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| 1 | Single nucleotide polymorphism in the tumor necrosis factor-alpha gene affects inflammatory bowel diseases risk显示文摘AIM: To investigate the role that single nucleotide polymorphisms (SNPs) in the promoter of the tumour necrosis factor-alpha (TNF-α) gene play in the risk of inflammatory bowel diseases (IBDs) in a New Zealand population, in the context of international studies. METHODS: DNA samples from 388 patients with Crohn's disease (CD), 405 ulcerative colitis (UC), 27 indeterminate colitis (IC) and 201 randomly selected controls, from Canterbury, New Zealand were screened for 3 common polymorphisms in the TNF-α receptor: -238 G→A, -308 G→A and -857C→T, using a TaqmanR assay. A meta-analysis was performed on the data obtained on these polymorphisms combined with that from other published studies. RESULTS: Individuals carrying the -308 G/A allele had a significantly (OR = 1.91, χ2 = 17.36, P < 0.0001) increased risk of pancolitis, and a 1.57-fold increased risk (OR = 1.57, χ2 = 4.34, P = 0.037) of requiring a bowel resection in UC. Carrying the -857 C/T variant decreased the risk of ileocolonic CD (OR = 0.56, χ2 =4.32, P = 0.037), and the need for a bowel resection (OR = 0.59, χ2 = 4.85, P = 0.028). The risk of UC was reduced in individuals who were smokers at diagnosis, (OR = 0.48, χ2 = 4.86, P = 0.028). CONCLUSION: TNF-α is a key cytokine known to play a role in inflammatory response, and the locus for the gene is found in the IBD3 region on chromosome 6p21, known to be associated with an increased risk for IBD. The -308 G/A SNP in the TNF-α promoter is functional, and may account in part for the increased UC risk associated with the IBD3 genomic region. The -857 C/T SNP may decrease IBD risk in certain groups. Pharmaco- or nutrigenomic approaches may be desir- able for individuals with such affected genotypes. | Lynnette R Ferguson Claudia Huebner Ivonne Petermann Richard B Gearry Murray L Barclay Pieter Demmers Alan McCulloch Dug Yeo Han | 2008 | World Journal of Gastroenterology2008，14，29： | 7 |
| 2 | DNA repair pathwaysas targets for cancer therapy显示文摘 | Helleday T Petermann E Lundin C | 2008 | Nat Rev Cancer2008，8，3： | 1 |
| 3 | Dual-polarization wavelength conversion of 16-QAM signals in a single silicon waveguide with a lateral p-i-n diode[Invited]显示文摘A polarization-diversity loop with a silicon waveguide with a lateral p-i-n diode as a nonlinear medium is used to realize polarization insensitive four-wave mixing. Wavelength conversion of seven dual-polarization 16-quadrature amplitude modulation(QAM) signals at 16 GBd is demonstrated with an optical signal-to-noise ratio penalty below 0.7 dB. High-quality converted signals are generated thanks to the low polarization dependence(≤0.5 dB) and the high conversion efficiency(CE) achievable. The strong Kerr nonlinearity in silicon and the decrease of detrimental free-carrier absorption due to the reverse-biased p-i-n diode are key in ensuring high CE levels. | FRANCESCO DA Ros ANDRZEJ GAJDA ERIK LIEBIG EDSON P.DA SILVA ANNA PECZEK PETER D.GIROUARD ANDREAS MAI KLAUS PETERMANN LARS ZIMMERMANN MICHAEL GALILI LEIF K.OXENLOWE | 2018 | Photonics Research2018，6，5： | 1 |
| 4 | Podocyte that detach in vivo are viable:Novel insights into cell loss显示文摘 | Petermann AT Hiromura K Pippin J | 2002 | J Am Soc Nephrol2002，，： | 1 |
| 5 | Quality of life in women with idiopathic scoliosis 显示文摘 | Freidel K Petermann F Reichel D | 2002 | Spine (Phila Pa 1976)2002，27，4： | 1 |
| 6 | 显示文摘 | Petermann T Piwonkav V Perez F | 1999 | Hum Peprod1999，14，6： | 1 |
| 7 | Statistical detection and analysis of mismatch negativity derived by a multi -deviant design from normal hearing children 显示文摘 | Petermann M Kummer P Burger M | 2009 | Hearing Research2009，247，2： | 1 |
| 8 | Multifunctional composites by high-pressure spray processes显示文摘 | Petermann M Knez Z | 2003 | Current Opinion in Solid State and Materials Science2003，7，45： | 1 |
| 9 | A new method for the preparation of high modulus thermoplastic films显示文摘 | Petermann J Gohil R M | 1979 | J Mater Sci1979，14，9： | 1 |
| 10 | DNA damage is a novel response to sublytic complement C5b-9-induced injury in podocytes 显示文摘 | Pippin JW Durvasula R Petermann A | 2003 | J Clin Invest2003，111，6： | 1 |
| 11 | Mechanical stress reduces podocyte proliferation in vitro 显示文摘 | Petermann AT Hiromura K Blonski M | 2002 | Kidney Int2002，61，1： | 1 |
| 12 | Evalua- tion of paraffin/water emulsion as a phase change slurry for cooling applications显示文摘 | Li Huang Marcus Petermann Christian Doetsch | 2009 | Energy2009，34，： | 1 |
| 13 | Activation of a local tissue angiotensin system in podocytes by mechanical strain显示文摘 | Durvasula RV Petermann AT Hiromura K | 2004 | Kidney Int2004，65，1： | 1 |
| 14 | Semiconductor laser noise in an interferometer system 显示文摘 | Klaus Petermann | 1981 | IEEE Journal of Quantum Electronics1981，17，： | 1 |
| 15 | Hepatitis B virus DNA in sera and liver tissue of HBsAg negative patients with chronic hepatitis C显示文摘 | Kazemi-Shirazi L Petermann D Muller C | 2000 | J Hepatol2000，33，5： | 1 |
| 16 | A compa rative study of levofloxacin and ceftriaxonc in the treat ment of hospitalized patients with pneumonia显示文摘 | Norrby SR Petermann W Willcox PA | 1998 | Scand J Infect Dis1998，30，4： | 1 |
| 17 | Somatoform disorders:30 years of debate about criteria! What about children and adolescents?显示文摘 | Schulte IE Petermann F | 2011 | J Psychosom Res2011，70，3： | 1 |
| 18 | Characterization and evaluation of hydrophobically modified chitosan scaffolds: Towards design of enzyme immobilized flow-through electrodes 显示文摘 | Cooney MJ Petermann J | 2009 | Carbohydr Polym2009，75，3： | 1 |
| 19 | Estimation of General Intelligence in Neurological Settings by a Short Form of the WAIS-IV显示文摘 | M. Daseking F. Petermann H.-C. Waldmann | 2014 | Akt Neurol2014，，06： | 1 |
| 20 | Urinary podocyte loss is a more specific marker of ongoing glomerular damage than proteinuria 显示文摘 | Yu D Petermann A Kunter U | 2005 | J Am Soc Nephrol2005，16，4： | 1 |
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