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您的检索式：作者名="Francesca Cavalieri"
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| 1 | Assembly and Functionalization of DNA-Polymcr Microcapsulcs 显示文摘 | Francesca Cavalieri Almar Postma Lillian Lee | 2009 | ACS Nano2009，3，1： | 1 |
| 2 | A physico-chemical study on the polysaccharide ulvan from hot water extraction of the macroalga Ulva 显示文摘 | Gaio Paradossi Francesca Cavalieri Laura Pizzoferrato | 1999 | Biological Macromolecules1999，25，： | 1 |
| 3 | Aggregation properties of a therapeutic peptide for rheumatoid arthritis:A spectroscopic and molecular dynamics study显示文摘The biological properties of therapeutic peptides,such as their pharmacokinetics and pharmacodynamics,are correlated with their structure and aggregation properties.Herein,we studied the aggregation properties of a therapeutic peptide(CIGB-814),currently in phase 2 clinical trial,for the treatment of rheumatoid arthritis over a wide range of concentrations(μM-mM).We applied spectroscopic techniques(fluorescence,circular dichro-ism,resonance,and dynamic light scattering),atomic force microscopy,and molecular dynamics simulations to determine the aggregation mechanism of CIGB-814.We found that the hierarchical aggregation of CIGB-814 at micromolar concentrations was initiated by the formation of peptide oligomers.Subsequently,the peptide oligomers trigger the nucleation and growth of peptide nanostructures(cac=123μM),ultimately leading to the fibrillization of CIGB-814(cac’=508μM).These results pave the way for a deeper understanding of the CIGB-814 therapeutic activity and may give important insights on its pharmacokinetics. | Rita Cimino Marco Savioli Noemi Ferrante Carrante Ernesto Placidi Hilda Garay-Perez Matilde López-Abad Alexis Musacchio Lasa Maria Del Carmen Domínguez-Horta Emanuela Gatto Francesca Cavalieri Gianfranco Bocchinfuso Mariano Venanzi | 2022 | ChemPhysMater2022，1，1： | 0 |
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