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您的检索式：作者名="Sandeep Kumar Kalva"
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| 1 | Single-sweep volumetric optoacoustictomography of whole mice显示文摘Applicability of optoacoustic imaging in biology and medicine is determined by several key performance characteristics.In particular,an inherent trade-off exists between the acquired field-of-view(FOV)and temporal resolution of the measurements,which may hinder studies looking at rapid biodynamics at the whole-body level.Here,we report on a single-sweep volumetric optoacoustic tomography(sSVOT)system that attains whole body three-dimensional mouse scans within 1.8 s with better than 200μm spatial resolution.sSVOT employs a spherical matrix array transducer in combination with multibeam illumination,the latter playing a critical role in maximizing the effective FOV and imaging speed performance.The system further takes advantage of the spatial response of the individual ultrasound detection elements to mitigate common image artifacts related to limited-view tomographic geometry,thus enabling rapid acquisitions without compromising image quality and contrast.We compare performance metrics to the previously reported whole-body mouse imaging implementations and alternative image compounding and reconstruction strategies.It is anticipated that sSVOT will open new venues for studying large-scale biodynamics,such as accumulation and clearance of molecular agents and drugs across multiple organs,circulation of cells,and functional responses to stimuli. | SANDEEP KUMAR KALVA XOSE LUIS DEAN-BEN DANIEL RAZANSKY | 2021 | Photonics Research2021，9，6： | 1 |
| 2 | Polyester-tethered near-infrared fluorophores confined in colloidal nanoparticles:Tunable and thermoresponsive aggregation and biomedical applications显示文摘Intricate assembly of multiple molecular chromophores assisted by protein scaffolds is essential in tuning the optical absorption and energy transfer in the light-harvesting complexes of the photosynthetic systems in nature.However,it remains a challenge to achieve such structural complexity and functionality in synthetic polymer-chromophore systems.Here,we report a series of polyester-tethered pyrrolopyrrole cyanine derivatives and their colloidal nanoparticles dispersed in water,which show tunable J-or H-aggregation excitonic coupling and near-infrared fluorescence by precise control of the polymer chain lengths,composition,and temperature.Moreover,the optimal fluorescence or photothermal effect of the Jaggregate nanoparticles enables broad applications in fluorescence or photoacoustic bioimaging and phototherapy. | Cangjie Yang Wei Zhang Xin Pang Fan Xiao Sandeep Kumar Kalva Yipeng Zhang Manojit Pramanik Leilei Tian Gang Liu Mingfeng Wang | 2023 | Aggregate2023，4，2： | 0 |
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