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| 1 | Effect of two different extracts of red maca in male rats with testosterone-induced prostatic hyperplasia显示文摘瞄准:在更男的 ats 决定红 maca 的二篇不同摘录的效果。方法:Prostatic 增生与睾丸激素 enanthate (TE ) 在雄的老鼠被导致。Thestudy 包括了六个组:一个控制组(组 1 ),与 TE (组 2 )对待的一个组,与 TE 对待的二个组和红 maca 的水的摘录(组织 3 和 4 ),一个组对待红 maca (组 5 )的 withhydroalcoholic 摘录,一个组与 finasteride 对待( 0.1 mg , group6 )。在沸腾的时间的长度上的水的摘录依赖者的差别,是否为 2 个 or3 小时,为组, 3 和 4 被估计。红 maca 的摘录包含了 0.1 mg ofbenzylglucosinolate。此后,在红 maca 摘录的 benzylglucosinolates (0.02-0.08 mg ) 的不同剂量的剂量反应效果被估计。结果:前列腺重量在与红 maca 的水的摘录在沸腾的 2 和 3 个小时以后准备了的 freeze-dried 对待的老鼠是类似的。红 maca 的 Freeze-dried 水的摘录,红 maca 和 finasteride 的水疗院酒鬼摘录与职业人员静电干扰增生在老鼠减少了前列腺重量。没有差别在从水的摘录或红 maca 的水疗院酒鬼摘录获得的数据之间被观察。前列腺重量的剂量依赖者减小随红 macaextracts 的 benzylglucosinolates 的剂量的增加被观察。结论:现在的学习在 prostatichyperplasia 被 TE 在导致了的雄的老鼠给那个水疗院酒鬼或红 macacontaining 的水的摘录看了 benzylglucosinolate 罐头还原剂前列腺尺寸的 0.1 mg。 | Gustavo F. Gonzales Vanessa Vasquez Daniella Rodriguez Carmen Maldonado Juliet Mormontoy Jimmy Portella Monica Pajuelo León Villegas Manuel Gasco | 2007 | Asian Journal of Andrology2007，9，2： | 14 |
| 2 | Efficacy of peroral endoscopic myotomy vs other achalasia treatments in improving esophageal function显示文摘AIM: To assess and compare the esophageal function after peroral endoscopic myotomy(POEM) vs other conventional treatments in achalasia.METHODS: Chart review of all achalasia patients who underwent POEM, laparoscopic Heller myotomy(LHM) or pneumatic dilation(PD) at our institution between January 2012 and March 2015 was performed. Patient demographics, type of achalasia, prior treatments, pre- and post-treatment timed barium swallow(TBE) and high-resolution esophageal manometry(HREM) findings were compared between the three treatment groups. Patients who had both pre- and 2 mo posttreatment TBE or HREM were included in the final analysis. TBE parameters compared were barium column height, width and volume of barium remaining at 1 and 5 min. HREM parameters compared were basal lower esophageal sphincter(LES) pressures and LES-integrated relaxation pressures(IRP). Data are presented as mean ± SD, median [25th, 75 th percentiles] or frequency(percent). Analysis of variance, KruskalWallis test, Pearsons χ~2 test and Fishers Exact tests were used for analysis.RESULTS: A total of 200 achalasia patients were included of which 36 underwent POEM, 22 underwent PD and 142 underwent LHM. POEM patients were older(55.4 ± 16.8 years vs 46.5 ± 15.7 years, P = 0.013) and had higher BMI than LHM(29.1 ± 5.9 kg/m^2 vs 26 ± 5.1 kg/m^2, P = 0.012). More number of patients in POEM and PD groups had undergone prior treatments compared to LHM group(72.2% vs 68.2% vs 44.3% respectively, P = 0.003). At 2 mo post-treatment, all TBE parameters including barium column height, width and volume remaining at 1 and 5 min improved significantly in all three treatment groups(P = 0.01 to P < 0.001) except the column height at 1 min in PD group(P = 0.11). At 2 mo post-treatment, there was significant improvement in basal LES pressure and LES-IRP in both LHM(40.5 mm Hg vs 14.5 mm Hg and 24 mm Hg vs 7.1 mm Hg respectively, P < 0.001) and POEM groups(38.7 mm Hg vs 11.4 mm Hg and 23.6 mm Hg vs 6.6 mm Hg respectively, P < 0.001). However, when the efficacy of three treatments were compared to each other in terms of improvement in TBE or HREM parameters at 2 mo, there was no significant difference(P > 0.05).CONCLUSION: POEM, PD and LHM were all effective in improving esophageal function in achalasia at shortterm. There was no difference in efficacy between the three treatments. | Madhusudhan R Sanaka Umar Hayat Prashanthi N Thota Ramprasad Jegadeesan Monica Ray Scott L Gabbard Neha Wadhwa Rocio Lopez Mark E Baker Sudish Murthy Siva Raja | 2016 | World Journal of Gastroenterology2016，22，20： | 7 |
| 3 | Combination of corticosteroids and 5-aminosalicylates or corticosteroids alone for patients with moderate-severe active ulcerative colitis:A global survey of physicians'practice显示文摘AIM To examine treatment decisions of gastroenterologists regarding the choice of prescribing 5-aminosalycilates(5ASA) with corticosteroids(CS) versus corticosteroids alone for patients with active ulcerative colitis(UC). METHODS A cross-sectional questionnaire exploring physicians' attitude toward 5ASA + CS combination therapy vs CS alone was developed and validated. The questionnaire was distributed to gastroenterology experts in twelve countries in five continents. Respondents' agreement with stated treatment choices were assessed by standardized Likert scale. Background professional characteristics of respondents were analyzed for correlation with responses. RESULTS Six hundred and sixty-four questionnaires were distributed and 349 received(52.6% response rate). Of 340 eligible respondents, 221(65%) would continue 5ASA in a patient hospitalized for intravenous CS treatment due to a moderate-severe UC flare, while 108(32%) would stop the 5ASA(P < 0.001), and 11(3%) are undecided. Similarly, 62% would continue 5ASA in an out-patient starting oral CS. However, only 140/340(41%) would proactively start 5ASA in a hospitalized patient not receiving 5ASA before admission. Most(94%) physicians consider the safety profile of 5ASA as very good. Only 52% consider them inexpensive, 35% perceive them to be expensive and 12% are undecided. On multi-variable analysis, less years of practice and perception of a plausible additive mechanistic effect of 5ASA + CS were positively associated with the decision to continue 5ASA with CS. CONCLUSION Despite the absence of data supporting its benefit, most gastroenterologists endorse combination of 5ASA + CS for patients with active moderate-to-severe UC. Randomized controlled trials are needed to assess if 5ASA confer any benefit for these patients. | Shomron Ben-Horin Jane M Andrews Konstantinos H Katsanos Florian Rieder Flavio Steinwurz Konstantinos Karmiris Jae Hee Cheon Gordon William Moran Monica Cesarini Christian D Stone Doron Schwartz Marijana Protic Xavier Roblin Giulia Roda Min-Hu Chen Ofir Har-Noy Charles N Bernstein | 2017 | World Journal of Gastroenterology2017，23，16： | 3 |
| 4 | Plant adaptation to low phosphorus availability:Core signaling,crosstalks,and applied implications显示文摘Phosphorus(P)is an essential nutrient for plant growth and reproduction.Plants preferentially absorb P as orthophosphate(Pi),an ion that displays low solubility and that is readily fixed in the soil,making P limita-tion a condition common to many soils and Pi fertilization an inefficient practice.To cope with Pi limitation,plants have evolved a series of developmental and physiological responses,collectively known as the Pi starvation rescue system(PSR),aimed to improve Pi acquisition and use efficiency(PUE)and protect from Pi-starvation-induced stress.Intensive research has been carried out during the last 20 years to un-ravel the mechanisms underlying the control of the PSR in plants.Here we review the results of this research effort that have led to the identification and characterization of several core Pi starvation signaling components,including sensors,transcription factors,microRNAs(miRNAs)and miRNA inhibitors,kinases,phosphatases,and components of the proteostasis machinery.We also refer to recent results revealing the existence of intricate signaling interplays between Pi and other nutrients and antagonists,N,Fe,Zn,and As,that have changed the initial single-nutrient-centric view to a more integrated view of nutrient homeostasis.Finally,we discuss advances toward improving PUE and future research priorities. | Javier Paz-Ares Maria Isabel Puga Monica Rojas-Triana Iris Martinez-Hevia Sergio Diaz Cesar Poza-Carrión Miguel Mi(n)ambres Antonio Leyva | 2022 | Molecular Plant2022，15，1： | 2 |
| 5 | Leptospirosis: a zoonotic disease of global importance显示文摘 | Ajay R Bharti Jarlath E Nally Jessica N Ricaldi Michael A Matthias Monica M Diaz Michael A Lovett Paul N Levett Robert H Gilman Michael R Willig Eduardo Gotuzzo Joseph M Vinetz | 2003 | The Lancet Infectious Diseases2003，，12： | 2 |
| 6 | Drug screening of neuraprotee- tive agents on an organotypic - based model of' spinal cord exeitotoxic damage 显示文摘 | Monica S Guzman L Xavier N | 2009 | Restorative Neurol Neuros~:i2009，27，： | 1 |
| 7 | Biosynthesis and biochemical properties of the hepatitis C virus core protein显示文摘 | Santolini E Migliaccio G La Monica N | 1994 | J Virol1994，68，： | 1 |
| 8 | Cytokine and chemokine and chemokine expression profiles of maturing dendritic cells using multiprotein platform arrays显示文摘 | Dirk N Francesco MM Monica CP | 2004 | Cytokine2004，25，1： | 1 |
| 9 | Hepatitis C virus core protein impairs in vitro priming of specific T cell responses by dendritic cells and hepatocytes显示文摘 | Zimmermann M Flechsig C La Monica N | 2008 | J Hepatol2008，48，1： | 1 |
| 10 | Differential Role of Hippocampal cAMP-Dependent Protein Kinase in Short- and Long-Term Memory显示文摘 | Monica R. M. Vianna Luciana A. Izquierdo Daniela M. Barros Patricia Ardenghi Patricia Pereira Cleverson Rodrigues Beatriz Moletta Jorge H. Medina Iván Izquierdo | 2000 | Neurochemical Research2000，，5： | 1 |
| 11 | Novel perspective on p53 function in neural stem cells and brain tumor 显示文摘 | Sanna-Maria H Inga N Monica N | 2011 | J Oncology2011，2011，： | 1 |
| 12 | Baculovirus vectors elicit antigen-specific immune responses in mice显示文摘 | FACCIABENE A AURISICCHIO L LA MONICA N | 2004 | J Virol2004，78，16： | 1 |
| 13 | PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1 显示文摘 | Monica K Galili N Nourse J | 1991 | Mol Cell BioI1991，11，12： | 1 |
| 14 | Effect of high pressure treatments on peroxidase and polyphenoloxidase activities显示文摘 | Monica A Cristina N Gianfranco D A | | 0，，19： | 1 |
| 15 | Histamine treatment induces rearrangements of orthogonal arrays of particles(OAPs)in human AQP4 expressing gastric cells显示文摘 | Monica C Giuseppe P Grazia P N | 2001 | J Cell Bio2001，154，6： | 1 |
| 16 | Effect of temperature on chitin and as- taxanthin recoveries from shrimp waste using lactic acid bac- teria显示文摘 | PACHECO N MONICA GARNICA-GONZLEZA JESSICA Y | 2009 | Bioresource Technol2009，，100： | 1 |
| 17 | Multiple Effects of Berberine Derivatives on Colon Cancer Cells显示文摘 | Luis Miguel Guamán Ortiz Micol Tillhon Michael Parks Ilaria Dutto Ennio Prosperi Monica Savio Andrea G. Arcamone Franco Buzzetti Paolo Lombardi Anna Ivana Scovassi Steve Winder | 2014 | BioMed Research International2014，，： | 1 |
| 18 | Optimizing the use of anthracyelines in older patients with breast cancer显示文摘 | Patrick G Morris Monica N | 2011 | Critical Reviews in Oncology/Hematology2011，77，2： | 1 |
| 19 | Stability promotion of Ni/α-Al2O3 catalysts by tin added via surface organometallic chemistry on metal application in methane reforming processes 显示文摘 | Nora N Niehio Monica L Casella Gerardo F Santori | 2000 | Catal Today2000，62，23： | 1 |
| 20 | Nafcillin-loaded PLGA nanoparticles for treatment of osteomyelitis显示文摘 | Rajeev Raghavan Pillai Shankari N Somayaji Monica Rabinovich Michael C Hudson Kenneth E Gonsalves | 2008 | Biomedical Materials2008，，3： | 1 |
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