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| 1 | Different effects of ghrelin, des-acyl ghrelin and obestatin on gastroduodenal motility in conscious rats显示文摘Three peptides, ghrelin, des-acyl ghrelin and obestatin are derived from a common prohormone, preproghrelin by posttranslational processing, originating from endocrine cells in the stomach. To examine the effects of these peptides, we applied the manometric measurement of gastrointestinal motility in freely moving conscious rat models. Ghrelin exerts stimulatory effects on the motility of antrum and duodenum in both fed and fasted state of animals. Des-acyl ghrelin exerts inhibitory effects on the motility of antrum, but not on the motility of duodenum in the fasted state of animals. Obestatin exerts inhibitory effects on the motility of antrum and duodenum in the fed state, but not in the fasted state of animals. NPY Y2 or Y4 receptors in the brain may mediate the action of ghrelin, CRF type 2 receptors in the brain mediate the action of des-acy ghrelin, whereas CRF type 1 and type 2 receptors in the brain mediate the action of obestatin. Vagal afferent pathways might be involved in the action of ghrelin, but not involved in the action of des-acyl ghrelin, whereas vagal afferent pathways might be partially involved in the action of obestatin. | Mineko Fujimiya Akihiro Asakawa Koji Ataka Ikuo Kato Akio Inui | 2008 | World Journal of Gastroenterology2008，14，41： | 12 |
| 2 | Naringenin prevents experimental liver fibrosis by blocking TGFβ-Smad3 and JNK-Smad3 pathways显示文摘AIM To study the molecular mechanisms involved in the hepatoprotective effects of naringenin(NAR)on carbon tetrachloride(CCl4)-induced liver fibrosis.METHODS Thirty-two male Wistar rats(120-150 g)were randomly divided into four groups:(1)a control group(n=8)that received 0.7%carboxy methyl-cellulose(NAR vehicle)1 m L/daily p.o.;(2)a CCl4 group(n=8)that received 400 mg of CCl4/kg body weight i.p.3 times a week for 8 wk;(3)a CCl4+NAR(n=8)group that received 400 mg of CCl4/kg body weight i.p.3times a week for 8 wk and 100 mg of NAR/kg body weight daily for 8 wk p.o.;and(4)an NAR group(n=8)that received 100 mg of NAR/kg body weight daily for 8 wk p.o.After the experimental period,animals were sacrificed under ketamine and xylazine anesthesia.Liver damage markers such as alanine aminotransferase(ALT),alkaline phosphatase(AP),γ-glutamyl transpeptidase(γ-GTP),reduced glutathione(GSH),glycogen content,lipid peroxidation(LPO)and collagen content were measured.The enzymatic activity of glutathione peroxidase(GPx)was assessed.Liver histopathology was performed utilizing Masson’s trichrome and hematoxylin-eosin stains.Zymography assays for MMP-9 and MMP-2 were carried out.Hepatic TGF-β,α-SMA,CTGF,Col-I,MMP-13,NF-κB,IL-1,IL-10,Smad7,Smad3,p Smad3 and p JNK proteins were detected via western blot.RESULTS NAR administration prevented increases in ALT,AP,γ-GTP,and GPx enzymatic activity;depletion of GSH and glycogen;and increases in LPO and collagen produced by chronic CCl4 intoxication(P<0.05).Liver histopathology showed a decrease in collagen deposition when rats received NAR in addition to CCl4.Although zymography assays showed that CCl4 produced an increase in MMP-9 and MMP-2gelatinase activity;interestingly,NAR administration was associated with normal MMP-9 and MMP-2 activity(P<0.05).The anti-inflammatory,antinecrotic and antifibrotic effects of NAR may be attributed to its ability to prevent NF-κB activation and the subsequent production of IL-1 and IL-10(P<0.05).NAR completely prevented the increase in TGF-β,α-SMA,CTGF,Col-1,and MMP-13 proteins compared with the CCl4-treated group(P<0.05).NAR prevented Smad3phosphorylation in the linker region by JNK since this flavonoid blocked this kinase(P<0.05).CONCLUSION NAR prevents CCl4 induced liver inflammation,necrosis and fibrosis,due to its antioxidant capacity as a free radical inhibitor and by inhibiting the NF-κB,TGF-β-Smad3 and JNK-Smad3 pathways. | Erika Hernández-Aquino Natanael Zarco Sael Casas-Grajales Erika Ramos-Tovar Rosa E Flores-Beltrán Jonathan Arauz Mineko Shibayama Liliana Favari Víctor Tsutsumi José Segovia Pablo Muriel | 2017 | World Journal of Gastroenterology2017，23，24： | 10 |
| 3 | Potential effects of mesenchymal stem cell derived extracellular vesicles and exosomal miRNAs in neurological disorders显示文摘Mesenchymal stem cells are multipotent cells that possess anti-inflammatory,antiapoptotic and immunomodulatory properties.The effects of existing drugs for neurodegenerative disorders such as Alzheimer’s disease are limited,thus mesenchymal stem cell therapy has been anticipated as a means of ameliorating neuronal dysfunction.Since mesenchymal stem cells are known to scarcely differentiate into neuronal cells in damaged brain after transplantation,paracrine factors secreted from mesenchymal stem cells have been suggested to exert therapeutic effects.Extracellular vesicles and exosomes are small vesicles released from mesenchymal stem cells that contain various molecules,including proteins,mRNAs and microRNAs.In recent years,administration of exosomes/extracellular vesicles in models of neurological disorders has been shown to improve neuronal dysfunctions,via exosomal transfer into damaged cells.In addition,various microRNAs derived from mesenchymal stem cells that regulate various genes and reduce neuropathological changes in various neurological disorders have been identified.This review summarizes the effects of exosomes/extracellular vesicles and exosomal microRNAs derived from mesenchymal stem cells on models of stroke,subarachnoid and intracerebral hemorrhage,traumatic brain injury,and cognitive impairments,including Alzheimer’s disease. | Masako Nakano Mineko Fujimiya | 2021 | Neural Regeneration Research2021，16，12： | 9 |
| 4 | Anal cushion lifting method is a novel radical management strategy for hemorrhoids that does not involve excision or cause postoperative anal complications显示文摘AIM: To describe the anal cushion lifting(ACL) method with preliminary clinical results. METHODS: Between January to September 2007, 127 patients who received ACL method for hemorrhoid was investigated with informed consent. In this study, three surgeons who specialized in anorectal surgery performed the procedures. Patients with grade two or more severe hemorrhoids according to Goligher's classification were considered to be indicated for surgery. The patients were given the choice to undergo either the ACL method or theligation and excision method. ACL method is an original technique for managing hemorrhoids without excision. After dissecting the anal cushion from the internal sphincter muscle, the anal cushion was lifted to oral side and ligated at the proper position. Clinical characteristics and outcomes of patients were recorded including complications after surgery. RESULTS: A total of 127 patients were enrolled. Their median age was 42(19-84) years, and 74.8% were female. In addition, more than 99% of the patients had grade 3 or worse hemorrhoids. The median followup period was 26(0-88) mo, and the median operative time was 15(4-30) min. After surgery, analgesics were used for a median period of three days(0-21). Pain control was achieved using extra-oral analgesic drugs, although some patients required intravenous injections of analgesic drugs. The median duration of the patients' postoperative hospital stay was 7(2-13) d. A total of 10 complications(7.9%) occurred. Bleeding was observed in one patient and was successfully controlled with manual compression. Urinary retention occurred in 6 patients, but it disappeared spontaneously in all cases. Recurrent hemorrhoids developed in 3 patients after 36, 47, and 61 mo, respectively. No anal stenosis or persistent anal pain occurred. CONCLUSION: We consider that the ACL method might be better than all other current methods for managing hemorrhoids. | Gentaro Ishiyama Toshihiko Nishidate Yuji Ishiyama Akihiko Nishio Ken Tarumi Maiko Kawamura Kenji Okita Toru Mizuguchi Mineko Fujimiya Koichi Hirata | 2015 | World Journal of Gastrointestinal Surgery2015，7，10： | 3 |
| 5 | Experimental Amebiasis: A Selected Review of Some In Vivo Models显示文摘 | Víctor Tsutsumi Mineko Shibayama | 2006 | Archives of Medical Research2006，，2： | 2 |
| 6 | The exercise of selfcare agency scale显示文摘 | MINEKO Y | 1998 | W est J Nurs Res1998，20，3： | 1 |
| 7 | Multielement compositions of marine phytoplankton samples from coastal areas of japan by instrumental neutron activation analysis显示文摘 | Toshiyuki Masuzawa Teruyuki Suzuki Kayoko Seki Tsuyoshi Kosugi Yuriko Hibi Mineko Yamamoto Jitsuya Takada Rokuji Matsushita Mitsuru Yanada | 1999 | Biological Trace Element Research1999，，1： | 1 |
| 8 | The exercise of self - care agency scale 显示文摘 | Mineko Yomashita | 1998 | Western Journal of Nursing Research1998，20，3： | 1 |
| 9 | Isolation and characterization of the mouse liver/bone/kindney-type aldaline phosphatase gene显示文摘 | Mineko TERAO Michela STUDER Maurizio GIANNI | 1991 | Biochem1991，268，： | 1 |
| 10 | The Exercise of Self-Care Agency Scale显示文摘 | Mineko Yamashita | 1998 | Western Journal of Nursing Research1998，20，3： | 1 |
| 11 | Significance of consecutive bilateral surgeries for patients with acute subdural hematoma who develop contralateral acute epi- or subdural hematoma显示文摘 | Akira Matsuno Haruko Katayama Hiromi Wada Kentaro Morikawa Kotaro Tanaka Hideki Tanaka Mineko Murakami Nobuo Fuke Tadashi Nagashima | 2003 | Surgical Neurology2003，，1： | 1 |
| 12 | The exercise of self-care agency scale 显示文摘 | Mineko Y | 1998 | West J NursRes1998，20，3： | 1 |
| 13 | Resveratrol and trimethylated resveratrol protect from acute liver damage induced by CC14 in the rat 显示文摘 | HORACIO R MINEKO S VIVTOR T | 2008 | J Appl Toxicol2008，28，2： | 1 |
| 14 | The exercise of self - care agency scale 显示文摘 | Mineko Yamashita | 1998 | Western J of Nurs Res1998，20，3： | 1 |
| 15 | The exercise of self-care agency scale显示文摘 | Mineko Yamashita | 1998 | Western Jof Nurs Res1998，20，3： | 1 |
| 16 | Biological productivity, terrigenous influence and noncrustal elements supply to the Central Indian Ocean Basin: Paleoceanography during the past ~ 1 Ma显示文摘 | J. N. Pattan Toshiyuki Masuzawa D. V. Borole G. Parthiban Pratima Jauhari Mineko Yamamoto | 2005 | Journal of Earth System Science2005，，1： | 1 |
| 17 | The exercise of selfcare agency scale显示文摘 | Mineko Yamashita | 1998 | Western Journal of Nursing Research1998，20，3： | 1 |
| 18 | Peptidergic regulation of gastrointestinal motility in rodents显示文摘 | Mineko Fujimiya Akio Inui | 2000 | Peptides2000，，： | 1 |
| 19 | Isolation and characterization of variant cDNAs encoding mouse tyrosinase显示文摘 | Mineko T Linda T Enrico G | 1989 | Biophys Res Commun1989，159，2： | 1 |
| 20 | The Exercise of self-care agency scale显示文摘 | Mineko Y | 1998 | Western Journal of Nursing research1998，20，3： | 1 |
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