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| 1 | Immunotherapy against cancer-related viruses显示文摘世界范围的约 12% 所有癌症与病毒的感染被联系。迄今为止,八个病毒被显示了贡献人的癌症的发展,包括 Epstein-Barr 病毒(EBV ) ,肝炎 B 和 C 病毒,和人的乳突淋瘤病毒,在其它之中。这些 DNA 和 RNA 病毒通过不同机制生产 oncogenic 效果。首先,病毒可以通过他们表示的基因导致宿主细胞生长和幸存的持续混乱,或可以在宿主细胞导致 DNA 损坏反应,接着,增加它招待染色体不稳定性。第二,他们可以导致长期的发炎和在主人房间赞成 oncogenic 过程的发展的第二等的织物损坏。病毒相似 HIV 能通过有免疫力的抑制为癌症开发创造更容许的环境,但是我们将在这评论集中于以前的二机制。不同于不能把感染的房间与非感染的房间区分开来的传统的癌症治疗,免疫疗法特别地被装备指向联系病毒的恶意。与有免疫力的反应联系的指向并且工作的机制能被利用由种痘阻止病毒的感染,并且能也被用来在癌症建立前治疗感染。在使用免疫系统根除的成功由联系病毒的肿瘤房间的选择识别建立了恶意当前被报导。例如,产生病毒特定的 T 房间显示出的前 vivo 的采纳转移的众多的临床的试用与联系 EBV 的恶意在病人甚至为确定的肿瘤受益。在另外的联系病毒的肿瘤的另外的研究也被开始了,在这评论,我们为联系病毒的恶意描述免疫疗法的当前的地位并且讨论未来前景。 | Haruko Tashiro Malcolm K Brenner | 2017 | Cell Research2017，27，1： | 4 |
| 2 | Improvement of liver fibrosis by infusion of cultured cells derived from human bone marrow显示文摘 | Haruko Tanimoto Shuji Terai Takami Taro Yasuhiko Murata Kouichi Fujisawa Naoki Yamamoto Isao Sakaida | 2013 | Cell and Tissue Research2013，，3： | 3 |
| 3 | Implications of hepatic dysfunction in Kawasaki disease:Time-related changes in aspartate aminotransferase, alanine aminotransferase,total bilirubin,and C-reactive protein levels显示文摘Importance:The cause of the hepatic dysfunction that commonly accompanies Kawasaki disease(KD)remains unclear.Objective:We tried to clarify the cause of the hepatic dysfunction.Methods:A total of 381 consecutive patients with acute KD,who had undergone inpatient treatment with intravenous immunoglobulin until the 7th day of illness,were divided into a group of 199 patients with an alanine aminotransferase(ALT)level≥40 IU/L on admission(group I),a group of 52 patients with an ALT level≥40 IU/L at some point after admission(group II),and a group of 130 patients with ALT levels consistently<40 IU/L throughout hospitalization(group III).Aspartate aminotransferase(AST),ALT,total bilirubin(T-Bil),and C-reactive protein(CRP)levels were analyzed over time,and time-courses were compared.results:In the initial stage of illness,in group I,AST,ALT,T-Bil peaked on days 1-3,and AST tended to improve significantly on the 4th day(P<0.001).T-Bil improved on day 5(P<0.01),and ALT improved significantly on day 6(P<0.001).CRP increased every day up to day 6(P<0.001).In group II,AST and ALT increased after admission,and thereafter CRP increased,then decreased.The frequency of use of aspirin and aspirin doses did not differ significantly in the three groups.Interpretation:Recovery from liver dysfunction occurred in the initial stage of illness in group I-within the period of CRP exacerbation,which is an indicator of systemic inflammation. | Yasuhiko Tomita Takashi Fukaya Yasuko Yamaura Rie Tsujiguchi Haruko Muratani Maki Shimaya | 2019 | Pediatric Investigation2019，3，1： | 3 |
| 4 | The binding of pullulan modified cholesteryl nanogels to Aβ oligomers and their suppression of cytotoxicity 显示文摘 | SEBASTIEN B HARUKO T KAZUNARI A | 2009 | Biomaterials2009，30，29： | 1 |
| 5 | 16S rRNA-Targeted identification of cyanobacterial genera using oligonucleotide-probes immobilized on bacterial magnetic particles显示文摘 | Tadashi Matsunaga Haruko Takeyama Hideki Nakayama | 2001 | Journal of Applied Phycology2001，，4： | 1 |
| 6 | Evaluation and indications of ultrasound-guided vacuum-assisted core needle breast biopsy显示文摘 | Satoko Nakano Haruko Sakamoto Masahiko Ohtsuka Akemi Mibu Hitomi Sakata Masahiro Yamamoto | 2007 | Breast Cancer2007，，3： | 1 |
| 7 | Evaluation and indications of ultrasound-guided vacuum-assisted core needle breast biopsy显示文摘 | Satoko N Haruko S Masahiko O | 2007 | Breast Cancer2007，14，： | 1 |
| 8 | Simultaneous quantification of retinol,retinal,and retinoic acid isomers by high-performance liquid chromatography with a simple gradiation显示文摘 | MICHIKO M HIROKAZU Y HARUKO | 2001 | J Chromatogr B2001，757，： | 1 |
| 9 | Malignant peripherinl sheath tumor of the parotid gland 显示文摘 | Shun-Ichi lmamura Haruko Suzuki Eiko Koda | 2003 | Ann Otol Rhinol Laryngol2003，112，7： | 1 |
| 10 | Different effects of pravastatin and cerivastatin on the media of the carotid arteries as assessed by integrated backscatter ultrasound 显示文摘 | Yoko M D Masanori M D Haruko Y K | 2004 | Cire J2004，6，8： | 1 |
| 11 | Differential secretion of cytokines and adhesion molecules by HUVEC stimulated with low concentrations of bleomycin显示文摘 | Haruko M Isamu S Arata A | 2002 | Cellular Immunology2002，219，： | 1 |
| 12 | Ellagitannins from Lagerstroemia specious as activators of glucose transport in fat cells显示文摘 | Takeo H Haruko M Royji K | 2002 | Planta Med2002，68，： | 1 |
| 13 | Acarbose improved severe postprandial hypotension in a patient with diabetes mellitus显示文摘 | Eun Sasaki Koshi Goda Koji Nagata Haruko Kitaoka Nakaaki Ohsawa Toshiaki Hanafusa | 2001 | Journal of Diabetes and Its Complications2001，，3： | 1 |
| 14 | Production of eicosapentaenoic acid by a recombinant marine cyanobacterium, Synechococcus sp.显示文摘 | Reiko Yu Akiko Yamada Kazuo Watanabe Kazunaga Yazawa Haruko Takeyama Tadashi Matsunaga Ryuichiro Kurane | 2000 | Lipids2000，，10： | 1 |
| 15 | Significance of consecutive bilateral surgeries for patients with acute subdural hematoma who develop contralateral acute epi- or subdural hematoma显示文摘 | Akira Matsuno Haruko Katayama Hiromi Wada Kentaro Morikawa Kotaro Tanaka Hideki Tanaka Mineko Murakami Nobuo Fuke Tadashi Nagashima | 2003 | Surgical Neurology2003，，1： | 1 |
| 16 | Abscisic acid induces CBF gene transcription and subsequent induction of cold-regulated genes via the CRT promoter element 显示文摘 | HEATHER K DANIEL G Z HARUKO O | 2004 | Plant Physiol2004，，135： | 1 |
| 17 | Dementia caregivers' burdens and use of public services显示文摘 | Haruko Tanji Marl Ootsuki | 2005 | Geriatrics and Gerontology International2005，5，： | 1 |
| 18 | Digestion and lymphatic transport of eicosapentaenoic and docosahexaenoic acids given in the form of triacylglycerol,free acid and ethyl ester in rats 显示文摘 | IKUO I EIJI S HARUKO Y | 1995 | International Journal of Biochemistry Biophysics and Molecular Biology1995，1259，： | 1 |
| 19 | Isolation of Magnetospirillum magneticum AMB-1 mutants defective in bacterial magnetic particle synthesis by transposon mutagenesis显示文摘 | Aris Tri Wahyudi Haruko Takeyama Tadashi Matsunaga | 2001 | Applied Biochemistry and Biotechnology (-)2001，，1： | 1 |
| 20 | Population ageing and wellbeing: lessons from Japan's long-term care insurance policy显示文摘 | NANAKO TAMIYA HARUKO NOGUCHI AKIHIRO NISHI MICHAEL R REICH NAOKI IKEGAMI HIDEKI HASHIMOTO KENJI SHIBUYA ICHIRO KAWACHI JOHN CREIGHTON CAMPBELL | 2011 | The Lancet2011，，378： | 1 |
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