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| 1 | STUDIES ON PHOTOSENSITIZED OXIDATION OF DITERPENOIDS FROM HEDYCHIUM GENUS显示文摘STUDIESONPHOTOSENSITIZEDOXIDATIONOFDITERPENOIDSFROMHEDYCHIUMGENUSQingZHAO;XiaoJiangHao;/YaoZuChen;ChengZou(DepartmentofChemis... | Qing ZHAO Xiao Jiang Hao / Yao Zu Chen Cheng Zou (Department of Chemistry,Lanzhou University, Lanzhou 730000)(Laboratory of Phytochemistry,Kunming institute of Botany,the Chinese Academy of Sciences, Kunming 650204) | 1996 | Chinese Chemical Letters1996，7，1： | 5 |
| 2 | 25-Hydroxycholesterol is a potent SARS-CoV-2 inhibitor显示文摘Dear Editor,As of July,2020,the ongoing pandemic of coronavirus diseases 2019(COVID-19)caused by the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2,previously 2019-nCoV)has caused more than 10.3 million human infections,with more than 506,000 deaths worldwide according to the World Health Organization.The clinical manifestations of COVID-19 vary from no asymptomatic infection,mild“flu-like”symptoms,to lethal acute respiratory distress syndrome.The case mortality and fatality rates in people infected with SARS-CoV-2 increase steeply with age,and fatal outcomes are almost exclusively seen in people older than 50 years.1 Although the Food and Drug Administration has authorized emergency use of remdesivir for COVID-19 treatment in the US,the need for safe and effective antiviral drugs against SARS-CoV-2 remains urgent and unmet. | Shulong Zu Yong-Qiang Deng Chao Zhou Jie Li Lili Li Qi Chen Xiao-Feng Li Hui Zhao Sarah Gold Jun He Xiang Li Changqing Zhang Heng Yang Genhong Cheng Cheng-Feng Qin | 2020 | Cell Research2020，30，11： | 3 |
| 3 | Synergetic Effects of UV/Fe^(3+) Combined with Electrocatalysis for p-Nitrophenol Degradation显示文摘Synergetic effects for p-nitrophenol degradation were observed in the combination of two-advanced oxidation processes, UV/Fe3+ and electrocatalysis. The enhancement of removal rate for p-nitrophenol and COD was around 123% and 278%, respectively. The possible contributions for the synergetic effects were the electrochemically regeneration of ferric ion and the role of the oxygen that formed on the anode. | Ming Hua ZHOU, Zu Cheng WU*, Da Hui WANG Department of Environmental Science and Engineering, Zhejiang University, Hangzhou 310027 | 2002 | Chinese Chemical Letters2002，13，4： | 3 |
| 4 | Some Bonnesen-style Inequalities for Higher Dimensions显示文摘We discuss the higher dimensional Bonnesen-style inequalities.Though there are many Bonnesen-style inequalities for domains in the Euclidean plane R2 few results for general domain in R n(n ≥ 3) are known.The results obtained in this paper are for general domains,convex or non-convex,in Rn. | Jia Zu ZHOU Yan Hua DU Fei CHENG | 2012 | Acta Mathematica Sinica,English Series2012，28，12： | 2 |
| 5 | Genetically modified CD7-targeting allogeneic CAR-T cell therapy with enhanced efficacy for relapsed/refractory CD7-positive hematological malignancies:a phase I clinical study显示文摘Chimeric antigen receptor(CAR)-T cell therapy against T cell malignancies faces major challenges including fratricide between CAR-T cells and product contamination from the blasts.Allogeneic CAR-T cells,generated from healthy donor T cells,can provide ready-to-use,blast-free therapeutic products,but their application could be complicated by graft-versus-host disease(GvHD)and host rejection.Here we developed healthy donor-derived,CD7-targeting CAR-T cells(RD13-01)with genetic modifications to resist fratricide,GvHD and allogeneic rejection,as well as to potentiate antitumor function.A phase I clinical trial(NCT04538599)was conducted with twelve patients recruited(eleven with T cell leukemia/lymphoma,and one with CD7-expressing acute myeloid leukemia).All patients achieved pre-set end points and eleven proceeded to efficacy evaluation.No dose-limiting toxicity,GvHD,immune effector cell-associated neurotoxicity or severe cytokine release syndrome(grade≥3)were observed.28 days post infusion,81.8%of patients(9/11)showed objective responses and the complete response rate was 63.6%(7/11,including the patient with AML).3 of the responding patients were bridged to allogeneic hematopoietic stem cell transplantation.With a median follow-up of 10.5 months,4 patients remained in complete remission.Cytomegalovirus(CMV)and/or Epstein-Barr virus(EBV)reactivation was observed in several patients,and one died from EBV-associated diffuse large B-cell lymphoma(DLBCL).Expansion of CD7-negative normal T cells was detected post infusion.In summary,we present the first report of a Phase I clinical trial using healthy donor-derived CD7-targeting allogeneic CAR-T cells to treat CD7^(+)hematological malignancies.Our results demonstrated the encouraging safety and efficacy profiles of the RD13-01 allogeneic CAR-T cells for CD7^(+)tumors. | Yongxian Hu Yali Zhou Mingming Zhang Houli Zhao Guoqing Wei Wengang Ge Qu Cui Qitian Mu Gong Chen Lu Han Tingting Guo Jiazhen Cui Xiaoyan Jiang Xiujun Zheng Shuhui Yu Xiaolong Li Xingwang Zhang Mingxi Chen Xiuju Li Ming Gao Kang Wang Cheng Zu Hao Zhang Xiaohong He Yanbin Wang Dongrui Wang Jiangtao Ren He Huang | 2022 | Cell Research2022，32，11： | 2 |
| 6 | Influence of copper minerals on cyanide leaching of gold显示文摘The paper thermodynamically examined the behavior of various copper minerals in cyanide solu tions and investigated the influence of copper minerals on cyanide leaching of gold. In elucidating the influence of copper minerals on cyanide leaching of gold, copper minerals were classified into two types according to their solubility in cyanide solutions by proposing two concepts, cyaniding easily soluble copper (E Cu ) and cyaniding insoluble copper. The former involves copper occurrence in metal, oxides and secondary sulfides, and the latter refers mainly to primary sulfides. Experimental results show that not all the total copper in an ore affected cyanide leaching of gold, while cyaniding easily soluble copper turns out to be the decisive factor that interferes with gold cyanidation by causing decrease in gold cyanidation recovery and increase in cyanide consumption. When cyaniding easily soluble copper content ( w E(Cu) ) lies in the range of 0 0.25%, it linearly affects gold cyanidation recovery ( R ) as well as cyanide consumption ( m c). The regression equations have been worked out to be R (%)=94.177 5-142.735 7 w E(Cu) with a correlation coefficient of -0.902 and m c=5.590 7+33.572 9 w E(Cu) with a correlation coefficient of 0.945, respectively. | JIANG Tao,ZHANG Yu zu,YANG Yong bin,HUANG Zhu cheng (Department of Mineral Engineering, Central South University, Changsha 410083, China) | 2001 | Journal of Central South University of Technology2001，8，1： | 2 |
| 7 | Highly selective and sensitive detection of coralyne based on the binding chemistry of aptamer and graphene oxide显示文摘 | Pu Zhang Yi Wang Fei Leng Zu Hong Xiong Cheng Zhi Huang | 2013 | Talanta2013，，： | 1 |
| 8 | Mapping of Bnms4 and Bnrf to a common microsyntenic region of Arabidopsis thaliana chromosome 3 using intron polymorphism markers 显示文摘 | Xia S Q Cheng L Zu F | 2012 | Theor Appl Genet2012，124，7： | 1 |
| 9 | Dynamic analysis of an optical fiber coupler in telecommunications 显示文摘 | Cheng G Zu J W | 2003 | Journal of Sound and Vibration2003，268，： | 1 |
| 10 | A Rapid and Convenient Procedure for the Permethylation of Polysaccharides显示文摘Butyllithium was directly added to the solution of polysaccharides in dimethyl sulfoxide. The methylsulfinyl carbanion, as a sugar alkoxide forming reagent, was generated from the solution. All the operations were performed as one-pot reactions. Five polysaccharides from different traditional Chinese medicines and three dextrans were methylated and satisfactory results have been achieved. | Cheng Gang HUANG Chen LI Zhi Xiao LI Yao Zu CHEN(Department of Chemistry, Zhejiang University, Hangzhou 310027 State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000) | 1998 | Chinese Chemical Letters1998，9，4： | 1 |
| 11 | The characteristics of wavefront and far-field optical pattern from high power laser mirror 显示文摘 | ZHOU Ci-ming CHENG Zu hai ZHANG Yao-ning | 2003 | Czechoslovak Journal of Physics2003，53，12： | 1 |
| 12 | High prevalence of a novel porcine bocavirus in weanling piglets with respiratory tract symptoms in China显示文摘 | Zhai Shao-lun Yue Cheng Wei Zu | 2010 | Arch Virol2010，155，： | 1 |
| 13 | Mapping of BnMs4 and BnRf to a conmlon microsyntenic region of Arabidopsis thaliana chromosome 3 using intron polymorphism markers 显示文摘 | Xia S Cheng L Zu F | 2012 | The- oretical and Applied Genetics2012，124，7： | 1 |
| 14 | Exploring pathogenesis in subjects with subjective Tinnitus having kidney deficiency pattern in terms of Traditional Chinese Medicine based on serum metabolic profiles显示文摘OBJECTIVE: To investigate the metabolic pathogenesis in subjects with subjective tinnitus(ST)having kidney deficiency pattern(KDP)(ST/KDP) in terms of Traditional Chinese Medicine.METHODS: Three groups of subjects, including healthy individuals, subjects with ST/KDP, and subjects who were healthy initially and then developed ST/KDP one year later(healthy → ST/KDP),were recruited for this study. Serum metabolic profiles of all subjects were analyzed using ultra-performance liquid chromatography coupled with quadruple-time-of-flight mass spectrometry. The metabolic characteristics of the ST/KDP subjects were determined, and the corresponding biomarkers were predicted. The metabolomics data from the healthy → ST/KDP subjects were collected for further verification.RESULTS: Twelve metabolites in the ST/KDP subjects were different from those of the healthy control subjects. Of these metabolites, according to the prediction, except for octanoic acid, other metabolites might characterize ST/KDP. Ten metabolites at the outcome ST/KDP stage were different from those at the initial(control) stage. Through the comparison of these metabolites with the predicted metabolites, five common metabolites, including upregulated glutamate, serotonin, oroticacid and 8-oxoguanine, as well as downregulated taurine, were found. These common metabolites were significantly associated with canonical pathways including calcium signaling, γ-aminobutyric acid(GABA) receptor signaling, purine and pyrimidine biosynthesis, taurine biosynthesis, and serotonin receptor signaling.CONCLUSION: The metabolic pathogenesis in ST/KDP subjects was characterized by upregulated glutamate, serotonin, orotic acid and 8-oxoguanine, as well as downregulated taurine, additionally, perturbations of calcium signaling, GABA receptor signaling, purine and pyrimidine biosynthesis, taurine biosynthesis, and serotonin receptor signaling. | Tan Yong Shen Shanshan Guan Fulan He Bing Lu Cheng Xiao Cheng Jiang Miao Zhao Ning Li Li Cheng Shiping Zu Xianpeng Zhang Weidong Liu Xinru Lü Aiping | 2018 | Journal of Traditional Chinese Medicine2018，38，5： | 1 |
| 15 | Vitamin B6 regulates IL-33 homeostasis to alleviate type 2 inflammation显示文摘Interleukin-33(IL-33)is a crucial nuclear cytokine that induces the type 2 immune response and maintains immune homeostasis.The fine-tuned regulation of IL-33 in tissue cells is critical to control of the type 2 immune response in airway inflammation,but the mechanism is still unclear.Here,we found that healthy individuals had higher phosphate-pyridoxal(PLP,an active form of vitamin B6)concentrations in the serum than asthma patients.Lower serum PLP concentrations in asthma patients were strongly associated with worse lung function and inflammation.In a mouse model of lung inflammation,we revealed that PLP alleviated the type 2 immune response and that this inhibitory effect relied on the activity of IL-33.A mechanistic study showed that in vivo,pyridoxal(PL)needed to be converted into PLP,which inhibited the type 2 response by regulating IL-33 stability.In mice heterozygous for pyridoxal kinase(PDXK),the conversion of PL to PLP was limited,and IL-33 levels were increased in the lungs,aggravating type 2 inflammation.Furthermore,we found that the mouse double minute 2 homolog(MDM2)protein,an E3 ubiquitin-protein ligase,could ubiquitinate the N-terminus of IL-33 and sustain IL-33 stability in epithelial cells.PLP reduced MDM2-mediated IL-33 polyubiquitination and decreased the level of IL-33 through the proteasome pathway.In addition,inhalation of PLP alleviated asthma-related effects in mouse models.In summary,our data indicate that vitamin B6 regulates MDM2-mediated IL-33 stability to constrain the type 2 response,which might help develop a potential preventive and therapeutic agent for allergy-related diseases. | Songling Zhu Shufen Zhong Kebin Cheng Li-Sha Zhang Jiu-wu Bai Zu Cao Su Wang Wen Chen Shipeng Cheng Liyan Ma Zhiyang Ling Yuying Huang Wangpeng Gu Xiaoyu Sun Chunyan Yi Meng Zhao Shuo Liang Jin-Fu Xu Bing Sun Yaguang Zhang | 2023 | Cellular & Molecular Immunology2023，20，7： | 1 |
| 16 | The electromagnetic shielding effectiveness of carbon nanotubes polymer composites显示文摘 | Jou Were Shiarng Cheng Huy Zu Hsu Chih Feng | 2007 | Journal of Alloys and Compounds2007，435，： | 1 |
| 17 | Dynamics of a dry friction oscillator under two-frequency excitations显示文摘 | Cheng G Zu J W | 2004 | Journal of Sound and Vibration2004，275，345： | 1 |
| 18 | Self-regeneration of activated carbon modified with palladium catalyst for electrochemical dechlorination显示文摘催化剂再生和高催化活的保留仍然是在环境申请的关键问题。新奇使流体化的煤气的液体固体电气化学的反应堆被开发同时移开使氯化的污染物质并且在 situ 改革废催化剂。与钯催化剂(交流 Pd ) 修改的活性炭为电气化学的 dechlorination 作好准备。为起始浓度 200 mg L 的 4-chlorophenol 废水(? 1 ) ,移动效率能将近在不到 30 min 到达 100% 。没有特殊新生,交流 Pd 催化剂的催化活甚至在连续骑车跑有效地被保存。哦激进分子,由电气化学的反应产生了,在交流 Pd 的自我新生起了一个关键作用。花的交流 Pd 催化剂的高催化活在废水处理提供了一种吸引人的选择。 | Yan Qing Cong Zu Cheng Wu | 2007 | Chinese Chemical Letters2007，18，8： | 1 |
| 19 | Dynamic analysis of an optical fiber coupler in telecommunications 显示文摘 | Cheng G Zu J W | 2003 | Journal of Sound and Vibration2003，268，： | 1 |
| 20 | Dynamic analysis of an optical fiber coupler in telecommunications 显示文摘 | Cheng G Zu J W | 2003 | Journal of Sound and Vibration2003，268，： | 1 |
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