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| 1 | 中国淮阳山地区由新蜱传布尼亚病毒引起的出血热显示文摘研究背景 2009-2010年4月至7月,我国淮阳山地区农民中出现不明原因的严重出血热样病例.方法 采集疑似病例的临床标本(血液、尿液、粪便和咽拭子),在患者所在地采集蚊和蜱.从2例患者的血液样本中分离到2株病毒,并进行全基因组测序分析.采用病毒特异的RT-PCR对其他病例及节肢动物进行病毒检测,对RT-PCR阳性病例的临床和流行病学资料进行分析.结果 从2例患者的血液及从犬身上采集到的长角血蜱中分离到1种未知病毒.全基因组测序分析发现该病毒为布尼亚病毒科的一个新成员,与白蛉病毒属最接近,是其中的一个新分支.58例疑似病例中33例RT-PCR结果阳性.病例临床特征主要表现为发热、乏力、恶心、呕吐和腹泻.主要实验室结果包括白细胞及血小板减少,凝血时间异常和肝酶升高.3例患者出现出血症状,5例死亡(死亡率15%).结论 我国淮阳山地区存在着一种严重威胁生命健康的新蜱传布尼亚病毒.对于该病毒的流行病学、地理分布,以及脊椎动物宿主的生态学等需要作进一步的研究. | 张永振 周敦金 熊衍文 陈小萍 贺永文 孙强正 余滨 李娟 代永安 田俊华 覃新程 金东 崔志刚 罗雪莲 李伟 卢珊 王文 彭劲松 郭文平 李明慧 李振军 张少敏 陈晨 王艳 Menno D.de Jong 徐建国 | 2011 | 中华流行病学杂志2011，32，3： | 96 |
| 2 | 中国淮阳山地区由新蜱传布尼亚病毒引起的出血热显示文摘病毒性出血热是一种临床症状表现为急性发热和出血的疾病。病原体为人兽共患及节肢动物携带传播的RNA病毒,包括丝状病毒科(如埃博拉出血热、马尔堡出血热)、沙粒病毒科(拉沙热)、黄病毒科(如登革出血热、黄热病)和布尼亚病毒科(如克里米亚一刚果出血热、肾综合征出血热)。 | 张永振 周敦金 田俊华 覃新程 李明慧 李振军 熊衍文 陈小萍 贺永文 孙强正 余滨 李娟 代永安 金东 崔志刚 罗雪莲 李伟 卢珊 王文 彭劲松 郭文平 张少敏 陈晨 王艳 Menno D.de Jong 徐建国 | 2011 | 中华流行病学杂志2011，32，8： | 21 |
| 3 | Scavenger receptor BI: A multi-purpose player in cholesterol and steroid metabolism显示文摘Scavenger receptor class B type Ⅰ (SR-BI) is an important member of the scavenger receptor family of integral membrane glycoproteins. This review highlights studies in SR-BI knockout mice, which concern the role of SR-BI in cholesterol and steroid metabolism. SR-BI in hepatocytes is the sole molecule involved in selective uptake of cholesteryl esters from high-density lipoprotein (HDL). SR-BI plays a physiological role in binding and uptake of native apolipoprotein B (apoB)-containing lipoproteins by hepatocytes, which identif ies SR-BI as a multipurpose player in lipid uptake from the blood circulation into hepatocytes in mice. In adrenocortical cells, SR-BI mediates the selective uptake of HDL-cholesteryl esters, which is eff iciently coupled to the synthesis of glucocorticoids (i.e. corticosterone). SR-BI knockout mice suffer from adrenal glucocorticoid insuff iciency, which suggests that functional SR-BI protein is necessary for optimal adrenal steroidogenesis in mice. SR-BI in macrophages plays a dual role in cholesterol metabolism as it is able to take up cholesterol associated with HDL and apoBcontaining lipoproteins and can possibly facilitate cholesterol efflux to HDL. Absence of SR-BI is associated with thrombocytopenia and altered thrombosis susceptibility, which suggests a novel role for SR-BI in regulating platelet number and function in mice. Transgenic expression of cholesteryl ester transfer protein in humanized SR-BI knockout mice normalizes hepatic delivery of HDL-cholesteryl esters. However, other pathologies associated with SR-BI def iciency, i.e. increased atherosclerosis susceptibility, adrenal glucocorticoid insuffi ciency, and impaired platelet function are not normalized, which suggests an important role for SR-BI in cholesterol and steroid metabolism in man. In conclusion, generation of SR-BI knockout mice has signif icantly contributed to our knowledge of the physiological role of SR-BI. Studies using these mice have identif ied SR-BI as a multi-purpose player in cholesterol and steroid metabolism because it has distinct roles in reverse cholesterol transport, adrenal steroidogenesis, and platelet function. | Menno Hoekstra Theo JC Van Berkel Miranda Van Eck | 2010 | World Journal of Gastroenterology2010，16，47： | 11 |
| 4 | 感染人类的禽流感病毒A(H5N1)研究进展显示文摘 | Abdel-Nasser Abdel-Ghafar Tawee Chotpitayasunondh Zhancheng Gao Frederick G. Hayden Nguyen Duc Hien Menno D. de Jong Azim Naghdaliyev J.S. Malik Peiris Nahoko Shindo Santoso Soeroso Timothy M. Uyeki 钟晓琴(译) 王关嵩(校) | 2009 | 中华肺部疾病杂志(电子版)2009，2，1： | 4 |
| 5 | Radiofrequency Lesion Adjacent to the Dorsal Root Ganglion for Cervicobrachial Pain: A Prospective Double Blind Randomized Study显示文摘 | Maarten van Kleef Leon Liem Richel Lousberg Gerard Barendse Fons Kessels Menno E. Sluijter | 1996 | Neurosurgery1996，，6： | 2 |
| 6 | Ximelagatran与低分子肝素加华法令治疗深静脉血栓的比较 随机试验显示文摘背景:Ximelagatran是一种起效快、溶栓作用肯定的口服药,可直接抑制凝血酶。它用药简单,有望取代当前治疗急性静脉血栓栓塞的标准疗法。 | Jean-Noel Fiessinger,MD Menno V. Huisman, MD Bruce L. Davidson, MD 王莉华(译) 诸骏仁(校) | 2005 | 美国医学会杂志(中文版)2005，24，6： | 2 |
| 7 | Endothelial Cell-Specific NF-κB Inhibition Protects Mice from Atherosclerosis显示文摘 | Ralph Gareus Elena Kotsaki Sofia Xanthoulea Ingeborg van der Made Marion J.J. Gijbels Rozina Kardakaris Apostolos Polykratis George Kollias Menno P.J. de Winther Manolis Pasparakis | 2008 | Cell Metabolism2008，，5： | 2 |
| 8 | Evolution of the Internet AS-level topology:From nodes and edges to components显示文摘Studying the topology of infrastructure communication networks(e.g., the Internet) has become a means to understand and develop complex systems. Therefore, investigating the evolution of Internet network topology might elucidate disciplines governing the dynamic process of complex systems. It may also contribute to a more intelligent communication network framework based on its autonomous behavior. In this paper, the Internet Autonomous Systems(ASes) topology from 1998 to 2013 was studied by deconstructing and analysing topological entities on three different scales(i.e., nodes,edges and 3 network components: single-edge component M1, binary component M2 and triangle component M3). The results indicate that: a) 95% of the Internet edges are internal edges(as opposed to external and boundary edges); b) the Internet network consists mainly of internal components, particularly M2 internal components; c) in most cases, a node initially connects with multiple nodes to form an M2 component to take part in the network; d) the Internet network evolves to lower entropy. Furthermore, we find that, as a complex system, the evolution of the Internet exhibits a behavioral series,which is similar to the biological phenomena concerned with the study on metabolism and replication. To the best of our knowledge, this is the first study of the evolution of the Internet network through analysis of dynamic features of its nodes,edges and components, and therefore our study represents an innovative approach to the subject. | 刘晓 王进法 景薇 Menno de Jong Jeroen S Tummers 赵海 | 2018 | Chinese Physics B2018，27，12： | 2 |
| 9 | Ximelagatran vs Low-Molecular-Weight Heparin and Warfarin for the Treatment of Deep Vein Thrombosis显示文摘 | Jena-Noel Fiessinger Menno V Huisman Bruce L Davidson | 2005 | JAMA2005，293，： | 1 |
| 10 | MicroRNA expression profiling is a potential diagnostic tool for thyroid cancer显示文摘 | Menno R. Vriens Julie Weng Insoo Suh Nhung Huynh Marlon A. Guerrero Wen T. Shen Quan‐Yang Duh Orlo H. Clark Electron Kebebew | 2011 | Cancer2011，，13： | 1 |
| 11 | Effective stain removal:Ci- ba's Tinocat TRS KB1 oxidation catalyst is a gentle and cost-effective additive to laundry bleaching aids 显示文摘 | Hazenkamp M F Menno H Werner | 2006 | Household & Personal Prod- ucts Industry2006，43，： | 1 |
| 12 | New ammonia synthesis catalyst with no iron显示文摘 | Menno P G | 1993 | Appl Catal1993，93，： | 1 |
| 13 | High Prevalence of Anti‐Apolipoprotein/A‐1 Autoantibodies in Maintenance Hemodialysis and Association With Dialysis Vintage显示文摘 | Menno Pruijm Jan Schmidtko Anthony Aho Sabrina Pagano Pascale Roux‐Lombard Daniel Teta Michel Burnier Nicolas Vuilleumier | 2012 | Therapeutic Apheresis and Dialysis2012，，6： | 1 |
| 14 | Real-time seam tracking for robotic la-ser welding using trajectory-based control显示文摘 | Graaf de Menno Aarts R | 2010 | Control EngineeringPractice2010，18，： | 1 |
| 15 | The pathogenesis of psoriasis:immunological facts and speculations显示文摘 | Bos JD Menno A De R | 1999 | Immunol Today1999，20，1： | 1 |
| 16 | Amygdala activity in obsessive-compulsive disorder with contamination fear: a study with oxygen-15 water positron emission tomography显示文摘 | Odile A. van den Heuvel Dick J. Veltman Henk J. Groenewegen Raymond J. Dolan Danielle C. Cath Ronald Boellaard Catalina T. Mesina Anton J.L.M. van Balkom Patricia van Oppen Menno P. Witter Adriaan A. Lammertsma Richard van Dyck | 2004 | Psychiatry Research: Neuroimaging2004，，3： | 1 |
| 17 | Hyperflexion Sprain of the cervical spine显示文摘 | Menno Brahman Reindeer Brahman | 1987 | Acta Orthop Sctand1987，58，： | 1 |
| 18 | Bending-mode vibration of a suspended nanotube resonator显示文摘 | Benoit Witkamp Menno Poot Herre S J van der zant | 2006 | Nano Letters2006，6，12： | 1 |
| 19 | The pathogenesis of psoriasis immun - ological facts and speculations 显示文摘 | Bos JD Menno A De R | 1999 | Immunol Today1999，20，1： | 1 |
| 20 | Pathogenicity of highly pathogenic avian influenza virus in mammals显示文摘 | Emmie de Wit Yoshihiro Kawaoka Menno D. de Jong Ron A.M. Fouchier | 2008 | Vaccine2008，，： | 1 |
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