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| 1 | Clinical and histopathological correlations of fecal calprotectin release in colorectal carcinoma显示文摘AIM:To determine calprotectin release before and after colorectal cancer operation and compare it to tumor and histopathological parameters.METHODS:The study was performed on patients with diagnosed colorectal cancer admitted for operation.Calprotectin was measured in a single stool sample before and three months after the operation using an enzymelinked immunosorbent assay(ELISA).Calprotectin levels greater than or equal to 50μg/g were considered positive.The compliance for collecting stool samples was assessed and the value of calprotectin was correlated to tumor and histopathological parameters of intra-and peri-tumoral inflammation.Surgical specimens were fixed in neutral buffered formalin and stained with hematoxylin and eosin.Staging was performed according to the Dukes classification system and the 7th edition tumor node metastasis classification system.Intra-and peri-tumoral inflammation was graded according to the Klintrup criteria.Immunohistochemical quantification was performed for MPO,CD45R0,TIA-1,CD3,CD4,CD8,CD57,and granzyme B.Statistical significance was measured using Wilcoxon signed rank test,Kruskal Wallis test and Spearman’s rank correlation coefficient as appropriate.RESULTS:Between March 2009 and May 2011,80 patients with colorectal cancer(46 men and 34 women,with mean age of 71±11.7 years old)were enrolled in the study.Twenty-six patients had rectal carcinoma,29 had left-side tumors,23 had right-side tumors,and2 had bilateral carcinoma.In total,71.2%of the patients had increased levels of calprotectin before the operation(median 205μg/g,range 50-2405μg/g)and experienced a significant decrease three months after the operation(46μg/g,range 10-384μg/g,P<0001).The compliance for collecting stool samples was 89.5%.Patients with T3 and T4 tumors had significantly higher values than those with T1 and T2 cancers(P=0.022).For all other tumor parameters(N,M,G,L,V,Pn)and location,no significant difference in calprotectin concentration was found.Furthermore,the calprotectin levels and histological grading of both peri-and intra-tumoral inflammation was not correlated.Additional testing with specific markers for lymphocytes and neutrophils also revealed no statistically significant correlation.CONCLUSION:Fecal calprotectin decreases significantly after colorectal cancer operation.Its value depends exclusively on the individual T-stage,but not on other tumor or histopathological parameters. | Frank Serge Lehmann Francesca Trapani Ida Fueglistaler Luigi Maria Terracciano Markus von Flüe Gieri Cathomas Andreas Zettl Pascal Benkert Daniel Oertli Christoph Beglinger | 2014 | World Journal of Gastroenterology2014，20，17： | 6 |
| 2 | Xylem water transport: is the available evidence consistent with the cohesion theory显示文摘 | ZIMMERMANN U MEINZER F C BENKERT R ZHU J J SCHNEIDER H GOLDSTEIN G KUCHENBROD E HAASE A | 1994 | Plant Cell Environ1994，17，： | 1 |
| 3 | An overview of the clinical efficacy of mirtazapine 显示文摘 | Benkert O Muller M Szegedi A | 2002 | Hum Psychophamlacol2002，17，1： | 1 |
| 4 | Long-term xylem pressure measurements in the liana Tetrastigma voinerianum by means of the xylem pressure probe显示文摘 | BENKERT R ZHU J J ZIMMERMANN G TURK R BENTRUP FW ZIMMERMANN U | 1995 | Planta1995，196，： | 1 |
| 5 | An overview of clinical efficacy of mirtazapine显示文摘 | Benkert O Muller M Szegedi A | 2002 | Hum Psychopharmacol2002，17，1： | 1 |
| 6 | Diurnal changes in xylem pressure and meso- phyll cell turgor pressure of the liana Tetrastigma voinierianum: the role of cell turgor in long-distance water transport显示文摘 | THtJRMER F ZHU J J GIERLINGER N SCHNEIDER H BENKERT R GESSNER P HERRMANN B BENTRUP F W ZIMMERMANN U | 1999 | Protoplasma1999，206，： | 1 |
| 7 | Mirtazapine compared with paroxetine in major depression显示文摘 | Benkert O Szegedi A Kohnen R | 2000 | J Clin Psychiatry2000，61，9： | 1 |
| 8 | Long-term xylem pressure measurements in the liana Tetrastigma voinerianum by means of the xylem pressure probe显示文摘 | Benkert R Zhu J J Zimmermann G | | 0，，04： | 1 |
| 9 | Mirtazapine compared with paroxetine in major depression显示文摘 | Benkert O Szegedi A Kohnen R | 2000 | J Clin Psychiatry2000，61，9： | 1 |
| 10 | Mirtazapine compared with paroxetine in major depression 显示文摘 | Benkert O Szegedi A Kohnen R | 2000 | J Clin Psychiatry2000，61，9： | 1 |
| 11 | QMEAN Server for Protein Model Quality Estimation显示文摘 | Benkert P Kuenzli M Schwede T | | 0，，： | 1 |
| 12 | Mirtazapine compared with paroxetine in major depression显示文摘 | BENKERT O SZEGEDI A KOHNEN R | 2000 | J Clin Psychiatry2000，61，9： | 1 |
| 13 | Treatment of complicated pleural fluid collections with image-guided drainage and intracavitary urokinase 显示文摘 | Moulton J Benkert RE Weisiger KH | 1995 | Chest1995，108，5： | 1 |
| 14 | Mirtazapine compared with Paroxetine in major depression显示文摘 | Otto Benkert MD Armin szegedi | 2000 | J Clin Psychiaty2000，61，： | 1 |
| 15 | Electrochemical immunoassays 显示文摘 | Warsinke A Benkert A Scheller FW | 2000 | Fresenius J Anal Chest2000，366，6： | 1 |
| 16 | Amisulpride versus flupentixol in schizophrenia with predominantly positive symptomatology – a double-blind controlled study comparing a selective D2-like antagonist to a mixed D1-/D2-like antagonist显示文摘 | H. Wetzel G. Gründer A. Hillert M. Philipp W. F. Gattaz H. Sauer G. Adler J. Schr?der W. Rein O. Benkert | 1998 | Psychopharmacology1998，，3： | 1 |
| 17 | An overview of the clinical efficacy of mirtazapine 显示文摘 | Benkert O Muller M Szegedi A | 2002 | Hum Psychopharmacol2002，1，： | 1 |
| 18 | mirtazapine Compared with parexetine in major depression显示文摘 | Benkert O Szegedi A Kohnen R | 2000 | J Clin Psychiatry2000，61，： | 1 |
| 19 | Nitrate-responsive NarX-NarL represses arginine-mediated induction of the Pseudomonas aeruginosa arginine fermentation arcDABC operon 显示文摘 | BENKERT B QUACK N SCHREIBER K | 2008 | Microbiology2008，154，10： | 1 |
| 20 | A randomized, double - blind comparison of a rapidly escalating dose of venlafaxine and imipramine in inpatients with major depression and melancholia 显示文摘 | Benkert O Grtinder G Wetzel H | 1996 | J Psychiatr Res1996，30，6： | 1 |
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