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| 1 | Bone alterations in inflammatory bowel diseases显示文摘Inflammatory bowel diseases(IBDs)are characterized by a multifactorial partially unknown etiology that involves genetic,immunological and environmental factors.Up to 50%of IBD patients experience at least one extraintestinal manifestation;among them is the involvement of bone density which is referred to as metabolic bone disease(MBD),including osteopenia and osteoporosis.Bone alterations in IBDs population appear to have a multifactorial etiology:Decreased physical activity,inflammation-related bone resorption,multiple intestinal resections,dietary malabsorption of minerals and vitamin D deficiency,genetic factors,gut-bone immune signaling interaction,steroid treatment,microbiota and pathogenic micro-organisms interaction,and dietary malabsorption of minerals,that,all together or individually,may contribute to the alteration of bone mineral density.This review aims to summarize the prevalence and pathophysiology of metabolic bone alterations in IBD subjects outlining the main risk factors of bone fragility.We also want to underline the role of the screening and prophylaxis of bone alterations in Crohn’s disease and ulcerative colitis patients and the importance of treating appropriately MBD. | Dolores Sgambato Francesca Gimigliano Cristiana De Musis Antimo Moretti Giuseppe Toro Emanuele Ferrante Agnese Miranda Domenico De Mauro Lorenzo Romano Giovanni Iolascon Marco Romano | 2019 | World Journal of Clinical Cases2019，7，15： | 8 |
| 2 | European evidence based consensus for endoscopy in inflammatory bowel disease显示文摘 | Vito Annese Marco Daperno Matthew D. Rutter Aurelien Amiot Peter Bossuyt James East Marc Ferrante Martin G?tz Konstantinos H. Katsanos Ralf Kie?lich Ingrid Ordás Alessandro Repici Bruno Rosa Shaji Sebastian Torsten Kucharzik Rami Eliakim | 2013 | Journal of Crohn’s and Colitis2013，，12： | 7 |
| 3 | A review of the sentinel prey method as a way of quantifying invertebrate predation under field conditions显示文摘哨兵猎物能在地条件下面提供 predation 的一项直接、量的措施。实时哨兵猎物提供更现实主义的数据,但是很少允许划分全部的 predation 压力;人工的猎物是不太自然的,但是不同食肉动物离开的踪迹是可看作是相同的,为比较研究使它合适。我们考察了无脊椎的哨兵猎物的两种类型的使用的可得到的证据。57 份报纸使用了真实猎物,通常测量 predation 在上一焦点(经常害虫) 种类,与从北美洲压倒性地学习。中部的 predation 是 25.8% d 1 。人工的哨兵猎物(45 份报纸) 在适度、热带的区域被使用,比在地面把更多放在地面上面水平。最通常使用的人工的猎物模仿了一条毛虫。多达 14 个食肉动物组被识别,登记一 8.8% d 1 predation 中部;半研究报导了仅仅鸟 predation。真实猎物上的 Predation 比在人工的,而是无脊椎动物上 predation 不比脊椎动物 predation 高的高。Invertertebrate 然而并非脊椎动物 predation 是否定地与猎物尺寸有关。赤道附近的 Predation 不比的高在更高的纬度,也不在比 noncultivated 栽培了产地。哨兵猎物的使用是还没 standardised 以猎物尺寸,安排,暴露时期或数据报导。由于方法的简洁和容易使用,如此的标准化可以增加比较研究的实用性,贡献重要性的理解和在世界范围的各种各样的产地的 predation 的水平。 | Gabor L. Lovei Marco Ferrante | 2017 | Insect Science2017，24，4： | 3 |
| 4 | Obesity Activates a Program of Lysosomal-Dependent Lipid Metabolism in Adipose Tissue Macrophages Independently of Classic Activation显示文摘 | Xiaoyuan Xu Ambar Grijalva Alicja Skowronski Marco van Eijk Mireille J. Serlie Anthony W. Ferrante | 2013 | Cell Metabolism2013，，6： | 1 |
| 5 | Pipe system diagnosis and leak detection by unsteady-state tests显示文摘 | Marco Ferrante Bruno Brunone | 2003 | Advances in Water Resources2003，26，1： | 1 |
| 6 | Coronary atherosclerotic burden in patients with infection by CagA-positive strains of Helicobacter pylori显示文摘 | Giampaolo Niccoli Francesco Franceschi Nicola Cosentino Bianca Giupponi Guido De Marco Giuseppe Merra Micaela Conte Rocco Antonio Montone Giuseppe Ferrante Marco Bacà Antonio Gasbarrini Nicolò Gentiloni Silveri Filippo Crea | 2010 | Coronary Artery Disease2010，，4： | 1 |
| 7 | Benefits and risks of long-term duration of dual antiplatelet therapy after drug-eluting stenting: A meta-analysis of randomized trials显示文摘 | Marco Valgimigli Seung-Jung Park Hyo-Soo Kim Kyung Woo Park Duk-Woo Park Pierluigi Tricoci Giuseppe Ferrante | 2013 | International Journal of Cardiology2013，，： | 1 |
| 8 | Can the growing of transgenic maize threaten protected Lepidoptera in Europe?显示文摘We evaluated whether protected European butterflies can potentially be at risk if transgenic maize is extensively grown in Central Europe.We explored potential consequences of both insect resistant(IR)and herbicide resistant(HR)transgenic maize.IR maize can produce pollen that is toxic to lepidopteran larvae,and this puts butterfly species at possible risk if the presence of young larvae coincides with maize flowering,during which large quantities of maize pollen can be deposited on vegetation.By considering the timing of maize flowering in Europe and the phenology of the protected Lepidoptera species,we found that 31 species had at least one generation where 50%of the larval stage overlapped with maize flowering,and 69 species for which first instar larvae were present during maize pollen shedding.HR maize allows high concentration herbicide treatments on fields without seasonal limitation,which can drastically reduce weed densities.In cases where such weed species are host plants for protected butterflies,reduced host plant/food availability can result,causing population decreases.By using published information,we first identified the important weed species in major maize-growing European countries.Subsequently,we checked whether the host plants of protected Lepidoptera included species that are common maize weeds.We identified 140 protected species having food plants that are common weeds in one or more of the major European maize-growing countries.If HR maize is grown in Europe,there is a potential hazard that their food plants will seriously decline,causing a subsequent decline of these protected species. | Gábor L.Lövei Andreas Lang Marco Ferrante Victor Bacle | 2021 | Insect Science2021，28，4： | 0 |
| 9 | Impact of severe left ventricular dysfunction on mid-term mortality in elderly patients undergoing transcatheter aortic valve implantation显示文摘有减少的左室的功能的 BackgroundWhether 病人在大动脉的阀门培植(TAVI ) 是的 transcatheter 以后介绍更坏的结果争论。这研究的目的是估计基线的影响严重的在有大动脉的狭窄的 TAVI.MethodsSix-hundred-forty-nine 病人后面的死亡上的左室的喷射部分(LVEF ) 的缺陷与 CoreValve 系统(92.8%) 或爱德华兹智慧阀门系统(7.2%) 经历了 TAVI。基线 LVEF 被 echocardiographic Simpson 方法测量。LVEF ≤ 的影响;30% 被考克斯 regression.ResultsPatients 与 LVEF ≤ 在死亡上估计;30%(n = 63 ) ,作为与那些相比与 LVEF >30%(n = 586 ) ,有 NHYA 班 > 的更高的流行;2 (P <0.001 ) 并且与更高的 Euroscore 介绍了(P <0.001 ) 。程序的成功在两个组是类似的(98.4% 对 97.2% , P = 1 ) 。在 436 天的中部的后续以后(25 th -75 th 百分位数, 357-737 天) ,所有原因死亡[23.8% 对 23.7% , P = 0.87,危险比率(HR ) :0.96, 95% 信心间隔(CI ) :0.56-1.63 ] 并且心脏的死亡(19.1% 对 17.6% , P = 0.89, HR:1.04, 95% CI:0.57-1.90 ) 在有 LVEF ≤ 的病人是类似的;30% 作为与那些相比与 LVEF >30% 。三十天的所有原因死亡不在二个组之间是显著地不同的(11.1% 对 6.3% , P = 0.14, HR:1.81, 95% CI:0.81-4.06 ) 。有 LVEF ≤ 的病人;30% 向 30 天的心脏的死亡的更高的风险有一个趋势(11.1% 对 5.3% ;P = 0.06, HR:2.16, 95% CI:0.95-4.90 ) ,它消失在 multivariable 调整以后(P = 0.22 ).ConclusionsBaseline LVEF 的严重缺陷不是一个预言者在 TAVI 以后增加了短期、中间的死亡。有左室的功能的严重缺陷的选择病人不应该被拒绝 TAVI。 | Giuseppe Ferrante Patrizia Presbitero Paolo Pagnotta Anna Sonia Petronio Nedy Brambilla Federico De Marco Claudia Fiorina Cristina Giannini Fabrizio D'Ascenzo Silvio Klugmann Marco L Rossi Federica Ettori Francesco Bedogni Luca Testa | 2016 | Journal of Geriatric Cardiology2016，13，4： | 0 |
| 10 | Predation pressure in maize across Europe and in Argentina: an intercontinental comparison显示文摘Humankind draws important benefits from large-scale ecological processes termed ecosystem services, yet the status of several of them is declining. Reliable monitoring methods are essential for tracking the status of ecosystem services. Predation is the mainstay of natural pest control, a key ecosystem service. We used green plasticine caterpillars to monitor predation pressure, and to obtain baseline data on predator activity in transgenic Bt versus non-Bt maize fields in Old and New World countries. Predation pressure was measured at ground and canopy levels using an identical, small-plot experimental design in four European countries (Denmark, Slovakia, Romania and Italy) and Argentina. Total predation rate in maize was l l.7%d^-1 (min. 7.2%d^-1 in Argentina, max. 29.0%d^-1 in Romania). Artificial caterpillars were attacked both by invertebrates (mostly chewing insects with 42.0% of the attack marks, and ants with 7.1%, but also predatory and parasitoid wasps, spiders and slugs), and vertebrates (small mammals 25.5%, and birds 20.2%). Total predation at ground level (15.7%d^-1) was significantly higher than in maize canopies (6.0%d^-1) in all countries, except Argentina. We found no significant differences between predator pressure in Bt versus non-Bt maize plots. The artificial caterpillar method provided comparable, quantitative data on predation intensity, and proved to be suitable for monitoring natural pest control. This method usefully expands the existing toolkit by directly measuring ecological function rather than structure. | Marco Ferrante Gabor L. Lovei Serena Magagnoli Lenka Minarcikova Elena Larisa Tomescu Giovanni Burgio Ludovit Cagan Mihael Cristin Ichim | 2019 | Insect Science2019，26，3： | 0 |
| 11 | Aggregation properties of a therapeutic peptide for rheumatoid arthritis:A spectroscopic and molecular dynamics study显示文摘The biological properties of therapeutic peptides,such as their pharmacokinetics and pharmacodynamics,are correlated with their structure and aggregation properties.Herein,we studied the aggregation properties of a therapeutic peptide(CIGB-814),currently in phase 2 clinical trial,for the treatment of rheumatoid arthritis over a wide range of concentrations(μM-mM).We applied spectroscopic techniques(fluorescence,circular dichro-ism,resonance,and dynamic light scattering),atomic force microscopy,and molecular dynamics simulations to determine the aggregation mechanism of CIGB-814.We found that the hierarchical aggregation of CIGB-814 at micromolar concentrations was initiated by the formation of peptide oligomers.Subsequently,the peptide oligomers trigger the nucleation and growth of peptide nanostructures(cac=123μM),ultimately leading to the fibrillization of CIGB-814(cac’=508μM).These results pave the way for a deeper understanding of the CIGB-814 therapeutic activity and may give important insights on its pharmacokinetics. | Rita Cimino Marco Savioli Noemi Ferrante Carrante Ernesto Placidi Hilda Garay-Perez Matilde López-Abad Alexis Musacchio Lasa Maria Del Carmen Domínguez-Horta Emanuela Gatto Francesca Cavalieri Gianfranco Bocchinfuso Mariano Venanzi | 2022 | ChemPhysMater2022，1，1： | 0 |
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