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| 1 | 持续性姿势-感知性头晕(PPPD)诊断标准:Bárány学会前庭疾病分类委员会共识显示文摘本文提出被纳入前庭疾病国际分类(International Classification of Vestibular Disorders,ICVD)的持续性姿势-感知性头晕(PPPD)的诊断标准。PPPD虽然是一个新的医学术语,但该病的存在由来已久。前庭疾病分类委员会深入汇总、分析了近30年来恐惧性姿势性眩晕(Phobic Postural Vertigo,PPV)、空间运动不适(Space℃Motion Discomfort,SMD)、视觉性眩晕(Visual Vertigo,VV)和慢性主观性头晕(Chronic Subjective Dizziness,CSD)相关的研究,在此基础上提出了PPPD的诊断标准。临床上,头晕、不稳、非旋转性眩晕为PPPD的3个核心症状。PPPD患者常表现为这3个核心症状中的一个或多个,症状持续时间超过3个月,并且在直立姿势、主动/被动运动、暴露于移动视觉刺激或复杂视觉环境中时症状出现加重。PPPD可能与影响平衡系统或引起眩晕、不稳及头晕的疾病所触发有关,包括周围或中枢前庭病变、其他内科疾病或心理疾病。临床上,PPPD既可单独存在,也可与其他临床疾病共病。PPPD可能的亚型分类尚需进一步识别和验证。迄今为止,PPPD确切的病理生理机制尚不明确。新近研究表明,PPPD可能与躯体姿势控制、多感觉信息处理、威胁评估系统与空间定向系统皮质整合的功能异常相关。因此,PPPD被归类为慢性功能性前庭疾病,并不是结构性前庭疾病或精神心理性前庭疾病。 | 李康之(译) 刘博(译) 顾平(审校) 杨旭(审校) Jeffrey PStaab Annegret Eckhardt-Henn Arata Horii Rolf Jacob Michael Strupp Thomas Brandt Adolfo Bronstein | 2020 | 神经损伤与功能重建2020，15，2： | 20 |
| 2 | Platelet-rich plasma for regeneration of neural feedback pathways around dental implants: a concise review and outlook on future possibilities显示文摘Along with the development of new materials, advanced medical imaging and surgical techniques, osseointegrated dental implants are considered a successful and constantly evolving treatment modality for the replacement of missing teeth in patients with complete or partial edentulism. The importance of restoring the peripheral neural feedback pathway and thus repairing the lack of periodontal mechanoreceptors after tooth extraction has been highlighted in the literature. Nevertheless, regenerating the nerve fibers and reconstructing the neural feedback pathways around osseointegrated implants remain a challenge. Recent studies have provided evidence that platelet-rich plasma(PRP) therapy is a promising treatment for musculoskeletal injuries.Because of its high biological safety, convenience and usability, PRP therapy has gradually gained popularity in the clinical field.Although much remains to be learned, the growth factors from PRP might play key roles in peripheral nerve repair mechanisms.This review presents known growth factors contributing to the biological efficacy of PRP and illustrates basic and(pre-)clinical evidence regarding the use of PRP and its relevant products in peripheral nerve regeneration. In addition, the potential of local application of PRP for structural and functional recovery of injured peripheral nerves around dental implants is discussed. | Yan Huang Michael M Bornstein Ivo Lambrichts Hai-Yang Yu Constantinus Politis Reinhilde Jacobs | 2017 | International Journal of Oral Science2017，9，1： | 10 |
| 3 | Obese diet-induced mouse models of nonalcoholic steatohepatitis-tracking disease by liver biopsy显示文摘AIM:To characterize development of diet-induced nonalcoholic steatohepatitis(NASH)by performing live biopsy in wild-type and genetically obese mice.METHODS:Male wild-type C57BL/6J(C57)mice(DIO NASH)and male Lep ob/Lep ob(ob/ob)mice(ob/ob-NASH were maintained on a diet high in trans-fat(40%)fructose(22%)and cholesterol(2%)for 26 and 12 wk respectively.A normal chow diet served as control in C57 mice(lean chow)and ob/ob mice(ob/ob chow)After the diet-induction period,mice were liver biopsied and a blinded histological assessment of steatosis and fibrosis was conducted.Mice were then stratified into groups counterbalanced for steatosis score and fibrosi stage and continued on diet and to receive daily PO dosing of vehicle for 8 wk.Global gene expression in liver tissue was assessed by RNA sequencing and bioin formatics.Metabolic parameters,plasma liver enzyme and lipids(total cholesterol,triglycerides)as well a hepatic lipids and collagen content were measured b biochemical analysis.Non-alcoholic fatty liver disease activity score(NAS)(steatosis/inflammation/ballooningdegeneration)and fibrosis were scored.Steatosis and fibrosis were also quantified using percent fractional area.RESULTS:Diet-induction for 26 and 12 wk in DIONASH and ob/ob-NASH mice,respectively,elicited progressive metabolic perturbations characterized by increased adiposity,total cholesterol and elevated plasma liver enzymes.The diet also induced clear histological features of NASH including hepatosteatosis and fibrosis.Overall,the metabolic NASH phenotype was more pronounced in ob/ob-NASH vs DIO-NASH mice.During the eight week repeated vehicle dosing period,the metabolic phenotype was sustained in DIO-NASH and ob/ob-NASH mice in conjunction with hepatomegaly and increased hepatic lipids and collagen accumulation.Histopathological scoring demonstrated significantly increased NAS of DIO-NASH mice(0 vs4.7±0.4,P<0.001 compared to lean chow)and ob/ob-NASH mice(2.4±0.3 vs 6.3±0.2,P<0.001compared to ob/ob chow),respectively.Furthermore,fibrosis stage was significantly elevated for DIO-NASH mice(0 vs 1.2±0.2,P<0.05 compared to lean chow)and ob/ob NASH(0.1±0.1 vs 3.0±0.2,P<0.001compared to ob/ob chow).Notably,fibrosis stage was significantly(P<0.001)increased in ob/ob-NASH mice,when compared to DIO-NASH mice.CONCLUSION:These data introduce the obese dietinduced DIO-NASH and ob/ob-NASH mouse models with biopsy-confirmed individual disease staging as a preclinical platform for evaluation of novel NASH therapeutics. | Maria Nicoline Baandrup Kristiansen Sanne Skovgard Veidal Kristoffer Tobias Gustav Rigbolt Kirstine Sloth Tolbol Jonathan David Roth Jacob Jelsing Niels Vrang Michael Feigh | 2016 | World Journal of Hepatology2016，8，16： | 10 |
| 4 | Depression risk in patients with coronary heart disease in Germany显示文摘AIM To determine the prevalence of depression and its risk factors among patients with coronary heart disease(CHD) treated in German primary care practices.METHODS Longitudinal data from nationwide general practices in Germany(n = 1072) were analyzed.Individuals initially diagnosed with CHD(2009-2013) were identified,and 59992 patients were included and matched(1:1) to 59992 controls.The primary outcome measure was an initial diagnosis of depression within five years after the index date among patients with and without CHD.Cox proportional hazards models were used to adjust for confounders.RESULTS Mean age was equal to 68.0 years(SD = 11.3).A total of 55.9% of patients were men.After a five-year follow-up,21.8% of the CHD group and 14.2% of the control group were diagnosed with depression(P < 0.001).In the multivariate regression model,CHD was a strong risk factor for developing depression(HR =1.54,95%CI:1.49-1.59,P < 0.001).Prior depressive episodes,dementia,and eight other chronic conditions were associated with a higher risk of developing depression.Interestingly,older patients and women were also more likely to be diagnosed with depression compared with younger patients and men,respectively.CONCLUSION The risk of depression is significantly increased among patients with CHD compared with patients without CHD treated in primary care practices in Germany.CHD patients should be routinely screened for depression to ensure improved treatment and management. | Marcel Konrad Louis Jacob Michael A Rapp Karel Kostev | 2016 | World Journal of Cardiology2016，8，9： | 8 |
| 5 | INT-767 improves histopathological features in a dietinduced ob/ob mouse model of biopsy-confirmed nonalcoholic steatohepatitis显示文摘AIM To characterize the efficacy of the dual FXR/TGR5 receptor agonist INT-767 upon histological endpoints in a rodent model of diet-induced and biopsy-confirmed non-alcoholic steatohepatitis(NASH).METHODS The effects of INT-767 on histological features of NASH were assessed in two studies using Lep^(ob/ob)(ob/ob) NASH mice fed the AMLN diet(high fat with transfat, cholesterol and fructose). In a proof-of-conceptstudy, Lep^(ob/ob)(ob/ob) NASH mice were first dosed with INT-767(3 or 10 mg/kg for 8 wk). A second ob/ob NASH study compared INT-767(3 and 10 mg/kg) to obeticholic acid(OCA)(10 or 30 mg/kg; 16 wk). Primary histological endpoints included qualitative and quantitative assessments of NASH. Other metabolic and plasma endpoints were also assessed. A comparative assessment of INT-767 and OCA effects on drug distribution and hepatic gene expression was performed in C57 Bl/6 mice on standard chow. C57 Bl/6 mice were orally dosed with INT-767 or OCA(1-30 mg/kg) for 2 wk, and expression levels of candidate genes were assessed by RNA sequencing and tissue drug levels were measured by liquid chromatography tandem-mass spectrometry.RESULTS INT-767 dose-dependently(3 and 10 mg/kg, PO, QD, 8 wk) improved qualitative morphometric scores on steatohepatitis severity, inflammatory infiltrates and fibrosis stage. Quantitative morphometric analyses revealed that INT-767 reduced parenchymal collagen area, collagen fiber density, inflammation(assessed by Galectin-3 immunohistochemistry) and hepatocyte lipid droplet area following INT-767 treatment. In a comparative study(16 wk), the FXR agonists OCA(10 and 30 mg/kg) and INT-767(3 and 10 mg/kg) both improved NASH histopathology, with INT-767 exerting greater therapeutic potency and efficacy than OCA. Mechanistic studies suggest that both drugs accumulate similarly within the liver and ileum, however, the effects of INT-767 may be driven by enhanced hepatic, but not ileal, FXR function. CONCLUSION These findings confirm the potential utility of FXR and dual FXR/TGR5 activation as disease intervention strategies in NASH. | Jonathan D Roth Michael Feigh Sanne S Veidal Louise KD Fensholdt Kristoffer T Rigbolt Henrik H Hansen Li C Chen Mathieu Petitjean Weslyn Friley Niels Vrang Jacob Jelsing Mark Young | 2018 | World Journal of Gastroenterology2018，24，2： | 7 |
| 6 | New frontiers for the materials genome initiative显示文摘The Materials Genome Initiative(MGI)advanced a new paradigm for materials discovery and design,namely that the pace of new materials deployment could be accelerated through complementary efforts in theory,computation,and experiment.Along with numerous successes,new challenges are inviting researchers to refocus the efforts and approaches that were originally inspired by the MGI.In May 2017,the National Science Foundation sponsored the workshop“Advancing and Accelerating Materials Innovation Through the Synergistic Interaction among Computation,Experiment,and Theory:Opening New Frontiers”to review accomplishments that emerged from investments in science and infrastructure under the MGI,identify scientific opportunities in this new environment,examine how to effectively utilize new materials innovation infrastructure,and discuss challenges in achieving accelerated materials research through the seamless integration of experiment,computation,and theory.This article summarizes key findings from the workshop and provides perspectives that aim to guide the direction of future materials research and its translation into societal impacts. | Juan J.de Pablo Nicholas E.Jackson Michael A.Webb Long-Qing Chen Joel E.Moore Dane Morgan Ryan Jacobs Tresa Pollock Darrell G.Schlom Eric S.Toberer James Analytis Ismaila Dabo Dean M.DeLongchamp Gregory A.Fiete Gregory M.Grason Geoffroy Hautier Yifei Mo Krishna Rajan Evan J.Reed Efrain Rodriguez Vladan Stevanovic Jin Suntivich Katsuyo Thornton Ji-Cheng Zhao | 2019 | npj Computational Materials2019，，1： | 7 |
| 7 | Three-dimensional bioprinted glioblastoma microenvironments model cellular dependencies and immune interactions显示文摘Brain tumors are dynamic complex ecosystems with multiple cell types.To model the brain tumor microenvironment in a reproducible and scalable system,we developed a rapid three-dimensional(3D)bioprinting method to construct clinically relevant biomimetic tissue models.In recurrent glioblastoma,macrophages/microglia prominently contribute to the tumor mass.To parse the function of macrophages in 3D,we compared the growth of glioblastoma stem cells(GSCs)alone or with astrocytes and neural precursor cells in a hyaluronic acid-rich hydrogel,with or without macrophage.Bioprinted constructs integrating macrophage recapitulate patient-derived transcriptional profiles predictive of patient survival,maintenance of stemness,invasion,and drug resistance.Whole-genome CRISPR screening with bioprinted complex systems identified unique molecular dependencies in GSCs,relative to sphere culture.Multicellular bioprinted models serve as a scalable and physiologic platform to interrogate drug sensitivity,cellular crosstalk,invasion,context-specific functional dependencies,as well as immunologic interactions in a species-matched neural environment. | Min Tang Qi Xie Ryan C.Gimple Zheng Zhong Trevor Tam Jing Tian Reilly L.Kidwell Qiulian Wu Briana C.Prager Zhixin Qiu Aaron Yu Zhe Zhu Pinar Mesci Hui Jing Jacob Schimelman Pengrui Wang Derrick Lee Michael H.Lorenzini Deobrat Dixit Linjie Zhao Shruti B.hargava Tyler E.Miller Xueyi Wan Jing Tang Bingjie Sun Benjamin F.Cravatt Alysson R.Muotri Shaochen Chen Jeremy N.Rich | 2020 | Cell Research2020，30，10： | 6 |
| 8 | Millisecond synthesis of CoS nanopartides for highly efficient overall water splitting显示文摘High performance and low-cost electrocatalysts for overall water splitting,i.e.,catalyzing hydrogen and oxygen evolution reactions with the same material,are of great importance for large-scale,renewable energy conversion processes.Here,we report an ultrafast(~7 ms)synthesis tech nique for tran sition metal chalcoge nide n anoparticles assisted by high temperature treatme nt.As a proof of con cept,we dem on strate that cobalt sulfide(~20 nm in diameter)@few-layer graphe ne(~2 nm in thick ness)core-shell nan oparticles embedded in RGO nano sheets exhibit remarkable bifunctional electrocatalytic activity and stability for overall water splitting,which is comparable to commercial 40 wt.%platinum/carbon(Pt/C)electrocatalysts.After 60 h of continuous operation,10 mA crrT?water splitting current density can still be achieved at a low potential of^1.77 V without any activity decay,which is among the most active for non-noble material based electrocatalysts.The presented study provides prospects in synthesizing highly efficient bifunctional electrocatalysts for large-scale energy conversion application via a simple yet efficient technique. | Yanan Chen Shaomao Xu Shuze Zhu Rohit Jiji Jacob Glenn Pastel Yanbin Wang Yiju Li Jiaqi Dai Fengjuan Chen Hua Xie Boyang Liu Yonggang Yao Lourdes G. Salamanca-Riba Michael R. Zachariah Teng Li Liangbing Hu | 2019 | Nano Research2019，12，9： | 6 |
| 9 | Nosocomial Pneumonia After Acute Stroke: Implications for Neurological Intensive Care Medicine显示文摘 | Ruediger Hilker Carsten Poetter Nahide Findeisen Jan Sobesky Andreas Jacobs Michael Neveling Wolf-Dieter Heiss | 2003 | Stroke: Journal of the American Heart Association2003，，4： | 6 |
| 10 | Metabolic and hepatic effects of liraglutide,obeticholic acid and elafibranor in diet-induced obese mouse models of biopsy-confirmed nonalcoholic steatohepatitis显示文摘AIM To evaluate the pharmacodynamics of compounds in clinical development for nonalcoholic steatohepatitis(NASH) in obese mouse models of biopsy-confirmedNASH.METHODS Male wild-type C57 BL/6 J mice(DIO-NASH) and Lep^(ob/ob)(ob/ob-NASH) mice were fed a diet high in trans-fat(40%), fructose(20%) and cholesterol(2%) for 30 and 21 wk, respectively. Prior to treatment, all mice underwent liver biopsy for confirmation and stratification of liver steatosis and fibrosis, using the nonalcoholic fatty liver disease activity score(NAS) and fibrosis staging system. The mice were kept on the diet and received vehicle, liraglutide(0.2 mg/kg, SC, BID), obeticholic acid(OCA, 30 mg/kg PO, QD), or elafibranor(30 mg/kg PO, QD) for eight weeks. Within-subject comparisons were performed on changes in steatosis, inflammation, ballooning degeneration, and fibrosis scores. In addition, compound effects were evaluated by quantitative liver histology, including percent fractional area of liver fat, galectin-3, and collagen 1 a1.RESULTS Liraglutide and elafibranor, but not OCA, reduced body weight in both models. Liraglutide improved steatosis scores in DIO-NASH mice only. Elafibranor and OCA reduced histopathological scores of hepatic steatosis and inflammation in both models, but only elafibranor reduced fibrosis severity. Liraglutide and OCA reduced total liver fat, collagen 1 a1, and galectin-3 content, driven by significant reductions in liver weight. The individual drug effects on NASH histological endpoints were supported by global gene expression(RNA sequencing) and liver lipid biochemistry.CONCLUSION DIO-NASH and ob/ob-NASH mouse models show distinct treatment effects of liraglutide, OCA, and elafibranor, being in general agreement with corresponding findings in clinical trials for NASH. The present data therefore further supports the clinical translatability and utility of DIO-NASH and ob/ob-NASH mouse models of NASH for probing the therapeutic efficacy of compounds in preclinical drug development for NASH. | Kirstine S Tolbol Maria NB Kristiansen Henrik H Hansen Sanne S Veidal Kristoffer TG Rigbolt Matthew P Gillum Jacob Jelsing Niels Vrang Michael Feigh | 2018 | World Journal of Gastroenterology2018，24，2： | 5 |
| 11 | Influence of lanthanum level and interactions with nitrogen source on early development of Juglans nigra显示文摘稀土元素元素在中国农业被用于 30 年改进生长和产量。众多的科学研究在生理学,矿物质营养,和生长显示出改进,尽管有害效果可以也发生。很少的研究在木质的种类上被执行了。我们指数地使肥沃一个年旧黑核桃(Juglans nigra L.) 有 0, 0.1, 1, 10,或 100 mg 镧(La ) 和 800 mg 氮(N) 的幼苗作为 NaNO3,(NH4 ) 2SO4, NH4NO3,或没有 N。一月追随者期末考试授精,生长,矿物质营养,光合作用,叶绿素,和硝酸盐 reductase 活动被估计。植物与 La 的高水平使肥沃减少了好根生长,镁的集中,钙,镍,和磷,光合作用层次,和叶绿素一个内容。叶的 La 集中显示出相互作用效果,与乘在在到给 10 mg La 为的那些的 100 mg La 喂的植物的更大的集中的三~四(NH4 ) 2SO4 和 NH4NO3 处理。在层次的 La 增加的建议不有益的效果在在 N 之间的这研究和相互作用使用了的结果采购原料, La 层次没在黑核桃幼苗的生长,矿物质营养,或生理学上有重要影响。 | Nicodemus Michael A Salifu K Francis Jacobs Douglass F | 2009 | Journal of Rare Earths2009，27，2： | 4 |
| 12 | Pancreatic intraepithelial neoplasia arising from an ectopic pancreas in the small bowel显示文摘BACKGROUND: Ectopic pancreatic tissue is relatively uncommon, and is characterized as pancreatic tissue with no contact with the normal pancreas, and with its own ductal system and blood supply. It is usually asymptomatic, and can be incidentally diagnosed by conventional imaging studies.METHOD: A 69-year-old woman with a prior history of bilateral breast carcinoma presented with ectopic pancreatic intraepithelial neoplasia (PanI N) that was identified incidentally in the small bowel during an oncological resection of a synchronous primary pancreatic adenocarcinoma, and renal cell carcinoma.RESULTS: The patient underwent subtotal pancreatectomy with splenectomy, regional lymphadenectomy, radical left nephrectomy, and small bowel resection with primary anastomosis of ectopic Pan IN-2. She had an uneventful hospitalization and was discharged home on postoperative day 7.CONCLUSIONS: The occurrence of ectopic PanI N is extremely unusual with only few cases previously reported in the literature. The need for negative margins after surgical resection of ectopic PanI N lesions remains controversial. | Francisco Igor Macedo Deepa Taggarshe Tafadzwa Makarawo Barry Herschman Michael J Jacobs | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，6： | 4 |
| 13 | New oral pharmacotherapeutic agents for venous thromboprophylaxis after total hip arthroplasty显示文摘Patients undergoing total hip arthroplasty(THA)are at high risk for developing venous thromboembolism and,therefore,require short term prophylaxis with antithrombotic agents.Recently,target specific oral anticoagulants(TSOA)including the direct thrombin inhibitor,dabigatran,and the factorⅩa inhibitors rivaroxaban,apixaban,and edoxaban have been approved for THA thrombopropylaxis in various countries.The TSOAs provide a rapid acting,oral alternative to parenteral agents including low-molecular weight heparins(LMWH)and fondaparinux;and compared to warfarin,they do not require routine laboratory monitoring and possess much fewer drug-drug interactions.Based on phaseⅢclinical studies,TSOAs have established themselvesas an effective and safe option for thromboprophylaxis after THA compared to LMWH,particularly enoxaparin,but require additional evaluation in specific populations such as the renally impaired or elderly.The ability to monitor and reverse these TSOAs in the case of bleeding complications or suspected sub-or supra-therapeutic anticoagulation is of importance,but remains investigational.This review will focus on the drug-specific characteristics,efficacy,safety,and economic impact of the TSOAs for thromboprophylaxis following THA,as well as the aspects of therapeutic monitoring and anticoagulation reversal in the event of bleeding complications or a need for urgent reversal. | Garrett B Aikens Jacob R Osmundson Michael P Rivey | 2014 | World Journal of Orthopedics2014，5，3： | 3 |
| 14 | The Role of RNA Structure in Posttranscriptional Regulation of Gene Expression显示文摘当更多的信息在抄写和翻译的机制上被聚集,这些过程高度被调整,正在变得明显。第二等的 mRNA 和第三级的结构的形成是一个如此的规章的过程直到最近,它没深入地被分析。这些 mRNA 结构的形成有潜力提高并且禁止抄本的其他的拼接,并且调整翻译的率和数量。当,这规章的机制潜在地在 transcriptional 和翻译水平影响潜在地也利用非编码的 RNA 的广阔数组,它保证进一步的调查。当前,包括 RNA 结构(同等) 的平行分析的许多高产量的定序技术,定序的破碎(FragSeq ) 和选择 2 氢氧根 acylation 由教材扩展(形状) 分析了在 mRNA 的染色体宽的鉴定和分析带路结构形成。这些新定序技术加亮 transcriptome 的差异和复杂性,并且表明能为新治疗学的途径成为一个目标的另一规章的机制。 | Elina Jacobs James D.Mills Michael Janitz | 2012 | Journal of Genetics and Genomics2012，39，10： | 3 |
| 15 | Preventive treatment of alveolar pulmonary edema of cardiogenic origin显示文摘Objective To evaluate the efficacy of preventive treatment (PT) on alveolar pulmonary edema (APE) of cardiogenic origin using a monitor based on principles of internal thoracic impedance (ITI) measurements.Methods We conducted blinded clinical trials on patients with ST-elevation myocardial infarction (STEMI) and monitored whether the condition would progress to APE. ITI was measured noninvasively by the Edema Guard Monitor (EGM, model RS-207) every 30 min. The measurement threshold for the diagnosis of APE was fixed at > 12% decrease in ITI from baseline as described in our methodology. The patients were divided into one group that received standard treatment after the appearance of clinical signs of APE without considering the prediction of APE by EGM devise (Group 1), and another group of asymptomatic patients in whom development of APE was predicted by using only EGM measurements (Group 2). The latter participants’PT consisted of furosemide, intravenous nitroglycerine and supplemental oxygen. Results One-hundred and fifty patients with acute STEMI were enrolled into this study. Group 1 included 100 patients (53% males, age 64.1 ±12.6 years). Treatment was started after the clinical appearance of overt signs of APE. Group 2 included 50 patients (54% males, age 65.2 ±11.9 years) who received PT based on EGMmeasurements. Group 2 had significantly fewer cases of APE (n = 4, 8%) than Group 1 (n = 100, 100%) (P > 0.001). While APE was lethal in six (6%) Group 1 patients, PT resulted in prompt resolution of APE in all four (8%) Group 2 patients. Conclusion ITI is a usefulmodality for early diagnosis and PT of pulmonary edema of cardiogenic origin. | Gideon Charach Michael Shochat Alexander Rabinovich Oded Ayzenberg Jacob George Lior Charach Pavel Rabinovich | 2012 | Journal of Geriatric Cardiology2012，9，4： | 3 |
| 16 | A search engine for 3D models显示文摘 | Thomas Funkhouser Patrick Min Michael Kazhdan Joyce Chen Alex Halderman David Dobkin David Jacobs | 2003 | ACM Transactions on Graphics (TOG)2003，，1： | 3 |
| 17 | Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source显示文摘BACKGROUND The trans-fat containing AMLN(amylin liver non-alcoholic steatohepatitis,NASH)diet has been extensively validated in C57BL/6J mice with or without the Lep^ob/Lep^ob(ob/ob)mutation in the leptin gene for reliably inducing metabolic and liver histopathological changes recapitulating hallmarks of NASH.Due to a recent ban on trans-fats as food additive,there is a marked need for developing a new diet capable of promoting a compatible level of disease in ob/ob and C57BL/6J mice.AIM To develop a biopsy-confirmed mouse model of NASH based on an obesogenic diet with trans-fat substituted by saturated fat.METHODS Male ob/ob mice were fed AMLN diet or a modified AMLN diet with trans-fat(Primex shortening)substituted by equivalent amounts of palm oil[Gubra amylin NASH,(GAN)diet]for 8,12 and 16 wk.C57BL/6J mice were fed the same diets for 28 wk.AMLN and GAN diets had similar caloric content(40%fat kcal),fructose(22%)and cholesterol(2%)level.RESULTS The GAN diet was more obesogenic compared to the AMLN diet and impaired glucose tolerance.Biopsy-confirmed steatosis,lobular inflammation,hepatocyte ballooning,fibrotic liver lesions and hepatic transcriptome changes were similar in ob/ob mice fed the GAN or AMLN diet.C57BL/6J mice developed a mild to moderate fibrotic NASH phenotype when fed the same diets.CONCLUSION Substitution of Primex with palm oil promotes a similar phenotype of biopsyconfirmed NASH in ob/ob and C57BL/6J mice,making GAN diet-induced obese mouse models suitable for characterizing novel NASH treatments. | Michelle L Boland Denise Oro Kirstine S T■lb■l Sebastian T Thrane Jens Christian Nielsen Taylor S Cohen David E Tabor Fiona Fernandes Andrey Tovchigrechko Sanne S Veidal Paul Warrener Bret R Sellman Jacob Jelsing Michael Feigh Niels Vrang James L Trevaskis Henrik H Hansen | 2019 | World Journal of Gastroenterology2019，25，33： | 3 |
| 18 | BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc显示文摘 | Jake E. Delmore Ghayas C. Issa Madeleine E. Lemieux Peter B. Rahl Junwei Shi Hannah M. Jacobs Efstathios Kastritis Timothy Gilpatrick Ronald M. Paranal Jun Qi Marta Chesi Anna C. Schinzel Michael R. McKeown Timothy P. Heffernan Christopher R. Vakoc P. Lei | 2011 | Cell2011，，6： | 3 |
| 19 | Historical trends of degradation,loss,and recovery in the tropical forest reserves of Ghana显示文摘The Upper Guinean Forest region of West Africa,a globally significant biodiversity hotspot,is among the driest and most human-impacted tropical ecosystems.We used Landsat to study forest degradation,loss,and recovery in the forest reserves of Ghana from 2003 to 2019.Annual canopy cover maps were generated using random forests and results were temporally segmented using the LandTrendr algorithm.Canopy cover was predicted with a predicted-observed r2 of 0.76,mean absolute error of 12.8%,and mean error of 1.3%.Forest degradation,loss,and recovery were identified as transitions between closed(>60%cover),open(15–60%cover)and low tree cover(<15%cover)classes.Change was relatively slow from 2003 to 2015,but there was more disturbance than recovery resulting in a gradual decline in closed canopy forests.In 2016,widespread fires associated with El Niño drought caused forest loss and degradation across more than 12%of the moist semi-deciduous and upland evergreen forest types.The workflow was implemented in Google Earth Engine,allowing stakeholders to visualize the results and download summaries.Information about historical disturbances will help to prioritize locations for future studies and target forest protection and restoration activities aimed at increasing resilience. | Michael C.Wimberly Francis K.Dwomoh Izaya Numata Foster Mensah Jacob Amoako Dawn M.Nekorchuk Andrea McMahon | 2022 | International Journal of Digital Earth2022，15，1： | 2 |
| 20 | Total laparoscopic removal of accessory gallbladder:A case report and review of literature显示文摘Accessory gallbladder is a rare congenital anomaly occurring in 1 in 4000 births, that is not associated with any specific symptoms. Usually this cannot be diagnosed on ultrasonography and hence they are usually not diagnosed preoperatively. Removal of the accessory gallbladder is necessary to avoid recurrence of symptoms. H-type accessory gallbladder is a rare anomaly. Once identified intra-operatively during laparoscopic cholecystectomy, the surgery is usually converted to open. By using the main gallbladder for liver traction and doing a dome down technique for the accessory gallbladder, we were able to perform the double cholecystectomy with intra-operative cholangiogram laparoscopically. Laparoscopic cholecystectomy was performed in 27-year-old male for biliary colic. Prior imaging with computer tomography-scan and ultrasound did not show a duplicated gallbladder. Intraoperatively after ligation of cystic artery and duct an additional structure was seen on its medial aspect. Intraoperative cholangiogram confirmed the patency of intra-hepatic and extra-hepatic biliary ducts. Subsequent dissection around this structure revealed a second gallbladder with cystic duct(H-type). Pathological analysis confirmed the presence of two gallbladders with features of chronic cholecystitis. It is important to use cholangiogram to identify structural anomalies and avoid complications. | Yaniv Cozacov Gokulakkrishna Subhas Michael Jacobs Janak Parikh | 2015 | World Journal of Gastrointestinal Surgery2015，7，12： | 2 |
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