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| 1 | CapOX as neoadjuvant chemotherapy for locally advanced operable colon cancer patients: a prospective single-arm phase Ⅱ trial显示文摘Objective: The aim of this prospective, single-arm phase II trial was to confirm the safety and efficacy of neoadjuvant chemotherapy(NAC) using oxaliplatin plus capecitabine(Cap OX) for patients with operable locally advanced colon cancer(CC).Methods: Patients with computed tomography-defined T4 or lymph node-positive CCs were enrolled. After radiological staging, patients were treated with at least 2 cycles of NAC consisting of 130 mg/m2 oxaliplatin on d 1,plus 1,000 mg/m2 capecitabine twice daily for 14 d every 3 weeks, followed by surgery, and then with the rest cycles of adjuvant chemotherapy. Radiological response was evaluated after 2 cycles of NAC. Tumor response, treatment toxicity, and surgical complications were recorded. The pathological response to therapy was evaluated according to the tumor regression grade(TRG) score. The primary endpoint was pathologic tumor response. This trial is registered in Clinical Trials.gov(No: NCT02415829).Results: Forty-seven patients were enrolled in the study. Forty-two patients completed the planned treatments.The total radiological response rate was 68%(32/47), including complete and partial response rates of 2%(1/47)and 66%(31/47), respectively. Stable disease was observed in 32%(15/47) and progressive disease was observed in none. Complete pathologic response, major regression, and at least moderate regression were achieved in 1(2%), 2(4%), and 29(62%) patients, respectively. Four patients developed grade 3 treatment toxicities. One patient with wound infection occurred after operation(1/47, 2%). There was no treatment-related death.Conclusions: Our results suggest that NAC with Cap OX is an effective and safe treatment option for patients with locally advanced CCs. | Fangqi Liu Li Yang Yuchen Wu Cong Li Jiang Zhao Adili Keranmu Hongtu Zheng Dan Huang Lei Wang Tong Tong Junyan Xu Ji Zhu Sanjun Cai Ye Xu | 2016 | Chinese Journal of Cancer Research2016，28，6： | 14 |
| 2 | Measuring the thermal conductivity and interfacial thermal resistance of suspended MoS2 using electron beam self-heating technique显示文摘Establishment of a new technique or extension of an existing technique for thermal and thermoelectric measurements to a more challenging system is an important task to explore the thermal and thermoelectric properties of various materials and systems. The bottleneck lies in the challenges in measuring the thermal contact resistance. In this work, we applied electron beam self-heating technique to derive the intrinsic thermal conductivity of suspended Molybdenum Disulfide(MoS_2) ribbons and the thermal contact resistance, with which the interfacial thermal resistance between few-layer MoS_2 and Pt electrodes was calculated. The measured room temperature thermal conductivity of MoS_2 is around ~30 W/(m K),while the estimated interfacial thermal resistance is around ~2 × 10^(-6)m^2 K/W. Our experiments extend a useful branch in application of this technique for studying thermal properties of suspended layered ribbons and have potential application in investigating the interfacial thermal resistance of different twodimensional(2 D) heterojunctions. | Adili Aiyiti Xue Bai Jing Wu Xiangfan Xu Baowen Li | 2018 | Science Bulletin2018，63，7： | 3 |
| 3 | MicroRNAs and JAK/STAT3 signaling:A new promising therapeutic axis in blood cancers显示文摘Blood disorders include a wide spectrum of blood-associated malignancies resulting from inherited or acquired defects.The ineffectiveness of existing therapies against blood disorders arises from different reasons,one of which is drug resistance,so different types of leukemia may show different responses to treatment.Leukemia occurs for a variety of genetic and acquired reasons,leading to uncontrolled proliferation in one or more cell lines.Regarding the genetic defects,oncogene signal transducer and activator of transcription(STAT)family transcription factor,especially STAT3,play an essential role in hematological disorders onset and progress upon mutations,dysfunction,or hyperactivity.Besides,microRNAs,as biological molecules,has been shown to play a dual role in either tumorigenesis and tumor suppression in various cancers.Besides,a strong association between STAT3 and miRNA has been reported.For example,miRNAs can regulate STAT3 via targeting its upstream mediators such as IL6,IL9,and JAKs or directly binding to the STAT3 gene.On the other hand,STAT3 can regulate miRNAs.In this review study,we aimed to determine the role of either microRNAs and STAT3 along with their effect on one another's activity and function in hematological malignancies. | Mehdi Sajjadi-Dokht Talar Ahmad Merza Mohamad Heshu Sulaiman Rahman Marwah Suliman Maashi Svetlana Danshina Navid Shomali Saeed Solali Faroogh Marofi Elham Zeinalzadeh Morteza Akbari Ali Adili Ramin Aslaminabad Majid Farshdousti Hagh Mostafa Jarahian | 2022 | Genes & Diseases2022，9，4： | 2 |
| 4 | Strength of soil reinforced with fiber materials (Papyrus)显示文摘 | Aqeel Adili Rafig Azzam Giovanni Spagnoli Joerg Schrader | 2012 | Soil Mechanics and Foundation Engineering2012，，6： | 2 |
| 5 | Single uucleotide polym orphisms in the proximal promoter region of the adiponectin gene are associated with type 2diabetes in Swedish Caucasians显示文摘 | Harvest FG Adili A Claes GO | 2004 | Diabetes2004，53，： | 1 |
| 6 | Femoral head resurfacing for the treatment of osteonecrosis in the young patients 显示文摘 | Adili A Trousdale RT | 2003 | Clin Orthop Relat Res2003，417，12： | 1 |
| 7 | Sequential bilateraltotal knee arthroplasty under 1 anesthetic in patients > or = 75years old : complications and functional outcomes 显示文摘 | Adili A Bhandari M Petruccelli D | 2001 | JArthroplasty2001，16，： | 1 |
| 8 | High and low pressure pulsatile lavage of contaminated tibial fractures:an in vitro study of bacterial adherence and bone damage显示文摘 | Bhandari M Schemitsch EH Adili A | 1999 | J Orthop Trauma1999，13，： | 1 |
| 9 | Femoral head resurfacing for the treatment of osteonecrosis in the young patient显示文摘 | Adili A Trousdale RT | 2003 | Clin Orthop Relat Res2003，41，7： | 1 |
| 10 | Single nucleotide polymorphisms in the proximal promoter region of the adiponectin gene are associated with type 2 diabetes in Swedish Caucasians显示文摘 | Harvest FG Adili A Claes GO | 2004 | Diabetes2004，53，： | 1 |
| 11 | Strength Of Soil Reinforced With Fiber Materilas (PAPYRUS)显示文摘 | Aqeel Al Adili Rafig Azzam Giovanni Spagnoli Joerg Schrader | 2012 | Soil Mechanics and Foundation Engineering2012，48，： | 1 |
| 12 | The biomechanical effect of high-pressure irrigation on diaphyseal fracture healing in vivo显示文摘 | Adili A Bhandari M Schemitsch EH | 2002 | J Orthop Trauma2002，16，6： | 1 |
| 13 | Predictors of early and late instability following conservative treatment of extra artic ular distal radius fractures显示文摘 | LEONE J BHANDARI M ADILI A | 2004 | Arch Orthop Trauma Surg2004，124，： | 1 |
| 14 | High and low pressure pulsatile lavage of contaminated tibial fractures: an in vitro study of bacterial adherence and bone damage显示文摘 | Bhandari M Schemitsch EH Adili A | | J Orthop Trauma0，13，8： | 1 |
| 15 | Sequential bilateral total knee arthroplasty undaer 1 anesthetic in patients > or =75 years old :complications and functional outcomes 显示文摘 | Adili A Bhandari M Petruccelli D | 2001 | J Arthmplasty2001，16，3： | 1 |
| 16 | The biomechanical effect of high-pressure irrigation on diaphyseal fracture healing in vivo显示文摘 | Adili A Bhandari M Schemitsch EH | 2002 | J Orthop Trauma2002，16，6： | 1 |
| 17 | Sequential bilateral total knee arthroplasty under lanesthetic in patients≥75 years old:complications and functional outcomes显示文摘 | Adili A Bhandari M Petruccelli D | | 0，，03： | 1 |
| 18 | Predictors of early and late instability following conservative treatment of extra articular distal radius fractures显示文摘 | Leone J Bhandari M Adili A | 2004 | Arch Orthop Trauma Surg2004，124，1： | 1 |
| 19 | Predictors of early and late instabili- ty following conservative treatment of extra-articular distal radius frac- tures显示文摘 | Leone J Bhandari M Adili A | 2004 | Arch Orthop Trauma Surg2004，124，1： | 1 |
| 20 | Transactivation of lifeguard(LFG)by Akt-/LEF-1pathway in MCF-7and MDA-MB 231human breast cancer cells显示文摘 | Bucan V Adili MY Choi CY | 2010 | Apoptosis2010，15，7： | 1 |
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