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| 1 | Potential applications of lactic acid bacteria and bacteriocins in antimycobacterial therapy显示文摘Tuberculosis(TB) is a communicable disease caused by Mycobacterium tuberculosis(M. tuberculosis). WHO estimated that 10.4 million new(incident) TB cases worldwide in year 2016. The increased prevalence of drug resistant strains and side effects associated with the current anti-tubercular drugs make the treatment options more complicated. Hence, there are necessities to identify new drug candidates to fight against various sub-populations of M. tuberculosis with less or no toxicity/side effects and shorter treatment duration. Bacteriocins produced by lactic acid bacteria(LAB) attract attention of researchers because of its 'Generally recognized as safe' status. LAB and its bacteriocins possess an effective antimicrobial activity against various bacteria and fungi. Interestingly bacteriocins such as nisin and lacticin 3147 have shown antimycobacterial activity in vitro. As probiotics, LAB plays a vital role in promoting various health benefits including ability to modulate immune response against various infectious diseases. LAB and its metabolic products activate immune system and thereby limiting the M. tuberculosis pathogenesis. The protein and peptide engineering techniques paved the ways to obtain hybrid bacteriocin derivatives from the known peptide sequence of existing bacteriocin. In this review, we focus on the antimycobacterial property and immunomodulatory role of LAB and its metabolic products. Techniques for large scale synthesis of potential bacteriocin with multifunctional activity and enhanced stability are also discussed. | Anbarasu Sivaraj Revathy Sundar Radhakrishnan Manikkam Krupakar Parthasarathy Uma Rani Vanaja Kumar | 2018 | Asian Pacific Journal of Tropical Medicine2018，11，8： | 2 |
| 2 | Androgen receptor mRNA expression in the bovine ovary显示文摘 | Hampton J H Manikkam M Lubahn D B | 2004 | Domestic Animal Endoerinol2004，27，1： | 1 |
| 3 | Transforming growth factor β signaling,vascular remodeling,and hypertension显示文摘 | Phyllis A Manikkam S | 2006 | N Engl J Med2006，354，25： | 1 |
| 4 | Developmental programming:follicular persistence in prenatal testosterone - treated sheep is not programmed by androgenic actions of testosterone 显示文摘 | Steckler T Manikkam M Inskeep EK Padmanabhan V | 2007 | Endocrinology2007，148，： | 1 |
| 5 | Cytotoxic Impact of costunolide isolated from Costus speciosus on breast cancer via differential regulation of cell cycle-an in-vitro and in-silico approach 显示文摘 | Roy A Manikkam R | 2015 | Phytother Res2015，29，10： | 1 |
| 6 | Fetal programming: prenatal testosterone excess leads to fetal growth retardation and postnatal catch-up growth in sheep显示文摘 | Manikkam MvCrespi EJ Doop DD | 2004 | Endocrinology2004，145，2： | 1 |
| 7 | Transgenerational actions of environmental compounds on reproductive disease and identi- fication of epigenetic biomarkers of ancestral exposures 显示文摘 | Manikkam M Guerrero-Bosagna C Tracey R | 2012 | PLOS One2012，7，31： | 1 |
| 8 | Angiogenic Factors in Superimposed Preeclampsia: A Longitudinal Study of Women With Chronic Hypertension During Pregnancy显示文摘 | Uma Perni Cristina Sison Vijay Sharma Geri Helseth Amret Hawfield Manikkam Suthanthiran Phyllis August | 2012 | Hypertension2012，，3： | 1 |
| 9 | Transgenerational actions of environmental compounds on repro-duc- five disease and identification of epigenetic biomarkers of an-cestral exposures 显示文摘 | MANIKKAM M GUERRERO-BOSAGNA C TRACEY R | 2012 | PLOS One2012，7，31： | 1 |
| 10 | Mean Arterial Blood Pressure While Awaiting Kidney Transplantation Is Associated With the Risk of Primary Nonfunction显示文摘 | Allison Webber Judith Hambleton Ashtar Chami Heejung Bang Surya Seshan Aarti Sharma Phyllis August Sandip Kapur Manikkam Suthanthiran Darshana Dadhania | 2012 | Transplantation2012，，1： | 1 |
| 11 | Fetal programming : excess prenatal testosterone reduces postnatal L H, but not FSH responsiveness to estradiol negative feedback in the female 显示文摘 | Sarma H N Manikkam M Herkimer C | 2005 | Endocrinology2005，146，10： | 1 |
| 12 | Fetal programming: Excess prenatal testosterone reduces postnatal luteinizing hormone, but not follicle-stimulating hormone responsiveness, to estradiol negative feedback in the female 显示文摘 | Sarma H N Manikkam M Herkimer C | 2005 | Endocrinol2005，146，： | 1 |
| 13 | Fetal pro- gramming: excess prenatal testosterone reduces postnatal luteinizing hormone, but not follicle-stimulating hormone responsiveness, to estradiol negative feedback in the fe- male 显示文摘 | Sarma HN Manikkam M Herkimer C | 2005 | Endocrinology2005，146，10： | 1 |
| 14 | Transgenerational actions of environmental compounds on reproductive disease and identification of epigenetic biomarkers of ancestral exposures显示文摘 | Manikkam M Guerrero-Bosagna C Tracey R | 2012 | PLoS One2012，7，31： | 1 |
| 15 | Dioxin (TC- DD) induces epigenetic transgenerational inheritance of adult on- set disease and sperm epimutations显示文摘 | Manikkam M Tracey R Guerrero-Bosagna C | 2012 | PLoS One2012，7，46： | 1 |
| 16 | Polyomavirus-Associated Nephropathy in Renal Transplantation: Interdisciplinary Analyses and Recommendations显示文摘 | Hans H. Hirsch Daniel C. Brennan Cinthia B. Drachenberg Fabrizio Ginevri Jennifer Gordon Ajit P. Limaye Michael J. Mihatsch Volker Nickeleit Emilio Ramos Parmjeet Randhawa Ron Shapiro Juerg Steiger Manikkam Suthanthiran Jennifer Trofe | 2005 | Transplantation2005，，10： | 1 |
| 17 | Transgenerational actions of environmental :ompounds on reproductive disease and identification of epigenetic biomarkers of ancestral exposures显示文摘 | Manikkam M Guerrero-Bosagna C Tracey R Haque MM Skinner MK | 2012 | PLoS One2012，7，2： | 1 |
| 18 | Preliminary screening for antibacterial and antimycobacterial activity of actinomycetes from less explored ecosystems显示文摘 | Manikkam Radhakrishnan S. Suganya Ramasamy Balagurunathan Vanaja Kumar | 2010 | World Journal of Microbiology and Biotechnology2010，，3： | 1 |
| 19 | Fetal programming:prenatal testosterone treatment leads to follicular persistence/luteal defects;partial restoration of ovarian function by cyclic progesterone treatment显示文摘 | Manikkam M Steckler TL Welch KB | 2006 | Endocrinology2006，147，4： | 1 |
| 20 | Fetal programming:excess prenatal testosterone reduces postnatal LH,but not FSH responsiveness to estradiol negative feedback in the female显示文摘 | Sarma HN Manikkam M Herkimer C | 2005 | Endocrinology2005，146，10： | 1 |
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