulated by interleukin-8显示文摘The development and maintenance of an abundant blood supply is essential for the healing of wound and neoplastic tissues.Angiogenesis,the development of new vessels from adjacent capillary networks,plays an important role in physiologic and as well as in | Minjun Zou,Xiaoheng Liu,Yi Lai,Ye Zeng,Xianliang Huang(Institute of Biomedical Engineering,West China Center of Medical Sciences,Sichuan University,Chengdu,610041,China | 2009 | 医用生物力学2009，24，S1： | 0 |
| 10 | Impaired SERCA2a phosphorylation causes diabetic cardiomyopathy through impinging on cardiac contractility and precursor protein processing显示文摘Diabetic cardiomyopathy(DCM)is currently a progressive and nonstoppable complication in type 2 diabetic patients.Metabolic insults and insulin resistance are involved in its pathogenesis;however,the underlying mechanisms are still not clearly understood.Here we show that calcium dysregulation can be both a cause and a consequence of cardiac insulin resistance that leads to DCM.A western diet induces the development of DCM through at least three phases in mice,among which an early phase depends on impaired Thr^(484)-phosphorylation of sarcoplasmic/endoplasmic reticulum calcium ATPase 2a(SERCA2a)elicited by insulin resistance.Mutation of SERCA2a-Thr^(484) to a nonphosphorylatable alanine delays calcium re-uptake into the sarcoplasmic reticulum in the cardiomyocytes and decreases cardiac function at the baseline.Importantly,this mutation blunts the early phase of DCM,but has no effect on disease progression in the following phases.Interestingly,impairment of sarcoplasmic reticulum calcium re-uptake caused by the SERCA2a-Thr^(484) mutation inhibited processing of insulin receptor precursor through FURIN convertase,resulting in cardiac insulin resistance.Collectively,these data reveal a bidirectional relationship between insulin resistance and impairment of calcium homeostasis,which may underlie the early pathogenesis of DCM.Our findings have therapeutic implications for early intervention of DCM. | Chao Quan Sangsang Zhu Ruizhen Wang Jiamou Chen Qiaoli Chen Min Li Shu Su Qian Du Minjun Liu Hong-Yu Wang Shuai Chen | 2022 | Life Metabolism2022，1，1： | 0 |
| 11 | Modification strategies on 2D Ni-Fe MOF-based catalysts in peroxydisulfate activation for efficient organic pollutant removal显示文摘This study reports several modification strategies to optimize and enhance the performance of twodimensional(2D) metal organic frameworks(MOFs)-derived catalysts in peroxydisulfate(PDS) activation.The raw 2D Ni-MOF and 2D Ni-Fe-MOF without modification show poor catalytic activities for PDS activation and high metal ion leaching. The carbonization of 2D MOF can increase the activity of the catalyst but cannot solve the metal leaching problem. The further acid treatment of carbonization products can further improve the catalytic activity and decrease the metal ion leaching. The in-situ growth of2D MOF on graphene oxide(GO) support with subsequent carbonization and acid treatment offers the best performance in PDS activation for organic pollutant removal with low metal ion leaching. Compared with other PDS systems, the Ni-Fe-C-acid/GO system displays much lower catalyst and PDS dosages for p-chloroaniline degradation. This study presents new insights in the modification strategies of 2D MOFbased catalysts in PDS activation. | Minjun Liu Ying Liu Xinru Liu Chengcheng Chu Ducheng Yao Shun Mao | 2023 | Chinese Chemical Letters2023，34，4： | 0 |
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