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| 1 | Structures and antifouling properties of low surface energy non-toxic antifouling coatings modified by nano-SiO_2 powder显示文摘Antifouling coatings are used to improve the speed and energy efficiency of ships by preventing or- ganisms, such as barnacles and weed, building up on the underwater hull and helping the ships movement through the water. Typically, marine coatings are tributyltin self-polishing copolymer paints containing toxic molecules called biocides. They have been the most successful in combating bio- fouling on ships, but their widespread use has caused severe pollution in the marine ecosystem. The low surface energy marine coating is an entirely non-toxic alternative, which reduces the adhesion strength of marine organisms, facilitating their hydrodynamic removal at high speeds. In this paper, the novel low surface energy non-toxic marine antifouling coatings were prepared with modified acrylic resin, nano-SiO2, and other pigments. The effects of nano-SiO2 on the surface structure and elastic modulus of coating films have been studied, and the seawater test has been carried out in the Dalian Bay. The results showed that micro-nano layered structures on the coating films and the lowest surface energy and elastic modulus could be obtained when an appropriate mass ratio of resin, nano-SiO2, and other pigments in coatings approached. The seawater exposure test has shown that the lower the sur- face energy and elastic modulus of coatings are, the less the marine biofouling adheres on the coating films. | CHEN MeiLing, QU YuanYuan, YANG Li & GAO Hong Laboratory of Marine Coatings, Dalian Jiaotong University, Dalian 116028, China | 2008 | Science China Chemistry2008，51，9： | 17 |
| 2 | In vitro Anthocyanin Induction and Metabolite Analysis in Malus spectabilis Leaves Under Low Nitrogen Conditions显示文摘Anthocyanins are the most widely produced secondary metabolites in plants,and they play an important role in plant growth and reproduction.The nitrogen source is an important factor affecting anthocyanin production,but the nitrogen concentrations on metabolism and the underlying genetic basis remain unclear.In this study,in vitro anthocyanin induction was conducted on Malus spectabilis.The leaf explants were cultivated in media containing different nitrogen concentrations.The results suggested that when the nitrogen contents decreased in limit,the color of leaf explants turned from green to red,and increased anthocyanin accumulation led to a change in phenotype.Furthermore,the content of other flavonoids,such as dihydroquercetin,epicatechin,and catechin,increased under low nitrogen conditions.The transcription levels of the general flavonoid pathway genes,from phenylalanine ammonia lyase(PAL)to anthocyanidin synthase(ANS),were associated with the concentration of corresponding flavonoid compounds and phenotype changes.In particular,the expression level of ANS increased substantially under a low nitrogen treatment,which was significantly and positively correlated with the anthocyanin levels(R2=0.72,P<0.05).The increased expression patterns of anthocyanin pathway genes were similar to that of the transcription factor MYB10.We further verified MYB10 played an important role in the anthocyanin pathway in leaves of Malus spectabilis.These results suggested that we can improve the desirable ornamental plant phenotypes by controlling nitrogen content.This process may offer clues to further development of new agricultural practices. | Jiaxin Meng Yan Gao Meiling Han Pengyuan Liu Chen Yang Ting Shen Houhua Li | 2020 | Horticultural Plant Journal2020，6，5： | 13 |
| 3 | Design and control of methyl acetate-methanol separation via heat-integrated pressure-swing distillation显示文摘Design and control of pressure-swing distillation(PSD) with different heat integration modes for the separation of methyl acetate/methanol azeotrope are explored using Aspen Plus and Aspen Dynamics. First, an optimum steady-state separation configuration conditions are obtained via taking the total annual cost(TAC) or total reboiler heat duty as the objective functions. The results show that about 27.68% and 25.40% saving in TAC can be achieved by the PSD with full and partial heat integration compared to PSD without heat integration. Second,temperature control tray locations are obtained according to the sensitivity criterion and singular value decomposition(SVD) analysis and the single-end control structure is effective based on the feed composition sensitivity analysis. Finally, the comparison of dynamic controllability is made among various control structures for PSD with partial and full heat integration. It is shown that both control structures of composition/temperature cascade and pressure-compensated temperature have a good dynamic response performance for PSD with heat integration facing feed flowrate and composition disturbances. However, PSD with full heat integration performs the poor controllability despite of a little bit of economy. | Zhishan Zhang Qingjun Zhang Guijie Li Meiling Liu Jun Gao | 2016 | Chinese Journal of Chemical Engineering2016，24，11： | 12 |
| 4 | The apricot(Prunus armeniaca L.)genome elucidates Rosaceae evolution and beta-carotenoid synthesis显示文摘Apricots,scientifically known as Prunus armeniaca L,are drupes that resemble and are closely related to peaches or plums.As one of the top consumed fruits,apricots are widely grown worldwide except in Antarctica.A high-quality reference genome for apricot is still unavailable,which has become a handicap that has dramatically limited the elucidation of the associations of phenotypes with the genetic background,evolutionary diversity,and population diversity in apricot.DNA from P.armeniaca was used to generate a standard,size-selected library with an average DNA fragment size of~20 kb.The library was run on Sequel SMRT Cells,generating a total of 16.54 Gb of PacBio subreads(N50=13.55 kb).The high-quality P.armeniaca reference genome presented here was assembled using long-read single-molecule sequencing at approximately 70×coverage and 171×Illumina reads(40.46 Gb),combined with a genetic map for chromosome scaffolding.The assembled genome size was 221.9 Mb,with a contig NG50 size of 1.02 Mb.Scaffolds covering 92.88%of the assembled genome were anchored on eight chromosomes.Benchmarking Universal Single-Copy Orthologs analysis showed 98.0%complete genes.We predicted 30,436 protein-coding genes,and 38.28%of the genome was predicted to be repetitive.We found 981 contracted gene families,1324 expanded gene families and 2300 apricot-specific genes.The differentially expressed gene(DEG)analysis indicated that a change in the expression of the 9-cis-epoxycarotenoid dioxygenase(NCED)gene but not lycopene beta-cyclase(LcyB)gene results in a lowβ-carotenoid content in the white cultivar“Dabaixing”.This complete and highly contiguous P.armeniaca reference genome will be of help for future studies of resistance to plum pox virus(PPV)and the identification and characterization of important agronomic genes and breeding strategies in apricot. | Fengchao Jiang Junhuan Zhang Sen Wang Li Yang Yingfeng Luo Shenghan Gao Meiling Zhang Shuangyang Wu Songnian Hu Haoyuan Sun Yuzhu Wang | 2019 | Horticulture Research2019，6，1： | 9 |
| 5 | Ni(OH)_(2) nanoparticles encapsulated in conductive nanowire array for high-performance alkaline seawater oxidation显示文摘Design and development of high-efficiency and durable oxygen evolution reaction(OER)electrocatalysts is crucial for hydrogen production from seawater splitting.Herein,we report the in situ electrochemical conversion of a nanoarray of Ni(TCNQ)2(TCNQ=tetracyanoquinodimethane)on graphite paper into Ni(OH)_(2) nanoparticles confined in a conductive TCNQ nanoarray(Ni(OH)_(2)-TCNQ/GP)by anode oxidation.The Ni(OH)_(2)-TCNQ/GP exhibits high OER performance and demands overpotentials of 340 and 382 mV to deliver 100 mA·cm^(−2) in alkaline freshwater and alkaline seawater,respectively.Meanwhile,the Ni(OH)_(2)-TCNQ/GP also demonstrates steady long-term electrochemical durability for at least 80 h under alkaline seawater. | Longcheng Zhang Jiaqian Wang Pengyu Liu Jie Liang Yongsong Luo Guanwei Cui Bo Tang Qian Liu Xuedong Yan Haigang Hao Meiling Liu Rui Gao Xuping Sun | 2022 | Nano Research2022，15，7： | 5 |
| 6 | Nanosheet-structured K–Co–MoS_2 catalyst for the higher alcohol synthesis from syngas: Synthesis and activation显示文摘The nanosheets structured K–Co–MoS_2 catalyst was prepared through a one-step hydrothermal synthesis combined with the wetness impregnation. The fresh catalyst has a high dispersion of Co–Mo–S active phase and no Co_9S_8 is found. The pure H_2 activated catalyst shows a higher intrinsic activity, especially the C_(2+) OH selectivity for the higher alcohol synthesis compared to the one activated by 5% H_2/N_2 atmosphere. The reason is attributed to that the pure H_2 activation more effectively suppresses the formation of Co_9S_8 and stabilizes the Co–Mo–S active phase during the reaction due to the formation of SH species. | Huan Li Wei Zhang Yinyin Wang Meiling Shui Song Sun Jun Bao Chen Gao | 2019 | Journal of Energy Chemistry2019，28，3： | 5 |
| 7 | Correlating Fe source with Fe-N-C active site construction: Guidancefor rational design of high-performance ORR catalyst显示文摘Pyrolyzed Fe-N_X/C materials derived from Fe-doped ZIF-8 are recently emerged as promising alternatives to noble metal platinum-based catalysts towards oxygen reduction reaction(ORR) and elucidating the dependacne of Fe source on the active site structure and final ORR performance is highly desirbale for further development of these materials. Here, we designed and synthesized a series of Fe-N-C catalysts using ZIF-8 and various iron salts(Fe(acac)_3, FeCl_3, Fe(NO_3)_3) as precusors. We found that the iron precursors,mainly the molecular size, hydrolysis extent, do play a major role in determining the final morphology of Fe, namely forming the Fe-Nx coordination or Fe_3C nanoparticles, as well as the site density, therefore,significantly affecting the ORR activity. Among the three iron sources, Fe(acac)_3 is most advantageous to the preferential formation of single-atom Fe-Nx active sites and the derived catalyst demonstrated best ORR performance. | Liqin Gao Meiling Xiao Zhao Jin Changpeng Liu Jianbing Zhu Junjie Ge Wei Xing | 2018 | Journal of Energy Chemistry2018，27，6： | 4 |
| 8 | Oxygen-vacancy-rich TiO_(2)enables highly active and durable water electrolysis of urchin-like RuO_(2)catalyst显示文摘The material innovation is prerequisite to accelerating sluggish oxygen evolution reaction(OER)kinetics,thus promoting the realization of hydrogen energy community.Herein,we develop an oxygen-vacancy-rich TiO_(2)supported RuO_(2)catalyst(RuO_(2)@r-TiO_(2))towards improved OER activity and stability.The oxygen vacancy on TiO_(2)not only supplies electrons to produce lower valence Ru,but also provides sufficient anchoring site for the deposition of RuO_(2)nanocrystal.Beyond that,it can generate strong electronic interaction between TiO_(2)and supported RuO_(2),and thereby tailors the intermediates’adsorption energy on the RuO_(2)surface.As a result,the derived RuO_(2)@r-TiO_(2)catalyst exhibits superior OER activity and stability with the overpotential of 211 mV at a current density of 10 mA cm^(−2)and negligible activity degradation after 6 h operation,outperforming the non-oxygen-vacancy counterpart(223.3 mV,12.75%activity loss)and RuO_(2)catalyst(234.6 mV,42.86%activity loss). | GAO HongMei XIAO MeiLing LI GuoQiang GAO LiQin MENG QingLei LUO ZhaoYan LUO ErGui LIU ChangPeng JIN Zhao GE JunJie XING Wei | 2022 | Science China(Technological Sciences)2022，65，10： | 3 |
| 9 | In vitro expansion of human sperm through nuclear transfer显示文摘Dear Editor,Mammalian haploid embryonic stem cells(haESCs)represent an ideal tool for genetic analysis due to the presence of only one set of genetic materials.HaESCs fall into two readily distinguishable groups based on their genome origins:parthenogenetic haESCs(PG-haESCs)that are derived from oocyte-originated parthenogenetic embryos and androgenetic haESCs(AG-haESCs)that are produced through sperm nuclear transfer.Both PG-and AGhaESCs are feasible for delineating genome function at cellular level in vitro.Importantly,AG-haESCs can be used as a sperm replacement and applied to deciphering gene function at organismal level when combined with CRISPR-Cas9 technology.1 However,while PG-haESCs have been generated from both rodent and primates,2-5 AG-haESCs can only be obtained in rodent to date. | Xiaoyu Merlin Zhang Keliang Wu Yuxuan Zheng Han Zhao Junpeng Gao Zhenzhen Hou Meiling Zhang Jiaoyang Liao Jingye Zhang Yuan Gao Yuanyuan Li Lin Li Fuchou Tang Zi-Jiang Chen Jinsong Li | 2020 | Cell Research2020，30，4： | 3 |
| 10 | Cycle number of neoadjuvant chemotherapy might influence survival of patients with T1-4N2-3M0 nasopharyngeal carcinoma显示文摘Objective: Stage N2-3 nasopharyngeal carcinoma(NPC) shows a high risk of distant metastasis, which will finally cause death. This study aimed to evaluate the impact of neoadjuvant chemotherapy(NACT) of various cycles before radical radiotherapy on distant metastasis and survival of patients with stage N2-3 diseases.Methods: In this study, a total of 1,164 consecutive patients with non-metastatic N2-3 NPC were recruited and prospectively observed. Then 231 patients who received NACT of 4 cycles(NACT=4 group) were matched 1:2:1 to 462 patients treated with NACT of 2 cycles(NACT=2 group) and 231 patients treated without NACT(NACT=0 group), according to age, histological subtype, N stage and NACT regimen. Five candidate variables(sex, T stage, concurrent chemotherapy, intensity-modulated radiation therapy and cycle number of NACT) were analyzed for their association with patients' survival.Results: After matching, the overall survival(OS), disease-free survival(DFS), local-recurrence-free survival(RFS) and distant-metastasis-free survival(MFS) of the NACT=4 group(89.2%, 81.0%, 83.3% and 84.8%,respectively) were better than those of the NACT=2 group(83.3%, 72.5%, 81.2% and 77.9%, respectively) and the NACT=0 group(74.0%, 63.2%, 74.0% and 68.8%, respectively). In multivariate analysis, the cycle number of NACT maintained statistical significance on the OS, DFS, RFS and MFS(all P<0.05).Conclusions: For N2-3 NPC, cycle number of NACT appeared to be an independent factor associated with an improvement of survival. | Jiawang Wei Huixia Feng Weiwei Xiao Qiaoxuan Wang Bo Qiu Shiliang Liu Meiling Deng Lixia Lu Hui Chang Yuanhong Gao | 2018 | Chinese Journal of Cancer Research2018，30，1： | 2 |
| 11 | Hydrogen etching induced hierarchical meso/micro-pore structure with increased active density to boost ORR performance of Fe-N-C catalyst显示文摘Rational regulation on pore structure and active site density plays critical roles in enhancing the performance of Fe-N-C catalysts. As the microporous structure of the carbon substrate is generally regarded as the active site hosts, its hostility to electron/mass transfer could lead to the incomplete fulfillment of the catalytic activity. Besides, the formation of inactive metallic Fe particles during the conventional catalyst synthesis could also decrease the active site density and complicate the identification of real active site. Herein, we developed a facial hydrogen etching methodology to yield single site Fe-N-C catalysts featured with micro/mesoporous hierarchical structure. The hydrogen concentration in pyrolysis process was designated to effectively regulate the pore structure and active site density of the resulted catalysts.The optimized sample achieves excellent ORR catalytic performance with an ultralow H2O2 yield(1%)and superb stability over 10,000 cycles. Our finding provides new thoughts for the rational design of hierarchically porous carbon-based materials and highly promising non-precious metal ORR catalysts. | Liqin Gao Meiling Xiao Zhao Jin Changpeng Liu Junjie Ge Wei Xing | 2019 | Journal of Energy Chemistry2019，28，8： | 2 |
| 12 | Activation, characterization and hydrogen storage properties of the mesoporous carbon CMK-3显示文摘 | Kaisheng Xia Qiuming Gao Chundong Wu Shuqing Song Meiling Ruan | 2007 | Carbon2007，，10： | 1 |
| 13 | Rapid detection of quinoline yellow in soft drinks using polypyrrole/single-walled carbon nanotubes composites modified glass carbon electrode显示文摘 | Gao Yunqiao Wang Meiling Yang Xiongbo | 2014 | Journal of Electroanalytical Chemistry2014，735，1： | 1 |
| 14 | Modelling synergistic interactions between HER2, Sprouty2 and PTEN in driving prostate carcinogenesis显示文摘 | Imran Ahmad Meiling Gao Rachana Patel Hing Y Leung | 2013 | Asian Journal of Andrology2013，15，3： | 1 |
| 15 | Characterization of tub_4^(P287L), a β-tubulin mutant,revealed new aspects of microtubule regulation in shade显示文摘When sun plants, such as Arabidopsis thaliana, are under canopy shade, elongation of stems/petioles will be induced as one of the most prominent responses. Plant hormones mediate the elongation growth. However, how environmental and hormonal signals are translated into cell expansion activity that leads to the elongation growth remains elusive. Through forward genetic study, we identifi ed shade avoidance2(sav2) mutant, which contains a P287 L mutation in b-TUBULIN 4. Cortical microtubules(c MTs) play a key role in anisotropic cell growth. Hypocotyls of sav2 are wild type-like in white light, but are short and highly swollen in shade and dark. We showed that shade not only induces c MT rearrangement, but also affects c MT stability and dynamics of plus ends. Even though auxin and brassinosteroids are required for shade-induced hypocotyl elongation, they had little effect on shade-induced rearrangement of c MTs.Blocking auxin transport suppressed dark phenotypes of sav2, while overexpressing EB1b-GFP, a microtubule plus-end binding protein, rescued sav2 in both shade and dark,suggesting that tub4P287 L represents a unique type of tubulin mutation that does not affect c MT function in supporting cell elongation, but may affect the ability of c MTs to respond properly to growth promoting stimuli. | Jie Yu Hong Qiu Xin Liu Meiling Wang Yongli Gao Joanne Chory Yi Tao | 2015 | Journal of Integrative Plant Biology2015，57，9： | 1 |
| 16 | Improved refractory wound healing with administration of acidic fibroblast growth factor in diabetic rats显示文摘 | Liyun Xie Meiling Zhang Baijun Dong Mimi Guan Meifei Lu Zhifeng Huang Hongchang Gao Xiaokun Li | 2011 | Diabetes Research and Clinical Practice2011，，： | 1 |
| 17 | Polarization modulation with optical lock-in detection reveals universal fluorescence anisotropy of subcellular structures in live cells显示文摘The orientation of fluorophores can reveal crucial information about the structure and dynamics of their associated subcellular organelles.Despite significant progress in super-resolution,fluorescence polarization microscopy remains limited to unique samples with relatively strong polarization modulation and not applicable to the weak polarization signals in samples due to the excessive background noise.Here we apply optical lock-in detection to amplify the weak polarization modulation with super-resolution.This novel technique,termed optical lock-in detection super-resolution dipole orientation mapping(OLID-SDOM),could achieve a maximum of 100 frames per second and rapid extraction of 2D orientation,and distinguish distance up to 50 nm,making it suitable for monitoring structural dynamics concerning orientation changes in vivo.OLID-SDOM was employed to explore the universal anisotropy of a large variety of GFP-tagged subcellular organelles,including mitochondria,lysosome,Golgi,endosome,etc.We found that OUF(Orientation Uniformity Factor)of OLID-SDOM can be specific for different subcellular organelles,indicating that the anisotropy was related to the function of the organelles,and OUF can potentially be an indicator to distinguish normal and abnormal cells(even cancer cells).Furthermore,dual-color super-resolution OLID-SDOM imaging of lysosomes and actins demonstrates its potential in studying dynamic molecular interactions.The subtle anisotropy changes of expanding and shrinking dendritic spines in live neurons were observed with real-time OLID-SDOM.Revealing previously unobservable fluorescence anisotropy in various samples and indicating their underlying dynamic molecular structural changes,OLID-SDOM expands the toolkit for live cell research. | Meiling Guan Miaoyan Wang Karl Zhanghao Xu Zhang Meiqi Li Wenhui Liu Jing Niu Xusan Yang Long Chen Zhenli Jing Micheal Q.Zhang Dayong Jin Peng Xi Juntao Gao | 2022 | Light(Science & Applications)2022，11，1： | 1 |
| 18 | Mechanical performance and cyocompatibility of PU/PLCL nanofibrous electrospun scaffolds for skin regeneration显示文摘Skin tissue engineering with considerable skin regeneration capability is an urgent need for the wound site.The current challenge for researchers is to develop a bionic scaffold that imitates the extracellular matrix for the regeneration of the damaged regions.In our study,poly(L-lactide-co-caprolactone)(PLCL)was blended with polyurethane(PU)to obtain nanofibrous scaffolds via electrospinning.The electrospun fibers with 50%PLCL content had a certain number of intersections and jointing points,and exhibited significantly enhanced mechani-cal properties combined with suitable porosity.Moreover,cell activities demonstrated that PU/PLCL membranes had significantly biological advantages in enhanced growth of human skin fibroblasts with spreading morphology compared with PU membranes,indicating good cytocompatibility of composite scaffolds.These findings proved that PU/PLCL electrospun membranes have great potential in applications of skin tissue engineering. | Xiang Gao Meiling Wen Yang Liu Tian Hou Meiwen An | 2022 | Engineered Regeneration2022，3，1： | 1 |
| 19 | Erratum to Mechanical performance and cyocompatibility of PU/PLCL nanofibrous electrospun scaffolds for skin regeneration显示文摘The publisher regrets that ethical approval was not included in the published version.Upon request,the authors have provided the appropriate ethical approval statement,which states that the human skin fibroblasts used in this study were derived from normal skin tissues of patients after scar resection at Shanxi Bethune Hospital,and were obtained under ethical requirements.The experimental process strictly adhered to relevant ethical requirements and guidelines,and was granted approval by the ethics committee with protocol number SBQLL-2021-065 from Shanxi Bethune Hospital. | Xiang Gao Meiling Wen Yang Liu Tian Hou Meiwen An | 2023 | Engineered Regeneration2023，4，2： | 0 |
| 20 | Enhancing the HSV-1-mediated antitumor immune response by suppressing Bach1显示文摘Background In 2015,herpes simplex virus 1(HSV-1)-derived talimogene laherparepvec(T-VEC)was the first oncolytic virus approved by the US Food and Drug Administration as a therapeutic agent for cancer treatment.However,its antitumor application is limited to local treatment of melanoma,and there is a lack of understanding of the mechanisms underlying the regulation of HSV-1 replication in cancer cells and the associated antitumor immunity.We hypothesized that increasing the replication capacity of HSV-1 in tumor cells would enhance the antitumor effect of this virus.Methods We systematically identified IFN-stimulated genes induced by HSV-1 by performing functional screens and clarified the mechanism by which BACH1 acts against HSV-1.Then,we tested the effect of BACH1 deficiency on immunogenic cell death induced by HSV-1.Furthermore,we investigated the antitumor effect of BACH1 deficiency on HSV-1 in MCA205 and B16 murine tumor models.Results We identified eight IFN-stimulated genes(ISGs)controlling HSV-1 replication,among which BTB and CNC homology 1(BACH1)suppressed HSV-1 replication by inhibiting the transcription of ICP4,ICP27,and UL39.Loss of Bach1 function not only increased HSV-1 proliferation but also promoted HSV-1-induced cell apoptosis,HMGB1 secretion,and calreticulin exposure in tumor cells.More importantly,hemin,an FDA-approved drug known to downregulate BACH1,significantly enhanced HSV-1-mediated antitumor activity with increased T lymphocyte infiltration at the tumor site.Conclusions Our studies uncovered a novel antiviral activity of BACH1 and provided a new strategy for improving the clinical efficiency of the oncolytic virus HSV-1. | Chaohu Pan Qiaomei Cai Xiaorong Li Lili Li Liping Yang Yu Chen Junxiao Liu Wancheng Liu Meiling Gao Tianqi Sui Xiaoyang Wang Huiming Fan Jiayin Ruan Yueyue Shi Saihua Chen Lucy S.Cheng Jiayong Liu Heng Yang Genhong Cheng | 2022 | Cellular & Molecular Immunology2022，19，4： | 0 |
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