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447篇 您的检索式:作者名="Sterner"
    题名 作者 年代 出处 被引量
1葛根素和大豆甙元抑制^3H-氟硝西泮和体外大鼠脑膜的结合显示文摘目的从中药葛根中提取脑内苯并二氮杂卓(BZ)受体活性化合物。方法用体外的放射配体-受体结合法(RRA)和高压液相法(HPLC)提取、分离、纯化BZ受体活性化合物,用核磁共振和质谱仪确定活性化合物的结构。后用GABA比和Scatchardplot分析确定它们的作用特性。结果从葛根中提取、分离到葛根素和大豆甙元2种活性化合物。它们在体外可抑制3H-氟硝西泮和脑细胞膜的结合,IC50值分别为(18.46±2.34)μmol/L和(15.4±31.89)μmol/L。大豆甙元还可抑制3H-呱唑嗪和α1-肾上腺素受体的结合(IC50值为89μmol/L)。2种化合物的GABA比分别为1.11和1.12,提示2种黄酮化合物是BZ受体的拮抗剂或部分激动剂。Scatchardplot分析显示2种化合物对3H-氟硝西泮和脑膜结合的抑制是通过竞争性与非竞争性混合机制而实现的。结论葛根素和大豆甙元是脑内BZ受体的拮抗剂或部分激动剂。它们的抑制作用是通过竞争性与非竞争性混合机制而实现的。沈行良 Witt MR Nielsen M Sterner O 2004海南医学院学报2004,10,3:3
2Innovation and diffusion of environmental technology: Industrial NOx abatement in Sweden under refunded emission payments显示文摘Thomas Sterner Bruno Turnheim 2009Ecological Economics2009,,12:2
3Human Influences on Nitrogen Removal in Lakes显示文摘Jacques C. Finlay Gaston E. Small Robert W. Sterner 20132013 (6155)2013,,6155:2
4Acetylation of histones and transcription-related factors 显示文摘Sterner D E Berger S L 2000Microbiol Mol Biol Rev2000,64,2:1
5Freezing point de- pression of NaC1-KCI-H20 solutions 显示文摘Hall D L Sterner S M and Bodner R J 1988Economic Geology1988,100,5:1
6Biological stoichiometry from genes to ecosystems显示文摘Elser J J Sterner R W Gorokhova E 2000Ecology Letters2000,3,6:1
7The Pathogenesis of Lupus Ne- phritis 显示文摘Sterner RM Hartono SP Grande JP 2014J Clin Cell Immunol2014,5,2:1
8Balance training for persons with functionally unstable ankles显示文摘Rozzi SL Lephart SM Sterner R 1999J Orthop Sports Phys Ther1999,29,8:1
9Decomposition of Changes in Energy Intensity: a Comparison of the Divisia Index and Other Methods 显示文摘Boyd G A Hanson D A Sterner T 1988Energy Economics1988,10,4:1
10Freezing point depression of NaCl-KCl-H2O solutions显示文摘Hall D L Sterner S M Bodnar R J 1988Economic Geology1988,83,:1
11Preferential water loss from synthetic fluid inclusions显示文摘Donald L. Hall S. Michael Sterner 1993Contributions to Mineralogy and Petrology1993,,4:1
12Freezing point depression of NaC1-KCI-HzO solutions显示文摘HALL D L STERNER S M BODNAR R J 1988Economic Geology1988,83,:1
13Plasma Homocysteine in Renal Failure 显示文摘HULTBERG B ANDERSON A STERNER G 1993Clin Nephrol1993,40,:1
14Partial nephrectomy and chronic renal failure, the 'adult' rat model显示文摘Sterner G Wennberg A 1988Contr Nephot1988,60,2:1
15Freezing point de- pression of NaC1-KC1-H20 solutions 显示文摘Hall D L Sterner S M Bodnar R J 1988Econ Geol1988,83,:1
16Decomposition of changes in energy intensity: a comparison of the Divisia index and other methods 显示文摘BOYD G A HANSON D A STERNER T 1988Energy Economics1988,10,4:1
17New Transformerless Topology for AC-fed Traction Vehicles Using Multi-star Induction Motors显示文摘M Sterner 2000EPE Journal2000,10,:1
18Algal Growth in Warm Temperate Reservioirs:Kinetie Examination of Nitrogen,temperate,Light,and other Nutrients显示文摘Rober W Sterner James P Grover 1998Water Research1998,32,:1
19Oxygenated Sesquiterpenoids from a Nonpoisonous Sardinian Chemotype of Giant fennel (ferula communis) 显示文摘Appendino G Cravotto F Sterner O 2001J Nat Prod2001,64,:1
20Comparison of the antimicrobial and cytotoxic activities of twenty unsaturated sesquiterpene dialdehydes from plants and mushrooms 显示文摘Anke H Sterner O 1991Planta Med1991,57,4:1
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