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| 1 | 自然杀伤细胞与癌症--杀伤细胞免疫球蛋白样受体(KIR)的调控显示文摘自然杀伤(natural killer,NK)细胞是先天性免疫效应细胞,约占人外周血淋巴细胞总数的10%-15%,主要参与免疫监视,以消除转化细胞和病毒感染细胞。NK细胞最初被界定是由于它们具有自发消除少数主要组织相容性复合物I类(major histocompatibility class I,MHC-I)自身分子表达缺乏细胞的能力,即常说的'丢失自我'识别能力。NK细胞表面表达的MHC-I特异性抑制性受体,可使NK细胞对表达MHC-I的正常细胞耐受,此为丢失自我识别能力的分子基础。由于缺乏抑制性受体的配体,表面MHC-I表达下调的肿瘤细胞和病毒感染细胞易受NK细胞攻击。杀伤细胞免疫球蛋白样受体(KIR;CD158)组成MHC-I结合受体家族,对调节人NK细胞和部分T细胞的活化阈值起重要作用。KIR多样性使NK细胞具有多种功能,在此我们将综述多个水平上的KIR多样性,并诠释KIR多样性是如何影响各种疾病(包括癌症)的易感性的。我们将进一步阐述通过针对KIR进行癌症治疗的策略:利用KIR/MHC-I配体的错配以强化造血干细胞移植的效果,以及通过阻滞KIR以增强对肿瘤细胞的杀伤力。 | Amanda K. PURDY Kerry S. CAMPBELL 王伟强(翻译) 李书军(翻译) 南娟(校对) 丁燕(校对) | 2010 | 中国肺癌杂志2010，13，7： | 3 |
| 2 | Progressive Fibrosis in Nonalcoholic Steatohepatitis: Association With Altered Regeneration and a Ductular Reaction显示文摘 | Michelle M. Richardson Julie R. Jonsson Elizabeth E. Powell Elizabeth M. Brunt Brent A. Neuschwander–Tetri Prithi S. Bhathal John B. Dixon Martin D. Weltman Herbert Tilg Alexander R. Moschen David M. Purdie Anthony J. Demetris Andrew D. Clouston | 2007 | Gastroenterology2007，，1： | 2 |
| 3 | A review on goat sperm cryopreservation显示文摘 | P.H. Purdy | 2005 | Small Ruminant Research2005，，3： | 2 |
| 4 | Procedural simulation:medical student preference and value of three task trainers for ultrasound guided regional anesthesia显示文摘BACKGROUND: Ultrasound guided regional anesthesia is widely taught using task trainer models. Commercially available models are often used; however, they can be cost prohibitive. Therefore, alternative 'homemade' models with similar fidelity are often used. We hypothesize that professional task trainers will be preferred over homemade models. The purpose of this study is to determine realism, durability and cleanliness of three different task trainers for ultrasound guided nerve blocks.METHODS: This was a prospective observational study using a convenience sample of medical student participants in an ultrasound guided nerve block training session on January 24 th, 2015. Participants were asked to perform simulated nerve blocks on three different task trainers including, 1 commercial and 2 homemade. A questionnaire was then given to all participants to rate their experiences both with and without the knowledge on the cost of the simulator device.RESULTS: Data was collected from 25 participants. The Blue Phantom model was found to have the highest fidelity. Initially, 10(40%) of the participants preferred the Blue Phantom model, while 10(40%) preferred the homemade gelatin model and 5(20%) preferred the homemade tofu model. After cost awareness, the majority, 18(72%) preferred the gelatin model.CONCLUSION: The Blue Phantom model was thought to have the highest fidelity, but after cost consideration the homemade gelatin model was preferred. | Shadi Lahham Taylaur Smith Jessa Baker Amanda Purdy Erica Frumin Bret Winners Sean P.Wilson Abdulatif Gari John C.Fox | 2017 | World Journal of Emergency Medicine2017，8，4： | 2 |
| 5 | Time-dependent changes in rat brain neuroactive steroid concentrations and GABAA receptor function after acute stress显示文摘 | Barbaccia ML Roscetti G Trabucchi M Mostallino MC Concas A Purdy RH | 1996 | Neuroendocrinology1996，63，2： | 1 |
| 6 | Meta-analysis of sentinel node biopsy in ductal carcinoma in situ of the breast显示文摘 | Ansari B Ogslon SA Purdie CA | 2008 | Br J Surg2008，95，5： | 1 |
| 7 | Gross tumor volume, critical prognostic factor in patients treated with three-dimensional conformal radiation therapy for non-small cell lung carcinoma显示文摘 | Bradley JD Ieumwananonthachai N Purdy JA | 2002 | Int J Radiat Oncol Biol Phys2002，52，1： | 1 |
| 8 | From new frontiers to new standards of practice: advances in radiotherapy planning and delivery显示文摘 | Purdy JA | 2007 | Front Radiat Ther Oncol2007，40，： | 1 |
| 9 | A Supplier Development Program: Rational Process or Institutional Image Construction? 显示文摘 | Rogers K W Purdy L Safayeni F Duimering P R | 2007 | Journal of Operations Management2007，25，2： | 1 |
| 10 | CT imaging af angiogenesis显示文摘 | Lee TH Purdie TG Stewart E | 2003 | Quarterly J Nuclear Medicine2003，47，： | 1 |
| 11 | Clinical dose-volume histogram analysis for pneumonitis after 3D treatment for non-small-cell lung cancer显示文摘 | Graham MV Purdy JA Emami B | 1999 | Int J Radiat Oncol Biol Phys1999，45，2： | 1 |
| 12 | Early reversal of rapacuronium with neostigmine显示文摘 | Purdy R Bevan DR Donati F | 1999 | Anesthesiology1999，91，： | 1 |
| 13 | Management of hemorrhagic complications from preoperative embolization of arteriovenous malformations显示文摘 | Purdy PD Batjer HH Samson D | 1991 | J Neurosurg1991，74，2： | 1 |
| 14 | Isolation of a cDNA from the virus responsible for enterically transmitted non-A,non-B hepatitis 显示文摘 | Reyes GR Purdy MA Kim JP | 1990 | Science1990，247，4948： | 1 |
| 15 | Recent advancement in fla vivirus vaccine development显示文摘 | Chang G J Kuno G Purdy D E | 2004 | Exp Rev Vaccines2004，3，2： | 1 |
| 16 | Development and Validation of a Standardized Method for Contouring the Brachial Plexus: Preliminary Dosimetric Analysis Among Patients Treated With IMRT for Head-and-Neck Cancer显示文摘 | William H. Hall Michael Guiou Nancy Y. Lee Arthur Dublin Samir Narayan Srinivasan Vijayakumar James A. Purdy Allen M. Chen | 2008 | International Journal of Radiation Oncology Biology Physics2008，，5： | 1 |
| 17 | Clinical dose-volume histo- gram analysis for pneumonitis after 3 D treatment for non - small cell lung cancer (NSCLC) 显示文摘 | Graham MV Purdy JA Emami B | 1999 | Int J Radiat Oncol Biol Phys1999，45，2： | 1 |
| 18 | Sclerotinia sclerotiorum:History diseases symp- tomatology host range geographic distribution and impact显示文摘 | Purdy L H | 1979 | Phy- topathology1979，69，： | 1 |
| 19 | Pa- tient dose from kilo - voltage cone beam computed tomography imaging in radiation therapy 显示文摘 | Islam M K Purdie T G Non'linger B D | 2006 | Med Phys2006，33，6： | 1 |
| 20 | Dose to normal tissues outside the radiation therapy patient's treated volume: a review of different radiation therapy techniques显示文摘 | Purdy JA | 2008 | Health Phys2008，95，5： | 1 |
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