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| 1 | Management of liver transplantation biliary stricture: Results from a tertiary hospital显示文摘AIM: To review results of endoscopic treatment for anastomotic biliary strictures after orthotopic liver transplantation(OLT) during an 8-year period. METHODS: This is a retrospective review of all endoscopic retrograde cholangiopancreatographys(ERCPs) performed between May 2006 and June 2014 in deceased OLT recipients with anastomotic stricture at a tertiary care hospital. Patients were divided into 2 groups, according to the type of stent used(multiple plastic or covered self-expandable metal stents), which was chose on a case-by-case basis and their characteristics. The primary outcome was anastomotic stricture resolution rate determined if there was no more than a minimum waist at cholangiography and a 10 mm balloon could easily pass through the anastomosis with no need for further intervention after final stent removal. Secondary outcomes were technical successrate, number or ERCPs required per patient, number of stents placed, stent indwelling, stricture recurrence rate and therapy for recurrent anastomotic biliary stricture(AS). Stricture recurrence was defined as clinical laboratorial and/or imaging evidence of obstruction at the anastomosis level, after it was considered completely treated, requiring subsequent interventional procedure.RESULTS: A total of 195 post-OLT patients were assessed for eligibility. One hundred and sixty-four(164) patients were diagnosed with anastomotic biliary stricture. ERCP was successfully performed in 157/164(95.7%) patients with AS, that were treated with either multiple plastic(n = 109) or metallic billiary stents(n = 48). Mean treatment duration, number of procedures and stents required were lower in the metal stent group. Acute pancreatitis was the most common procedure related complication, occurring in 17.1% in the covered self-expandable metal stents(c SEMS) and 4.1% in the multiple plastic stent(MPS) group. Migration was the most frequent stent related complication, observed in 4.3% and 5.5%(c SEMS and MPS respectively). Stricture resolution was achieved in 86.8% in the c SEMS group and in 91% in MPS group. Stricture recurrence after a median follow up of 20 mo was observed in 10(30.3%) patients in the c SEMS and 7(7.7%) in the plastic stent group, a statistically significant difference(P = 0.0017). Successful stricture resolution after secondary treatment was achieved in 66.6% and 62.5% of patients respectively in the c SEMS and plastic stents groups. CONCLUSION: Multiple plastic stents are currently the first treatment option for AS in patients with duct-toduct anastomosis. c SEMS was associated with increased pancreatitis risk and higher recurrence rate. | Fernanda Prata Martins Michel Kahaleh Angelo P Ferrari | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，7： | 10 |
| 2 | 心率作为冠心病与左室收缩障碍患者的预后危险因素(BEAUTIFUL):一项随机、对照试验的一个亚组分析显示文摘背景BEAUTIFUL研究对降心率药物伊伐布雷定的发病率与病死率收益进行了评估。BEAUTIFUL试验中的安慰剂组是由稳定型冠心病与左室收缩功能障碍的大型患者队列组成。我们对该安慰剂组进行了亚组分析,旨在检验这样一种假设,即基线静息心率升高是心血管疾病发病与死亡的标志。
方法采用Cox比例风险模型,对心率≥70次/min患者(2693例)以及〈70次/min患者(2745例)进行对比,分析基线静息心率与心血管结局之间的关系。将心率作为一个连续变量,并采用更为精细的心率分类进行其他分析。
结果在对基线特征进行校正后,心率≥70次/min患者的心血管疾病死亡(34%,P=0.0041)、心力衰竭入院(53%,P=0.0001)、心肌梗死入院(46%,P=0.0066)及冠状动脉血运重建(38%,P=0.037)风险升高。心率每升高5次/min,患者的心血管疾病死亡(8%,P=0.0005)、心力衰竭入院(16%.P〈0.0001)、心肌梗死入院(7%,P=0.052)及冠状动脉血运重建(8%,P=0.034)风险亦升高。对心率精细分组的分析表明,心率〉70次/min患者的病死率与心力衰竭发生率持续升高,但这种相关性在冠状动脉结局方面并不显著。对于心力衰竭结局而言,静息心率对早期事件的预测价值较晚期事件的预测价值更强。
结论在冠心病和左室收缩功能障碍的患者中,心率升高(≥70次/min)意味着心血管疾病结局风险升高,同时对心力衰竭相关性结局与冠状动脉事件相关性结局有着不同的影响。 | Kim Fox Ian Ford P Gabriel Steg Michal Tendera Michele Robertson Roberto Ferrari 罗亮(译) | 2008 | 世界临床医学2008，2，6： | 5 |
| 3 | Hepatocellular Carcinoma Is Associated With an Increased Risk of Hepatitis B Virus Recurrence After Liver Transplantation显示文摘 | Luciana C. Faria Michelle Gigou Anne M. Roque–Afonso Mylene Sebagh Bruno Roche Guillaume Fallot Teresa C.A. Ferrari Catherine Guettier Elisabeth Dussaix Denis Castaing Christian Brechot Didier Samuel | 2008 | Gastroenterology2008，，7： | 2 |
| 4 | Adsorptionand partitioning of surfactants in liquid-liquid systems显示文摘 | Michele Ferrari Libero Liggieri | 2000 | Advances in Colloid and Interface Science2000，88，： | 1 |
| 5 | The role of venturecapital firms in Silicon Valley5 s complex innovation network显示文摘 | Ferrary Michel Granovetter and Mark | 2009 | Economy& Society2009，5，38： | 1 |
| 6 | The role of venture capital firmsin Silicon Valley’s complex innovation network显示文摘 | Michel Ferrary Mark Granovetter | 2009 | Economy and Society2009，，2： | 1 |
| 7 | The role of venture capital firms in Silicon Valley’s complex innovation network显示文摘 | Michel Ferrary Mark Granovetter | 2009 | Economy and Society2009，，2： | 1 |
| 8 | PARK6 is a common cause of familial parkinsonism显示文摘 | E.M. Valente F. Brancati V. Caputo E.A. Graham M.B. Davis A. Ferraris M.M.B. Breteler T. Gasser V. Bonifati A.R. Bentivoglio G. De Michele A. Dürr P. Cortelli A. Filla G. Meco B.A. Oostra A. Brice A. Albanese B. Dallapiccola N.W. Wood | 2002 | Neurological Sciences2002，，2： | 1 |
| 9 | Immunopathogenesis of HCV-related endocrine manifestations in chronic hepatitis and mixed cryoglobulinemia显示文摘 | Alessandro Antonelli Clodoveo Ferri Silvia Martina Ferrari Michele Colaci Poupak Fallahi | 2008 | Autoimmunity Reviews2008，，1： | 1 |
| 10 | Near infrared spectroscopy and class modelling techniques for the geographical authenticationof Ligurian extra virgin olive oil显示文摘 | Monica Casale Chiara Casolino Giuseppe Ferrari Michele Forina | 2008 | Journal of Near Infrared Spectroscopy2008，，1： | 1 |
| 11 | Improved Energy Harvesting from Wideband Vibrations by Nonlinear Piezoelectric Converters显示文摘 | Marco Ferrari Vittorio Ferrari Michele Guizzetti Bruno Andò Salvatore Baglio Carlo Trigona | 2009 | Procedia Chemistry2009，，1： | 1 |
| 12 | Immunopathogenesis of HCV-related endocrine manifestations in chronic hepatitis and mixed cryoglobulinemia显示文摘 | Alessandro Antonelli Clodoveo Ferri Silvia Martina Ferrari Michele Colaci Poupak Fallahi | 2008 | Autoimmunity Reviews2008，，1： | 1 |
| 13 | Hepatocellular Carcinoma Is Associated With an Increased Risk of Hepatitis B Virus Recurrence After Liver Transplantation显示文摘 | Luciana C. Faria Michelle Gigou Anne M. Roque–Afonso Mylene Sebagh Bruno Roche Guillaume Fallot Teresa C.A. Ferrari Catherine Guettier Elisabeth Dussaix Denis Castaing Christian Brechot Didier Samuel | 2008 | Gastroenterology2008，，7： | 1 |
| 14 | Migraine pathophysiology: lessons from mouse models and human genetics显示文摘 | Michel D Ferrari Roselin R Klever Gisela M Terwindt Cenk Ayata Arn M J M van den Maagdenberg | 2015 | Lancet Neurology2015，，1： | 1 |
| 15 | The Role of Ven- ture Capital Finns in Silicon Valley's Complex Innovation Network 显示文摘 | MICHEL FERRARY MARK GRANOVETrER | 2009 | Economy and Society2009，38，2： | 1 |
| 16 | Experimental investigation of dynamics effects on multiple- injection common rail system performance显示文摘 | Andrea E Catania Alessandro Ferrari Michele Manno | 2008 | Journal of Engineering for Gas Turbines and Power2008，130，3： | 1 |
| 17 | Specialized organizations and ambidextrous clusters in the open innovation paradigm显示文摘 | Michel Ferrary | 2011 | European Management Journal2011，29，18： | 1 |
| 18 | The role of venture capital firms in Silicon Valley's eomplex innovation network 显示文摘 | Michel Ferrary Mark Granovetter | 2009 | Eeonomy and Society2009，，2： | 1 |
| 19 | A Stakeholder’s Perspective on Human Resource Management显示文摘 | Michel Ferrary | 2009 | Journal of Business Ethics2009，，1： | 1 |
| 20 | Effectiveness of Unsedated Transnasal Endoscopy With White-light, Flexible Spectral Imaging Color Enhancement, and Lugol Staining for Esophageal Cancer Screening in High-risk Patients显示文摘 | Vitor Arantes Walton Albuquerque Jose Maria Porcaro Salles Carlos Alberto Freitas Dias Luiz Ronaldo Alberti Michel Kahaleh Teresa Cristina Abreu Ferrari Luiz Gonzaga Vaz Coelho | 2013 | Journal of Clinical Gastroenterology2013，，4： | 1 |
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