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| 1 | A new unconventional HLA-A2-restricted epitope from HBV core protein elicits antiviral cytotoxic T lymphocytes显示文摘细胞毒素的 T 房间(CTL ) 在肝炎 B 的控制起一个关键作用病毒(HBV ) 感染和病毒的清理。然而,大多数识别 CTL epitopes 从遗传型 A 和 D 的 HBV 被导出,并且很少在在亚洲更流行的遗传型 B 和 C 的病毒被定义。因为 HBV 核心蛋白质(HBc ) 是最保守、产生免疫性的部件,在这研究,我们使用了盖住 HBc 屏蔽并且识别特定的 CTL epitopes 的一个重叠 9-mer 肽水池。异乎寻常的 HLA-A2-restricted epitope HBc141149 被结晶化分析发现,在结构上描绘了。immunogenicity 和 anti-HBV 活动进一步在 HBV 和 HLA-A2 被决定转基因的老鼠。最后,我们证明在 HBc141149 epitope 的变化与病毒的参数被联系,在 HBV 的疾病前进感染了病人。我们的数据因此提供卓见进这异乎寻常的 epitope 绑定的结构特征给 MHC-I 分子,以及 epitope 特定的 CTL 活动在 HBV 安排 T 房间反应和有免疫力的避免感染的病人。 | Lu Sun Yu Zhang Bao Zhao Mengmeng Deng Jun Liu Xin Li Junwei Hou Mingming Gui Shuijun Zhang Xiaodong Li George F. Gao Songdong Meng | 2014 | Protein & Cell2014，5，4： | 7 |
| 2 | Sulfur nanoparticles encapsulated in reduced graphene oxide nanotubes for flexible lithium-sulfur batteries显示文摘灵活电子设备的快速的开发正在支持灵活精力存储设备的设计。锂硫(Li-S ) 电池为高精力密度精力存储设备被认为候选人同样有希望。因此,灵活 Li-S 电池被需要。在这研究,我们制作了独立减少的 graphene 氧化物 nanotubes 的合成电影由压 RGONTs@S 合成泡沫包了硫 nanoparticles (RGONTs@S ) ,它被把冷熄灭与 freeze-drying 和一个随后的减小过程相结合综合。这些 RGONTs@S 合成电影能是服务自食其力为没有另外的文件夹和传导性的代理人的 Li-S 电池的阴极。他们的互连的管状的结构允许在整个网络和帮助的容易的电子运输限制在控告 / 解除过程期间生产的 polysulfides。作为结果, RGONTs@S 合成电影展出了一个高起始的特定的能力,显著骑车稳定性,和优秀的率能力。更重要地, RGONTs@S 合成电影能在灵活 Li-S 电池用作电极。作为概念的一个证明,软包裹的 Li-S 电池用这些电极被装配,他们以不同弯曲状态显示了稳定的电气化学的性能。 | Kena Chen Jun Cao Qiongqiong Lu Qingrong Wang Minjie Yao Mingming Han Zhiqiang Niu Jun Chen | 2018 | Nano Research2018，11，3： | 6 |
| 3 | LSTM Based Reserve Prediction for Bank Outlets显示文摘Reserve allocation is a significant problem faced by commercial banking businesses every day. To satisfy the cash requirement of customers and abate the vault cash pressure, commercial banks need to appropriately allocate reserves for each bank outlet. Excessive reserve would impact the revenue of bank outlets. Low reserves cannot guarantee the successful operation of bank outlets. Considering the reserve requirement is effected by the past cash balance, we deal the reserve allocation problem as a time series prediction problem, and the Long Short Time Memory(LSTM) network is adapted to solve it. In addition, the proposed LSTM prediction model regards date property, which can affect the cash balance, as a primary factor. The experiment results show that our method outperforms some existing traditional methods. | Yu Liu Shuting Dong Mingming Lu Jianxin Wang | 2019 | Tsinghua Science and Technology2019，24，1： | 5 |
| 4 | Dent Resistance for Automobile Body Panels显示文摘Dent resistance of automobile body panels is an important property for automobile design and manufacture, but the study on this aspect is not still profound. This study is to summarize the testing methods and physical significations of static and dynamic dent resistance of automobile body panels combined with the author's study, and to analyze the dent behaviors in the round. Several influence factors on dent resistance are expatiated including the mechanical properties of materials, stress states after forming, bake hardening ability, modulus, methods of testing, and structure of specimens and so on. The automotive lightweight and application of high strength steel sheets and aluminum alloys sheets are analyzed, and the significance of testing of dent resistance, especially for dynamic dent resistance of auto-panels, and the finite element simulation analysis are emphasized. To explain the physical phenomenon of dent behaviors, the latest and concerned study results are also discussed. According to this study, a dent resistance test and evaluation standard of Society of Automotive Engineers of China for automotive body panel is presented and is being carried out, and an industry conference is hold to discuss the working-out of the standard, a primary schedule of this standard is confirmed now. The study can guide the further testing and study of dent resistant of auto-panels. | LU Hongzhou MA Mingm YOU Jianghai LI Zhigang | 2009 | Chinese Journal of Mechanical Engineering2009，22，6： | 5 |
| 5 | Ablation of Akt2 and AMPKα2 rescues high fat diet-induced obesity and hepatic steatosis through Parkin-mediated mitophagy显示文摘Given the opposing effects of Akt and AMP-activated protein kinase(AMPK)on metabolic homeostasis,this study examined the effects of deletion of Akt2 and AMPKα2 on fat diet-induced hepatic steatosis.Akt2–Ampkα2 double knockout(DKO)mice were placed on high fat diet for 5 months.Glucose metabolism,energy homeostasis,cardiac function,lipid accumulation,and hepatic steatosis were examined.DKO mice were lean without anthropometric defects.High fat intake led to adiposity and decreased respiratory exchange ratio(RER)in wild-type(WT)mice,which were ablated in DKO but not Akt2^(-/-) and Ampkα2^(-/-) mice.High fat intake increased blood and hepatic triglycerides and cholesterol,promoted hepatic steatosis and injury in WT mice.These effects were eliminated in DKO but not Akt2^(-/-) and Ampkα2^(-/-) mice.Fat diet promoted fat accumulation,and enlarged adipocyte size,the effect was negated in DKO mice.Fat intake elevated fatty acid synthase(FAS),carbohydrate-responsive element-binding protein(CHREBP),sterol regulatory element-binding protein 1(SREBP1),peroxisome proliferator-activated receptor gamma coactivator 1-alpha(PGC-1α),peroxisome proliferator-activated receptor-α(PPARα),PPARγ,stearoyl-CoA desaturase 1(SCD-1),phosphoenolpyruvate carboxykinase(PEPCK),glucose 6-phosphatase(G6Pase),and diglyceride O-acyltransferase 1(DGAT1),the effect was absent in DKO but not Akt2^(-/-) and Ampkα2^(-/-) mice.Fat diet dampened mitophagy,promoted inflammation and phosphorylation of forkhead box protein O1(FoxO1)and AMPKα1(Ser^(485)),the effects were eradicated by DKO.Deletion of Parkin effectively nullified DKO-induced metabolic benefits against high fat intake.Liver samples from obese humans displayed lowered microtubule-associated proteins 1A/1B light chain 3B(LC3B),Pink1,Parkin,as well as enhanced phosphorylation of Akt,AMPK(Ser^(485)),and FoxO1,which were consolidated by RNA sequencing(RNAseq)and mass spectrometry analyses from rodent and human livers.These data suggest that concurrent deletion of Akt2 and AMPKα2 offers resilience to fat diet-induced obesity and hepatic steatosis,possibly through preservation of Parkin-mediated mitophagy and lipid metabolism. | Shuyi Wang Jun Tao Huaguo Chen Machender R.Kandadi Mingming Sun Haixia Xu Gary D.Lopaschuk Yan Lu Junmeng Zheng Hu Peng Jun Ren | 2021 | Acta Pharmaceutica Sinica B2021，11，11： | 4 |
| 6 | Expert consensus on perioperative management of liver transplantation in adults with acute-on-chronic liver failure显示文摘Acute-on-chronic liver failure(ACLF)is a syndrome in which acute liver failure with extrahepatic organ failure occurs on chronic liver disease.Recently,liver transplantation is the only effective treatment for ACLF.There is still room for discussion on the optimal surgery timing for ACLF,perioperative infection prevention and control,and maintenance of nutrition and organ function.The Transplantation Immu-nology Committee of Branch of Organ Transplantation Physician of Chinese Medical Doctor Association and Enhanced Recovery of Liver Transplantation Group of Enhanced Recovery after Surgery Committee of Chinese Research Hospital Association invited relevant experts to discuss the perioperative management of ACLF liver transplantation in areas including surgery timing,organ protection,nutritional support,infection prevention and control,rehabilitation exercises,regulation of the internal environment,etc.An expert consensus was developed as reference for clinicians. | Transplantation Immunology Committee of Branch of Organ Transplantation Physician of Chinese Medical Doctor Association Enhanced Recovery of Liver Transplantation Group of Enhanced Recovery after Surgery Committee of Chinese Research Hospital Society Guihua Chen Yang Yang Huimin Yi Jianrong Liu Pinglan Lu Lijuan Li Mingming Fan Xiaomeng Yi Haijin Lv Xuxia Wei | 2021 | Liver Research2021，5，2： | 3 |
| 7 | Application of BP Neural Network Model in Fracturing Productivity Prediction of Fuyu Tight Oil Reservoir in Jilin Oilfield显示文摘1 Introduction Oil resources in tight reservoirs are widely distributed in China.Tight oil reservoirs have been discovered in Songliao Basin,Bohai Bay,Qaidam Basin,Tuha Basin,Sichuan Basin,etc.However,such oil reservoirs have poor physical properties.Conventional vertical wells are hard to bring about economic benefits,and the horizontal | JI Tianliang LU Shuangfang TANG Mingming WANG Min WANG Wenguang LIANG Hongru MIN Chunjia | 2015 | Acta Geologica Sinica(English Edition)2015，89，A01： | 3 |
| 8 | Seasonal and interannual variability of water mass sources of Indonesian throughflow in the Maluku Sea and the Halmahera Sea显示文摘So far, large uncertainties of the Indonesian throughflow(ITF) reside in the eastern Indonesian seas, such as the Maluku Sea and the Halmahera Sea. In this study, the water sources of the Maluku Sea and the Halmahera Sea are diagnosed at seasonal and interannual timescales and at different vertical layers, using the state-of-the-art simulations of the Ocean General Circulation Model(OGCM) for Earth Simulator(OFES). Asian monsoon leaves clear seasonal footprints on the eastern Indonesian seas. Consequently, the subsurface waters(around 24.5σ_θ and at ~150 m) in both the Maluku Sea and the Halmahera Sea stem from the South Pacific(SP) during winter monsoon, but during summer monsoon the Maluku Sea is from the North Pacific(NP), and the Halmahera Sea is a mixture of waters originating from the NP and the SP. The monsoon impact decreases with depth, so that in the Maluku Sea, the intermediate water(around 26.8σ_θ and at ~480 m) is always from the northern Banda Sea and the Halmahera Sea water is mainly from the SP in winter and the Banda Sea in summer. The deep waters(around27.2σ_θ and at ~1 040 m) in both seas are from the SP, with weak seasonal variability. At the interannual timescale,the subsurface water in the Maluku Sea originates from the NP/SP during El Ni?o/La Ni?a, while the subsurface water in the Halmahera Sea always originates from the SP. Similar to the seasonal variability, the intermediate water in Maluku Sea mainly comes from the Banda Sea and the Halmahera Sea always originates from the SP. The deep waters in both seas are from the SP. Our findings are helpful for drawing a comprehensive picture of the water properties in the Indonesian seas and will contribute to a better understanding of the ocean-atmosphere interaction over the maritime continent. | Lu Wang Lei Zhou Lingling Xie Quanan Zheng Qiang Li Mingming Li | 2019 | Acta Oceanologica Sinica2019，38，4： | 3 |
| 9 | Biological receptor-inspired flexible artificial synapse based on ionic dynamics显示文摘The memristor has been regarded as a promising candidate for constructing a neuromorphic computing platform that is capable of confronting the bottleneck of the traditional von Neumann architecture.Here,inspired by the working mechanism of the G-protein-linked receptor of biological cells,a novel double-layer memristive device with reduced graphene oxide(rGO)nanosheets covered by chitosan(an ionic conductive polymer)as the channel material is constructed.The protons in chitosan and the functional groups in rGO nanosheets imitate the functions of the ligands and receptors of biological cells,respectively.Smooth changes in the response current depending on the historical applied voltages are observed,offering a promising pathway toward biorealistic synaptic emulation.The memristive behavior is mainly a result of the interaction between protons provided by chitosan and the defects and functional groups in the rGO nanosheets.The channel current is due to the hopping of protons through functional groups and is limited by the traps in the rGO nanosheets.The transition from short-term to long-term potentiation is achieved,and learning-forgetting behaviors of the memristor mimicking those of the human brain are demonstrated.Overall,the bioinspired memristor-type artificial synaptic device shows great potential in neuromorphic networks. | Qifeng Lu Fuqin Sun Lin Liu Lianhui Li Yingyi Wang Mingming Hao Zihao Wang Shuqi Wang Ting Zhang | 2020 | Microsystems & Nanoengineering2020，6，1： | 2 |
| 10 | Research on the Heat Transfer Characteristics of a Loop Heat Pipe Used as Mainline Heat Transfer Mode for Spacecraft显示文摘An experimental research is conducted on the heat transfer characteristics of a loop heat pipe(LHP)used in the'mainline'heat transfer mode for spacecraft platform thermal control.The heat from multiple instruments scattered in different locations is collected by thermal control techniques such as axially grooved heat pipes and then transmitted to the radiant surface for dissipation through the LHP in an unified way.The research contents include the start-up characteristics,the operational stability characteristics,the operational blocking characteristics,the continuous blocking characteristics,the heat transfer capability,the thermal resistance,and the dynamic response characteristics under the change of the heat sink temperature.The results show that the higher the auxiliary starting power is,the easier it is to start the LHP;the higher the input power of the thermoelectric cooler is,the more beneficial it is to speed up the stabilization of the vapor-liquid interface in the condenser;the higher the blocking power,the shorter the blocking time of the LHP;the LHP can be operated stably within the heat sink temperature alteration process;the heat transfer ability is higher than 500 W with a systematic thermal resistance of 0.037℃/W. | WANG Lu MIAO Jianyin GONG Mingming ZHOU Qiangu LIU Changu ZHANG Hongxing FAN Hanlin | 2019 | Journal of Thermal Science2019，28，4： | 2 |
| 11 | Genetically modified CD7-targeting allogeneic CAR-T cell therapy with enhanced efficacy for relapsed/refractory CD7-positive hematological malignancies:a phase I clinical study显示文摘Chimeric antigen receptor(CAR)-T cell therapy against T cell malignancies faces major challenges including fratricide between CAR-T cells and product contamination from the blasts.Allogeneic CAR-T cells,generated from healthy donor T cells,can provide ready-to-use,blast-free therapeutic products,but their application could be complicated by graft-versus-host disease(GvHD)and host rejection.Here we developed healthy donor-derived,CD7-targeting CAR-T cells(RD13-01)with genetic modifications to resist fratricide,GvHD and allogeneic rejection,as well as to potentiate antitumor function.A phase I clinical trial(NCT04538599)was conducted with twelve patients recruited(eleven with T cell leukemia/lymphoma,and one with CD7-expressing acute myeloid leukemia).All patients achieved pre-set end points and eleven proceeded to efficacy evaluation.No dose-limiting toxicity,GvHD,immune effector cell-associated neurotoxicity or severe cytokine release syndrome(grade≥3)were observed.28 days post infusion,81.8%of patients(9/11)showed objective responses and the complete response rate was 63.6%(7/11,including the patient with AML).3 of the responding patients were bridged to allogeneic hematopoietic stem cell transplantation.With a median follow-up of 10.5 months,4 patients remained in complete remission.Cytomegalovirus(CMV)and/or Epstein-Barr virus(EBV)reactivation was observed in several patients,and one died from EBV-associated diffuse large B-cell lymphoma(DLBCL).Expansion of CD7-negative normal T cells was detected post infusion.In summary,we present the first report of a Phase I clinical trial using healthy donor-derived CD7-targeting allogeneic CAR-T cells to treat CD7^(+)hematological malignancies.Our results demonstrated the encouraging safety and efficacy profiles of the RD13-01 allogeneic CAR-T cells for CD7^(+)tumors. | Yongxian Hu Yali Zhou Mingming Zhang Houli Zhao Guoqing Wei Wengang Ge Qu Cui Qitian Mu Gong Chen Lu Han Tingting Guo Jiazhen Cui Xiaoyan Jiang Xiujun Zheng Shuhui Yu Xiaolong Li Xingwang Zhang Mingxi Chen Xiuju Li Ming Gao Kang Wang Cheng Zu Hao Zhang Xiaohong He Yanbin Wang Dongrui Wang Jiangtao Ren He Huang | 2022 | Cell Research2022，32，11： | 2 |
| 12 | Rapid estimation of soil heavy metal nickel content based on optimized screening of near-infrared spectral bands显示文摘In near-infrared spectroscopy,the traditional feature band extraction method has certain limitations.Therefore,a band extraction method named the three-step extraction method was proposed.This method combines characteristic absorption bands and correlation coefficients to select characteristic bands corresponding to various spectral forms and then uses stepwise regression to eliminate meaningless variables.Partial least squares regression(PLSR)and extreme learning machine(ELM)models were used to verify the effect of the band extraction method.Results show that the differential transformation of the spectrum can effectively improve the correlation between the spectrum and nickel(Ni)content.Most correlation coefficients were above 0.7 and approximately 20%higher than those of other transformation methods.The model effect established by the feature variable selection method based on comprehensive spectral transformation is only slightly affected by the spectral transformation form.Infive types of spectral transformation,the RPD values of the proposed method were all within the same level.The RPD values of the PLSR model were concentrated between 1.6 and 1.8,and those of the ELM model were between 2.5 and2.9,indicating that this method is beneficial for extracting more complete spectral features.The combination of the three-step extraction method and ELM algorithm can effectively retain important bands associated with the Ni content of the soil.The model based on the spectral band selected by the three-step extraction method has better prediction ability than the other models.The ELM model of the first-order differential transformation has the best prediction accuracy(RP^2=0.923,RPD=3.634).The research results provide some technical support for monitoring heavy metal content spectrum in local soils. | Qian Lu Shijie Wang Xiaoyong Bai Fang Liu Shiqi Tian Mingming Wang Jinfeng Wang | 2020 | Acta Geochimica2020，39，1： | 2 |
| 13 | Placenta-derived IL-32β activates neutrophils to promote preeclampsia development显示文摘Immune activation at the maternal-fetal interface is a main pathogenic factor of preeclampsia(PE).Neutrophils(PMNs)are activated in PE patients,but the mechanism and consequences of PMN activation need to be further explored.Here,we demonstrated that interleukin-32(IL-32)expression was significantly upregulated in syncytiotrophoblasts(STBs)and that IL-32β was the major isoform with increased expression in the placenta of severe PE(sPE)patients.Furthermore,the level of IL-32 expression in the placenta was correlated with its level in the serum of sPE patients,indicating that IL-32 in the serum is derived mainly from the placenta.Then,in vitro experiments showed that IL-32β could highly activate PMNs and that these IL-32β-activated PMNs were better able to adhere to endothelial cells(HUVECs)and enhance the expression of vascular cell adhesion molecule-1(VCAM-1)and intercellular cell adhesion molecule-1(ICAM-1)in HUVECs,which could be reversed by preincubation with the NADPH oxidase inhibitor VAS 2870.In addition,we showed that IL-32β mainly activated PMNs by binding to proteinase 3.Finally,IL-32β administration induced a PE-like phenotype in a pregnant mouse model.This study provides evidence of the involvement of IL-32β in the pathogenesis of PE. | Dan Liu Qiang Li Hailin Ding Guangfeng Zhao Zhiyin Wang Chenrui Cao Yimin Dai Mingming Zheng Xiangyu Zhu Qianwen Wu Ya Wang Honglei Duan Huirong Tang Xianyan Lu Yayi Hou Yali Hu | 2021 | Cellular & Molecular Immunology2021，18，4： | 2 |
| 14 | TSPAN1 functions as an oncogene in gastric cancer and is downregulated by miR-573显示文摘 | Zhengmao Lu Tianhang Luo Mingming Nie Tao Pang Xin Zhang Xiaojun Shen Liye Ma Jianwei Bi Guo Wei Guoen Fang Xuchao Xue | 2015 | FEBS Letters2015，，： | 1 |
| 15 | Synergistic chemical and electrochemical strategy for high-performance Zn//MnO_(2) batteries显示文摘Aqueous rechargeable Zn//MnO_(2)batteries have been considered as the promising candidate for future energy storage system due to their economic and environmental merits.However,the high-performance Zn//MnO_(2)batteries are plagued by poor sluggish reaction kinetics and capacity degradation due to the strong electrostatic interactions and complicated reaction process.Herein,the synergistic effect of atom defects engineering and phase transformation mechanism is confirmed as the effective strategy to enhance ion/charge transfer kinetics and structural stability.Defects gradient controlling and electrochemically induced phase transformation from spinel to layered structure render the aqueous Zn//λ-MnO_(2)system delivers a high discharge capacity of 285 m Ah/g and capacity retention of 81%after 500 cycles. | Mingming Han Jingjing Yao Jiwu Huang Yan Tang Xianwen Wu Bingan Lu Jiang Zhou | 2023 | Chinese Chemical Letters2023，34，2： | 1 |
| 16 | Mixed phase sodium manganese oxide as cathode for enhanced aqueous zinc-ion storage显示文摘Aqueous zinc-ion batteries have been regarded as a promising alternative to large-scale energy storage, due to associated low-cost, improved safety and environmental friendliness. However, a high-performance cathode material for both rate capability and specific capacity is still a challenge. One kind of the more promising candidates are sodium manganese oxide(NMO) materials, although they suffer from individual issues and need to be further improved. Herein, we present a novel mixed phase NMO material composed of nearly equal amounts of Na(0.55)Mn2O4 and Na(0.7)MnO(2.05). The structured configuration with particle size of 200–500 nm is found to be beneficial towards improving the ion diffusion rate during the charge/discharge process. Compared with Na(0.7)MnO(2.05) and Na(0.55)Mn2O4, the mixed phase NMO demonstrates an enhanced rate capability and excellent long-term cycling stability with a capacity retention of 83% after 800 cycles. More importantly, the system also delivers an impressive energy density and power density, as 378 W·h·kg^-1 at 68.7 W·kg^-1, or 172 W·h·kg^-1 at 1705 W·kg^-1. The superior electrochemical performance is ascribed to the fast Zn^2+ diffusion rate because of a large ratio of capacitive contribution(63.9% at 0.9 m V·s^-1). Thus, the mixed phase route provides a novel strategy to enhance electrochemical performance, enabling mixed phase NMO as very promising material towards large-scale energy-storage applications. | Xinyu Wang Xinghua Qin Qiongqiong Lu Mingming Han Ahmad Omar Daria Mikhailova | 2020 | Chinese Journal of Chemical Engineering2020，28，8： | 1 |
| 17 | Airborne Wide Band Coherent Radar for Ice Thickness Measurement显示文摘 | LIU Xiaojun ZHAO Bo ZHAO Mingming LU Cewu FANG Guangyou | 2008 | Chinese Journal of Electronics2008，17，4： | 1 |
| 18 | Energy Efficient Connected Coverage of Discrete Targets in Wireless Sensor Networks显示文摘 | Lu Mingming Wu Jie Cardei M | 2009 | International Journal of Ad Hoc and Ubiquitous Computing2009，4，34： | 1 |
| 19 | Bio-inspired flexible artificial synapses for pain perception and nerve injuries显示文摘Imitation of the perception system of living creatures is of great importance for the construction of artificial nerves and intelligent human-machine interfaces.However,a prominent challenge is to emulate the functions of the biological synapse,which is the basic building block of the neural system.Here,inspired by the pain perception mechanism of the living creatures,a flexible double-layer memristor was constructed,with 90%semiconducting single-wall carbon nanotubes(s-SWCNTs)covered by LiClO4 doped polyoxyethylene oxide(PEO:LiClO4)as the channel materials.The carriers(protons and Li+)from PEO:LiClO4 imitated the functions of Na+and K+in biological systems.A potentiation of the post-synaptic signal was observed with mild stimuli,while the post-synaptic signal was inhibited with severe stimuli with a pulse voltage larger than 1.4 V in this research.These behaviors resemble the sensation of pain,neuroprotection,and possible injuries to the neural system.To explore the underlying mechanism of the phenomenon,the fourier-transform infrared spectroscopy(FTIR),X-ray photoelectron spectroscopy(XPS),Raman spectrum,and current(IV)sweep were carried out.It was inferred that the observed results are attributable to the interaction between carriers in PEO:LiClO4 and functional groups and defects in the s-SWCNTs.The enhanced channel current results from the fulfillment of the traps by the carriers,and the suppression of the current is due to the intercalation of Li+in the s-SWCNTs.This flexible artificial synapse opens a new avenue for the construction of biocompatible electronic devices towards artificial intelligence systems. | Qifeng Lu Fuqin Sun Lin Liu Lianhui Li Mingming Hao Zihao Wang Ting Zhang | 2020 | npj Flexible Electronics2020，4，1： | 1 |
| 20 | Identification of quantitative trait loci associated with resistance to Xanthomonas oryzae pv. oryzae pathotypes prevalent in South China显示文摘Bacterial blight(BB), which is caused by Xanthomonas oryzae pv. oryzae(Xoo), is an important rice disease responsible for significant yield losses. In the rice-growing regions of South China where BB outbreaks are common, the resistance of cultivars with BB resistance genes Xa4 and Xa21 has been lost because of rapid changes in the Xoo population structure and virulence. In this study, 421 diverse rice accessions were evaluated regarding their resistance to two Xoo strains, namely GD1358(C5) and IV, which are prevalent pathotypes in South China and overcame the resistance of Xa4 and Xa21, respectively. Using the 4.8 mio filtered SNP dataset, we conducted a genome-wide association study, which identified 13 loci associated with BB resistance, including eight new quantitative trait loci(QTL) and five QTL harboring known BB resistance genes: Xa3/Xa26, xa5, Xa35(t), Xa36(t), Xa40, Xa43(t), and xa44(t). Intriguingly, a steep peak was detected on chromosomes 5 and 11. Six QTL including three new ones, were distributed on chromosome 11, whereas a new QTL q BB5.1 and a known QTL were detected on chromosome 5. Haplotype analyses indicated that the LOC;s05 g01610(Os PRAF2) gene within the q BB5.1 region, which encodes a PRAF protein, is associated with BB resistance. Furthermore, Os PRAF2 knockout lines generated using the CRISPR-Cpf1 system were significantly more resistant to Xoo strains than the wild-type plants. Our results provide researchers and breeders with useful information regarding QTL and gene resources,which may be relevant for developing new BB-resistant rice cultivars. | Jialing Lu Quanlin Li Chunchao Wang Mingming Wang Dan Zeng Fan Zhang Wenxue Zhai Yongli Zhou | 2022 | The Crop Journal2022，10，2： | 1 |
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