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| 1 | Characterization and functions of beta defensins in the epididymis显示文摘附睾β - defensins 由重复基因复制和分叉演变编码对病原体提供直接保护并且也在它的主要功能支持男繁殖的道的蛋白质的一个家庭。男道 defensins 也从病原体攻击便于恢复。β - defensins 拥有古老的保存顺序和在多细胞的有机体普遍的结构的特征,在种幸存建议基本角色。首领 SPAG11,二祖先地独立的β - defensin 基因的功能的熔化,生产根据 tissue-specificand 被表示的或者拼接的抄本的一个大家庭种类特定的限制。SPAG11 的复杂性在哺乳动物的进化的不同分支变化。有主人蛋白质的人的 SPAG11D 的相互作用在多重发信号的小径显示参与。 | Susan H. Hall Suresh Yenugu Yashwanth Radhakrishnan Maria Christina W. Avellar Peter Petrusz Frank S. French | 2007 | Asian Journal of Andrology2007，9，4： | 18 |
| 2 | Verification on Spray Simulation of a Pintle Injector for Liquid Rocket Engine显示文摘The pintle injector used for a liquid rocket engine is a newly re-attracted injection system famous for its wide throttle ability with high efficiency. The pintle injector has many variations with complex inner structures due to its moving parts. In order to study the rotating flow near the injector tip, which was observed from the cold flow experiment using water and air, a numerical simulation was adopted and a verification of the numerical model was later conducted. For the verification process, three types of experimental data including velocity distributions of gas flows, spray angles and liquid distribution were all compared using simulated results. The numerical simulation was performed using a commercial simulation program with the Eulerian multiphase model and axisymmetric two dimensional grids. The maximum and minimum velocities of gas were within the acceptable range of agreement, however, the spray angles experienced up to 25% error when the momentum ratios were increased. The spray density distributions were quantitatively measured and had good agreement. As a result of this study, it was concluded that the simulation method was properly constructed to study specific flow characteristics of the pintle injector despite having the limitations of two dimensional and coarse grids. | Min Son Kijeong Yu Kanmaniraja Radhakrishnan Bongchul Shin Jaye Koo | 2016 | Journal of Thermal Science2016，25，1： | 16 |
| 3 | Lipoprotein(a) in type 2 diabetic subjects and its relationship to diabetic microvascular complications显示文摘AIM: To estimate the level of serum lipoprotein (a) [Lp (a)] in type 2 diabetes mellitus patients and to determine the relationship between Lp(a) in type 2 diabetes mellitus patients and micro-vascular complications. METHODS: A cross sectional study was performed that enrolled 144 subjects with type 2 diabetes mellitus above the age of 25 years attending outpatient clinic of Government Medical College, Kozhikode. Lp(a) levels were measured quantitatively in venous samples using Turbidimetric Immunoassay in all subjects. Each patient was evaluated for micro vascular complications, namely diabetic retinopathy, nephropathy and neuropathy. The relationship between Lp(a) levels and the micro vascular complications was assessed by univariate analysis. RESULTS: Mean age of cases was 53.93 ± 10.74 years with a male to female ratio of 1.3:1. Mean duration of diabetes was 9.53 ± 7.3 years. Abnormal Lp(a) levels (≥ 30 mg/dL) were observed in 38 (26.4%) diabetic subjects. Seventy-eight (54.16%) cases had diabetic nephropathy and significantly higher Lp(a) levels were found among these cases [Median 28.2 mg/dL (Interquartile range; IQR 24.4-33.5) vs 19.3 mg/dL (IQR 14.7-23.5); P < 0.05]. Retinopathy was present among 66 (45.13%) cases and peripheral neuropathy was detected among 54 (37.5%) cases. However, Lp(a) levels were not significantly different among those with or without retinopathy and neuropathy. Positive correlation was found between higher Lp(a) levels and duration of diabetes (r = 0.165, P < 0.05) but not with HbA1c values (r = - 0.083). CONCLUSION: Abnormal Lp(a) levels were found among 26.4% of diabetic subjects. Patients with diabetic nephropathy had higher Lp(a) levels. No association was found between Lp(a) levels and diabetic retinopathy or neuropathy. Longer duration of diabetes correlated with higher Lp(a) levels. | Radhakrishnan Chandni Kollengode Parameswaran Ramamoorthy | 2012 | World Journal of Diabetes2012，3，5： | 13 |
| 4 | Endoscopic mucosal resection of colorectal polyps in typical UK hospitals显示文摘AIM:To evaluate the outcomes of endoscopic mucosal resection(EMR) for colorectal polyps,with particular regard to procedural complications and recurrence rate,in typical United Kingdom(UK) hospitals that perform an average of about 25 colonic EMRs per year.METHODS:A total of 239 colorectal polyps(≥ 10 mm) resected from 199 patients referred to Rochdale Infirmary,Salford Royal Hospital and Royal Oldham Hospital for EMR between January 2003 and January 2009 were studied.RESULTS:The mean size of polyps resected was 19.6 ± 12.4 mm(range 10-80 mm).The overall major complication rate was 2.1%.Complications were less frequent with non-adenomas compared with the other groups(Pearson's χ 2 test,P < 0.0001).Resections of largersized polyps were more likely to result in complications(unpaired t-test,P = 0.021).Recurrence was associated with histology,with carcinoma-in-situ more likely to recur compared with low-grade dysplasia [hazard ratio(HR) 186.7,95% confidence interval(95% CI):8.81-3953.02,P = 0.001].Distal lesions were also more likely to recur compared with right-sided and transverse colon lesions(HR 5.93,95% CI:1.35-26.18,P = 0.019).CONCLUSION:EMR for colorectal polyps can be performed safely and effectively in typical UK hospitals.Stricter follow-up is required for histologically advanced lesions due to increased recurrence risk. | Teegan R Lim Venkat Mahesh Salil Singh Benjamin HL Tan Mohamed Elsadig Nerukav Radhakrishnan Phil Conlong Chris Babbs Regi George | 2010 | World Journal of Gastroenterology2010，16，42： | 11 |
| 5 | Nonsurgical periodontal-therapy improves glycosylated hemoglobin levels in pre-diabetic patients with chronic periodontitis显示文摘AIM To evaluate the effect of nonsurgical periodontal therapy on glycosylated haemoglobin levels in pre-diabetic patients with chronic periodontitis(CHP).METHODS Sixty pre-diabetic patients with CHP were selected and equally allocated to case and control group. All subjects were evaluated at base line for periodontal parameters(plaque index, oral hygiene index, modified gingival index, probing pocket depth, clinical attachment level) and systemic parameters [glycosylated hemoglobin(HbA1c), fasting lipid profile, and fasting blood glucose]. The case group received non-surgical periodontal therapy. Subjects were re-evaluated for periodontal and systemic parameters after three months.RESULTS Both groups were comparable at baseline. Three months after non surgical periodontal therapy(NSPT), there was significant improvement in periodontal parameters in case group. The mean difference in systemic parameters like HbA1c and fasting plasma glucose from baseline to fourth month for case group was 0.22 ± 0.11 and 3.90 ± 8.48 respectively and control group was-0.056 ± 0.10 and-1.66 ± 6.04 respectively, which was significant between case and control group(P < 0.05). In the case group there was a significant decrease in HbA1c from baseline to three months following NSPT(P < 0.05).CONCLUSION This study showed that periodontal inflammation could affect the glycemic control in otherwise systemically healthy individuals. Periodontal therapy improved periodontal health status and decreased glycosylated haemoglobin levels, thus reducing the probability of occurrence of inflammation induced prediabetes in patients with CHP. | Rosamma Joseph Meera Sasikumar Jerry Mammen M G Joseraj Chandni Radhakrishnan | 2017 | World Journal of Diabetes2017，8，5： | 7 |
| 6 | Loss of oral mucosal stem cell markers in oral submucous fibrosis and their reactivation in malignant transformation显示文摘The integrity of the basal stem cell layer is critical for epithelial homoeostasis.In this paper,we review the expression of oral mucosal stem cell markers(OM-SCMs)in oral submucous fibrosis(OSF),oral potentially malignant disorders(OPMDs)and oral squamous cell carcinoma(OSCC)to understand the role of basal cells in potentiating cancer stem cell behaviour in OSF.While the loss of basal cell clonogenicity triggers epithelial atrophy in OSF,the transition of the epithelium from atrophic to hyperplastic and eventually neoplastic involves the reactivation of basal stemness.The vacillating expression patterns of OM-SCMs confirm the role of keratins 5,14,19,CD44,β1-integrin,p63,sex-determining region Y box(SOX2),octamer-binding transcription factor 4(Oct-4),c-MYC,B-cell-specific Moloney murine leukaemia virus integration site 1(Bmi-1)and aldehyde dehydrogenase 1(ALDH1)in OSF,OPMDs and OSCC.The downregulation of OM-SCMs in the atrophic epithelium of OSF and their upregulation during malignant transformation are illustrated with relevant literature in this review. | Mohit Sharma Felipe Paiva Fonseca Keith D.Hunter Raghu Radhakrishnan | 2020 | International Journal of Oral Science2020，12，3： | 7 |
| 7 | Severe chest pain in a pediatric ulcerative colitis patient after 5-aminosalicylic acid therapy显示文摘Severe reactions to mesalamine products are rarely seen in pediatric patients. We report a case of a 12-year-old boy who had a severe cardiac reaction to a mesalamine product Asacol. Past medical history is significant for ulcerative colitis (UC) diagnosed at 9 years of age. Colo- noscopy one week prior to admission revealed pancoli- tis. He was treated with Asacol 800 mg three times per day and prednisone 20 mg/d. He was subsequently ad- mitted to the hospital for an exacerbation of his UC and started on intravenous solumedrol. He had improvement of his abdominal pain and diarrhea. The patient com- plained of new onset of chest pain upon initiating Asacol therapy. Electrocardiogram (ECG) revealed non-specific ST-T wave changes with T-wave inversion in the lateral leads. Echocardiogram (ECHO) revealed low-normal to mildly depressed left ventricular systolic function. The left main coronary artery and left anterior descending artery were mildly prominent measuring 5 mm and 4.7 mm, respectively. His chest pain completely resolved within 24-36 h of discontinuing Asacol. A repeat echo- cardiogram performed two days later revealed normal left ventricular function with normal coronary arteries (< 3.5 mm). Onset of chest pain after Asacol and im- mediate improvement of chest pain, as well as improve- ment of echocardiogram and ECG findings after discon- tinuing Asacol suggests that our patient suffered from a rare drug-hypersensitivity reaction to Asacol. | Orhan Atay Kadakkal Radhakrishnan Janine Arruda Robert Wyllie | 2008 | World Journal of Gastroenterology2008，14，27： | 6 |
| 8 | Corporate disclosures by family firms显示文摘 | Ashiq Ali Tai-Yuan Chen Suresh Radhakrishnan | 2007 | Journal of Accounting and Economics2007，，1： | 4 |
| 9 | Controllability results for semilinear impulsive integrodifferential evolution systems with nonlocal conditions显示文摘In this paper, we establish sufficient conditions for the controllability of a class of semilinear impulsive integrodifferential systems with nonlocal initial conditions in Banach spaces. We derive the conditions using Hausdorff measure of noncompactness, Sadovskii fixed point theorem and operator semigroups in particular dropping compactness of the operator. | Bheeman RADHAKRISHNAN Krishnan BALACHANDRAN | 2012 | 控制理论与应用(英文版)2012，10，1： | 3 |
| 10 | A comparison of zooplankton assemblages in Nansi Lake and Hongze Lake,potential influences of the East Route of the South-to-North Water Transfer Project,China显示文摘Nansi Lake and Hongze Lake are both water storage lakes along the East Route of the South-to-North Water Transfer project(ESNT).Frequent changes in hydrologic properties are responsible factors for controlling the zooplankton community assemblages in both lakes,so we studied the possible influence of water transfer and environmental factors on zooplankton community structure and abundance.Zooplankton assemblages were investigated seasonally for one year in both lakes;a total of 133 and 122 zooplankton taxa were identified in Nansi Lake and Hongze Lake,respectively.The most dominant rotifer species were littoral,e.g.,Keratella tecta,Keratella valga and Lecane lunaris in Nansi Lake and Brachionus angularis,Brachionus forficula and Polyarthra vulgaris in Hongze Lake.Comparatively,Nansi Lake had a higher Shannon-Wiener diversity index value(5.13),while Hongze Lake had a higher species richness index(4.21).The average number of zooplankton across seasons in Nansi Lake(protozoa:774±63 ind./L,rotifers:4817±212 ind./L,cladocerans:896±14 ind./L,copepod:435±42 ind./L)was comparatively lower than Hongze Lake(protozoa:1238±63 ind./L,rotifers:6576±112 ind./L,cladocerans:1013±20 ind./L,copepod:534±25 ind./L).Canonical correspondence analysis identified differing environmental gradients that were most responsible for influencing zooplankton communities in the two lakes(Hongze Lake:NH4-N,total nitrogen,transparency and pH;Nansi:pH,temperature and total phosphorus).Frequent changes related to water transfer in lakes favoured the diversity of rotifers and protozoa communities.Zooplankton habitat preference,changes in community structure and opportunistic peaks and extinction of certain taxa were also observed in the study lakes. | Kandathil Radhakrishnan DIVYA Shasha ZHAO Yushun CHEN Fei CHENG Lei ZHANG Jiao QIN Thundiparambil Sathrajith ARUNJITH V.Bjorn SCHMIDT Songguang XIE | 2021 | Journal of Oceanology and Limnology2021，39，2： | 3 |
| 11 | Noncalcemic Actions of Vitamin D Receptor Ligands显示文摘 | Sunil Nagpal Songqing Na Radhakrishnan Rathnachalam | 2005 | Endocrine Reviews2005，，5： | 3 |
| 12 | Citric acid:An efficient and green catalyst for rapid one pot synthesis of quinoxaline derivatives at room temperature显示文摘有 1,2-dicarbonyl 混合物的 o-phenylenediamines 的冷凝作用在乙醇在房间温度在更高的收益面对柠檬性的酸负担得起相应 quinoxaline 衍生物,并且大多数反应在不到 1 min 被完成。 | Radhakrishnan Mahesh Arghya Kusum Dhar Tara Sasank T.V.N.V. Sappanimuthu Thirunavukkarasu Thangaraj Devadoss | 2011 | Chinese Chemical Letters2011，22，4： | 3 |
| 13 | Potential applications of lactic acid bacteria and bacteriocins in antimycobacterial therapy显示文摘Tuberculosis(TB) is a communicable disease caused by Mycobacterium tuberculosis(M. tuberculosis). WHO estimated that 10.4 million new(incident) TB cases worldwide in year 2016. The increased prevalence of drug resistant strains and side effects associated with the current anti-tubercular drugs make the treatment options more complicated. Hence, there are necessities to identify new drug candidates to fight against various sub-populations of M. tuberculosis with less or no toxicity/side effects and shorter treatment duration. Bacteriocins produced by lactic acid bacteria(LAB) attract attention of researchers because of its 'Generally recognized as safe' status. LAB and its bacteriocins possess an effective antimicrobial activity against various bacteria and fungi. Interestingly bacteriocins such as nisin and lacticin 3147 have shown antimycobacterial activity in vitro. As probiotics, LAB plays a vital role in promoting various health benefits including ability to modulate immune response against various infectious diseases. LAB and its metabolic products activate immune system and thereby limiting the M. tuberculosis pathogenesis. The protein and peptide engineering techniques paved the ways to obtain hybrid bacteriocin derivatives from the known peptide sequence of existing bacteriocin. In this review, we focus on the antimycobacterial property and immunomodulatory role of LAB and its metabolic products. Techniques for large scale synthesis of potential bacteriocin with multifunctional activity and enhanced stability are also discussed. | Anbarasu Sivaraj Revathy Sundar Radhakrishnan Manikkam Krupakar Parthasarathy Uma Rani Vanaja Kumar | 2018 | Asian Pacific Journal of Tropical Medicine2018，11，8： | 2 |
| 14 | Watershed Prioritization of Palar Sub-watershed Based on the Morphometric and Land Use Analysis显示文摘Morphometric analysis is an indispensable tool for hydrological investigation that involves the development and management of drainage basin. This study characterizes the micro watersheds in the Palar sub-watershed using morphometric analysis and assesses its risk by land use and land cover features in a particular micro watershed. Palar sub-watershed is divided into 6 micro watersheds for prioritization based on morphometric and land use analysis. Several morphometric parameters(linear, shape and relief)are determined from the drainage map; ranks are assigned based on their capacity to induce erodability and degradation. Final ranking is based on the composite index calculated from the sum of the ranks of each morphometric parameter. Morphometric analysis reveals micro watersheds 5 and 6 as most susceptible and 2 and 3 as low susceptible. Land use is mapped using IRS ID LISS III satellite data. The risk in terms of watershed degradation involved to each micro watershed is based on the ranks of each land use feature, obtained from a similar composite index as that of morphometric analysis. Land use analysis shows that micro watersheds 2 and 4 fall under high priority category while 5 and 6 under low priority category. Integration of the morphometric and land use analysis shows that only micro watershed 1 falls under the same category in both analyses. Control measures are suggested to contain degradation depending on its specific land use pattern and morphometric features. This study can be used to prepare a comprehensive watershed plan for the development or for planning resource conservation strategies, by integrating land use features with the drainage characteristics of the region, in particular for a hill ecosystem as the prioritization is at micro level. | Evangelin Ramani SUJATHA Radhakrishnan SELVAKUMAR Balasubramaniam RAJASIMMAN | 2014 | Journal of Mountain Science2014，11，4： | 2 |
| 15 | Integrability and singularity structure of coupled nonlinear Schrodinger equation显示文摘 | Radhakrishnan R Sahadevan R Lakshmanan M | 1995 | Chacs Solitons and Fractals1995，5，12： | 2 |
| 16 | Correlation of periodontal inflamed surface area with glycemic status in controlled and uncontrolled type 2 diabetes mellitus显示文摘BACKGROUND The bidirectional link between periodontitis and diabetes mellitus(DM)has been established.Periodontitis causes systemic inflammatory burden through inflammatory mediators.The currently utilized tools[clinical attachment loss(CAL)and probing pocket depth(PPD)]are linear measurements,that do not exactly quantify the inflammatory burden of periodontitis.Periodontal inflamed surface area(PISA)quantifies the surface area of bleeding pocket epithelium and estimates the inflammatory burden.Studies relating to the periodontal status of diabetic patients with and without microvascular complications are scarce.This study assessed the proportion of periodontitis and correlation of PISA with glycemic status in controlled,uncontrolled type 2 DM(T2DM)with and without microvascular complications.AIM To assess the proportion of periodontitis and correlation of PISA with glycemic status in controlled,and uncontrolled T2DM with and without microvascular complications.METHODS This study comprised 180 T2DM patients.Based on glycated hemoglobin(HbA1c)levels,they were grouped into:(1)Controlled T2DMgroup:(HbA1c≤7%);(2)Uncontrolled T2DM group:(HbA1c>7%)without microvascular complications;and(3)Uncontrolled T2DM group:(HbA1c>7%)with microvascular complications.Each group comprised 60 patients.All patients were assessed for periodontal parameters(Bleeding on Probing,PPD,CAL,Oral hygiene index simplified and PISA),and systemic parameters(HbA1c,fasting plasma glucose and post prandial plasma glucose).RESULTS The proportion of periodontitis among controlled T2DM group,uncontrolled T2DM group without microvascular complications,uncontrolled T2DM group with micro-vascular complications was 75%,93.4%and 96.6%respectively.Extent and severity of periodontitis were high in the uncontrolled T2DM group.A significant positive correlation was found between PISA and HbA1c among all patients(r=0.393,P<0.001).The dose–response relationship between PISA and HbA1c was observed.An increase of PISA with 168 mm^(2) was associated with a 1.0%increase of HbA1c.CONCLUSION High proportion and severity of periodontitis,and increased inflamed surface area in uncontrolled T2DM may have contributed to the poor glycemic control and microvascular complications. | Krishna Anil Rosamma Joseph Vadakkekuttical Chandni Radhakrishnan Fairoz Cheriyalingal Parambath | 2021 | World Journal of Clinical Cases2021，9，36： | 2 |
| 17 | Pro-apoptotic role of NF-κB: Implications for cancer therapy显示文摘 | Senthil K. Radhakrishnan Sitharthan Kamalakaran | 2006 | BBA - Reviews on Cancer2006，，： | 2 |
| 18 | Influence of two different dietary zinc sources in freshwater prawn Macrobrachium rosenbergii post larvae显示文摘A feeding experiment was conducted to evaluate the ef fects of bulk zinc(B-Zn) and zinc nanoparticles(Zn-NPs) on survival, growth, compositions of amino acid and fatty acid, and nonspeci?c immune responses of the freshwater prawn, Macrobrachium rosenbergii post larvae. The B-Zn(size 10 μm)and Zn-NPs(size 50 nm) were supplemented separately with the basal feeds of M. rosenbergii at 60 mg/kg and feed without supplementation of any Zn source was served as a control. M. rosenbergii were fed these feeds for 90 days and the results showed that signi?cant( P <0.05) improvements in survival, growth, feed intake,speci?c growth rate, essential amino acids, unsaturated fatty acids, nonspeci?c immune responses(total haemocytes and dif ferential haemocytes count) of M. rosenbergii fed with B-Zn and Zn-NPs supplemented feeds when compared to control. Among these Zn sources, Zn-NPs supplemented feeds fed prawns showed signi?cantly( P <0.05) better performance than that of B-Zn and control. Hence, present study suggests that the 60 mg/kg Zn-NPs can be supplemented with basal feeds of M. rosenbergii for regulating better survival and growth. | THIRUNAVUKKARASU Muralisankar PERIYAKALI Saravana Bhavan SUBRAMANIAN Radhakrishnan PERUMAL Santhanam | 2019 | Journal of Oceanology and Limnology2019，37，1： | 2 |
| 19 | Non-destructive method of leaf-area determination in ash gourd ( Benincasa hispida) 显示文摘 | Radhakrishnan V V Kumar P G S Oommen A | 1991 | Indian Journal of Agricultural Sciences1991，61，1： | 1 |
| 20 | Structure of MnOx/Al2O3 catalyst: a study using EXAFS, in situ laser raman spectroscopy and abinitio calculations 显示文摘 | Radhakrishnan R Oyama S T | 2001 | Journal of Physical Chemistry B2001，105，38： | 1 |
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