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| 1 | Clindamycin-induced acute cholestatic hepatitis显示文摘我们为牙齿的感染在 clindamycin 的管理以后在一个 42 岁的女人报导尖锐 hepatotoxicity 的一个案例。在治疗的 6 d 以后,她有疲劳,恶心,呕吐,厌食,瘙痒和黄疸。她的实验室分析显示出丙氨酸 aminotransferase (中高音) , 1795 IU/L (正常范围 0-40 ) ;aspartate aminotransferase (著名计算机生产厂商) , 1337 IU/L (正常范围 5-34 ) ;硷性磷酸酯酶(高山) , 339 IU/L (正常范围 40-150 ) ;gamma-glutamyl transpeptidase (GGT ) , 148 IU/L (正常范围 9-64 IU/L ) ;全部的胆红素, 4.1 mg/dL;直接胆红素, 2.9 mg/dL 和前凝血酶时间(磅) , 13.5 s 与国际规范的比率(INR ) , 1.04。她被就医,与立即的药中止。她的肝活体检视标本显示出混合类型(肝细胞和胆汁郁积的) 肝的损害,与导致药的肝炎的诊断兼容。用 Naranjo 概率规模的一个客观诱发性评价建议 clindamycin 是尖锐肝炎的可能的原因。在易受影响的个人, clindamycin 使用可以导致尖锐混合类型肝毒性。如果在严重肝损伤被建立以前,这药被中止,完全的恢复可能是可能的。 | Cem Aygün Orhan Kocaman Yesim Gürbüz mer Sentürk Sadettin Hülagü | 2007 | World Journal of Gastroenterology2007，13，40： | 6 |
| 2 | Effects of the myeloperoxidase 463 gene polymorphisms on development of atrophy in H pylori infected or noninfected gastroduodenal disease显示文摘AIM: To investigate the relationship between myelo- peroxidase polymorphisms as a host-related factor and atrophy caused by H pylori. METHODS: Our study enrolled 77 patients. Biopsy materials obtained during gastrointestinal endoscopies were evaluated for the presence of H pylori. Polymerase chain reaction-restriction fragment length polymorphism assay was used to characterize myeloperoxidase genotypes. RESULTS: Forty four patients (57.1%) were Hp (+) and 33 (42.9%) were Hp (-). Sixty six (85.7%) had GG genotype, 10 (12.9%) had GA genotype and 1 (1.29%) had AA genotype. The change in atrophy in relation to neutrophil infiltration was significant in Hp (+) patients (P = 0.0001). The change in atrophy in relation to neutrophil infiltration in patients with GG genotype was significant (P = 0.002). However, the change in atrophy in relation to neutrophil infiltration was not significiant in patients with Hp (+) GG genotype (r = 0.066, P = 0.63). CONCLUSION: Myeloperoxidase genotype is critical for development of atrophy in relation to the severity of inflammation. However, it is interesting to note that, H pylori does not show any additive effect on development of atrophy. | mer Yilmaz Hakan Dursun Nesrin Gürsan ibrahim Pirim Arif Yilmaz Nihat Okcu | 2007 | World Journal of Gastroenterology2007，13，8： | 6 |
| 3 | Development of Chromium(Ⅲ)-selective Potentiometric Sensor by Using Synthesized Pyrazole Derivative as an lonophore in PVC Matrix and its Applications显示文摘A novel poly(vinyl chloride)membrane potentiometric sensor for chromium(Ⅲ)ions based on the use of 5,5′-(1,4-phenylene)bis(3-(naphthalen-1-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide)as a neutral ionophore was developed.The optimum composition of the best performing membrane contained ionophore,potassium tetrakis(p-chlorophenyl)borate(KTpClPB),dibutyl phthalate(DBP),and poly(vinyl chloride)(PVC)in the ratio of 5.5:1.5:55:38(mg).The sensor exhibits a working concentration range of 1.0×10^(-5)-1.0×10^(-1 )mol L^(−1) and a detection limit of 1.7×10^(-6) mol L^(−1).The sensor shows good selectivity for chromium(III)ions over a number of cations including alkali,alkaline earth,heavy and transition metals.The response time of the sensor is 8 s.In addition,the developed sensor shows good reusability and stability.The sensor operates in the wide pH range of 5.0-11.0.The sensor could be used as an indicator electrode in the quantification of Cr^(3+)ions by potentiometric titration against ethylenediaminetetraacetic acid(EDTA).Finally,this sensor was successfully used for the determination of chromium(III)in commercial water,purification water and wastewater. | Ömer Isildak OguzÖzbek Meliha Burcu Gürdere | 2020 | Journal of Analysis and Testing2020，4，4： | 2 |
| 4 | Acetylation as a Transcriptional Control Mechanism—HDACs and HATs in Pancreatic Ductal Adenocarcinoma显示文摘 | Günter Schneider Oliver H. Kr?mer Roland M. Schmid Dieter Saur | 2011 | Journal of Gastrointestinal Cancer2011，，： | 1 |
| 5 | MCPH1 functions in an H2AX-dependent but MDC1 in Dependent path way in response toDNA damage显示文摘 | Wood JL Singh N Mer G | 2007 | J Biol Chem2007，282，35： | 1 |
| 6 | The role of biosimilars in the treatment of rheumatic diseases 显示文摘 | D~mer T Strand V Castafieda-Hern6ndez G | 2013 | Ann Rheum Dis2013，72，3： | 1 |
| 7 | Diagnostic sensitivty of serum cystatin for impaired glomerular filtration rat显示文摘 | Filer G Prien F Voll mer l | 1999 | Pediatri : Nephrol1999，13，6： | 1 |
| 8 | Structural dynamics of PMP-D2: an experimental and theoretical study 显示文摘 | MER G DEJAEGERE A STOTE R | 1996 | The Journal of Physical Chemistry1996，100，7： | 1 |
| 9 | MCPH1 functions in an H2AXdependent but MDC1-independent pathway in response to DNA damage显示文摘 | Wood JL Singh N Mer G | 2007 | J Biol Chem2007，282，35： | 1 |
| 10 | Universal slovation model based on solute electron density and on a contin- uum model of the solvent defined by the bulk dielectric constant and atomic surface tensions 显示文摘 | ALEKSANDR V MARENICH CHRISTOPHER J CRA- MER DONALD G TRUHLAR | 2009 | J Phys Chem B2009，113，18： | 1 |
| 11 | Relationship between monokaryotic growth rate and mating type in the edible basidiomycete Pleurotus ostreatus显示文摘 | LUIS ML GúMER P IňAKI I | 2001 | Appl Environ Microbiol2001，67，8： | 1 |
| 12 | Strategies for the design of inhibitors of aidose reductase,an enzyme showing pronouneed induced-fit adapatations显示文摘 | Klebe G Kr μMer O Sctriffer C | 2004 | Cell Mol Life Sci2004，61，78： | 1 |
| 13 | Arsenic related hearing loss in miners显示文摘 | Gülin G?k?en Kesici ?lhan ünlü Arzu Ba?türk Top?u Ceylan Demir Bal Engin Tutkun ?mer H?n? Y?lmaz | 2016 | American Journal of Otolaryngology--Head and Neck2016，，1： | 1 |
| 14 | Increased peripheral benzodiazepine binding sites in the brain of patients with Huntington's disease显示文摘 | Meβmer K Reynolds G P | | 0，，： | 1 |
| 15 | The effect of nitrogen fertilization on tocopherols in rapeseed genotypes显示文摘 | Cem (O)mer Egesel M Kemal Gül Fatih Kahr man | | 0，，03： | 1 |
| 16 | 3D printing of MRI compatible components: Why every MRI research group should have a low-budget 3D printer显示文摘 | Karl-Heinz Herrmann Clemens G?rtner Daniel Güllmar Martin Kr?mer Jürgen R. Reichenbach | 2014 | Medical Engineering and Physics2014，，10： | 1 |
| 17 | Microvessel density as a prognostic marker in bladder carcinoma: Correlation with tumor grade, stage and prognosis显示文摘 | Ali Cano?lu ?a?atay G??ü? Ya?ar Bedük Diclehan Orhan ?zden Tulunay Sümer Baltac? | 2004 | International Urology and Nephrology2004，，3： | 1 |
| 18 | Effects of Lipoprotein-Associated Phospholipase A2 on Arginase/Nitric Oxide Pathway in Hemodialysis Patients显示文摘 | Ay&scedil egü l Korkmaz Tekta&scedil Sema Uslu Ahmet U&gbreve ur Yalç in Garip &Scedil ahin Gö khan Temiz Mehmet Kara Halide Edip Temel Emine Sü tken Demirkan Ertu&gbreve rul Ç olak Ö mer Ç olak | 2012 | Renal Failure2012，，6： | 1 |
| 19 | MCPH1 functions in an H2AX-dependent but MDC1-independent pathway in response to DNA damage显示文摘 | Wood JL Singh N Mer G | | 0，，48： | 1 |
| 20 | Reconstruction of complicated scalp defect via skin traction 显示文摘 | Turgut G Ozcan A Su'mer O | 2009 | J Craniofac Surg2009，20，2： | 1 |
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