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| 1 | 动态增强磁共振成像对恶性血液病骨髓肿瘤浸润监测的初步研究显示文摘目的本研究旨在利用动态增强MR成像技术(DCE-MR)检测血液病患者骨髓强化特征变化,研究其与骨髓肿瘤细胞浸润状态的相关性。方法25例血液病经DCE-MR成像及髂嵴穿刺活检,测定骨髓灌注的最大强化率(PER),最大强化斜率值(Slopemax),峰值时间(TTP),平均时间(MT),以及骨髓活检分析肿瘤分数(TF)。结果肿瘤浸润组较缓解期组PER高(临床缓解期为0.252±0.156,肿瘤组为0.592±0.433),统计学上有显著性差异(P<0.05)。肿瘤浸润组较缓解期组的Slopemax高肿瘤组:(0.561±0.634)/s;缓解期组:(0.204±0.105)/s、TTP缩短肿瘤组:(68.12±42.18)s;缓解期组:(81.52±38.49)s,但统计学上无显著性差异(P>0.05),MT值两组差异不明显(P>0.05)。结论动态增强MR成像能够监测血液病骨髓肿瘤细胞浸润状态,为恶性血液病治疗随访提供了一种新的无创性监测手段。 | 张蕾 Catherine Mandel 杨振燕 Qing Yang Richard Nibbs David Westerman Alex G Pitman | 2006 | 中国医学影像技术2006，22，7： | 4 |
| 2 | Tumor infiltration of bone marrow in patients with hemato-logical malignancies: dynamic contrast-enhanced magnetic resonance imaging显示文摘扫描技术的背景常规磁性的回声(先生) 能识别包含主要胖的房间的骨头髓(BM ) 。但是他们不能区分 BMtumor 渗入, BM 纤维变性和正常红 BM。这在对周期性或倔强的 hematological 恶意的评价是特别地有问题的。这个预研项目使用了动态 contrast-enhancedMR 成像(DCE-MRI ) 评估骨头髓地位并且决定几个计算参数是否与髓的组织学的特征源于 DCE-MRI 相互关联,特别与肿瘤部分(TF ) 。方法 DCE-MRI 扫描与证明或知道的 hematological 恶意在 25 个病人被执行就要经历以后的肠骨的冠的骨头髓活体检视。为活体检视选择的地点与 MRI 被检验在活体检视以前的约一个小时。时间信号紧张曲线(TIC ) 从相应于计划活体检视地点的肠骨的冠的区域被产生。改进参数被计算,包括山峰改进比率(每) ,最大的改进斜坡(Slope_( 最大)) ,达到顶点的时间(TTP ) 和同时(MT ) 。活体检视标本概括性地被报导,与包括细胞质和肿瘤部分(TF ) 的相关报导参数。结果比为正常骨头髓组为骨头髓肿瘤渗入组每价值是显著地更高的(P <
0.05 ) 。重要积极关联被发现在之间每并且象 Slope_( 最大) 一样的 TF 和 TF。否定关联在 TTP 和 TF 之间被发现。在在 BM 肿瘤渗入组和正常骨头髓组之间的吝啬的 TTP 和 MTvalues 没有重要差别。在有 haematological 恶意的病人的弥漫的骨头髓渗入的结论 Thepresence 能用 DCE-MRI 被验证。 | ZHANG Lei Catherine Mandel YANG Zhen-yan YANG Qing Richard Nibbs David Westerman Alex Pitman | 2006 | Chinese Medical Journal2006，，15： | 1 |
| 3 | Strippable coatings显示文摘 | David L Westerman | 2000 | Metal Finishing2000，98，6： | 1 |
| 4 | A social network as information: The effect of system generated reports of connectedness on credibility on Twitter显示文摘 | David Westerman Patric R. Spence Brandon Van Der Heide | 2011 | Computers in Human Behavior2011，，1： | 1 |
| 5 | Survival of liver failure pigs by transplantation of reversibly immortalized human hepatocytes with Tamoxifen-mediated self-recombination显示文摘 | Toshinori Totsugawa Chen Yong Jorge David Rivas-Carrillo Alejandro Soto-Gutierrez Nalú Navarro-Alvarez Hirofumi Noguchi Teru Okitsu Karen A. Westerman Michinori Kohara Michael Reth Noriaki Tanaka Philippe Leboulch Naoya Kobayashi | 2007 | Journal of Hepatology2007，，1： | 1 |
| 6 | Strippable coatings 显示文摘 | David L Westerman | 2000 | Metal Finishing2000，98，6： | 1 |
| 7 | Prospective evaluation of health status, quality of life and clinical outcomes following implantable defibrillator generator exchange显示文摘BACKGROUND Little is known about health status and quality of life(QoL)after implantable cardioverter-defibrillator(ICD)generator exchange(GE).METHODS We prospectively followed patients undergoing first-time ICD GE.Serial assessments of health status were performed by administering the 36-Item Short Form Survey(SF-36).RESULTS Mean age was 67.5±14.3 years,left ventricle ejection fraction(LVEF)was 36.5%±15.0%and over 40%of the cohort had improved LVEF to>35%at the time of GE.SF-36 scores were significantly worse in physical/general health domains compared to domains of emotional/social well-being(P<0.001 for each comparison).Physical health scores were significantly worse among those with medical comorbidities including diabetes,chronic obstructive pulmonary disease and atrial fibrillation.Mean follow-up was 1.6±0.5 years after GE.Overall SF-36 scores remained stable across all domains during follow-up.Survival at 3 years post-GE was estimated at 80%.Five patients died during follow-up and most deaths were adjudicated as non-arrhythmic in origin.Four patients experienced appropriate ICD shocks after GE,three of whom had LVEF which remains impaired LVEF(i.e.,<35%)at the time of GE.CONCLUSION Patients undergoing ICD GE have significantly worse physical health compared to emotional/social well-being,which is associated with the presence of medical comorbidities.In terms of clinical outcomes,the incidence of appropriate shocks after GE among those with improvement in LVEF is very low,and most deaths post-procedure appear to be non-arrhythmic in origin.These data represent an attempt to more fully characterize the spectrum of QoL and clinical outcomes after GE. | Faisal M Merchant John Larson Leon Darghosian Paige Smith Soroosh Kiani Stacy Westerman Anand D.Shah David S.Hirsh Michael S.Lloyd Angel R.Leon Mikhael F.El-Chami | 2021 | Journal of Geriatric Cardiology2021，18，9： | 0 |
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