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| 1 | Identification of osteopontin as the most consistently over-expressed gene in intrahepatic cholangiocarcinoma: Detection by oligonucleotide microarray and real-time PCR analysis显示文摘AIM: To investigate the molecular pathways involved in human cholangiocarcinogenesis by gene expression profiling. METHODS: Oligonucleotide arrays (Affymetrix U133A) were used to establish a specific gene expression profile of intrahepatic CCC in comparison to corresponding non- malignant liver tissue. To validate the expression values of the most overexpressed genes, RT-PCR experiments were performed. RESULTS: Five hundred and fifty-two statistically differentially expressed genes/ESTs (221 probes significantly up-regulated, 331 probes down-regulated; P < 0.05; fold change > 2; ≥ 70%) were identified. Using these data and two-dimensional cluster analysis,a specific gene expression profile was obtained allowing fast and reproducible differentiation of CCC, which was confirmed by supervised neuronal network modelling. The most consistently overexpressed gene (median fold change 33.5, significantly overexpressed in 100%) encoded osteopontin. Furthermore, an association of various genes with the histopathological grading could be demonstrated. CONCLUSION: A highly specific gene expression profile for intrahepatic CCC was identified, allowing for its fast and reproducible discrimination against non- malignant liver tissue and other liver masses. The most overexpressed gene in intrahepatic CCC was the gene encoding osteopontin. These data may lead to a better understanding of human cholangiocarcinogenesis. | Holger G Hass Oliver Nehls Juergen Jobst Andrea Frilling Ulrich Vogel Stephan Kaiser | 2008 | World Journal of Gastroenterology2008，14，16： | 4 |
| 2 | Need and options for a regenerative energy supply in holiday facilities显示文摘 | Sven Bode Jobst Hapke Stefan Zisler | 2002 | Tourism Management2002，，3： | 2 |
| 3 | Highly porous thermally structurized polyacrylonitrile Ⅰ synthesis structure and electrical properties显示文摘 | Jobst K Sawtschenko L Schwarzenerg M | 1992 | Synth Met1992，47，： | 1 |
| 4 | Frontal lobe seizures显示文摘 | Jobst BC Williamson PD | 2005 | Psychiatr Clin North Am2005，28，3： | 1 |
| 5 | Characterization of Nanofiltration Membranes by Their Morphology, Charge and Filtration Performance Parameters显示文摘 | A Gamze H Jobst | 2006 | Desalination2006，200，1： | 1 |
| 6 | Intractable seizures of frontal lobe origin:clinical characteristics,localizing signs,and result of surgery显示文摘 | Jobst BC Siegel AM Thadani VW | 2000 | Epilepsia2000，41，9： | 1 |
| 7 | Propofol-associated fatal myocardial failure and rhabdomyolysis in an adult with status epilepticus显示文摘 | Zarovnaya EL Jobst BC Harris BT | 2007 | Epilepsia2007，48，5： | 1 |
| 8 | Association of atrophy of medial temporal lobe with reduced blood flow in patients with a clinical and pathological diagnosis of Alzheimer'sdisease显示文摘 | Smith AD Barker CS | 1992 | J Neurol Neurosurg Psychiatry1992，55，： | 1 |
| 9 | Management of pancreatic injury in pediatric bluntabdominal trauma显示文摘 | Jobst MA Canty TG Sr Lynch FP | 1999 | J Pediatr Surg1999，34，： | 1 |
| 10 | Bottom-ga*ed epi- taxial graphene显示文摘 | Waldmann D Jobst J Speck F | 2011 | Nat Mater2011，10，5： | 1 |
| 11 | Epilepsy in developing countries显示文摘 | Williamson TD Jobst BC | 2000 | Epilepsia2000，41，4： | 1 |
| 12 | Sensory perception in Par kinson disease显示文摘 | Jobst lEE Melnick ME Byl NN | 1997 | Archives of Neurology1997，54，： | 1 |
| 13 | Secondarily generalized seizures in mesial temporal epilepsy:clinical characteristics,lateralizing signs,and association with sleep-wake cycle显示文摘 | Jobst B C Williamson P D Neuschwander T B | 2001 | Epilepsia2001，42，10： | 1 |
| 14 | The probiotic Escherichia coli strain Nissle 1917 (EcN) stops acute diarrhoea in infants and toddlers显示文摘 | Jobst Henker Martin Laass Boris M. Blokhin Yuriy K. Bolbot Vitaliy G. Maydannik Martina Elze Corinna Wolff Jürgen Schulze | 2007 | European Journal of Pediatrics2007，，4： | 1 |
| 15 | Bronchial artery embolization in patients with hemoptysis including follow-up显示文摘 | Daliri A Probst NH Jobst B | 2011 | Acta Radiol2011，52，2： | 1 |
| 16 | Assessment of the eficacy and safety of three dose levels of cetiriz- ine given once daily in children with perennial allergic rhinitis 显示文摘 | Jobst S Wijngaart W Schubert A | 1994 | Allergy1994，49，8： | 1 |
| 17 | Probiotic Escherichia coli Nissle 1917 Versus Placebo for Treating Diarrhea of Greater Than 4 Days Duration in Infants and Toddlers显示文摘 | Jobst Henker Martin W. Laass Boris M. Blokhin Vitaliy G. Maydannik Yuriy K. Bolbot Martina Elze Corinna Wolff Armin Schreiner Jürgen Schulze | 2008 | The Pediatric Infectious Disease Journal2008，，6： | 1 |
| 18 | Molecular evolu- tion of the internal transcribed spacers (ITS1 and ITS2)and phylogenetic relationships among the species of the family Cucuitaceae显示文摘 | Jobst J King K Hemleben V | 1998 | MolPhylogenet Evol1998，9，1： | 1 |
| 19 | Cr supplementation decreases tyrosine phosphorylation of the CreaT in skele tal muscle during sepsis显示文摘 | Wang WY Jobst MA Brian B | 2002 | Am J Physiol Endo Crinol Metab2002，282，： | 1 |
| 20 | Folate, vitamin B12, serum total homocysteine levels in confirmed Alzheimer' s disease显示文摘 | Clark R Smith DA Jobst KA | 1998 | Arch Neurol1998，55，： | 1 |
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