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| 1 | Meta-analysis of probiotics for the treatment of irritable bowel syndrome显示文摘Irritable bowel syndrome (IBS) is a chronic condition affecting 3%-25% of the general population. As no curative treatment is available, therapy is aimed at reducing symptoms, often with little success. Because alteration of the normal intestinal microflora has been observed in IBS, probiotics (beneficial microbes taken to improve health) may be useful in reducing symptoms. This paper systematically reviews randomized, controlled, blinded trials of probiotics for the treatment of IBS and synthesizes data on efficacy across trials of adequate quality. PubMed, Medline, Google Scholar, NIH registry of clinical trials, metaRegister, and the Cochrane Central Register of Controlled Trials were searched from 1982-2007. We also conducted secondary searches of reference lists, reviews, commentaries, relevant articles on associated diseases, books and meeting abstracts. Twenty trials with 23 probiotic treatment arms and a total of 1404 subjects met inclusion criteria. Probiotic use was associated with improvement in global IBS symptoms compared to placebo [pooled relative risk (RRpooled) 0.77, 95% confidence interval (95% CI) 0.62-0.94]. Probiotics were also associated with less abdominal pain compared to placebo [RRpooled = 0.78 (0.69-0.88)]. Too few studies reported data on other IBS symptoms or on specific probiotic strains to allowestimation of a pooled RR. While our analyses suggest that probiotic use may be associated with improvement in IBS symptoms compared to placebo, these results should be interpreted with caution, given the methodological limitations of contributing studies. Probiotics warrant further study as a potential therapy for IBS. | Lynne V McFarland Sascha Dublin | 2008 | World Journal of Gastroenterology2008，14，17： | 27 |
| 2 | Immnohistochemical detection of p53 protein in mammry carcinoma:an important new independent indicator of prognosis显示文摘 | Barnes DM Dublin EA Fisher CJ | 1993 | Hum Pathol1993，24，： | 2 |
| 3 | Development and Validation of a Standardized Method for Contouring the Brachial Plexus: Preliminary Dosimetric Analysis Among Patients Treated With IMRT for Head-and-Neck Cancer显示文摘 | William H. Hall Michael Guiou Nancy Y. Lee Arthur Dublin Samir Narayan Srinivasan Vijayakumar James A. Purdy Allen M. Chen | 2008 | International Journal of Radiation Oncology Biology Physics2008，，5： | 1 |
| 4 | Ultrasound-guided biopsy of the thyroid : a comparison of technique with respect to diagnostic accu- racy显示文摘 | Schooled KE Dublin ME Peeler K | 2008 | Deign CytopathoI2008，36，11： | 1 |
| 5 | Maternal and neonatal outcomes after induction of labor without an identified indication显示文摘 | Dublin S Lydon-Rochelle M Kaplan RC | 2000 | Am J Obstet Gynecol2000，183，4： | 1 |
| 6 | Immunohistochemical detection of p53 protein in mammary carcinoma:an important new independent indicator of prognosis显示文摘 | BARNES D M DUBLIN E A FISHER C J | 1993 | Hum Pathol1993，24，2： | 1 |
| 7 | BAG-1 expression in human breast cancer:interrelationship between BAG-1 RNA,protein,HSC70 expression and clinico-pathological data显示文摘 | Townsend PA Dublin E Hart IR | 2002 | J Pathol2002，197，1： | 1 |
| 8 | BAG-1 expression in human breast cancer: interrelationship between BAG-1 RNA, protein, HSC70 expression and clinico-pathological data显示文摘 | Townsend PA Dublin E Hart IR | 2002 | J Pathol2002，197，1： | 1 |
| 9 | Invasive lobular and invasive ductal carcinoma of the breast show distinct pattems of vascular endotheliai growth factor expression and angiogenesis显示文摘 | Lee AH Dublin EA Bobrow LG | 1998 | J Pathol1998，185，4： | 1 |
| 10 | Uses of the life table in vital statistics 显示文摘 | Dublin LI Lotka AJ | 1937 | Am J Public Health1937，27，： | 1 |
| 11 | Photon correlation versus interference of single-atom fluorescence in a half-cavity显示文摘 | DUBLIN F ROTTER D MUKHERJEE M | 2007 | Physical Review Letters2007，98，18： | 1 |
| 12 | Invasive Iobular and invasive ductal carcinoma or the breast show distinct patterns of vascular endothelial growth factor expression and angiogenesis显示文摘 | Lee A ll Dublin E A Bobrow L G et at | 1998 | J Pathol1998，185，4： | 1 |
| 13 | Invasive lobular and invasive ductal carcinoma of the breast show distinct patterns of vascular endothelial growth factor expression and angiogenesis 显示文摘 | Lee A Dublin E Bobrow L | 1998 | J Pathol1998，185，4： | 1 |
| 14 | The association of braintem lesions with migraine-like headache:an imaging study of multiple sclerosis显示文摘 | Gee JR Chang j Dublin AB | 2005 | Headache2005，45，6： | 1 |
| 15 | Newly detected atrial fibrillation and compliance with antithrombotic guidelines 显示文摘 | Glazer NL Dublin S Smith NL | 2007 | Arch Intern Med2007，167，3： | 1 |
| 16 | Invasive lobular and invisive ductal carcinoma of the breast show distinct pat terns of vascular endothelial growth factor expression and angiogenesis 显示文摘 | Lee A Dublin E Bobrow L | 1998 | J Pathol1998，185，： | 1 |
| 17 | Invasive lobular and invasive ductal carcinoma of the breast show distinct patterns of vascular endothelial growth factor expression and angiogenesis显示文摘 | Lee A Dublin E Bobrow L | 1998 | J Pathol1998，185，4： | 1 |
| 18 | Atrial fibrillation and risk of dementia: a prospective cohort study显示文摘 | Dublin S Anderson ml Haneuse SJ | 2011 | J Am Geriatr Soc2011，59，8： | 1 |
| 19 | Use of proton pump inhibitors and H2 blockers and risk of pneumonia in older adults= a population based case-control study 显示文摘 | Dublin S Walker R L Jackson M L | 2010 | Pharmacoepidemiol Drug Saf2010，19，8： | 1 |
| 20 | P53 immunoreactivity in human malignant melanoma and dysplastic naevi 显示文摘 | McGregor JM Yu CC Dublin EA | 1993 | Br J Dermatol1993，128，6： | 1 |
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