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| 1 | Multispecies probiotic protects gut barrier function in experimental models显示文摘AIM:To investigate the effect of the probiotic combination Lactibiane Tolerance?(LT)on epithelial barrier function in vitro and in vivo.METHODS:The effect of the multispecies probiotic LT was assessed on several models of epithelial barrier function both in vitro(in basal and inflammatory conditions)and in vivo[visceral hypersensitivity induced by chronic stress or by colonic perfusion of a fecal supernatant(FSN)from patients with irritable bowel syndrome(IBS)].In vitro,we measured the permeability of confluent T84 cell monolayers incubated with or without LT by evaluating the paracellular flux of macromolecules,in basal conditions and after stimulation with lipopolysaccharide(LPS)or with conditioned medium of colonic biopsies from IBS patients(IBS-CM).In vivo,male C57/Bl6 mice received orally NaCl or LT for 15 d and were submitted to water avoidance stress(WAS)before evaluating visceral sensitivity by measuring the myoelectrical activity of the abdominal muscle and the paracellular permeability with 51Cr-EDTA.Permeability and sensitivity were also measured after colonic instillation of FSN.Tight-junctions were assessed by immunoblotting and TLR-4 expression was evaluated by immunohistochemistry RESULTS:Incubation of T84 cell monolayers with LT in basal conditions had no significant effect on permeability(P>0.05 vs culture medium).By contrast,addition of LT bacterial bodies(LT)completely prevented the LPS-induced increase in paracellular permeability(P<0.01 vs LPS 10 ng/mL(LPS 10);P<0.01 vs LPS 100ng/mL(LPS 100),P>0.05 vs culture medium).The effect was dose dependent as addition of 109 LT bacterial bodies induced a stronger decrease in absorbance than 106 LT(109 LT+LPS 10:-20.1%±13.4,P<0.01vs LPS 10;106 LT+LPS 10:-11.6%±6.2,P<0.01 vs LPS 10;109 LT+LPS 100:-14.4%±5.5,P<0.01 vs LPS 100;106 LT+LPS 100:-11.6%±7.3,P<0.05 vs LPS 100).Moreover,the increase in paracellular permeability induced by culturing T84 cells with conditioned medium of colonic biopsies from IBS patients(IBS-CM)was completely inhibited in the presence of 109 LT(P<0.01 vs IBS-CM).LT also significantly prevented the epithelial disruption induced by intracolonic infusion of fecal supernatant from IBS patients(P<0.01 vs IBS FSN)or water avoidance stress P<0.01 vs WAS)in C57/Bl6 mice and increased the expression of occludin in vitro and in vivo,as assessed by immnunoblotting.The WAS-induced effect on visceral sensitivity was prevented by LT treatment since values obtained for all steps of colorectal distension were significantly(P<0.01)different from the WAS group.Finally,LT downregulated the response mediated through TLR-4 in vitro(decrease in tumor necrosis factorαsecretion in response to LPS:-65.8%for 109 LT and-52.5%for 106LT,P<0.01 vs LPS)and in vivo(inhibition of WAS induced an increase in TLR-4 expression in the LT treated mice colon,P<0.01 vs WAS).CONCLUSION:The probiotic LT mix prevented the disruption to the epithelial barrier induced by LPS,stress or colonic soluble factors from IBS patients and prevented visceral hypersensitivity. | Mylene Nébot-Vivinus Cherryl Harkat Hanene Bzioueche Christel Cartier Raffaella Plichon-Dainese Lara Moussa Helene Eutamene Dorsa Pishvaie Sophie Holowacz Christian Seyrig Thierry Piche Vassilia Theodorou | 2014 | World Journal of Gastroenterology2014，20，22： | 12 |
| 2 | 法国经济情报研究:机遇与挑战显示文摘本文的目的是介绍关于法国经济情报的研究状况。经济情报是一个典型的法国概念,法国的研究者采用了独特的方法,如系统方法、人类学方法和政治学的方法,并围绕着这个概念形成了自己的研究特点。本文介绍了经济情报这一概念的历史、定义,相关的研究团队和研究领域,它所涉及的问题及其与法国文化相关的未来发展趋势。重点介绍了法国国家经济情报和区域经济情报的概念。 | Mylene HARDY 温宏建 | 2009 | 竞争情报2009，5，4： | 5 |
| 3 | Hepatocellular Carcinoma Is Associated With an Increased Risk of Hepatitis B Virus Recurrence After Liver Transplantation显示文摘 | Luciana C. Faria Michelle Gigou Anne M. Roque–Afonso Mylene Sebagh Bruno Roche Guillaume Fallot Teresa C.A. Ferrari Catherine Guettier Elisabeth Dussaix Denis Castaing Christian Brechot Didier Samuel | 2008 | Gastroenterology2008，，7： | 2 |
| 4 | Successful anti-hepatitis C virus therapy with telaprevir in an HIV/hepatitis C virus co-infected patient with a severe recurrence of hepatitis C virus infection on the liver graft显示文摘 | Teresa M. Antonini Valerie Furlan Elina Teicher Stephanie Haim-Boukobza Mylene Sebagh Audrey Coilly Laurence Bonhomme-Faivre Gilles Peytavin Anne-Marie Roque-Afonso Daniel Vittecoq Didier Samuel Anne-Marie Taburet Jean-Charles Duclos-Vallée | 2013 | AIDS2013，，16： | 2 |
| 5 | Hepatitis C virus therapy in liver transplant recipients: Response predictors, effect on fibrosis progression, and importance of the initial stage of fibrosis显示文摘 | Bruno Roche Mylene Sebagh Maria Laura Canfora Teresa Antonini Anne‐Marie Roque‐Afonso Valerie Delvart Faouzi Saliba Jean‐Charles Duclos‐Vallee Denis Castaing Didier Samuel | 2008 | Liver Transpl2008，，12： | 1 |
| 6 | Cadaveic full-size liver transplantation and the graft alternatives in adults: A comparative study from a single center 显示文摘 | Mylene S Funda Y Vincent K | 2006 | J Hepatoh2006，44，1： | 1 |
| 7 | Caval Inflow to the Graft for Liver Transplantation in Patients With Diffuse Portal Vein Thrombosis: A 12-Year Experience显示文摘 | Prashant Bhangui Chetana Lim Chady Salloum Paola Andreani Mylene Sebbagh Emir Hoti Philippe Ichai Faouzi Saliba Rene Adam Denis Castaing Daniel Azoulay | 2011 | Annals of Surgery2011，，6： | 1 |
| 8 | Reversed halo sign in invasive pulmonary fungal infections显示文摘 | Hisham Wahba Mylene T Truong Xiudong | 2008 | Clinical Infectious Diseases2008，46，11： | 1 |
| 9 | Hepatocellular Carcinoma Is Associated With an Increased Risk of Hepatitis B Virus Recurrence After Liver Transplantation显示文摘 | Luciana C. Faria Michelle Gigou Anne M. Roque–Afonso Mylene Sebagh Bruno Roche Guillaume Fallot Teresa C.A. Ferrari Catherine Guettier Elisabeth Dussaix Denis Castaing Christian Brechot Didier Samuel | 2008 | Gastroenterology2008，，7： | 1 |
| 10 | Incidental findings on integrated PET/CT that do not accumulate ^18F-FDG 显示文摘 | John F Mylene T Edith M | 2006 | AIR2006，187，： | 1 |
| 11 | National Pressure Ulcer Advisory Panel’s Updated Pressure Ulcer Staging System显示文摘 | Joyce Black Mona Mylene Baharestani Janet Cuddigan Becky Dorner Laura Edsberg Diane Langemo Mary Ellen Posthauer Catherine Ratliff George Taler | 2007 | Advances in Skin & Wound Care2007，，5： | 1 |
| 12 | Gene expression profiling reveals progesterone-mediated cell cycle and immunoregulatory roles of hoxa-10 in the preimplantation uterus显示文摘 | Mylene MW Lim H Schust DJ | 2003 | Molecular Endocrinol2003，17，4： | 1 |
| 13 | Cadaveic full-size liver transplantation and the graft alternatives in adults:A comparative study from a single centre显示文摘 | Mylene S Funda Y Vincent K | 2005 | Hepatology2005，42，8： | 1 |
| 14 | Long-term oxidation behavior and mechanical strength degradation of a pressurelessly sintered ZrB2-MoSi2 ceramic显示文摘 | DILETTA S MYLENE B ALIDA B | 2005 | Scripta Materialia2005，53，11： | 1 |
| 15 | Nucleotide sequence analysis of T-DNA of Agrobacterium rhizogenes agropine type plasmid identification of open reading frames 显示文摘 | Slightom J L Mylene D T Lise J | 1986 | The Journal of Biologycal Chemestry1986，261，1： | 1 |
| 16 | Detection of human food-borne and zoonotic viruses on irrigated,field-grown strawberries显示文摘 | Brassard Julie GagnéMarie-Josee Généreux Mylene | 2012 | Appl Environ Microbiol2012，，： | 1 |
| 17 | Clinical and pharmacokinetic study of TNP-470, an angiogenesis inhibitor, in combination with paclitaxel and carboplatin in patients with solid tumors显示文摘 | Hai T. Tran George R. Blumenschein Charles Lu Christina A. Meyers Vali Papadimitrakopoulou Frank V. Fossella Ralph Zinner Timothy Madden Lori G. Smythe Vinay K. Puduvalli Reggie Munden Mylene Truong Roy S. Herbst | 2004 | Cancer Chemotherapy and Pharmacology2004，，4： | 1 |
| 18 | Current status of surgical and nonsurgical management of ectopic pregnancy显示文摘 | Mylene Y Togas T | 1997 | Fertil Steril1997，67，： | 1 |
| 19 | ACUTE LUNG INJURY AND ACUTE RESPIRATORY DISTRESS SYNDROME IN SEPSIS AND SEPTIC SHOCK显示文摘 | Alan M. Fein Mylene G. Calalang-Colucci | 2000 | Critical Care Clinics2000，，2： | 1 |
| 20 | Optimiazation of large scale industrial process by genetic algorithms显示文摘 | Mylene C A F R Caliane B B C Aline C C | 2008 | Chemical Engineering Science2008，63，2： | 1 |
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