|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Suppression of m6A reader Ythdf2 promotes hematopoietic stem cell expansion显示文摘 | Zhenrui Li Pengxu Qian Wanqing Shao Hailing Shi Xi C. He Madelaine Gogol Zulin Yu Yongfu Wang Meijie Qi Yunfei Zhu John M. Perry Kai Zhang Fang Tao Kun Zhou Deqing Hu Yingli Han Chongbei Zhao Richard Alexander Hanzhang Xu Shiyuan Chen Allison Peak Kathyrn Hall Michael Peterson Anoja Perera Jeffrey S. Haug Tari Parmely Hua Li Bin Shen Julia Zeitlinger Chuan He Linheng Li | 2018 | Cell Research2018，28，9： | 18 |
| 2 | Multiple amino acid sensing inputs to mTORC1显示文摘rapamycin 建筑群 1 的 evolutionarily 保存的目标(TORC1 ) 是细胞生长和新陈代谢的一个主人管理者。在哺乳动物,生长因素和细胞的精力通过 TSC 建筑群(TSC1-TSC2-TBC1D7 ) 的抑制刺激 mTORC1 活动, mTORC1 的一个否定管理者。氨基酸独立于 TSC 建筑群发信号到 mTORC1。这里,我们考察连接氨基酸充足到 mTORC1 活动的最近识别的管理者并且影响这些管理者的变化怎么引起人的疾病。 | itsugu Shimobayashi Michael N Hall | 2016 | Cell Research2016，26，1： | 10 |
| 3 | Lean heart: Role of leptin in cardiac hypertrophy and metabolism显示文摘Leptin is an adipokine that has been linked with the cardiovascular complications resulting from obesity such as hypertension and heart disease. Obese patients have high levels of circulating leptin due to increased fat mass. Clinical and population studies have correlated high levels of circulating leptin with the development of cardiac hypertrophy in obesity. Leptin has also been demonstrated to increase the growth of cultured cardiomyocytes. However, several animal studies of obese leptin deficient mice have not supported a role for leptin in promoting cardiac hypertrophy so the role of leptin in this pathological process remains unclear. Leptin is also an important hormone in the regulation of cardiac metabolism where it supports oxidation of glucose and fatty acids. In addition, leptin plays a critical role in protecting the heart from excess lipid accumulation and the formation of toxic lipids in obesity a condition known as cardiac lipotoxicity. This paper focuses on the data supporting and refuting leptin's role in promoting cardiac hypertrophy as well as its important role in the regulation of cardiac metabolism and protection against cardiac lipotoxicity. | Michael E Hall Romain Harmancey David E Stec | 2015 | World Journal of Cardiology2015，7，9： | 7 |
| 4 | 渗透泵强化对流释放给药治疗恶性脑胶质瘤的裸小鼠模型显示文摘目的探寻渗透泵强化对流释放给药治疗脑肿瘤的祼小鼠模型,为新药的临床前期应用提供良好的实验动物模型。方法 14只祼小鼠基底节区种植4×105个人胶质瘤U87细胞,并安置渗透泵强化对流释放给药系统。裸小鼠按体重和活体荧光信号强度分为二组:治疗组(n=7)的泵内注入100μl(1μg)的DTATEGF,对照组(n=7)泵内注入100μl(1μg)的无关毒素DT。观察动物的生长特征,Kaplan-Meier生存曲线分析和脑内肿瘤的病理学特征。结果实验动物没有与渗透泵及外科手术相关的病残和病死发生。动物对渗透泵给药系统耐受好,无抓搔及渗透泵脱位,伤口无感染及裂开等情况。Kaplan-Meier生存曲线显示治疗组动物的中位生存期较对照组明显延长,差异有显著性。(治疗组126天vs.对照组68天,P=0.0002)。治疗组中有两只小鼠生存期超过180天。病理学检测祼小鼠脑内种植生长的肿瘤与人类胶质母细胞瘤的病理特征极为相似。结论该祼小鼠实验动物模型简便、实用、可靠,适用于新的药物包括单克隆抗体、靶向小分子、肿瘤疫苗等通过强化对流投递治疗脑内恶性肿瘤的临床前期应用。 | 黄军 龙小艳 李波 Yan Michael Li Walter A Hall 刘定阳 刘庆 王君宇 袁贤瑞 | 2012 | 国际神经病学神经外科学杂志2012，39，4： | 3 |
| 5 | Preoperative hematologic markers as independent predictors of prognosis in resected pancreatic ductal adenocarcinoma: neutrophil-lymphocyte versus platelet-lymphocyte ratio显示文摘 | Imran Bhatti Oliver Peacock Gareth Lloyd Michael Larvin Richard I. Hall | 2010 | The American Journal of Surgery2010，，2： | 3 |
| 6 | A Volt-Second Source for Calibration of Integrator in a Pulsed Field Magnetometer显示文摘 | 林安利 贺建 张跃 John Dudding Michael Hall | 2007 | Chinese Physics Letters2007，24，11： | 3 |
| 7 | A Simple, Cost-effective Method of Preventing Laryngoscope Handle Contamination显示文摘 | Michael J. Tobin G. W. Stevenson Steven C. Hall | 1995 | Anesthesiology1995，，3： | 2 |
| 8 | Cisplatin Resistance: A Cellular Self-Defense Mechanism Resulting from Multiple Epigenetic and Genetic Changes显示文摘 | Ding-Wu Shen Lynn M. Pouliot Matthew D. Hall Michael M. Gottesman | 2012 | Pharmacological Reviews2012，，3： | 2 |
| 9 | 脑肿瘤靶向毒素治疗的现状和展望显示文摘靶向毒素,亦称为免疫毒素或细胞毒素,是一种肿瘤细胞表面特异性抗原或受体相结合的细胞分子。如与EG-FR、IL-13受体等相结合的细胞分子,其毒素成份可杀死肿瘤细胞。目前研究的毒素多为以白喉毒素、假单胞杆菌外毒素等为母基合成的毒素。双重特异性靶向毒素能同时靶向肿瘤细胞和/或其新生血管上的两个过表达受体的毒素,如DTAT13靶向uPAR和IL-13受体,DTATEGF靶向EGFR和uPAR,其较单一靶向毒素具有更高的特异性和更强的毒性,同时免疫源性亦大为降低。寻找特异性的肿瘤细胞表面标志物、降低毒素的免疫源性及研究实体肿瘤毒素的投递方式是靶向毒素治疗脑肿瘤的研究方向。 | 黄军 Yan Michael Li Walter A Hall | 2011 | 国际神经病学神经外科学杂志2011，38，5： | 2 |
| 10 | Patients with elevated liver enzymes are not at higher risk for statin hepatotoxicity显示文摘 | Naga Chalasani Hisham Aljadhey Joe Kesterson Michael D. Murray Stephen D. Hall | 2004 | Gastroenterology2004，，5： | 2 |
| 11 | A Laboratory Model to Evaluate Cutout Resistance of Implants for Pertrochanteric Fracture Fixation显示文摘 | Mark B. Sommers Christoph Roth H. Hall Benjamin C. C. Kam Larry W. Ehmke James C. Krieg Steven M. Madey Michael Bottlang | 2004 | Journal of Orthopaedic Trauma2004，，6： | 2 |
| 12 | Water and nutrient and energy systems in urbanizing watersheds显示文摘 | Rodrigo VILLARROEL WALKER Michael Bruce BECKl, Jim W. HALL | 2012 | Frontiers of Environmental Science & Engineering2012，6，5： | 2 |
| 13 | TOR Signaling in Growth and Metabolism显示文摘 | Stephan Wullschleger Robbie Loewith Michael N. Hall | 2006 | Cell2006，，3： | 2 |
| 14 | mTOR signaling in disease显示文摘 | Eva Dazert Michael N Hall | 2011 | Current Opinion in Cell Biology2011，，6： | 2 |
| 15 | Development and Validation of a Standardized Method for Contouring the Brachial Plexus: Preliminary Dosimetric Analysis Among Patients Treated With IMRT for Head-and-Neck Cancer显示文摘 | William H. Hall Michael Guiou Nancy Y. Lee Arthur Dublin Samir Narayan Srinivasan Vijayakumar James A. Purdy Allen M. Chen | 2008 | International Journal of Radiation Oncology Biology Physics2008，，5： | 1 |
| 16 | COX-2 selective non-steroidal anti-inflammatory drugs and risk of serious coronary heart disease显示文摘 | Wayne A Ray C Michael Stein James R Daugherty Kathi Hall Patrick G Arbogast Marie R Griffin | 2002 | The Lancet2002，，9339： | 1 |
| 17 | Preferential water loss from synthetic fluid inclusions显示文摘 | Donald L. Hall S. Michael Sterner | 1993 | Contributions to Mineralogy and Petrology1993，，4： | 1 |
| 18 | Anatomy of the calcaneus显示文摘 | Reginald L Hall MD Michael J | 1993 | Clin Othop1993，293，： | 1 |
| 19 | Helicobacter pylori Genotypes in Israeli Children: The Significance of Geography显示文摘 | Shmuel Benenson David Halle Bernard Rudensky Joseph Faber Yechiel Schlesinger David Branski Nina Rabinowitz Michael Wilschanski | 2002 | Journal of Pediatric Gastroenterology and Nutrition2002，，5： | 1 |
| 20 | Com- parison of 12-core versus 8-core prostate biopsy: multivariate analysis of large series of US veterans 显示文摘 | Thura T Abd Michael Goodman John Hall | 2011 | Ambulatory and Office Urology2011，77，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员