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| 1 | Schistosoma japonicum infection induces macrophage polarization显示文摘The role of macrophages(Mφ)as the first line of host defense is well accepted.These cells play a central role in orchestrating crucial functions during schistosomal infection.Thus,understanding the functional diversity of these cells in the process of infection as well as the mechanisms underlying these events is crucial for developing disease control strategies.In this study,we adopted a Mφpolarization recognition system.Ml macrophage was characterized by expressing CD16/32,IL-12 and iNOS.M2 macrophage was characterized by expressing CD206,IL-10 and arg-1.In vivo(mouse peritoneal macrophages of different infection stages were obtained)and in vitro(different 5.japonicum antigens were used to stimulate RAW264.7)were characterized by using the above mentioned system.NCA and ACA stimulated RAW264.7 express significantly higher levels of IL-12 while significantly higher levels of IL-10 were detected after soluble egg antigen(SEA)stimulation.The results showed that dramatic changes of antigen in the microenvironment before and after egg production led to macrophage polarization.Furthermore,through TLR blocking experiments,the TLR4 signaling pathway was found to play a role in the process of macrophage polarization toward Ml.Our data suggest that macrophage polarization during S.japonicum infection had significant effects on host immune responses to S.japonicum. | Jingwei Xu Hao Zhang Lin Chen Donghui Zhang Minjun Ji Haiwei Wu Guanling Wu | 2014 | The Journal of Biomedical Research2014，28，4： | 20 |
| 2 | Antimicrobial susceptibility of Gram-negative bacteria causing intra-abdominal infections in China: SMART China 2011显示文摘 | Zhang Hui Yang Qiwen Xiao Meng Chen Minjun Robert E. Badal Xu Yingchun | 2014 | Chinese Medical Journal2014，，13： | 10 |
| 3 | Bioinformatic analysis of expressed sequence tags from sporophyte of Porphyra yezoensis (Bagiaceae, Rhodophyta)显示文摘719 个表示顺序标签(EST ) 的一个总数非聚类进 329 - 冗余的 EST 组从红 alage 的 sporophte cDNA 图书馆被获得, Porphyra yezoensis。基因本体论(去) 分析在描绘 60 最严格的 annotatd 被采用从象与在房间工作的酶和蛋白质有关的 COXI, Sod_Fe_C, GST_N, SHMT,和 RNase_PH 那样的 329 个 EST 组和一些领域的唯一的基因被 HMMPFAM 搜索识别了。作为它的叶状的配偶体,有 storong 偏爱的用法上的类似的鳕鱼在 P 被发现。yezoensis 细丝状的孢子体,不管在给定的氨基酸发现的一些差别。329 唯一的基因的平均 GC 内容是 53.0 % 。相反,鳕鱼在上的第三核苷酸比的展出一个更高的 GC 内容(72 %) 第一(58 %) 并且第二(42 %) 核苷酸。现在的学习的类似搜索显示出对 Porphyra EST 数据库的 60.2 % 的 noves EST 比率,建议向阐明的进一步的调查 Porphyrafunctional 的特征染色体。 | XU Minjun MAO Yunxiang ZHANG Xuecheng ZHOU Xiaojun SUI Zhenghong ZHOU Hailin LI Jinhong | 2006 | Progress in Natural Science:Materials International2006，16，1： | 4 |
| 4 | Nanopolyphenol rejuvenates microglial surveillance of multiple misfolded proteins through metabolic reprogramming显示文摘Microglial surveillance plays an essential role in clearing misfolded proteins such as amyloid-beta,tau,andα-synuclein aggregates in neurodegenerative diseases.However,due to the complex structure and ambiguous pathogenic species of the misfolded proteins,a universal approach to remove the misfolded proteins remains unavailable.Here,we found that a polyphenol,α-mangostin,reprogrammed metabolism in the disease-associated microglia through shifting glycolysis to oxidative phosphorylation,which holistically rejuvenated microglial surveillance capacity to enhance microglial phagocytosis and autophagy-mediated degradation of multiple misfolded proteins.Nanoformulation ofα-mangostin efficiently deliveredα-mangostin to microglia,relieved the reactive status and rejuvenated the misfolded-proteins clearance capacity of microglia,which thus impressively relieved the neuropathological changes in both Alzheimer’s disease and Parkinson’s disease model mice.These findings provide direct evidences for the concept of rejuvenating microglial surveillance of multiple misfolded proteins through metabolic reprogramming,and demonstrate nanoformulatedα-mangostin as a potential and universal therapy against neurodegenerative diseases. | Dayuan Wang Xiao Gu Xinyi Ma Jun Chen Qizhi Zhang Zhihua Yu Juan Li Meng Hu Xiaofang Tan Yuyun Tang Jianrong Xu Minjun Xu Qingxiang Song Huahua Song Gan Jiang Zaiming Tang Xiaoling Gao Hongzhuan Chen | 2023 | Acta Pharmaceutica Sinica B2023，13，2： | 1 |
| 5 | Size control and electronic manipulation of Ru catalyst over B,N codoped carbon network for high-performance hydrogen evolution reaction显示文摘Exploring highly efficient Pt-free catalysts for hydrogen evolution reaction(HER)is of great importance for hydrogen(H2)production.Herein,a novel HER electrocatalyst having abundant ultra-small(2–3 nm)Ru electronically confined by a B,N codoped polar carbon surface(Ru/(B-N)-PC)was constructed.The Ru/(B-N)-PC catalyst exhibits a low overpotential of 15 mV at the current density of 10 mA·cm^(−2),a low Tafel slope of 22.6 mV·dec^(−1),superior durability,which outperforms the benchmark Pt/C catalyst.Both experimental characterizations and theory calculations suggest that an electron communication established between B,N co-doped carbon surface and ultra-small Ru nanoparticles with electrons transferred from N atoms to Ru and backtransferred from Ru to B atoms,which exerts a moderate electronic modification of Ru.This,in turn,affords a modest H adsorption energy and a lower H2O dissociation barrier,leading to the high-performance hydrogen evolution reaction.The work provides meaningful insight into the size control and electronic modulation of Ru catalyst for intrinsic HER activity improvement. | Shuai Xu Mang Niu Guowei Zhao Shujun Ming Xingyun Li Qilong Zhu Liang-Xin Ding Minjun Kim Asma A.Alothman Mohammed Sheikh Saleh Mushab Yusuke Yamauchi | 2023 | Nano Research2023，16，5： | 1 |
| 6 | Evaluation of the in vitro antimicrobial activity of cefepime compared to other broad -spectrum beta -lactams tested against recent clinical isolates from 10 Chinese hospitals显示文摘 | Xu yingchun Chen minjun Douglas J | 1999 | Diagn Microbial Infect Dis1999，35，： | 1 |
| 7 | Construction of a Monascus purpureus mutant showing lower citrinin and higher pigment production by replacement of ctnA with pksl without using vector and resistance gene显示文摘 | XU Minjun YANG Zeliang LIANG Zhizhou | 2009 | Journal of Agricultural and Food Chemistry2009，57，20： | 1 |
| 8 | Modulating autophagic flux via ROS-responsive targeted micelles to restore neuronal proteostasis in Alzheimer’s disease显示文摘Compromised autophagy and defective lysosomal clearance significantly contribute to impaired neuronal proteostasis,which represents a hallmark of Alzheimer’s disease(AD)and other age-related neurodegenerative disorders.Growing evidence has implicated that modulating autophagic flux,instead of inducing autophagosome formation alone,would be more reliable to rescue neuronal proteostasis.Concurrently,selectively enhancing drug concentrations in the leision areas,instead of the whole brain,will maximize therapeutic efficacy while reduing non-selective autophagy induction.Herein,we design a ROS-responsive targeted micelle system(TT-NM/Rapa)to enhance the delivery efficiency of rapamycin to neurons in AD lesions guided by the fusion peptide TPL,and facilitate its intracellular release via ROS-mediated disassembly of micelles,thereby maximizing autophagic flux modulating efficacy of rapamycin in neurons.Consequently,it promotes the efficient clearance of intracellular neurotoxic proteins,β-amyloid and hyperphosphorylated tau proteins,and ameliorates memory defects and neuronal damage in 3×Tg-AD transgenic mice.Our studies demonstrate a promising strategy to restore autophagic flux and improve neuronal proteostasis by rationally-engineered nano-systems for delaying the progression of AD. | Shuting Xu Peng Yang Kang Qian Yixian Li Qian Guo Pengzhen Wang Ran Meng Jing Wu Jinxu Cao Yunlong Cheng Minjun Xu Qizhi Zhang | 2022 | Bioactive Materials2022，7，5： | 1 |
| 9 | Construction and Expression of Serratia Marcescens ECU1010 Lipase (lipA) in Pichia Pastoris显示文摘 | Faxiang Ye Liqiang Fan Jianhe Xu Jian Zhao Wanhong He Minjun Ni | 2010 | Journal of Life Sciences2010，4，3： | 1 |
| 10 | Evaluation of the in anti-microbial activity of cefepime compared to other troad-spectrum β-lactams testd against recent clinical isolates from 10 Chinese hopital显示文摘 | Xu Yingchun Chen Minjun | 1999 | Diagn Microbial Infect Dis1999，35，： | 1 |
| 11 | In vitro activity of cefditoren and other comparators against Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis causing community-acquired respiratory tract infections in China显示文摘 | Qiwen Yang Yingchun Xu Minjun Chen | 2012 | Diagnostic Microbiology and InfectiousDisease2012，73，2： | 1 |
| 12 | Multidimensional autophagy nano-regulator boosts Alzheimer's disease treatment by improving both extra/intraneuronal homeostasis显示文摘Intraneuronal dysproteostasis and extraneuronal microenvironmental abnormalities in Alzheimer’s disease(AD)collectively culminate in neuronal deterioration.In the context of AD,autophagy dysfunction,a multi-link obstacle involving autophagy downregulation and lysosome defects in neurons/microglia is highly implicated in intra/extraneuronal pathological processes.Therefore,multidimensional autophagy regulation strategies co-manipulating“autophagy induction”and“lysosome degradation”in dual targets(neuron and microglia)are more reliable for AD treatment.Accordingly,we designed an RP-1 peptide-modified reactive oxygen species(ROS)-responsive micelles(RT-NM)loading rapamycin or gypenoside XVII.Guided by RP-1 peptide,the ligand of receptor for advanced glycation end products(RAGE),RT-NM efficiently targeted neurons and microglia in AD-affected region.This nanocombination therapy activated the whole autophagy-lysosome pathway by autophagy induction(rapamycin)and lysosome improvement(gypenoside XVII),thus enhancing autophagic degradation of neurotoxic aggregates and inflammasomes,and promoting Aβ phagocytosis.Resultantly,it decreased aberrant protein burden,alleviated neuroinflammation,and eventually ameliorated memory defects in 3×Tg-AD transgenic mice.Our research developed a multidimensional autophagy nano-regulator to boost the efficacy of autophagy-centered AD therapy. | Yixian Li Peng Yang Ran Meng Shuting Xu Lingling Zhou Kang Qian Pengzhen Wang Yunlong Cheng Dongyu Sheng Minjun Xu Tianying Wang Jing Wu Jinxu Cao Qizhi Zhang | 2024 | Acta Pharmaceutica Sinica B2024，14，3： | 0 |
| 13 | Low cervical incision combined with video-assisted thoracoscopy for resection of a goiter extending to the posterior mediastinum:A case report and literature review显示文摘Approximately 25%of goiters extend to the substernal area,and most of them can be removed through a cervical incision.Goiters that extend into the posterior mediastinum are very rare,and resection usually requires thoracotomy.In recent years,there have been several reports of resection of substernal goiters by minimally invasive surgery.Here,we present a 75-year-old female with a giant substernal goiter who successfully underwent resection of the goiter extending to the posterior mediastinum using low cervical incision combined with video-assisted thoracoscopy. | Fei Tong Zhongyu Wu Shaohua Xu Ziyi Zhu Minjun Dong | 2023 | Laparoscopic, Endoscopic and Robotic Surgery2023，6，1： | 0 |
| 14 | Examining the Impact of Web Advertising on Reading: An Eye Tracking Study显示文摘 | Mike Z. Yao Jeffrey Ho Minjun Xu | 2012 | Journalism and Mass Communication2012，2，2： | 0 |
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