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| 1 | C-reactive protein is a prognostic indicator in patients with perihilar cholangiocarcinoma显示文摘AIM: To evaluate prognostic indicators for the outcome of patients with perihilar extrahepatic cholangiocarcinoma in an unselected cohort. METHODS: We retrospectively analyzed 98 patients with perihilar cholangiocarcinoma. Twenty-three patients (23.5%) underwent tumor resection. Patients with non- resectable tumors underwent either transpapillary or percutaneous transhepatic biliary drainage. Additionally, 32 patients (32.7%) received photodynamic therapy (PDT) and 18 patients (18.4%) systemic chemotherapy. Predefined variables at the time of diagnosis and characteristics considering the mode of treatment were entered into a Cox’s proportional hazards model. Included in the analysis were age, tumor stage following the modified Bismuth-Corlette classification, bilirubin, prothrombin time (PT), C-reactive protein (CRP), carbohydrate antigen 19-9 (CA19-9), history of weight loss, surgical resection, chemotherapy and PDT. RESULTS: The Kaplan-Meier estimate of overall median survival was 10.5 (95%CI: 8.4-12.6) mo. In the univariate analysis, low Bismuth stage, low CRP and surgical resection correlated significantly with better survival. In the multivariate analysis, only CRP (P = 0.005) and surgical resection (P = 0.029) were found to be independently predictive of survival in the cohort. Receiver operating characteristic (ROC) analysis identified a CRP level of 11.75 mg/L as the value associated with the highest sensitivity and specificity predicting a survival > 5 mo. Applying Kaplan-Meier analysis, patients with a CRP < 12 mg/L at the time of diagnosis had a signifi cantly longer median survival than patients with higher values (16.2 vs 7.6 mo; P = 0.009).CONCLUSION: This retrospective analysis identif ied CRP level at the time of diagnosis as a novel indicator for the prognosis of patients with perihilar cholangiocarcinoma. It should be evaluated in future prospective trials on this entity. | Thomas Gerhardt Sabine Milz Michael Schepke Georg Feldmann Martin Wolff Tilman Sauerbruch Franz Ludwig Dumoulin | 2006 | World Journal of Gastroenterology2006，12，34： | 5 |
| 2 | Treatment and prognosis of gastric stump carcinoma in comparison with primary proximal gastric cancer显示文摘 | Nico Schaefer Christoph Sinning Jens Standop Marcus Overhaus Andreas Hirner Martin Wolff | 2007 | The American Journal of Surgery2007，，1： | 2 |
| 3 | Predictors of serological cure and serofast state after treatment in HIV-negative persons with early syphilis显示文摘 | Sena AC Wolff M Martin DH | 2011 | Clin Infect Dis2011，53，11： | 1 |
| 4 | The probiotic Escherichia coli strain Nissle 1917 (EcN) stops acute diarrhoea in infants and toddlers显示文摘 | Jobst Henker Martin Laass Boris M. Blokhin Yuriy K. Bolbot Vitaliy G. Maydannik Martina Elze Corinna Wolff Jürgen Schulze | 2007 | European Journal of Pediatrics2007，，4： | 1 |
| 5 | Probiotic Escherichia coli Nissle 1917 Versus Placebo for Treating Diarrhea of Greater Than 4 Days Duration in Infants and Toddlers显示文摘 | Jobst Henker Martin W. Laass Boris M. Blokhin Vitaliy G. Maydannik Yuriy K. Bolbot Martina Elze Corinna Wolff Armin Schreiner Jürgen Schulze | 2008 | The Pediatric Infectious Disease Journal2008，，6： | 1 |
| 6 | Predictors of serological cure and serofast state after treatment in HIV-negative persons with early syphilis 显示文摘 | Seiia AC Wolff M Martin DH | 2011 | Clin Infect Dis2011，53，1： | 1 |
| 7 | Predictors of serological cure and Serofast State after treatment in HIV-negative persons with early syphilis显示文摘 | Se(n)a AC Wolff M Martin DH | 2011 | Clin Infect Dis2011，53，11： | 1 |
| 8 | Predictors of Serological Cure and Serofast State After Treatment in HIV-Negative Persons With Earl Syphilis 显示文摘 | Se a Arlene C Wolff Mark Martin David H | 2011 | Clinical Infectious Diseases2011，53，11： | 1 |
| 9 | Predictors of serological cure and serofast state after treatment in HIV-negative persons with early syphilis显示文摘 | Sena AC Wolff M Martin DH | 2011 | Clin Infect Dis2011，53，1： | 1 |
| 10 | Crossing the Industry-Line:Breakthrough Innovation through Cross-In- dustry Alliances with ' Non-Suppliers' 显示文摘 | Oliver Gassmann Marco Zeschky Timo Wolff Martin Stahl | 2010 | Long Range Planning2010，43，56： | 1 |
| 11 | Contractile hyporesponsiveness of hepatic arteries in humans with cirrhosis: Evidence for a receptor-specific mechanism显示文摘 | Michael Schepke J?rg Heller Sebastian Paschke Julia Thomas Martin Wolff Markus Neef Max Malago Gerhard J. Molderings Ulrich Spengler Tilman Sauerbruch | 2001 | Hepatology2001，，5： | 1 |
| 12 | Fatty acid composition of French infant formulas with emphasis on the content and detailed profile of trans fatty acids显示文摘 | Jean-Michel Chardigny Robert L. Wolff Estelle Mager Corine C. Bayard Jean-Louis Sébédio Lucy Martine W. M. N. Ratnayake | 1996 | Journal of the American Oil Chemists’ Society1996，，11： | 1 |
| 13 | China's English Mystery the Views of a China ' Foreign Expert' 显示文摘 | Martin Wolff | 2010 | English Today2010，，4： | 1 |
| 14 | The Chinglish syndrome:Do recent developments endanger the language policy of China显示文摘 | Niu Qiang Martin Wolff | | 0，，19： | 1 |
| 15 | Thrombosis of a large portal vein aneurysm: Treatment by thrombectomy, aneurysmorrhaphy, and portocaval shunt显示文摘 | Dr. Martin Wolff M.D. Nico Schaefer M.D. Joachim Schmidt M.D. Andreas Hirner M.D | 2006 | Journal of Gastrointestinal Surgery2006，，1： | 1 |
| 16 | Predictors of sero- logical cure and Serofast State after treatment in HIV-neg- ative persons with early syphilis 显示文摘 | Sena AC Wolff M Martin DH | 2011 | Clin Infect Dis2011，53，11： | 1 |
| 17 | Predictors of serologi cal cure and serofast state after treatment in hiv-negative per sons with early syphilis 显示文摘 | Se AAC Wolff M Martin DH | 2011 | Clinical Infectious Diseases2011，53，11： | 1 |
| 18 | Predictors of serological cure and Serofast State after treatment in HIV-negative persons with early syphilis 显示文摘 | Sefia AC Wolff M Martin DH | 2011 | Clin Infect Dis2011，53，11： | 1 |
| 19 | Structure and evolution of a pair-rule interaction element: runt regulatory sequences in D. melanogaster and D. virilis显示文摘 | Christian Wolff Melissa Pepling Peter Gergen Martin Klingler | 1999 | Mechanisms of Development1999，，1： | 1 |
| 20 | Morphing polylines: A step towards continuous generalization显示文摘 | Martin N?llenburg Damian Merrick Alexander Wolff Marc Benkert | 2008 | Computers Environment and Urban Systems2008，，4： | 1 |
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