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| 1 | Radioembolisation and portal vein embolization before resection of large hepatocellular carcinoma显示文摘Resectability of hepatocellular carcinoma in patients with chronic liver disease is dramatically limited by the need to preserve sufficient remnant liver in order to avoid postoperative liver insufficiency. Preoperative treatments aimed at downsizing the tumor and promoting hypertrophy of the future remnant liver may improve resectability and reduce operative morbidity. Here we report the case of a patient with a large hepatocellular carcinoma arising from chronic liver disease. Preoperative treatment, including tumor downsizing with transarterial radioembolization and induction of future remnant liver hypertrophy with right portal vein embolization, resulted in a 53% reduction in tumor volume and compensatory hypertrophy in the contralateral liver. The patient subsequently underwent extended right hepatectomy with no postoperativesigns of liver decompensation. Pathological examination demonstrated a margin-free resection and major tumor response. This new therapeutic sequence, combining efficient tumor targeting and subsequent portal vein embolization, could improve the feasibility and safety of major liver resection for hepatocellular carcinoma in patients with liver injury. | Fikri Bouazza Arthur Poncelet Camilo Alejandro Garcia Philippe Delatte Jean Luc Engelhom Maria Gomez Galdon Amélie Deleporte Alain Hendlisz Bruno Vanderlinden Patrick Flamen Vincent Donckier | 2015 | World Journal of Gastroenterology2015，21，32： | 2 |
| 2 | A single administration of fish oil inhibits the acute inflammatory response in rats显示文摘Objective: To investigate the antiinflammatory effects of a single administration of fish oil(FO) on the acute inflammatory response. Methods: The paw edema and pleurisy models were used to evaluate the effects of FO dissolved in olive oil(FOP) orally administered in a single dose in rats. Nitric oxide(NO) concentrations in the pleural exudate were performed according to the Griess method and the cytokine concentrations were determined by Luminex bead-based multiplex assay. Results: FOP treatment(30 and 300 mg/kg) significantly reduced paw edema. FOP treatment at 18.75, 37.5, 75.0, 150.0, and 300 mg/kg decreased both the volume of pleural exudate and cellular migration into the pleural cavity and each of these doses presented the same effectiveness. Treatment with FOP(300 mg/kg) reduced NO, TNF-α, IL-1β, and IL-6 concentrations in the pleural exudate. Conclusions: The present data provide evidence that FO has inhibitory effects on the acute inflammatory response when administered in a single dose in rats. This effect might be attributable to a direct inhibitory effect of FO on the production or release of inflammatory mediators that are involved in the pathological processes evaluated herein. | Laura Licia Milani de Arruda Franciele Queiroz Ames Damila Rodrigues de Morais Renata Grespan Ana Paula Maziero Gil Maria Angelica Raffaini Covas Pereira Silva Jesui Vergilio Visentainer Roberto Kenji Nakamura Cuman Ciomar Aparecida Bersani-Amado | 2017 | Asian Pacific Journal of Tropical Medicine2017，10，8： | 2 |
| 3 | Nitrogen uptake in relation to excess supply and its effects on the lichens Evernia prunastri (L.) Ach and Xanthoria parietina (L.) Th. Fr.显示文摘 | Gisela Gaio-Oliveira Lena Dahlman Kristin Palmqvist Maria Amélia Martins-Lou??o Cristina Máguas | 2005 | Planta2005，，5： | 1 |
| 4 | Low-dose Acitretin in Treat- ment of Plaque-type Psoriasis: Descriptive Study of Efficacy and Safety显示文摘 | Borghi A Corazza M Maria AM | 2015 | Aeta Derm Venereo12015，95，2： | 1 |
| 5 | Inhibition of melanoma cells tumorigenecity by the snake venom toxin jararhagin 显示文摘 | Correa MC Jr Maria DA Moura-da-Silva AM | 2002 | Toxicon2002，40，6： | 1 |
| 6 | Clinorotationinduced weightlessness influences the cytoskeleton of glial cells in culture显示文摘 | Bianca MU Maria AM Maddalena S | 2002 | Brain Research2002，934，： | 1 |
| 7 | Impact of obsessive compulsive disorder on quality of life 显示文摘 | Jane LE Maria AM Anthony P | 2006 | Compr Psychiatry2006，47，： | 1 |
| 8 | Inhibition of melanoma cells tumorigenicity by the snske venom toxin jararhagin显示文摘 | CORREA MC Jr MARIA DA MOUKA-DA-SILVA AM | 2002 | Toxicon2002，40，6： | 1 |
| 9 | Antimicrobial Effect Of Melaleuca Alternifolia Dental Gel In Orthodontic Patients显示文摘 | Milton Santamaria Klodyne Dayana Petermann Silvia Amélia Scudeler Vedovello Viviane Degan Adriana Lucato Cristina Maria Franzini | 2013 | American Journal of Orthodontics & Dentofacial Orthopedics2013，，： | 1 |
| 10 | Transvaginal col or dopp ler sonography versus sonohyster ography in the diagno2 sis of endometrial polyps显示文摘 | Juan LA Maria JG Jose AM | 2004 | Ultrasound2004，23，6： | 1 |
| 11 | Parathyroid adenoma associated with thy- morea in a female adult with primary hyperparathyroidism显示文摘 | Maria V Saad AM Ioannis F | 2013 | Interna- tional Journal of Surgery Case Reports2013，4，1： | 1 |
| 12 | How do Mycorrhizas Affect C and N Relationships in Flooded Aster tripolium Plants?显示文摘 | Domingos Neto Luís M. Carvalho Cristina Cruz Maria Amélia Martins-Lou??o | 2006 | Plant and Soil (-)2006，，1： | 1 |
| 13 | Thalidomide treatment down regulates SDF-1 alpha and CXCR4 expression in multiple myeloma patients显示文摘 | Oliveira AM Maria DA Metzger M | | 0，，07： | 1 |
| 14 | CarO, Acinetobacter baumannii outer membrane protein involved in carbapenem resistance, is essential for -ornithine uptake 显示文摘 | Maria AM Veronica MR Adriana SL | 2007 | FEBS Lett2007，581，29： | 1 |
| 15 | High prevalence of thrombophilic genotypes in patients with acute mesenteric vein thrombosis显示文摘 | Lucio Amitrano Vincenzo Brancaccio Maria Anna Guardascione Maurizio Margaglione Luigi Iannaccone Giovanna D’Andrea Paul R.J Ames Riccardo Marmo Sandro Mosca Antonio Balzano | 2001 | The American Journal of Gastroenterology2001，，1： | 1 |
| 16 | p27/kip1 expression in normal epithelium, benign and neoplastic breast lesions显示文摘 | De paola F Maria Vecci AM Granato AM | 2002 | J Pathol2002，196，1： | 1 |
| 17 | Detection of Mycoplasma pneumoniae in adult community - acquired peumonia by PCR and serology 显示文摘 | Maria AM Mauricio R Enna Z | 2008 | J Med Microbiology2008，57，： | 1 |
| 18 | Prenatal diagnosis of a congeni- tal postaxial longitudinal limb defect: A case report显示文摘 | Joana P Maria AM Luis MG | 2010 | Ob- stetrics and Gynecology International2010，，2010： | 1 |
| 19 | Active tuberculosis in inflammatory bowel disease patients under treatment from an endemic area in Latin America显示文摘BACKGROUND There has been an increase in cases of inflammatory bowel disease(IBD)in recent years.There is also greater access and availability of immunosuppressive and biological agents,which increase the risk of opportunistic infection despite improving the quality of life and promoting mucosal healing.Tuberculosis(TB)remains a public health problem,and it has a high incidence in several countries.Therefore,knowledge of the risk of developing TB in patients with IBD is important.AIM To evaluate the risk of active TB in patients with IBD under treatment from an endemic area in Latin America.METHODS A standard questionnaire included demographic variables,clinical aspects of IBD disease,history of active TB during treatment,active TB characteristics and evolution,initial screening and results and time from the start of anti-tumor necrosis factor alpha(TNFα)to TB development.RESULTS Azathioprine,anti-TNFα and the combination of these two drugs were associated with a higher risk of active TB incidence.The TNFα blockers increased the relative risk of developing active TB compared to other treatments.All four multivariable models showed that the use of TNFα blockers alone or in combination with azathioprine was an important risk factor for the incidence of active TB.After adjustment for sex,age,type of IBD and latent TB,anti-TNFα with azathioprine increased the relative risk to 17.8 times more than conventional treatment.Late TB,which was diagnosed 3 mo after the start of anti-TNFα,was the most frequent.CONCLUSION Treatment with anti-TNFα increased the risk of active TB in IBD patients from an endemic area in Latin America.This risk was increased when anti-TNFα was combined with azathioprine.The time from the beginning of the treatment to the active TB diagnosis suggests a new TB infection. | Flora Maria Lorenzo Fortes Ney Boa Sorte Victor D Mariano Laila D Andrade Fernanda A Oliveira Monique CA Santos Claudia Ivanilda N dos Santos Catharina A Passos Mila P Pacheco Valdiana C Surlo Neogelia P de Almeida Jaciane AM Fontes Andrea M Pimentel Raquel Rocha Genoile Oliveira Santana | 2020 | World Journal of Gastroenterology2020，26，44： | 1 |
| 20 | Transvaginal color doppler sonography versus sonohysterography in the diagnosis of endometrial polyps显示文摘 | Juan LA Maria JG Jose AM | 2004 | Ultrasound2004，23，： | 1 |
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